The annual reports relating to the research activity of the 1st, 2nd and 3rd year doctoral students are visible in the attachments. The annual report must be drawn up following the specimen available in the indicated section and must be sent to the Doctorate Secretariat Mrs. Angela Tilia (associazionedottorati.dsb@uniroma1.it) by 1 October.
During the FIRST YEAR OF THE COURSE, the doctoral students of the 37th cycle regularly attended the seminars (in electronic mode) and the teaching activities organized by the Teaching Body and the BeMM Doctoral School and defined the thesis project. Furthermore, they participated in courses and conferences organized, mainly, remotely. The lines of research addressed are the following: - Study of ferroxidase-permease systems involved in the transport of iron across membranes -Study of the structure-activity relationship in the Sigma 1 receptor -Biochemical characterization of the KH domains of FMRP, a protein involved in fragile X syndrome -Development and characterization of neutralizing antibodies for the treatment of COVID-19 -Biochemical characterization of bacterial metabolism of hydrogen sulphide: the case of Pseudomonas aeruginosa -3D bone bioprinting through direct differentiation of stem cells using Low Intensity Pulsed Ultrasound: study of the biological effects and pathways activated in vitro and in vivo by LIPUS. -Development of a "multi-omics" data integration platform for the inference of molecular interaction networks between pathogen and target cell -Theranostic nanosystems for the Drug Targeting of Sunitinib Maleate -Modulation of nitro-oxidative stress in eukaryotic cells: involvement of the nitric oxide signaling pathway in physio-pathological contexts compatible with the activation of inflammatory pathways -Human ferritins engineered for selective drug transport -Development of EPR methods for the study of proteins and radicals in cells
During the SECOND YEAR OF THE COURSE, the 36th cycle doctoral students regularly attended the seminars and activities organized by teaching board and the BeMM Doctoral School and continued the experimental activities relating to their thesis project. Furthermore, they participated in conferences (mainly organized remotely) relevant to their lines of research, listed below: -Structural biology for the synergistic development of innovative drugs (BIOSTRUCT-FARM) -Slippery memory: how olive oil polyphenols could spare us from neurodegeneration -Understanding the mechanisms of folding and binding of MATH and SPRY domains -The role of BVR-A in the development of brain insulin resistance -STAT3 mediated carcinogenesis and influence of organochlorine environmental pollutants on chemoresistance -Role of Gasotransmitters in energy metabolism and in bacterial resistance to nitrosative stress -In silico design and evaluation of exon skipping-inducing antisense oligonucleotides for therapeutic intervention in rare cancers -Study of the interactions between macromolecules by bio-layer interferometry and turbidimetry -The characterization of Frog Skin-derived antimicrobial peptides for the development of new anti-infective agents with expanding properties
During the THIRD YEAR OF THE COURSE, the 35th cycle doctoral students attended the lessons and seminars organized by teaching board and the BeMM Doctoral School and concluded the experimental activities relating to the thesis project. They did it to the drafting of the final thesis and all the theses were uploaded to the doctoral office website. The titles of the theses are as follows: -Structural bioinformatics analysis of the SARS-COV-2 proteome evolution to characterize the emerging variants of the virus and to suggest possible therapeutic strategies -Biocatalytic Applications of Lathyrus ccera amine oxidase -PARP-1 and Alzheimer’s disease: from molecular functions to biological outcomes in Drosophila melanogaster models -From root extract to antiarthritic facts: trip across a novel therapeutic approach to inflammation and pain -Comparison of the folding and the binding features of domains in isolation and in a multidomain construct -L-Arginine in Pseudomonas Aeruginosa controls c-di-GMP levels and biofilm formation