The tumour suppressor protein p53, cooperated by its family members p63 and p73, has an essential role in the response to toxic injury. Somatic cells largely rely on p53 to overcome genotoxic stress and to maintain genomic integrity. Inactivation of p53 is indeed considered the “point of no return” for genomic instability. In addition to the canonical p53 control of cell cycle arrest/apoptosis, recent evidence indicates that upon cellular stress p53 coordinates highly diverse processes, such as cellular metabolism, redox homeostasis, and inter-cellular communication and interaction with the external micro‐environment. Hence, p53 is a critical factor in maintaining cellular homeostasis following a wide range of (micro)-environmental insults. I will discuss the contribution of p53 mutations to the cellular response to hypoxia, interactions with the cellular epigenome and the potential implications for acquisition of aggressive phenotype and genomic instability.
17 Aprile 2020, ore 12, online
Prof. Ivano Amelio - Università di Roma Tor Vergata, e School of Life Sciences University of Nottingham, UK
Link al seminario
https://meet.google.com/gbs-swyw-hxp