Ligand binding is at the basis of all biological interactions and has long been subject to theoretical and experimental investigation. The presentation reviews basic mechanisms of ligand binding, from lock and key to induced fit and conformational selection (1). A case is made for the dominance of conformational selection in biology.
1. Di Cera E. Mechanisms of ligand binding. Biophys Rev (2020) 1, 011303.
May 27, 2022
Enrico Di Cera MD
Edward A. Doisy Department of Biochemistry and Molecular Biology
Saint Louis University
School of Medicine, St. Louis, USA
enrico@slu.edu
5:00 pm
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