29/05/2025
May 29, 2025 at 5.00 pm
Prof. Antonio Sica, Professor of General Pathology and Immunology at the Department of Pharmacological Sciences (DsF) of the University of Piedmont and Director of the Laboratory of Molecular Immunology at the Humanitas Clinical Institute in Rozzano, Milan
Emerging immunometabolic dysfunctions in cancer and relevance for antitumor therapy
Tumors promote immunometabolic stresses that induce alterations in myelopoietic production, termed emergency myelopoiesis, leading to the generation of specialized myeloid populations with pro-tumor activity. New evidence indicates that the acquisition of this myeloid phenotype is the result of a multistep process, including initial events originating in the bone marrow and subsequent steps operating in the tumor microenvironment, which together influence the immune context and antitumor immunity. On this background, I will discuss emerging metabolic pathways of functional diversion of myeloid cells, causing immune dysfunction and limiting therapeutic responses.
The lecture will be through remote participation and conducted virtually using the platform AIRC Science Seminars (https://scienceseminars.airc.it/it/login.html)
If you are not registered yet please sign up now at AIRC Science Seminars Registration in order to attend the lectures (https://scienceseminars.airc.it/it/register.html)