In recent years, it has become evident that metabolic alterations strongly influence the instigation and progression of many neurodegenerative disorders. Decreases in the functionality of several energy metabolism-related pathways in brain cells including glucose transport, mitochondrial electron transport, DNA repair, and neurotrophic factor signaling occur during normal aging and are further exacerbated in disorders such as Alzheimer's (AD), amyotrophic lateral sclerosis (ALS), Parkinson's (PD), and Huntington's (HD) diseases.
Detailed knowledge of biochemical mechanisms that regulate cellular metabolism and signaling is central to understand how metabolic defects translate into a pathological phenotype.
8 marzo 2019
The seminar will be held by Prof. Marzia Perluigi of the Department of Biochemical Sciences, Sapienza University of Rome, in room C (building CU010) at 12:00.