Structure-Function relationships in transporters: lessons from model fungal systems


This EMBO lecture will present a collection of genetic, functional and biophysical findings concerning structure-function relationships in the UapA purine transporter, a paradigmatic case of elevator-type transporters, present in all organisms. These findings shed light on how specific substrate recognition and transport is determined and provide hints on how the molecular knowledge obtained can be used to genetically modify transporters. Specific examples of fungal transporters in which cytosolic tails have acquired, through evolution, novel functions related to control of transporter biogenesis and turnover, but also how cytosolic tails affect transport catalysis from a distance, will be presented.

13/5/2024

EMBO Lecture

"Structure-Function relationships in transporters: lessons from model fungal systems"

Prof. George Diallinas
Department of Biology
National and Kapodistrian University of Athens

May 13th, 2024 - 9.00-11.00 am
Aula Pasquini - Ed. Zoologia

Per info: simone.ferrari@uniroma1.it

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