Non-coding RNAs: Regulators, Targets, and Therapeutics
16/12/2024
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Ex vivo gene therapy for DMD
16/12/2024
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The role of (lnc)RNA-protein interactions at the interface of chromatin and cancer biology
02/12/2024
Over the past two decades RNA molecules have emerged as active regulators across a
variety of biological processes. Among them, the class of long non-coding RNAs
(lncRNAs) is under the spotlight for their contribution to several cancer hallmarks.
I will introduce a newly identified chromatin-enriched lncRNA, which we named
Chromosome Segregation Regulating noncoding RNA (CHERR). CHERR is a cancer-
relevant lncRNA, and its depletion in lung cancer cells leads to the non-genetic loss of a
known tumor suppressor, ARID2, a key subunit of the SWI/SNF chromatin remodelling
complex. Our findings indicate that CHERR binds to the SWI/SNF subunits, potentially
promoting the stability of the complex. In line with this, loss of CHERR disrupts ARID2
association with chromatin.
Additionally, I’ll present our ongoing efforts to dissect RNA-protein interactions across cell
cycle stages and I’ll introduce TREX, an RNA-centric method to map endogenous RNA-
protein interactions with region resolution.
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Sulfur metabolism, tRNA thiolation and stress adaptation
31/10/2024
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Analysis of gene regulatory networks
29/10/2024
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A (molecular) naturalist’s journey through Fe-S cluster biogenesis
28/10/2024
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Applying proteomics and metabolomics to understand basic biological problems - integration of proteomics and metabolomics data
21/10/2024
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Cellular and molecular actors of human muscle fibrosis in muscular disorders
10/09/2024
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Understanding synaptic connectivity through protein structure and function
12/07/2024
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Rett syndrome and beyond: molecular mechanisms and innovative therapeutic approaches
01/07/2024
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