Research activity report for PhD students enrolled in the 38th cycle:
The PhD students carried out their projects consistently with the research topic agreed with the tutor, obtaining good results as demonstrated by the reports carried out during the transition of the year organized in the main hall of the Mendel Institute on 12 October 2023. Two doctoral students ( Noemi Scafa, Manuel Mangoni) have participated in funded projects (as described below).
The research lines of the doctoral students are shown below:Davide Pallucci: “On the Immunoregulatory role of Platelets in B cell activation and differentiation”;
Noemi Scafa: “Molecular mechanisms of intestinal fibrosis”, financed with funds from Progetto Ateneo Medio 2021, Sapienza University of Rome and from funds provided by Cadigroup Farmaceutici;
Carolina Figlioli: “Investigating MUS81 as a new factor affecting chemosensitivity of cancer exhibiting BRCAness”;
Manuel Mangoni: “A Machine-Learning Framework to infer Pathogenic Patterns in Dynamic Networks of Genetic Diseases”, financed with funds from the project “MITOLOGY: multi-scale simulation of the Mitochondrial Respiratory Chain subunits” (EuroHPC Regular Access Call - EHPC-REG-2023R01-129 - PRACE EU Call);
Francesca Tarani: "Genetic basis of the association between Very Early Onset-Inflammatory Bowel Disease and Primary sclerosing cholangitis in children";
Valeria Maselli: “Clinical relevance of rare autosomal aneuploidies and copy number variations (CNV) detected by Non Invasive Prenatal Testing (NIPT)”;
Giusy Russo: "The role of vitamin D in controlling esophageal inflammation in Eosinophilic Esophagitis";
Giovanni Iaquinta: “Validazione di un pannello NGS per utilizzo clinico e di ricerca nell'identificazione di varianti in campo somatico nelle neoplasie oncoematologiche di origine mieloide”.
Research activity report for PhD students enrolled in the 37th cycle:
The PhD students carried out their projects consistently with the research topic agreed with the tutor, obtaining good results as demonstrated by the reports carried out during the transition of the year organized in the main hall of the Mendel Institute on 12 October 2023. Four doctoral students ( Francesco Greco, Francesco Marocco, Alessia Fiore, Gioia Mastromoro) participated in funded projects (as described below).
The research lines of the doctoral students are shown below:
Francesco Greco: “5mC and 5hmC modification of human microRNAs: identification of writer enzymes and assessment of the effects of these epitranscriptomic modifications on microRNA activity.” funded by the Pasteur Institute Italy - Cenci Bolognetti Foundation and “SWI/SNF as a candidate modulator of YAP/TAZ transcriptional activity: implications for tumorigenesis and tissue regeneration” funded with PRIN 2017 funds (prot. 2017JWZKP2);
Francesco Marocco: “Role of RNA binding proteins in the sequence specific miRNA partition between cell and extracellular vescicles” funded by AIRC;
Alessia Fiore: “Analisi in vitro ed in vivo del potenziale cancerogenico della tossina CNF1” project Memorandum of understanding IARC-ISS:
Luiza Diniz Ferreira Borges : “Expression of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Forkhead Box I1 (FOXI1) in nasal brushing, in conditionally reprogramed stem cells (CRC) and in Air-Liquid Interface (ALI) cultured cells derived from nasal epithelial cells”;
Gioia Mastromoro: “Molecular mechanisms and phenotypic correlations of Mosaic Neurofibromatosis type 1” funded by projects "Advanced Molecular Diagnostics in fetal fluid collections" (protocol N. AR1221816BEE7A68) and "Mosaic Neurofibromatosis type 1: can deep-sequencing of genomic DNA avoid biopsy to obtain a molecular diagnosis?" (protocol N. AR123188B17AEBF7);
Martina Bartolone: “I difetti cardiaci congeniti da anomalie della settazione: analisi delle caratteristiche e correlazione genetica".
Research activity report for PhD students enrolled in the 36th cycle:
Third year PhD students participated in funded research projects (Sara Lazzari) and won projects such as PI (Salvatore Bianco).
The research lines of the doctoral students are shown below:
Veronica Consalvi: “Characterization of Transcriptional Complexes Enrolled by Yes-Associated Protein (YAP) in Liver Cells and Their Regulation by ERK5/MAPK”;
Tiziana Raja : “DNA methylation-dependent miR-29a regulation contributes to the amyloidogenic processing”;
Mattia Colucci: “The functional role of EZH2 inactivation in the pathogenesis of HOXA-overexpressing T-cell acute lymphoblastic leukemia”;
Sara Lazzari: winner of the project Ateneo 2022 (Avvio alla ricerca) “The role of non-coding DNA in human diseases: from disease-causing elements to phenotype modifiers”. Participant in the research activities of the Ateneo 2020 project “Clinical and molecular study of GLUT1 related phenotypes: functional studies and new genotype-phenotype correlations”;
Salvatore Bianco, winner of the call: "Call for funding for periods of mobility abroad of PhD students". Participant in the research activities of the project "Development of computational models of gene-specific pathogenicity" financed by the Ministry of Health, 5 per thousand funds (2022-2024). Participant in the research activities of the “SPONGE” project funded by Instruct-ERIC.