2023 – XXXIX Ciclo
I candidate interessati alle linee di ricerca possono scaricare il sommario delle ricerche proposte e, ove disponibile, la presentazione Powerpoint illustrativa. Per dettagli ulteriori o per qualsiasi altra informazione, I candidate sono pregati di contattare i proponent della linea di ricerca.
Research Lines available for 1 additional fellowship Ex D.M.117/2023
Intranasal delivery of human recombinant NGF in a young-rat model of traumatic brain injury: evaluation of behavioral, molecular, biochemical and morphological outcomes.
Supervisor: Marzia Soligo (marzia.soligo@ift.cnr.it)
Tutor: Egle De Stefano (egle.destefano@uniroma1.it)
Istituzione ospitante/Host institution: Centro Nazionale delle Ricerche
Research Lines available for the Sapienza and PNRR fellowships (alphabetical order of the proponents)
a) Sapienza fellowships (5 fellowships to be awarded)
Neural stem cell properties and neurogenesis in a knock in mouse model expressing an autism-associated mutation.
Docente guida/Supervisor: Emanuele Cacci (emanuele.cacci@uniroma1.it)
Summary of the Research (download)
Microbial dynamics in the gut–lung-skin axis during Elexacaftor-Tezacaftor-Ivacaftor therapy in people with cystic fibrosis.
Docente guida/ Supervisor: Enea Di Domenico (enea.didomenico@uniroma1.it)
Summary of the Research (download)
Investigating the role of T lymphocytes and their HLA-B27-mediatedcrosstalk with chondrocytes in autoimmune Spondyloarthritis.
Docente guida: Maria Teresa Fiorillo (mariateresa.fiorillo@uniroma1.it)
Summary of the Research (download)
Impacts of pectin methylesterase activity on multiple plant-microbe interactions
Docente guida/supervisor: Vincenzo Lionetti (vincenzo.lionetti@uniroma1.it)
Summary of the Research (download)
Cellular basis of the neurodegenerative dementia FENIB
Docente guida/supervisor: Maria Elena Miranda Banos (mariaelena.mirandabanos@uniroma1.it)
Summary of the Research (download)
b) PNRR ex D.M. 118 Fellowships (3 fellowships to be awarded)
Exploiting computational models toward personalised therapeutic strategies in Pancreatic ductal adenocarcinoma
Docente guida/supervisor: Livia Perfetto (livia.perfetto@uniroma1.it)
Summary of the Research (download)
Plant tissue damage: signalling gunshots and waves for immunity
Docente guida/supervisor: Daniela Pontiggia (daniela.pontiggia@uniroma1.it)
Summary of the Research (download)
Caenorhabditis elegans: a model for the farm to fork strategy
Docente guida/supervisor: Daniela Uccelletti (daniela.uccelletti@uniroma1.it)
Summary of the Research (download)
Research lines for followships supported by external Institutions (2 fellowships to be awarded)
Effects of an obesogenic diet on human adipose tissue and evaluation of the cross-talk between adipose tissue and central nervous system
Docente guida/supervisor: Maria Antonietta Ajmone-Cat (mariaantonietta.ajmone-cat@iss.it)
Tutor: Prof. Emanuele Cacci (emanuele.cacci@uniroma1.it)
Istituzione ospitante/Host institution: Istituto Superiore di Sanità
Summary of the Research (download)
Development of 3D human brain cell models for studying the molecular pathogenesis of leukodystrophies caused by astrocyte cell dysfunction
Docente guida/supervisor: Elena Ambrosini (elena.ambrosini@iss.it)
Tutor: Egle De Stefano (egle.destefano@uniroma1.it)
Istituzione ospitante/Host institution: Istituto Superiore di Sanità
Summary of the Research (download)
Other Research Lines available for the Sapienza fellowships (alphabetical order of the proponents)
Microalgae biomass valorization in agriculture as biostimulant, bioprotector and biofertilizer
Docente guida/supervisor: Simone Ferrari (simone.ferrari@uniroma1.it)
Summary of the Research (download)
Isolation and characterization from extreme environments of microorganisms effective for carbon biomineralization.
