Annual report, as per accreditation report
38 ciclo
All the PhD students of the PhD in Molecular Medicine carried out intense research activity on various project lines, listed below.
In some cases, PhD students also presented the results of their research as posters or oral presentations at national and/or international conferences. Some examples are listed below.
Finally, we report some publications resulting from the collaboration of PhD students and/or more relevant publications (Impact factor≥8).
RESEARCH PROJECTS
- Il citoscheletro nella regolazione della via del segnale di Hedgehog e nel medulloblastoma Hedgehog-dipendente: studio del ruolo della formina invertita 2, INF2.
- Riprogrammazione metabolica e terapia antitumorale: individuazione structure-based di nuove molecole inibitorie dell’enzima lattato deidrogenasi (LDH)
- Ruolo della riprogrammazione epigenetica mediata dal microbiota nella tumorigenesi intestinale
- Applicazioni della biopsia liquida all'oncologia di precisione per i tumori solidi: colture 3D da cellule tumorali circolanti e sviluppo di test multi-analita su sangue ed altri fluidi corporei.
- Micrometastasi linfonodali in HNSCC: profilo molecolare dei linfonodi istologicamente negativi per finalità prognostiche e terapeutiche
- i sistemi shuttle del NADH come bersaglio terapeutico nel cancro del colon-retto
- Studio sulla correlazione tra esposizione al fumo di sigaretta ed alcol in gravidanza e possibile disregolazione della sintesi e del rilascio di neurotrofine, implicate nei meccanismi di placentazione e di neurosviluppo fetale.
- Applicazione di una CRISPR-Cas9 Library per identificare microRNA come sensibilizzatori alla terapia in linee cellulari di Glioma
- Punteggio di rischio poligenico nelle cardiomiopatie e nella patologia neoplastica della mammella
- Humanina e Sirtuine come nuovi potenziali biomarkers della disfunzione dei miociti
- L’inibizione di EZH2 ripristina il programma oncosoppressivo di Notch nel cancro della cervice e nella leucemia mieloide acuta
- Analisi HPLC/MS di ormoni steroidei in differenti matrici biologiche (sangue, urine, saliva e culture cellulari ovariche)
- Studio della via di segnalazione di Notch1 in risposta all'attivazione del G2 damage checkpoint nella leucemia linfoblastica acuta a cellule T
- Studio del ruolo della via segnalazione di Hedgehog e del suo modulatore negativo KCASH2 nella carcinogenesi del colon nel topo
- Studio di una signature di miRNA come biomarcatori prognostici per decifrare la biologia del linfoma diffuso a grandi cellule B recidivo/refrattario (R/R DLBCL) per il miglioramento delle decisioni terapeutiche
- Farmaci anti-BCL-2 nel trattamento della Leucemia Linfoblastica Acuta a cellule T Notch-dipendente
(ORAL OR POSTER) PRESENTATIONS To Scientific Conferences held by PhD Students
ADABBO
The cytoskeleton regulator inverted formin INF2 regulates the SHH pathway and is involved in medulloblastoma tumorigenesis .Poster presentation. BraYn 6th Research Assembly for Young Neuroscientists- Napoli, Italy (27-29 Sept.2023).
DELLA ROCCA
- SELECTIVE TARGETING OF REDOX ALTERATIONS IN MEDULLOBLASTOMA TUMORS THROUGH NANOTECHNOLOGY BASED DELIVERY SYSTEMS" Poster presentation. MOLECULAR PATHOLOGY: FROM BENCH TO BEDSIDE SIPMeT Young Scientist Meeting, Parma (Italia) Settembre 2023.
