Call for application 41st cycle

Bando ordinario


Educational goals and objectives

MOLECULAR MEDICINE
The objectives of the PhD in Molecular Medicine are:
1. train researchers capable of carrying out bio-medical research projects with technologically advanced operating methods in the field of pathophysiological, diagnostic, prognostic, predictive and preventive medicine and molecular therapy, through an educational program and the implementation of research projects that aim to understand and transfer to the clinic the genetic/molecular bases of diseases, the use of genetic/molecular tools and procedures for the diagnosis and cure of pathological states;
2. to encourage the exploitation and investment of the entrepreneurial sectors of the emerging biotechnology industry and advanced translational biomedical research.

The educational project is divided into three curricula:
1) Molecular Medicine
2) Molecular Pathology and Physiopathology
3) Endocrine-Metabolic Pathophysiology
PhD students participate in theoretical-practical courses and seminars. Each PhD student will be entrusted with a research project to be carried out at one of the laboratories associated with the PhD program. Annually, PhD students will be evaluated through the preparation of a written draft and the discussion of a presentation with members of the PhD Board and the scientific staff.
PhD students can complete their training in a foreign laboratory. The course will end with the presentation of the results in the form of a written thesis and discussed/defended in a seminar open to the public.
Specific training objectives concern the following areas:
1) Genetic diseases and genome analysis techniques, with reference to hereditary cancer syndromes;
2) Signal transduction pathways and biochemical methods of analysis;
3) Modifications of gene expression in pathological conditions and methods for studying gene expression;
4) Modifications of the proteome, post-translation modifications and protein-protein interactions, protein stability and degradation in physiological and pathological conditions and related methods of analysis;
5) Tumor-host interactions, inflammation and immunity in neoplastic development and progression;
6) bioinformatics and biostatistic analyses applied to oncology;
7) Endocrine and metabolic pathologies, aberrations of cellular and bioenergetic metabolism associated with human disease and related methods of investigation;
8) Genetic, molecular and pathophysiological heterogeneity of autoimmune diabetes;
9) Development and analysis of cell models, organoid and 3D cultures;
10) Development and analysis of animal models; genome editing methodologies (i.e. CrispR / Cas9);
11) Development and use of vectors and methods for gene transfer, gene therapy approaches, also based on RNA.
12) Prognostic and predictive genetic profiles of efficacy for target therapies, liquid biopsy (cells, nucleic acids and circulating vesicles), with reference to cancer.
(more details at https://phd.uniroma1.it/web/MEDICINA-MOLECOLARE_nD3521_IT.aspx)

Specifiche economiche


Sapienza Scholarships Other Scholarships Departments Without scholarship
10 2 1 4

Themes, curriculum and specific competence



Borse ENTI TERZI, PARTENARIATI ESTESI, ECCELLENZA

Tematica: Oncologia molecolare e microambiente tumorale
Ente finanziatore: DIPARTIMENTO DI MEDICINA MOLECOLARE
Competenze richieste: nessuna competenza specifica richiesta

Tematica: FIS2 - Fisiopatologia e processi diagnostico-terapeutici del diabete mellito e delle sue complicanze croniche, con particolare riferimento alle complicanze periodontali - progetto FIS 2: “Systematic multidisciplinary approach for remote telemedicine (SMART): A new frontier to promote effective healthcare in type I diabetes and periodontitis patients”
Sul curriculum: FISIOPATOLOGIA ENDOCRINO-METABOLICA

Ente finanziatore: DIPARTIMENTO DI SCIENZE ODONTOSTOMATOLOGICHE E MAXILLO FACCIALI
Competenze richieste: nessuna competenza specifica richiesta

Tematica: FIS2- Studio delle basi molecolari delle alterazioni metaboliche delle complicanze multi-organo del diabete mellito, con particolare riferimento alle complicanze periodontali e sviluppo di conoscenze in tema di intelligenza artificiale a supporto della ricerca biomedica e di diagnostica digitale - progetto FIS 2: “Systematic multidisciplinary approach for remote telemedicine (SMART): A new frontier to promote effective healthcare in type I diabetes and periodontitis patients”
Sul curriculum: FISIOPATOLOGIA ENDOCRINO-METABOLICA

Ente finanziatore: DIPARTIMENTO DI SCIENZE ODONTOSTOMATOLOGICHE E MAXILLO FACCIALI
Competenze richieste: nessuna competenza specifica richiesta


Admission Procedure

Submission of a Research Prorject For the purposes of the selection process, it is MANDATORY to submit a RESEARCH PROJECT, written IN ENGLISH. Upload of the research project must occur before the application deadline.
The proposal should highlight the candidate's propensity for research and his/her ability to independently plan and organize the different phases of a research plan.
The project must be written IN ENGLISH according to the following scheme:
- Title;
- General purpose and aims of the project;
- Experimental procedures; - References.
The project must not exceed the maximum length of 8000 characters (including spaces).
For admitted candidates, the project presented for the selection does not bind them or the Doctorate to carrying out the same research activity in any way.