Docente guida/supervisor: Cristina Mazzoni (cristina.mazzoni@uniroma1.it)
Summary of the Research (download)
Characterization of epigenetic mechanisms involved in the regulation of pancreaticcancer associated fibroblasts upon metabolic alterations
Docente guida/supervisor: Francesco Spallotta (francesco.spallotta@uniroma1.it)
Summary of the Research (download)
Research lines for 3 positions with no financial support by Sapienza (alphabetical order of the proponents)
Role of one-carbon metabolism factors in NAFLD severity and possible implications in cognitive impairment
Docente guida/supervisor: Anna Alisi (anna.alisi@opbg.net)
Tuotr: Marco Fidaleo (marco.fidaleo@uniroma1.it)
Istituzione ospitante/Host institution: IRCCS Ospedale Pediatrico Bambino Gesù
Summary of the Research (download)
Characterization of pre-symptomatic phases in mouse models of Rett syndrome: potential new diagnostic tools and early pharmacological interventions
Docente guida/supervisor: Bianca De Filippis (bianca.defilippis@iss.it)
Tutor: Egle De Stefano (egle.destefano@uniroma1.it)
Istituzione ospitante/Host institution: Istituto Superiore di Sanità
Summary of the Research (download)
Role of the extracellular vesicles in the development of muscle insulin resistance associated with metabolic diseases
Docente guida/supervisor: Luciana Dini (luciana.dini@uniroma1.it) / Sophie Rome (sophie.rome@univ-lyon1.fr)
Istituzione ospitante: Dip. Biologia e biotecnologie "Charles Darwin", Sapienza/ University of Lyon
Summary of the Research (download)
Aberrant chromatin-nuclear lamina interactions in stromal cells as underlying mechanism of rhabdomyosarcoma initiation
Docente guida/supervisor: Chiara Mozzetta (chiara.mozzetta@uniroma1.it)
Istituzione ospitante/Host institution: IBPM-CNR
Summary of the Research (download)
Comprehensive genomic analysis and bacterial virulence factors affecting antibiotic resistance of Klebsiella pneumoniae lineages in onco-hematological patients
Docente guida/supervisor: Fulvia Pimpinelli (fulvia.pimpinelli@ifo.it)
Tutor: Fiorentina Ascenzioni (fiorentina.ascenzioni@uniroma1.it)
Istituzione ospitante/Host institution: IRCCS S. Gallicano Institute, Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy
Summary of the Research (download)
Study of neural stem cell reactivation in mouse models of aging and with defective neurogenesis
Docente guida/supervisor: Felice Tirone (felice.tirone@cnr.it)
Tutor: Prof. Emanuele Cacci (emanuele.cacci@uniroma1.it)
Istituzione ospitante/Host institution: CNR - Institute of Biochemistry and Cell Biology
Summary of the Research (download)
Astrocytes and interleukin-9: a novel axis regulating neuroinflammation in progressive multiple sclerosis
Docente guida/supervisor: Elisabetta Volpe (e.volpe@hsantalucia.it)
Tutor: Loretta Tuosto (loretta.tuosto@uniroma1.it)
Istituzione ospitante/Host institution: Fondazione Santa Lucia
Summary of the Research (download)
-------------------------------------
2022 - XXXVIII Cycle
Candidates interested in the research lines can download the summary of the proposed research and, where available, the illustrative Power Point presentation. For further details or for any other information, candidates are requested to contact the proponents of the research line.
Research Lines available for the Sapienza and PNRR fellowships (alphabetical order of the proponents)
Yeast response to environmental factors: metabolism and regulation
Docente guida/Supervisor: Prof. Michele Bianchi (michele.bianchi@uniroma1.it)
Summary of the Research (download)
Involvement of Multidrug efflux pumps in the virulence of pathogenic E. coli
Docente guida/ Supervisor: Prof. Bianca Colonna (bianca.colonna@uniroma1.it)
Summary of the Research (download)
Cross-talk between gut microbiota and brain: effect of probiotics on behavior and function
Docente guida: Antonella De Jaco (antonella.dejaco@uniroma1.it))
Summary of the Research (download)
Analysis of the effect of CFTR modulators on the innate immune response of people with cystic fibrosis
Docente guida/supervisor: Prof. Paola Del Porto (paola.delporto@uniroma1.it)
Summary of the Research (download)
Molecular and genetic basis of the priming of defense responses in Arabidopsis thaliana
Docente guida/supervisor: Prof. Simone Ferrari (Simone.ferrari@uniroma1.it)
Summary of the Research (download)
Saccharomyces cerevisiae and Bacillus cereus group to study molecules of pharmaceutical interest.
Docente guida/supervisor: Prof. Teresa Rinaldi (Teresa.rinaldi@uniroma1.it)
Summary of the Research (download)
Interaction between M2 muscarinic receptor and β1-arrestin in human glioblastoma: implication in cell proliferation and migration
Docente guida/supervisor: Prof. Ada Maria Tata (Adamaria.Tata@uniroma1.it)
Summary of the Research (download)
BORSA PNRR CN2 Spoke 7
Bio-based conversion of agricultural waste biomasses into products for sustainable crop protection
Summary of the Research (download)
BORSA PNRR ex D.M. 351
Role of cell wall Damage-Associated Molecular Patterns in root-microbiota interaction for plant health, defense and development.