DE MEO
- Genomic landscape and survival analysis of ctDNA “neo-RAS wild-type” patients with originally RAS mutant metastatic colorectal cancer. Oral Presentation. 6th Advances in Circulating Tumor Cells: “Liquid Biopsy and Precision Oncology: Where do we stand now?" 20/09/2023 – 23/09/2023 – Skiathos Island, Greece
- Expansion and culture of circulating tumor cells in vitro as a clinical and preclinical tool in precision oncology. Oral Presentation. "ECCELLENZA DEL FUTURO: TRA SALUTE, NUOVI MODELLI E NUOVE TECNOLOGIE". 20/05/2023 – Policlinico Umberto I, Roma
DI GIULIANI
A diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TSK5modulation in human gliomas" Oral presentation. Alleanza contro il cancro (ACC) "New technologies and strategies to fight cancer"; 21-23 settembre 2022 presso Policlinico Gemelli Roma;
EL HACHMI
- Genetic And Molecular Dissection of Breast Cancer By ‘Omics’: Toward Personalized Medicine. Oral Presentation. - Introduzione alla Genetica Moderna - 16.05.2023, Université Alger (Algeria), Facoltà di Medicina
- Pregnancy in Women with vEDS: Recurrence Risk, Maternal Morbidity, Prenatal Diagnosis, Mode of Delivery, and Vascular Surveillance. Oral Presentation. - Giornata Nazionale Francese Malattie Arteriali Rare (CRMR: Maladies Artérielles Rares) - 15.06.2023, Parigi, Hopital Georges Pompidou
- Oncogenetics and Lynch Syndrome: From Genetic Counseling to Genetic Testing and Personalized Clinical Management: Toward Personalized Medicine & Gender Medicine in Oncology. Oral Presentation. - Congresso Nazionale Malattie EredoFamiliari e Varianti Germinali in OncoEmatologia. - 23/09/2023, Perugia, Facoltà di Medicina e Chirurgia
- Étude de la mortalité maternelle dans le syndrome vasculaire d'Ehlers-Danlos (vEDS) dans une cohorte française. Poster presentation - 10.01.2024 Assise génétique, Parigi
- Identification des altérations des Copy Number Variation (CNV) chez les patients atteints de cancer colorectal héréditaire sans polypose (HNPCC). Poster presentation - 10.01.2024 Assise génétique, Parigi
Syndrome d’Ehlers-Danlos Vasculaire et Complications Obstétricales. Poster presentation - 10.01.2024 Assise génétique, Parigi
PACE
- Targeting EZH2 activates Notch signaling in cervical cancer and acute myeloid leukemia. Poster presentation. SIPMet Young Scientist Meeting 2023 “General Pathology: the trunk of the tree of medicine”, Parma 22-23 Settembre
- The Histone Methyltransferase EZH2 Suppresses Notch Signaling in Cervical Cancer and Acute Myeloid Leukemia. Poster presentation. The Notch Meeting XII, Atene 1 – 5 Ottobre 2023
SIMEONE
Role of Notch signaling pathway in G2 damage checkpoint in T-cell acute lymphoblastic leukemia (T-ALL)”, Oral presentation, “The Notch Meeting XII”, New Benaki Museum, Athens, Greece, 1-5 October 2023.
VARI
- Different genome-wide approaches to identify microRNAs related to DLBCL resistance to immune-chemotherapy. Poster presentation. 50° Congresso Nazionale Società Italiana Ematologia (SIE), 23-25 ottobre 2023, Marriott Park Hotel, Roma
- Different genome-wide approaches to identify microRNAs related to DLBCL resistance to immune-chemotherapy. Presentation 50° CONGRESSO NAZIONALE SIE. Roma 23-25 ottobre 2023
VARRICCHIO
- Hyperactive Notch3 derails CXCR4-dependent maturation of DN thymocytes to sustain T-cell Acute Lymphoblastic Leukemia progression. Poster presentation. SIPMeT 2022 - General pathology: the trunk of the tree of medicine, Data: 22/09/2023 - 23/09/2023 – Parma.
- The role of the microRNAs in CXCR4-dependent maturation of thymocytes in a Notch3-induced Acute Lymphoblastic Leukemia model. Poster presentation. 1st Epigenetics Society (ES) International Meeting: Epigenetics of Disease and Development; Data: 12/10/2023 - 14/10/2023; Roma.
PAPERS INVOLVING COLLABORATION BETWEEN PHD STUDENTS AND /OR WITH IF≥8
- Occhicone, Agostino; Sinibaldi, Alberto; Chiappetta, Daniele; Di Matteo, Paola; Pileri, Tommaso; DE PASCALE, VALENTINA; Michelotti, Francesco. Detection of anti-SARS CoV-2 antibodies in human serum by means of Bloch surface waves on 1D photonic crystal biochips. BIOSENSORS AND BIOELECTRONICS. Volume 15, December 2023, 100413.
