The lecture will present a collection of genetic, functional and biophysical findings
concerning structure-function relationships in the UapA purine transporter, a paradigmatic case
of elevator-type transporters, present in all organisms. These findings shed light on how specific
substrate recognition and transport is determined and provide hints on how the molecular
knowledge obtained can be used to genetically modify transporters. Specific
examples of fungal transporters in which cytosolic tails have acquired, through evolution, novel
functions related to control of transporter biogenesis and turnover, but also how cytosolic tails
affect transport catalysis from a distance, will be presented.
13/5/2024
EMBO Lecture
"Structure-Function relationships in transporters: lessons from model fungal systems"
Prof. George Diallinas
Department of Biology
National and Kapodistrian University of Athens
13 maggio 2024 9.00-11.00
Aula Pasquini - Ed. Zoologia
Per info: simone.ferrari@uniroma1.it