Call for application 39th cycle

Bando ordinario (expired 22/06/2023)


Educational goals and objectives

HUMAN BIOLOGY AND MEDICAL GENETICS
The PhD in Human Biology and Medical Genetics aims to provide a high-profile preparation in integrated and highly advanced topics, including both basic research and its applicative aspects in cellular physiology, pathology and medical genetics.
The primary objective is to train young researchers by inserting them in innovative research projects of high scientific depth, encouraging them towards a rigorous, independent, critical and creative attitude. The PhD course affiliates to the BeMM PhD school (Biology and Molecular Medicine) that offer multiple interdisciplinary seminars and theoretical and practical courses. Students are strongly encouraged to participate in national and international congresses and courses, and to attend laboratories abroad to provide the skills to finalize scientific publications in highly prestigious journals.
The PhD in Human Biology and Medical Genetics is divided into two curricula: Human Biology and Medical Genetics
RESEARCH THEMES
A) Curriculum of Human Biology:
1. Study of the molecular, cellular and tissue bases of the physiopathology of the hepatic stem cell and of hepatocyte differentiation
2. Transcriptional control mediated by non-coding RNAs in hepatocyte transformation
3. Molecular basis of exosome-mediated intercellular communication
4. Translational regulation in tumorigenesis
5. Molecular biology of non-coding RNAs in human cells.
6. Study of the molecular mechanisms that regulate the autophagic process
7. Molecular and cellular basis of the tumor microenvironment in the metastasis of cancer cells
8. Organoids of normal or tumor human thyrocytes as an experimental model for the study of pathophysiology and thyroid tumorigenesis
9. Study of the molecular mechanisms that regulate chronic inflammatory processes in human diseases
10. Molecular genetics, personalized therapy and gene therapy of cystic fibrosis.
11. Epigenetics and molecular genetics of human diseases
12. DNA methylation and demethylation in the modulation of gene expression and cell differentiation in neuromuscular model systems.
13. Study of the crosstalk between platelets and leukocytes in both sterile and infectious thromboinflammatory diseases
B) Curriculum Medical Genetics:
1. Characterization of the molecular basis of mendelian diseases
2. Development and application of bioinformatics tools for genomic data analysis
3. Study of non-coding RNA-mediated mechanisms in physiological and pathological conditions
4. Oncological and oncohematological genetics
5. Pharmacogenetics/pharmacogenomics
6. Molecular and epidemiological genetics of type 2 diabetes and cardiovascular complications
7. Translational research in rare diseases: study of the metabolome, genetic determinants, identification of biomarkers and development of new therapeutic approaches.
8. The human hematopoietic/stromal stem compartment and tissue regeneration after transplantation

Specifiche economiche

Tipologia 1: DM118
Transizione digitale Generiche Pubblica Amministrazione Patrimonio culturale
0 3 0 0

Tipologia 2: DM117 Tipologia 3: PE/PNC/CN/TP Tipologia 4:Enti terzi
PE/PNC CN/TP
0 0 0 2

Tipologia 5: Sapienza Senza borsa
3 2

Tematiche, curriculum e competenze specifiche
Themes, curriculum and specific competence

C_PNRR - DM118 GENERICHE - non associata a curriculum

- Approcci innovativi nella ricerca biomedica
Ente finanziatore: PNRR
Competenze richieste: nessuna competenza specifica richiesta
- Innovative approaches in biomedical research
Founded by: PNRR
Required skills: no specific skill required

C_PNRR - DM118 GENERICHE - non associata a curriculum

- Approcci multidisciplinari per lo studio di meccanismi biologici
Ente finanziatore: PNRR
Competenze richieste: nessuna competenza specifica richiesta
- Multidisciplinary approaches to study biological mechanisms
Founded by: PNRR
Required skills: no specific skill required

C_PNRR - DM118 GENERICHE - non associata a curriculum

- Ricerca in biomedicina
Ente finanziatore: PNRR
Competenze richieste: nessuna competenza specifica richiesta
- Research in biomedicine
Founded by: PNRR
Required skills: no specific skill required

F - ENTI TERZI - non associata a curriculum

- Unravelling the role of bacterial toxins in colorectal carcinogenesis
Ente finanziatore: ISTITUTO SUPERIORE DI SANITA'
Competenze richieste: nessuna competenza specifica richiesta

F - ENTI TERZI - non associata a curriculum

- Studio della rilevanza di meccanismi di rimodellamento della forca di replicazione nei processi di chemiosensibilità e resistenza in modelli umani e tumorali
Ente finanziatore: ISTITUTO SUPERIORE DI SANITA'
Competenze richieste: nessuna competenza specifica richiesta

Il candidato sceglierà una tematica in fase di presentazione della candidatura on line


Admission Procedure

Qualifications assessment The following will be evaluated: (1) academic background, considering: master's degree, specialized degree, or single-cycle degree, ongoing degree (limited to master's degree or single-cycle degree); (2) publications; (3) scientific background, taking into account: national and international research experiences (including Erasmus), training courses, and research scholarships.

Oral interview The oral examination will consist of two parts: (1) Presentation of a research project: the candidate is required to present a project that is consistent with the research areas of the PhD program in Human Biology and Medical Genetics. The evaluation will be based on knowledge of the state of the art, originality and innovative content, clarity, and completeness of the presentation of objectives, methodologies, and potential results, feasibility of the project, relevance of the project to the educational objectives of the PhD program. It is emphasized that a written project should NOT be submitted, and the presentation does not involve the use of a computer; (2) Skills assessment: the candidate will be asked questions related to basic knowledge of cellular/molecular biology and general/medical genetics, acquired technical skills, and the ability to master them.
At the end of the oral examination, an English language proficiency test will be conducted, which will involve reading and translating a paragraph from an article in English on a topic related to the themes of the PhD program.
language ITALIANO


contacts and info Oriana D'Angelo Gargano (oriana.dangelogargano@uniroma1.it); Laura Stronati (laura.stronati@uniroma1.it);

Curriculum studiorum

Graduation date and grade of the Master's degree
detailed list of exams including completion dates and scores of Masters's degree
History of Scholarships, Research Grants (or similar)
Certificates of participation in post-graduate university courses
certificates of Participation in research groups
certificates of Participation in internships
Other University Awards/Degrees (e.g.: awards in competition, second degree)

Required documentation

§ List of publications
optional, the file must be uploaded within 22/06/2023 ore 14:00 (ora italiana)

§ Curriculum Vitae et Studiorum
mandatory, the file must be uploaded within 22/06/2023 ore 14:00 (ora italiana)

Language Skills

the candidate must know the following languages
ENGLISH

Exam Schedule

Qualifications assessment
day14/07/2023
notesnone
publication on notice boardNO
publication on the web siteYes
web sitehttps://phd.uniroma1.it/web/BIOLOGIA-UMANA-E-GENETICA-MEDICA_nD3490.aspx
date of publication14/07/2023
contactsLaura Stronati (laura.stronati@uniroma1.it)

Oral interview
day17/07/2023
notesnone
time09:00
classroomAula Magna, Istituto CSS-Mendel
addressViale Regina Margherita, 261
publication on notice boardNO
publication on the web siteYes
web sitehttps://phd.uniroma1.it/web/BIOLOGIA-UMANA-E-GENETICA-MEDICA_nD3490.aspx
date of publication18/07/2023
contactsLaura Stronati (laura.stronati@uniroma1.it)

Evaluation scale

file:visualizza il file
file (eng):visualizza il file (eng)

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