- Quaglio D, Infante P, Cammarone S, Lamelza L, CONENNA M, Ghirga F, ADABBO G, Pisano L, Di Marcotullio L, Botta B, Mori M. Exploring the Potential of Anthraquinone-Based Hybrids for Identifying a Novel Generation of Antagonists for the Smoothened Receptor in HH-Dependent Tumour. Chemistry. 2023 Nov 8;29(62):e202302237. doi: 10.1002/chem.202302237.
- Sandesh Kumar Patel, Nadezda Zhdanovskaya, ILARIA SERGIO, Antonella Cardinale, MARCO ROSICHINI, CLAUDIA VARRICCHIO, ELEONORA PACE, Carlo Capalbo, Franco Locatelli, Alberto Macone, Enrico Velardi, Rocco Palermo and Maria Pia Felli. Thymic-Epithelial-Cell-Dependent Microenvironment Influences Proliferation and Apoptosis of Leukemic Cells”. International Journal of Molecular Sciences. 2024
- Díaz Méndez AB, Sacconi A, Tremante E, Lulli V, Caprara V, Rosanò L, Goeman F, Carosi M, DI GIULIANI M, VARI G, Silvani A, Pollo B, Garufi C, Ramponi S, Simonetti G, Ciusani E, Mandoj C, Scalera S, Villani V, Po A, Ferretti E, Regazzo G, Rizzo MG. A diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas. J Exp Clin Cancer Res. 2023 Mar 17;42(1):66. doi: 10.1186/s13046-023-02639-8.
- Masci D, Puxeddu M, Di Magno L, D'Ambrosio M, Parisi A, Nalli M, Bai R, Coluccia A, Sciò P, Orlando V, D'Angelo S, Biagioni S, Urbani A, Hamel E, Nocentini A, Filiberti S, Turati M, Ronca R, Kopecka J, Riganti C, Fionda C, Bordone R, DELLA ROCCA G, Canettieri G, Supuran CT, Silvestri R, La Regina G. 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells. J Med Chem. 2023 Nov 9;66(21):14824-14842. doi: 10.1021/acs.jmedchem.3c01424.
- Coni S, Bordone R, IVY DM, Yurtsever ZN, Di Magno L, D'AMICO R, Cesaro B, Fatica A, Belardinilli F, Bufalieri F, Maroder M, De Smaele E, Di Marcotullio L, Giannini G, Agostinelli E, Canettieri G.
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation. Cancer Lett. 2023 Apr 10;559:216120. doi: 10.1016/j.canlet.2023.216120.
37 ciclo
All the PhD students of the PhD in Molecular Medicine carried out intense research activity on various project lines, listed below.
In some cases, PhD students also presented the results of their research as posters or oral presentations at national and/or international conferences. Some examples are listed below.
Finally, we report some publications resulting from the collaboration of PhD students and/or more relevant publications (Impact factor≥8).
RESEARCH PROJECTS
- Caratterizzazione immuno-metabolica e fenotipica del diabete autoimmune e sue conseguenze.
- Targeted therapies for malignant mesothelioma.
- Role of KCash2 in neurogenesis in central nervous system.
- Role of NBS1 in cerebellar development and carcinogenesis.
- Using Crispr-Cas9 technology to investigate the role of NBS1 mutations on ciliogenesis as a model for the Nijmegen Breakage Syndrome.
- Matched germline and tumor profiling in male breast cancer patients
- Caratterizzazione morfologica e molecolare di organoidi di carcinoma mammario in seguito al trattamento con modulatori di sirtuine.
- Molecular dissection of Notch3-Pin1 cross-talk to overcome platinum resistance in ovarian cancer.
- Dissecting the role of the Cullin3-Ren/Kctd11 E3 ubiquitin ligase complex in the control of the hedgehog pathway and medulloblastoma tumorigenesis. - Characterization of Pik3γ inhibition in macrophages and tumour immune infiltrate mediated by Men1611.
