The dual use research dilemma: biotechnology and bioterrorism
21/05/2025
Mercoledì 21/05/2025 Auletta Seminari (piano interrato) Ed. Fisiologia Generale CU022
|
The Intracellular Life of an Extracellular Pathogen: Pseudomonas aeruginosa”
10/03/2025
LUNEDI 10 Marzo 2025 ore 12.30 Aula “Franco Tatò” Via dei Sardi 70, II piano
|
The unexpected lipid connection of telomeres
21/2/2025
|
"Cancer cells hijack canonical signaling pathways: unexpected roles of Caspase-8"
17/02/2025
Lunedì 17 Febbraio ore 12.30 Polo San Lorenzo Aula "Franco Tatò" (Via dei Sardi 70, II piano)
|
Molecular genetics of hereditary retinal diseases
17/02/2025
Lunedì 17 febbraio 2025
Ore 09:30
Aula B - Tecce
(Ed. Fisiologia generale e Antropologia CU026)
|
"Neurogenetica clinica: 30 anni di esperienze, considerazioni e problemi aperti”
10/02/2025
Lunedì 10 Febbraio ore 12.30 Polo San Lorenzo Aula "Franco Tatò" (Via dei Sardi 70, II piano)
|
From a danger signal to the biosynthesis of novel phenolic compounds
04/02/2025
Plant cell wall is an extracellular matrix composed of polysaccharides, polyphenols and proteins. The enzymatic hydrolysis of cell wall polysaccharides results in the production of oligosaccharides with nature of damage-associated molecular patterns (DAMPs) that are perceived by plants as danger signals1. Oligosaccharide-oxidases (OSOXs), flavoenzymes belonging to the sub-family of “berberine bridge enzyme-like proteins”, oxidize these oligosaccharides by quenching their DAMP action and concomitantly converting molecular O2 into H2O2 2-4. Here we show a novel reaction mechanism through which the oxidizing activity on short oligosaccharides, instead of producing H2O2, led to the reduction of oxidized phenols (bi- phenoquinones), highlighting a possible application of OSOXs in synthetic biology5. By combining the oxidative-polymerizing activity of metalloenzymes on simple phenolics and the reducing activity of OSOXs on bi-phenoquinones, we succeeded at synthetizing a variety of novel oligo-phenols potentially exploitable in different industrial sectors.
Keywords: plant cell wall, DAMPs, oligosaccharide oxidase, bi-phenoquinone, oligo-phenols, synthetic biology.
1 Benedetti et al., 2015. doi: 10.1073/pnas.1504154112
2 Benedetti et al., 2018. doi: 10.1111/tpj.13852
3 Locci et al., 2019. doi: 10.1111/tpj.14237
4 Costantini et al., 2024. doi: 10.1093/plphys/kiad457
5 Giovannoni et al., 2025. doi: 10.1016/j.plaphy.2024.109466
|
Patient-derived organoids: powerful models for understanding molecular features and actionable vulnerabilities of human cancers
24/1/2025
|
L'immunità innata vista da un botanico per caso
24/1/2025
|
“New Human Reference Genomes for Functional Genomics”
31/03/2025
Simona Giunta (Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza Università di Roma)
|
|