"Modulation of the plant immune system by aphid salivary effector proteins"
24/10/2025
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Symmetry establishment during gynoecium development: the geometry of plant reproduction
15/10/2025
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Root Signals in Context: From Molecular Dialogues to Microbiome Assembly and Function
28/5/2025
Alga Zuccaro Root Signals in Context: From Molecular Dialogues to Microbiome Assembly and Function 28/5/2025 h. 9.30 Aula Pasquini, Ed. Zoologia (CU008)
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The dual use research dilemma: biotechnology and bioterrorism
21/05/2025
Mercoledì 21/05/2025 Auletta Seminari (piano interrato) Ed. Fisiologia Generale CU022
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Harnessing the Power of Plants and Green Infrastructures for Urban Renewal and Climate Action
14/5/2025
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The multifaceted role of the AcrAB efflux pump in the entomopathogenic bacterium Photorhabdus laumondii: from antibiotic resistance to beyond
28/04/2025
Ziad Abi Khattar "The multifaceted role of the AcrAB efflux pump in the entomopathogenic bacterium Photorhabdus laumondii: from antibiotic resistance to beyond" Lunedì 28 Aprile, ore 12.30 Aula "Franco Tatò" (Via dei Sardi 70, II piano)
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Plant Breeding at Enza Zaden: Focus on the Role of the Cell Biology Department
23/04/2025
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Sindrome di Rett: dalle basi biologiche alle prospettive terapeutiche
14/04/2025
Nicoletta Landsberger “Sindrome di Rett: dalle basi biologiche alle prospettive terapeutiche” 14 Aprile, ore 12.30 Aula "Franco Tatò" (Via dei Sardi 70, II piano).
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IMMUNE AND METABOLIC CONTROL OF SENSORYMOTOR FUNCTION AND REPAIR
11/04/2025
Simone di Giovanni "IMMUNE AND METABOLIC CONTROL OF SENSORYMOTOR FUNCTION AND REPAIR" 11/04/2025 11:00 am Aula La Ginestra (edificio S. Cannizzaro, CU014)
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Predicted or Not, Here They Come: Shedding Light on Domains and Their Grammar
02/04/2025
Predicting biological function from sequence and large-scale experimental data is crucial for understanding regulatory mechanisms in complex systems. However, functional annotation remains a major challenge, particularly in non-model organisms. To address this, we leverage machine learning and large-scale datasets to predict key regulatory features in biological systems. By identifying sequence-based determinants of function, we enable de novo discovery of signaling interactions and gene regulatory elements across species. These predictive models provide scalable frameworks for decoding biological complexity, offering new insights into cellular regulation. Ultimately, our approach contributes to the broader goals of systems biology and the development of data-driven strategies for understanding biological function.
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Epigenetic marks over the genome in response to environmental change
21/03/2025
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Plant Cell Wall: innate immunity and sustainable biomass valorization
20/03/2025
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Cell Wall Integrity and its Role in Apical Hook Development
19/3/2025
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The Intracellular Life of an Extracellular Pathogen: Pseudomonas aeruginosa”
10/03/2025
LUNEDI 10 Marzo 2025 ore 12.30 Aula “Franco Tatò” Via dei Sardi 70, II piano
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The unexpected lipid connection of telomeres
21/2/2025
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"Cancer cells hijack canonical signaling pathways: unexpected roles of Caspase-8"
17/02/2025
Lunedì 17 Febbraio ore 12.30 Polo San Lorenzo Aula "Franco Tatò" (Via dei Sardi 70, II piano)
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Molecular genetics of hereditary retinal diseases
17/02/2025
Monday February 17th, 2025
09:30 a.m.
Room B - Tecce
(Ed. Fisiologia generale e Antropologia CU026)
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"Neurogenetica clinica: 30 anni di esperienze, considerazioni e problemi aperti”
10/02/2025
Lunedì 10 Febbraio ore 12.30 Polo San Lorenzo Aula "Franco Tatò" (Via dei Sardi 70, II piano)
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From a danger signal to the biosynthesis of novel phenolic compounds
04/02/2025
Plant cell wall is an extracellular matrix composed of polysaccharides, polyphenols and proteins. The enzymatic hydrolysis of cell wall polysaccharides results in the production of oligosaccharides with nature of damage-associated molecular patterns (DAMPs) that are perceived by plants as danger signals1. Oligosaccharide-oxidases (OSOXs), flavoenzymes belonging to the sub-family of “berberine bridge enzyme-like proteins”, oxidize these oligosaccharides by quenching their DAMP action and concomitantly converting molecular O2 into H2O2 2-4. Here we show a novel reaction mechanism through which the oxidizing activity on short oligosaccharides, instead of producing H2O2, led to the reduction of oxidized phenols (bi- phenoquinones), highlighting a possible application of OSOXs in synthetic biology5. By combining the oxidative-polymerizing activity of metalloenzymes on simple phenolics and the reducing activity of OSOXs on bi-phenoquinones, we succeeded at synthetizing a variety of novel oligo-phenols potentially exploitable in different industrial sectors.
Keywords: plant cell wall, DAMPs, oligosaccharide oxidase, bi-phenoquinone, oligo-phenols, synthetic biology.
1 Benedetti et al., 2015. doi: 10.1073/pnas.1504154112
2 Benedetti et al., 2018. doi: 10.1111/tpj.13852
3 Locci et al., 2019. doi: 10.1111/tpj.14237
4 Costantini et al., 2024. doi: 10.1093/plphys/kiad457
5 Giovannoni et al., 2025. doi: 10.1016/j.plaphy.2024.109466
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Patient-derived organoids: powerful models for understanding molecular features and actionable vulnerabilities of human cancers
24/1/2025
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L'immunità innata vista da un botanico per caso
24/1/2025
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Seminario Prof. Marco Trizzino - 11 Aprile - Aula Seminari
11/04/2025
"Arm-race between the genome and its parasites: The contribution of transposable elements to human evo-devo"
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“The multifaceted role of the AcrAB efflux pump in the entomopathogenic bacterium Photorhabdus laumondii: from antibiotic resistance to beyond”
28/04/2025
Ziad Abi Khattar (Department of Biomedical Sciences, University of Balamand, Kalhat, Lebanon)
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Sindrome di Rett: dalle basi biologiche alle prospettive terapeutiche
14/04/2025
Nicoletta Landsberger (Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Universita' degli Studi di Milano)
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“New Human Reference Genomes for Functional Genomics”.Simona Giunta (Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza Università di Roma)
31/03/2025
Lunedì 31 Marzo, ore 12.30
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Cell Wall Integrity and its Role in Apical Hook Development
19/03/2025
Sapienza Università di Roma. Aula B, Chimica “Cannizzaro” Ed. CU014 ore 10,00
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“New Human Reference Genomes for Functional Genomics”
31/03/2025
Simona Giunta (Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza Università di Roma)
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“The Intracellular Life of an Extracellular Pathogen: Pseudomonas aeruginosa”
10/03/2025
Livia Leoni (Dipartimento di Scienze, Università Roma Tre)
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