- New strategies to reprogram immunosenescence.
- Targeting redox alterations and sensors in colorectal cancer.
- Identificazione di nuove strategie per la rigenerazione timica.
- The role of cGas/Sting pathway in MYCN-driven neuroblastoma.
- The role of the microRNAs in Cxcr4-dependent maturation of thymocytes in a Notch3-induced acute lymphoblastic leukemia.
(ORAL OR POSTER) PRESENTATIONS To Scientific Conferences held by PhD Students
AMENDOLARA
Higher levels of autoantibodies directed against IFN-alpha in latent autoimmune diabetes in adults compared to type 1 diabetes. Oral Presentation 59° Congresso annuale della Società Europea di Diabetologia (EASD), Amburgo, Germania, 2-6 Ottobre 2023.
APOSTOLICO
- KCASH2ko mouse model: a tool to study the Hedgehog pathway. Poster presentation. SIPMeT, General Pathology: the trunk of the tree of medicine. Parma dal 22/09/23 al 23/09/23.
AUGUSTO
- A new role of NBS1 in the regulation of primary cilium. Poster Presentation. 5th Brainstorming research assembly for young neuroscientists. Rome 28-29-30 Settembre 2022.
- A new function of MRN complex in the regulation of primary ciliogenesis. Poster Presentation. ABCD National Congress 2023- (Paestum, Salerno 20-23 Settembre 2023).
BATTAGLINI
A new role of Nijmegen Breakage Syndrome gene in neuronal development. Poster Presentation. 5th Brainstorming research assembly for young neuroscientists (Rome 28-29-30 Settembre 2022).
CONTI
Improving gender-specific breast cancer precision prevention: genetic risk assessment using multi-gene panel testing in male breast cancer. POSTER presentation a Società Italiana di Patologia e Medicina Traslazionale (SIPMeT), 2022, Ancona, 22-24 Settembre 2022.
NATIELLO
- Uncovering the molecular mechanism governing PIN1-WWP2 antagonistic interplay on Notch3 on Ovarian Cancer". Poster presenation -ABCD 2023 - The Biennial Congress of Cell Biology and Differentiation tenutosi a Paestum dal 20 al 21 settembre.
- Uncovering the molecular mechanism governing PIN1-WWP2 antagonistic interplay on Notch3 on Ovarian Cancer. Poster presentation - The Notch meeting XII 2023, Atene dall'1 al 5 ottobre.
NAVACCI
- SALL4 is CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma - Flash oral presentation and poster. XVI FISV Congress, 3R: Research, Resilience and Reprise - Italy (14-16 Sept 2022)
- SALL4 is CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma – poster presentation. SIPMeT Congress 2022 "PATHOPHYSIOLOGY OF DISEASE" - Ancona, 22-24 September 2022
- SALL4 is CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma – poster presentation. SIrteps 3rd Meeting: Precision Medicine in the Era of Integrated Omics – Favignana, Trapani, Italy (17-20 May 2023)
- SALL4 is CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma – poster presentation. National ABCD PhD Meeting and National Congress – Paestum, Salerno, Italy (20-23 Sept 2023). ABCD Travel Grant for ABCD National Congress 2023 (ABCD Scientific Committee)
- SALL4 is CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma – poster presentation. 35th AICCInternational Meeting 2023 – L’Aquila, Italy (04-06 Dec 2023). Best Poster Award by Journal of Experimental and Clinical Cancer Research (AICC Congress 2023)
RIPA
-:Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment. Poster presentation. Molecular pathology: from bench to bedside- SIPMeT Young Scientist. Ancona (Italia) Settembre 2022.
- Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment’
ROSICHINI
- The impairment of thymic function observed in COVID-19 patients correlates with disease severity. Oral presentation. SIICA 2022 23-26/05/2022;
- NOVEL MECHANISMS REGULATING IMMUNE RECOVERY FOLLOWING HAEMATOLOGICAL INSULTS. Poster presentation. SIICA PhD retreat 2022, 15-17/09/2022;
PEDIATRIC BRAIN TUMOR PATIENTS DISPLAY REDUCED T AND B LYMPHOPOIESIS AT THE ONSET OF DISEASE. Poster presentation AIEOP 2023, 2-4/10/2023.
