The pivotal role of functional biochemistry in Precision medicine.

The number of people aged 65 years or more in the EU is expected to grow from around 84 million in 2008 to around 141 million by 2050 and they will account for 28.7% of the EU-28’s population by 2080. Italy is in second place in Europe by old age index, with strong consequences on health care system, due to the high number of chronically ill people. There is an urgent need for implementation in standard clinical practice of novel methods to ensure efficacy and safety of polypharmacy in the elderly. Precision Medicine (PM) represent a patient-centered model of health care, based on preemptive and monitoring strategies developed in the last decade thanks to the availability of novel cost-effective technologies to achieve deep molecular characterization of both patients and diseases. The striking impact of the proposed strategy derives by the system-level character of the project, intended to integrate a novel model of healthcare in an Italian National Health System (INHS) structure, that is the academic hospital Sant’Andrea of Rome. Such unique setting allow to integrate sophisticated preventive and monitoring strategies in the usual clinical workflow. The data constitute a proof-of-principle concerning the effectiveness of integration of PM in current clinical practice to improve adherence to therapies and clinical outcomes and is expected to provide evidence that translation of PM into the INHS is indeed actionable.

17/05/2024 Prof. Maurizio Simmaco Dipartimento di Neuroscienze, Salute mentale ed Organi di senso, Università Sapienza

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