Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Fusion and fission balance of the mitochondrial network is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. We study mitochondrial dynamics in lymphocytes physiology, and we recently highlighted their crucial role in several cell processes such as development, and proliferation, differentiation, migration, death. Interestingly, all these events are importantly involved also in T cell immune-surveillance and, in perspective, possible modulations of mitochondria morphology could open the way to future therapeutic approaches to modulate T cell response.
May 22, 2020, 12 am, online
Prof. Silvia Campello Department of Biology Tor Vergata University of Rome
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