RULLO
-Repression of the STING pathway by MYCN contributes to the cold immunophenotype of MYCN-driven tumors- Poster presentation. al Congresso Immune Responses & DNA Repair - Cancer Fields Converging EACR-AACR -SIC, Firenze, 15-17 marzo 2023
- Exploiting the STING pathway for the therapy of MYCN amplified neuroblastoma”. Presentazione di poster al Young Scientists Meeting 2023 GENERAL PATHOLOGY: THE TRUNK OF THETREE OF MEDICINE Parma 22nd - 23rd September 2023
SERGIO
Ho partecipato ai seguenti convegni:
- Notch3 deregulates CXCR4 expression in immature thymocytes to sustain Acute Lymphoblastic Leukemia progression. Poster presentation “EACR 2022 Congress Siviglia,P1-436; Data: 20-23/06/22
- Notch3 deregulates CXCR4 expression in immature thymocytes to sustain Acute Lymphoblastic Leukemia progression. Poster presentation. The Notch Meeting” congress in Athens,Data: 01-05/10/23.
TERRIACA
- SMURF proteins are negative modulators of the Hedgehog pathway. Poster presentation. ABCD 2023 National Congress, Paestum, Salerno, Italy (20-23 Sept 2023).
PAPERS INVOLVING COLLABORATION BETWEEN PHD STUDENTS AND /OR WITH IF≥8
- D'Onofrio L, Fogolari M, AMENDOLARA R, Siena A, De Fata R, Davini F, Coraggio L, Mignogna C, Moretti C, Maddaloni E, Angeletti S, Buzzetti R. Reduced early response to SARS-CoV2 vaccination in people with type 1 and type 2 diabetes, a 6 months follow-up study: The CoVaDiab study I. Diabetes Metab Res Rev. 2023 Mar;39(3):e3601. doi: 10.1002/dmrr.3601. Epub 2022 Dec 27. PMID: 36533777; PMCID: PMC9877797.
- D'Onofrio L, AMENDOLARA R (co-primo), MIGNOGNA C, Leto G, Tartaglione L, Mazzaferro S, Maddaloni E, Buzzetti R. Lack of Association between Serum Chitotriosidase Activity and Arterial Stiffness in Type 2 Diabetes without Cardiovascular Complications. Int J Mol Sci. 2023 Oct 31;24(21):15809. doi: 10.3390/ijms242115809. PMID: 37958794; PMCID: PMC10648693.
- Maddaloni E, Coraggio L, Amendolara R, Baroni MG, Cavallo MG, Copetti M, Cossu E, D'Angelo P, D'Onofrio L, Cosmo S, Leonetti F, Morano S, Morviducci L, Napoli N, Prudente S, Pugliese G, Park K, Holman RR, Trischitta V, Buzzetti R; SUMMER Study in Diabetes Group. Association of osteocalcin, osteoprotegerin, and osteopontin with cardiovascular disease and retinopathy in type 2 diabetes. Diabetes Metab Res Rev. 2023 Jul;39(5):e3632. doi: 10.1002/dmrr.3632. Epub 2023 Mar 20. PMID: 36880127.
- Petroni M, La Monica V, Fabretti F, AUGUSTO M, BATTAGLINI D, POLONARA F, Di Giulio S, Giannini G. The Multiple faces of MRN complex: Roles in Medulloblastoma and Beyond. Cancers (Basel). 2023 July 13;15 (14):3599
- Valentini V, Bucalo A, CONTI G, Celli L,PORZIO V,Capalbo C, Silvestri V, Ottini L. Gender-specific genetic predisposition to Breast Cancer: BRCA genes and beyond (Manuscript under review).
- Bucalo A, CONTI G, Valentini V, Capalbo C, Bruselles A, Tartaglia M et al. Male breast cancer risk associated with pathogenic variants in genes other than BRCA1/2: an Italian case-control study. Eur J Cancer. 2023 Jul;188:183-191.