Candidates who obtained at least 40/60 in the project evaluation are admitted to the oral exam.
language INGLESE
Oral interview The ORAL EXAMINATION will include a discussion of the research project submitted by the candidate and discussion on the main topics of the PhD program. The candidate can opt for a discussion in English.

The minimum positive score for the oral test is 40/60.
language ITALIANO

contacts and info EMAIL: dottorato.medicinamolecolare@uniroma1.it; Tel. Number: 0649255123; PhD Link: https://phd.uniroma1.it/web/MEDICINA- MOLECOLARE_nD3521_IT.aspx
more info The RESEARCH PROPOSAL must be written in english and mast be uploaded by the application deadline.
On candidate choice, the oral exam can be taken in english and include a brief evaluation on the language skills.

Curriculum studiorum

Graduation date and grade of the Master's degree
detailed list of exams including completion dates and scores of Masters's degree
Graduation date and grade of the Bachelor’s degree
History of Scholarships, Research Grants (or similar)
Certificates of Foreign Languages
Certificates of participation in post-graduate university courses
Computer skills

Required documentation

§ research project
mandatory, the file must be uploaded within le ore 23:59 del 19/06/2025
§ List of publications
optional, the file must be uploaded within le ore 23:59 del 19/06/2025
§ letter of motivation (by the candidate)
optional, the file must be uploaded within le ore 23:59 del 19/06/2025

Language Skills

the candidate must know the following languages
ENGLISH

Exam Schedule

Altra tipologia (Submission of a Research Prorject)
day01/07/2025
notesnone
time99:99
classroomnon richiesto
addressnon richiesto
publication on notice boardNO
publication on the web siteYes
web sitehttps://phd.uniroma1.it/web/MEDICINA-MOLECOLARE_nD3521_IT.aspx
date of publication08/07/2025
contacts0649255123

Oral interview
day15/07/2025
notesnone
time09:30
classroomaula 201 al II piano dell'Edificio D Regina Elena, Viale Regina Elena, 295 - Roma
addressEdificio D, Viale Regina Elena, 295 - Roma
publication on notice boardNO
publication on the web siteYes
web sitehttps://phd.uniroma1.it/web/MEDICINA-MOLECOLARE_nD3521_IT.aspx
date of publication15/07/2025
contacts 0649255123


Evaluation scale

Altra tipologia (Submission of a Research Prorject)

Altra tipologia

Presentazione di un Progetto di Ricerca
Submission of a Research Prorject

Punteggio massimo complessivo per la prova/overall max score: 60

Capacità di sintesi, chiarezza nella stesura e conoscenza della letteratura
Ability to summarize, clarity in writing and knowledge of the literature

Punteggio massimo/max score: 20

Fattibilità del progetto e sua pertinenza con gli obiettivi formativi del Dottorato
Feasibility of the project and its relevance to the educational objectives of the Doctorate

Punteggio massimo/max score: 20

Originalità e contenuto innovativo
Originality and innovative content

Punteggio massimo/max score: 20
Oral interview

Prova orale

Punteggio massimo complessivo per la prova/overall max score: 60

Valutazione competenza lingua inglese: si/no
Evaluation language competence: yes/no

Punteggio massimo/max score: 0

Discussione sulle tematiche oggetto del Programma di Dottorato
Discussion on the topics covered by the Doctoral Program

Punteggio massimo/max score: 20

Chiarezza espositiva, capacità di sintesi e terminologia scientifica appropriata
Clarity of presentation, ability to synthesize and appropriate scientific terminology

Punteggio massimo/max score: 15

Discussione e valutazione del progetto di ricerca proposto
Discussion and evaluation of the proposed research project

Punteggio massimo/max score: 25
Finanziato dal Fondo italiano per la scienza - Bando FIS

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