Summary of the research (download)
Other Research Lines available for the Sapienza fellowships (alphabetical order of the proponents)
Role of protein isoforms of class 5 histone demethylase (KDM5) in transcription
Docente guida/supervisor: Valerio Licursi (Valerio.licursi@uniroma1.it)
Summary of the Research (download)
Research lines for 2 positions with no financial support by Sapienza (alphabetical order of the proponents)
Targeting BCL-2 protein in combination with immunotherapy to improve melanoma treatment
Docente guida/Supervisor: Dr. Donatella Del Bufalo, UOSD Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome (donatella.delbufalo@ifo.gov.it)
Summary of the Research (download)
Studio dell’interazione di esosomi ingegnerizzati per l’espressione di antigeni tumorali con cellule dendritiche e macrofagi esprimenti il recettore del mannosio e loro ruolo nell’induzione di una risposta CTL (linfociti T citotossici)
Docente guida/Supervisor: Maria Luisa Fiani (paola.delporto@uniroma1.it)
Summary of the Research (download)
Attività di farmaci ed espressione genica in micobatteri a crescita lenta e rapida, aerobi, dormienti e persistenti
Docente guida/Supervisor: Federico Giannoni (federico.giannoni@iss.it)
Summary of the Research (download)
Il ruolo dei recettori del dominio discoidinico (DDRs) nell’invasione tumorale: una prospettiva per nuove strategie terapeutiche
Docente guida/Supervisor: Laura Rosanò (laura.rosano@cnr.it)
Summary of the Research (download)
Studio delle basi molecolari dei processi fibrotici e infiammatori nell’epidermolisi bollosa distrofica: caratterizzazione di meccanismi patogenetici e identificazione di bersagli terapeutici
Docente guida/Supervisor: Giovanna Zambruno (mauro.giorgi@uniroma1.it)
Summary of the Research (download)
--------------------------------------------------------------------------------------------------------------------------------------------------------------
2021 - XXXVII Cycle
Research Lines available for the Sapienza fellowships (alphabetical order of the proponents)
Inhibition of colistin resistance in gram-negative pathogens
Docente guida/Supervisor: Prof. Ascenzioni Fiorentina (fiorentina.ascenzioni@uniroma1.it
Summary of the Research (download)
Yeast response to environmental factors: metabolism and regulation/Risposta del lievito ai fattori ambientali: metabolismo e regolazione
Docente guida/ Supervisor: Prof. Michele M. Bianchi (michele.bianchi@uniroma1.it)
Summary of the Research (download)
The Arabidopsis Berberine Bridge Enzyme-like family in the homeostasis of cell-wall derived DAMPs during immunity and development
Docente guida/ Supervisor: Prof. Giulia De Lorenzo (giulia.delorenzo@uniroma1.it)
Summary of the Research (download)
The complex link in neuromuscular disorders: from muscles to the nervous system and viceversa
Docente guida: Maria Egle De Stefano (egle.destefano@uniroma1.it)
Summary of the Research (download)
Looking at bacterial efflux pumps as valuable targets for challenging multidrug resistance bloodstream infections in cancer patients and as potential virulence factors
Docente guida/supervisor: Prof. Milena Grossi (milena.grossi@uniroma1.it)
Summary of the Research (download)
Molecular pathways regulating neural stem cell proliferation and differentiation.
Docente guida/supervisor: Prof. Giuseppe Lupo (giuseppe.lupo@uniroma1.it)
Summary of the Research (download)
Other Research Lines available for the Sapienza fellowships (alphabetical order of the proponents)
Molecular mechanisms responsible in plants for elicitor-induced resistance to pathogens
Docente Guida/Supervisor: Prof. Simone Ferrari (simone.ferrari@uniroma1.it)
Summary of the Research (download)
Role of Vitamin B12 in neurological homeostasis and possible rescue from deficiency or metabolic defect using nanotechnology complexes
Docente guida/Supervisor: Marco Fidaleo (marco.fidaleo@uniroma1.it)
Summary of the Research (download)
Spastin-elevating approaches: new therapeutic perspectives in Hereditary Spastic Paraplegia Type 4 (SPG4-HSP)
Docente guida/Supoevisore: Prof. Cinzia Rinaldo (cinzia.rinaldo@uniroma1.it)
Summary of the Research (download)
Research lines for 2 positions with no financial support by Sapienza (alphabetical order of the proponents)
New strategies to rejuvenate immunity
Docente guida/Supervisor: Dr. Alessio Lanna (alessio.lanna@sentcell.life)
Struttura ospitante: Fondazione Santa Lucia
Summary of the Research (download)
Valutazione preclinica della somministrazione intranasale di varianti proteiche di NGF ricombinante umano per il trattamento delle lesioni cerebrali traumatiche da impatto.
Docente guida/Supervisor: Dr. Marzia Soligo (marzia.soligo@ift.cnr.it)
Struttura ospitante: Istituto di Farmacologia Traslazionale – Consiglio Nazionale delle Ricerche
Summary of the Research (download)
Il ruolo dell'acetiltransferasi ATAT-1 (alfa-tubulina N-acetiltransferasi 1) nella progressione e aggressività del tumore del polmone
Docente guida/Supervisor: Daniela Trisciuoglio (daniela.trisciuoglio@uniroma1.it)
Struttura ospitante: IBPM-CNR
Summary of the Research (download)
Research line financially supported by Merck
Supervisor in Merck: Ornella Finocchiaro- ornella.finocchiaro@merckgroup.com
Summary of the Research (download)