- Lospinoso Severini L, Loricchio E, NAVACCI S, Basili I, Alfonsi R, Bernardi F, Moretti M, CONENNA M, Cucinotta A, Coni S, Petroni M, De Smaele E, Giannini G, Maroder M, Canettieri G, Mastronuzzi A, Guardavaccaro D, Ayrault O, Infante P, Bufalieri F, Di Marcotullio L. SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma. Cell Death Differ. 2023 Dec 7. doi: 10.1038/s41418-023-01246-6.
- MARCO ROSICHINI, Veronica Bordoni, Domenico Alessandro Silvestris, Davide Mariotti, Giulia Matusali, Antonella Cardinale, Giovanna Zambruno, Angelo Giuseppe Condorelli, Sara Flamini, Shirley Genah, Marialuigia Catanoso, Franca Del Nonno, Matteo Trezzi, Lorenzo Galletti, Cristiano De Stefanis, Nicolò Cicolani, Stefania Petrini, Concetta Quintarelli, Chiara Agrati, Franco Locatelli, Enrico Velardi.SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity”. J Allergy Clin Immunol. 2023 Apr;151(4):911-921. doi: 10.1016/j.jaci.2023.01.022.
- Sandesh Kumar Patel, Nadezda Zhdanovskaya, ILARIA SERGIO, Antonella Cardinale, MARCO ROSICHINI, CLAUDIA VARRICCHIO, ELEONORA PACE, Carlo Capalbo, Franco Locatelli, Alberto Macone, Enrico Velardi, Rocco Palermo and Maria Pia Felli. Thymic-Epithelial-Cell-Dependent Microenvironment Influences Proliferation and Apoptosis of Leukemic Cells”. International Journal of Molecular Sciences. 2024
- Zizzari IG, Di Filippo A, Botticelli A, Strigari L, Pernazza A, RULLO E, Pignataro MG, Ugolini A, Scirocchi F, Di Pietro FR, Rossi E, Gelibter A, Schinzari G, D'Amati G, Rughetti A, Marchetti P, Nuti M, Napoletano C. Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer. Clin Cancer Res. 2022 Mar 1;28(5):1027-1037. doi: 10.1158/1078-0432.CCR-21-2918. PMID: 34980602; PMCID: PMC9377756. IF:13,8
- Del Gaizo, M., SERGIO, I., LAZZARI, S., Cialfi, S., Pelullo, M., Screpanti, I., & Felli, M. P. (2022). MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia. International Journal of Molecular Sciences, 23(2), 829.
-Valentini E, Di Martile M, Brignone M, Di Caprio M, Manni I, Chiappa M, SERGIO I, Chiacchiarini M, Bazzichetto C, Conciatori F, D'Aguanno S, D'Angelo C, Ragno R, Russillo M, Colotti G, Marchesi F, Bellone ML, Dal Piaz F, Felli MP, Damia G, Del Bufalo D. Bcl-2 family inhibitors sensitize human cancer models to therapy. Cell Death Dis. 2023 Jul 17;14(7):441. doi: 10.1038/s41419-023-05963-1.
36 ciclo
All the PhD students of the PhD in Molecular Medicine carried out intense research activity on various project lines, listed below.
In some cases, PhD students also presented the results of their research as posters or oral presentations at national and/or international conferences. Some examples are listed below.
Finally, we report some publications resulting from the collaboration of PhD students and/or more relevant publications (Impact factor≥8).
RESEARCH PROJECTS
- MDSC/NK cell cross-talk in notch-dependent t-cell acute lymphoblastic leukemia: the possible role of the PD-1/PD-L1 pathway.
- Ruolo delle HECT-E3 Ubiquitina Ligasi SMURFs nella modulazione della via di Hedgehog.
- Ruolo della matrice extracellulare nella fisiopatologia umana.
- The role of the cytoskeleton regulator inverted formin 2 (INF2) in medulloblastoma.
- Blocking the Hedgehog-dependent tumor growth by a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor.
- Jagged1, a novel non-canonical player in pancreatic cancer. Identification of novel target drugs.
- Biopsia liquida nell'ambito della oncologia di precisione attraverso l'utilizzo di fluidi corporei non convenzionali.
- Translational mechanisms of MYC-related metastasis.
