Curriculum A: Experimental and Clinical Research Metodologies in Oncological Surgery This profile aims, among other objectives, to allow the doctoral student to identify predictive prognostic factors in solid tumours mainly in GI tract, lung and gynecology tract. The treatment of neoplasias can be conditioned by prognostic factors that indicate the evolution of the disease and allow us to evaluate patient treatment. Predictive factors allow us to select those patients that have the greatest possibility of obtaining positive treatment outcomes. These factors can be determined through tumoral tissue, peripheral blood samples and other bodily liquids. Furthermore, the doctoral programme addresses the analysis and identification of gene and genetic mutations via molecular biology. In addition, doctoral students learn to evaluate and identify the oncogenic mechanisms and relative molecular targets on which to focus the target therapy. Tumour cell lines contain a range of genetic alterations; notwithstanding this complexity, their growth can be blocked by the inactivation of one or more oncogenes. This phenomenon provides a rational explanation for aimed molecular therapy. The identification of new genes involved in this process provides an important tool for the study of the development and progression of solid tumours.