Non-coding RNAs: Regulators, Targets, and Therapeutics
16/12/2024
|
Ex vivo gene therapy for DMD
16/12/2024
|
The role of (lnc)RNA-protein interactions at the interface of chromatin and cancer biology
02/12/2024
Over the past two decades RNA molecules have emerged as active regulators across a
variety of biological processes. Among them, the class of long non-coding RNAs
(lncRNAs) is under the spotlight for their contribution to several cancer hallmarks.
I will introduce a newly identified chromatin-enriched lncRNA, which we named
Chromosome Segregation Regulating noncoding RNA (CHERR). CHERR is a cancer-
relevant lncRNA, and its depletion in lung cancer cells leads to the non-genetic loss of a
known tumor suppressor, ARID2, a key subunit of the SWI/SNF chromatin remodelling
complex. Our findings indicate that CHERR binds to the SWI/SNF subunits, potentially
promoting the stability of the complex. In line with this, loss of CHERR disrupts ARID2
association with chromatin.
Additionally, I’ll present our ongoing efforts to dissect RNA-protein interactions across cell
cycle stages and I’ll introduce TREX, an RNA-centric method to map endogenous RNA-
protein interactions with region resolution.
|
Sulfur metabolism, tRNA thiolation and stress adaptation
31/10/2024
|
Analysis of gene regulatory networks
29/10/2024
|
A (molecular) naturalist’s journey through Fe-S cluster biogenesis
28/10/2024
|
Applying proteomics and metabolomics to understand basic biological problems - integration of proteomics and metabolomics data
21/10/2024
|
Cellular and molecular actors of human muscle fibrosis in muscular disorders
10/09/2024
|
Understanding synaptic connectivity through protein structure and function
12/07/2024
|
Rett syndrome and beyond: molecular mechanisms and innovative therapeutic approaches
01/07/2024
|
RNA G-quadruplexes at telomeres: molecular mechanisms and biological effects of putative interactors
24/06/2024
|
The dual use research dilemma: biotechnology and bioterrorism
19/06/2024
|
Neural Mechanisms of Optimal Performance
07/06/2024
|
Centromeres and retroelements: selfish DNAs strike a deal
07/06/2024
|
A journey from distress signals in plants to biotechnology for health and energy production (‘Stress is natural’)
31/05/2024
Plant development and stress responses are regulated by complex signalling networks that mediate specific and dynamic plant responses upon activation by various types of signals. Jasmonates (JAs) mediate responses to stress and act like growth inhibitors. The latest work has identified new regulatory nodes regulating diverse plant responses to developmental and environmental cues.
In my laboratory, we are interested in discovering the cellular components linking plant stress responses to growth processes with the aim to improve yield and adaptation of plants to their environment. We also exploit the ability of JAs to induce protective specialized metabolites to develop novel functional screenings to improve the understanding of key pathways leading to the production of economically important compounds. A second research line is aimed at tailoring the composition of cell wall polymers to improve processing of biomass and the improvement of key traits to produce biomass and biofuels in microbes and plants is achieved by affecting the composition of plant cell wall polymers. A review of the state of the art and the latest results will be presented.
|
Lights from the dark matter: noncoding RNAs in neuromuscular physiology and disease
27/05/2024
|
Routes and mechanisms of membrane protein trafficking, endocytosis and turnover under the challenge of polarity
14/5/2024
In this 2nd EMBO Lecture, Prof. Daillinas will highlight how previous and ongoing studies on membrane trafficking of UapA and other transporters unravel novel routes and mechanisms of endocytosis and
translocation to the plasma membrane via Golgi-bypass. These findings present paradigmatic
shifts in our knowledge on membrane cargo trafficking in eukaryotes.
|
Structure-Function relationships in transporters: lessons from model fungal systems
13/5/2024
This EMBO lecture will present a collection of genetic, functional and biophysical findings
concerning structure-function relationships in the UapA purine transporter, a paradigmatic case
of elevator-type transporters, present in all organisms. These findings shed light on how specific
substrate recognition and transport is determined and provide hints on how the molecular
knowledge obtained can be used to genetically modify transporters. Specific
examples of fungal transporters in which cytosolic tails have acquired, through evolution, novel
functions related to control of transporter biogenesis and turnover, but also how cytosolic tails
affect transport catalysis from a distance, will be presented.
|
"Axonal transport dysfunctions in neurodegenerative diseases"
10/05/2024
|
Developing innovative host-directed therapeutic strategies against the global emergence of multidrug resistant infections
06/05/2024
|
One-step nanoscale expansion microscopy reveals protein shapes using conventional microscopes
23/04/2024
|
Therapeutic targeting of mitochondrial dynamics vulnerabilities in multiple myeloma
22/04/2024
|
The cytoskeleton regulatory protein hMENA affects the tumor immune microenvironment of lung cancer
15/04/2024
|
Functional Genomics of Microsatellite Unstable Tumors and Therapeutic Target Discovery
12/04/2024
|
Spastin recovery: opening up new therapeutic perspectives for hereditary spastic paraplegia”
25/03/2024
|
New functional connections of the plant ER
20/03/2024
|
Prediction of protein-RNA interactions from single-cell transcriptomic data
18/03/2024
|