Seminars All seminars related to the themes of Cell biology and Development organized by this PhD course, by the Genetics and Molecular Biology doctorate, by the Departments of Sapienza, by the BEMM school and by other institutions are considered valid for the training of doctoral candidates and are punctually described in the fact sheets produced da the students at the end of the year. New functional connections of the plant ER 20/03/2024 Prediction of protein-RNA interactions from single-cell transcriptomic data 18/03/2024 Spastin recovery: opening up new therapeutic perspectives for hereditary spastic paraplegia” 25/03/2024 Functional Genomics of Microsatellite Unstable Tumors and Therapeutic Target Discovery 12/04/2024 One-step nanoscale expansion microscopy reveals protein shapes using conventional microscopes 23/04/2024 Structure-Function relationships in transporters: lessons from model fungal systems 13/5/2024 This EMBO lecture will present a collection of genetic, functional and biophysical findings concerning structure-function relationships in the UapA purine transporter, a paradigmatic case of elevator-type transporters, present in all organisms. These findings shed light on how specific substrate recognition and transport is determined and provide hints on how the molecular knowledge obtained can be used to genetically modify transporters. Specific examples of fungal transporters in which cytosolic tails have acquired, through evolution, novel functions related to control of transporter biogenesis and turnover, but also how cytosolic tails affect transport catalysis from a distance, will be presented. Routes and mechanisms of membrane protein trafficking, endocytosis and turnover under the challenge of polarity 14/5/2024 In this 2nd EMBO Lecture, Prof. Daillinas will highlight how previous and ongoing studies on membrane trafficking of UapA and other transporters unravel novel routes and mechanisms of endocytosis and translocation to the plasma membrane via Golgi-bypass. These findings present paradigmatic shifts in our knowledge on membrane cargo trafficking in eukaryotes. The cytoskeleton regulatory protein hMENA affects the tumor immune microenvironment of lung cancer 15/04/2024 Therapeutic targeting of mitochondrial dynamics vulnerabilities in multiple myeloma 22/04/2024 "Axonal transport dysfunctions in neurodegenerative diseases" 10/05/2024 123456