Pyridoxal phosphate dependent enzymes are key metabolic enzymes whose dysfunction causes a plethora of neurological disorders and disease. On the other hand, many PLP dependent enzymes are upregulated in highly proliferating cells because of their metabolic reprogramming, and therefore they are good targets for anti-cancer therapies. The catalytic mechanism of PLP enzymes has been long studied and is well established. However, in recent years it has become increasingly clear that these enzymes have multiple roles and participate in the regulation of many different cell processes though an interplay of protein-protein and protein-nucleic acid interactions. These interactions are often induced by an order-disorder or conformational transition of the enzymes.
The seminar will review the structural results that have contributed to change our perspective on the complex conformational landscape of three PLP dependent enzymes and their regulatory mechanisms.
April, 3d 2020, 12pm online
Dr Giorgio Giardina Department of Biochemical Sciences Sapienza University of Rome
The link to the seminar
https://meet.google.com/gbs-swyw-hxp