A journey from distress signals in plants to biotechnology for health and energy production (‘Stress is natural’)
31/05/2024
Plant development and stress responses are regulated by complex
signalling networks that mediate specific and dynamic plant
responses upon activation by various types of signals. Jasmonates
(JAs) mediate responses to stress and act like growth inhibitors.
The latest work has identified new regulatory nodes regulating
diverse plant responses to developmental and environmental cues.
In my laboratory, we are interested in discovering the cellular
components linking plant stress responses to growth processes
with the aim to improve yield and adaptation of plants to their
environment. We also exploit the ability of JAs to induce protective
specialized metabolites to develop novel functional screenings to
improve the understanding of key pathways leading to the production of economically important compounds.
A second research line is aimed at tailoring the composition of cell wall polymers to improve processing of
biomass and the improvement of key traits to produce biomass and biofuels in microbes and plants is
achieved by affecting the composition of plant cell wall polymers. A review of the state of the art and the
latest results will be presented.
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Routes and mechanisms of membrane protein trafficking, endocytosis and turnover under the challenge of polarity
14/5/2024
In this 2nd EMBO Lecture, Prof. Daillinas will highlight how previous and ongoing studies on membrane trafficking of UapA and other transporters unravel novel routes and mechanisms of endocytosis and
translocation to the plasma membrane via Golgi-bypass. These findings present paradigmatic
shifts in our knowledge on membrane cargo trafficking in eukaryotes.
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Structure-Function relationships in transporters: lessons from model fungal systems
13/5/2024
The lecture will present a collection of genetic, functional and biophysical findings
concerning structure-function relationships in the UapA purine transporter, a paradigmatic case
of elevator-type transporters, present in all organisms. These findings shed light on how specific
substrate recognition and transport is determined and provide hints on how the molecular
knowledge obtained can be used to genetically modify transporters. Specific
examples of fungal transporters in which cytosolic tails have acquired, through evolution, novel
functions related to control of transporter biogenesis and turnover, but also how cytosolic tails
affect transport catalysis from a distance, will be presented.
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One-step nanoscale expansion microscopy reveals protein shapes using conventional microscopes
23/04/2024
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Therapeutic targeting of mitochondrial dynamics vulnerabilities in multiple myeloma
22/04/2024
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The cytoskeleton regulatory protein hMENA affects the tumor immune microenvironment of lung cancer
15/04/2024
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Functional Genomics of Microsatellite Unstable Tumors and Therapeutic Target Discovery
12/04/2024
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Spastin recovery: opening up new therapeutic perspectives for hereditary spastic paraplegia
25/03/2024
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New functional connections of the plant ER
20/03/2024
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Prediction of protein-RNA interactions from single-cell transcriptomic data
18/03/2024
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