- Aspetti patologici e molecolari dei meningiomi cerebrali: analisi dei fattori prognostici
- Comparison of Immunohistochemical and histopathological findings between patients with diabetic and idiopathic carpal tunnel syndrome
- Caratterizzazione fenotipica in pazienti con tumore mammario BRCA relato e possibili opzioni di trattamento per la sindrome genito-urinaria della menopausa nelle survivors: confronto tra triplo negativo e luminale in una coorte di 171 donne.
- Pharmacological intervention to target the pro-calcific phenotypic drift of myeloid cells: a pilot study
- Le conseguenze degli inibitori dell'aromatasi nel trattamento del carcinoma mammario: una "nuova" forma di sindrome del tunnel carpale? Aromatase inhibitor consequences in breast cancer treatment: a “new” form of carpal tunnel syndrome?
- Role of gut microbiome and TMAO microbial metabolite in plaque instability.
- Drug delivery in anti cancer therapy
- Il ruolo di MEX3A nello sviluppo del glioblastoma come biomarcatore e marker prognostico
- Meccanismo dell'effetto antitumorale delle poliammine
(ORAL OR POSTER) PRESENTATIONS To Scientific Conferences held by PhD Students
ABDOLLAHZADEH
- MYELOID-DERIVED SUPPRESSOR CELLS AS A POTENTIAL TARGET OF IMMUNOTHERAPY IN NOTCH-DEPENDENT T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA POSTER "" in "the Notch Meeting XII” svolto ad Athens, Greece, 01/10/2023 - 05/10/2023 .
- MDSC/NK CELLS CROSS-TALK IN NOTCH-DEPENDENT T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: THE POSSIBLE ROLE OF THE PD-1/PD-L1 PATHWAY POSTER "," in Gordon Research Conference on Notch Signaling in Development, Regeneration and Disease held at Bates College in Lewiston, Maine, United States17/07/2022 - 22/07/2022
BORDIN
- Identification of SMURF proteins as negative regulators of the oncogenic Hedgehog/GLI1 pathway. 35th AICC ANNUAL CONFERENCE: From patient to cell and back. Poster Presentation: “”. L’Aquila 4-6 Dicembre 2023, ITALY.
- Identification of SMURF proteins as new Hedgehog pathway modulators. EMBO Workshop Hedgehog signaling: From molecular structure to developmental biology and diseases. Sant Feliu de Guixols 24-27 Aprile 2023, SPAIN. Poster presentation
- The KCASH2KO mouse: a new model to investigate the Hedgehog signaling in development and diseases. EMBO Workshop Hedgehog signaling: From molecular structure to developmental biology and diseases. Sant Feliu de Guixols 24-27 Aprile 2023, SPAIN. Poster presentation
- Characterization of SMURFs proteins as new possible modulators of the Hedgehog Signaling Pathway. EACR-OECI Joint Conference: Molecular Pathology Approach to Cancer. Poster presentation: Bergamo 28-30 Marzo 2023, ITALY.
- Characterization of the HECT-E3 Ubiquitin Ligase SMURF1 as a new possible modulator of the Hedgehog signaling pathway. MOLECULAR PATHOLOGY: FROM BENCH TO BEDSIDE-SIPMeT Young Scientist Meeting. Poster presentation: “.” Ancona 22-24 Settembre 2022, ITALY.
- New insights into the role of the HECT-E3 Ligase SMURF2 in the modulation of the Hedgehog Pathway. MOLECULAR PATHOLOGY: FROM BENCH TO BEDSIDE-SIPMeT Young Scientist Meeting. Poster presentation: Perugia 10-11 Dicembre 2021, ITALY
- HECT E3 Ligase SMURF2: a potential novel role in the modulation of the Hedgehog Pathway. 3rd AICC ANNUAL CONFERENCE: International meeting on cancer metabolism, Poster presentation: “.” Torino 22-24 Novembre 2021.
CHIRIVÌ
- Extracellular matrix stiffness promptly modulates the phenotype and gene expression of infiltrating T lymphocytes; presentazione poster; ABCD National PhD meeting, 24-25 Marzo 2022, Salerno (Italia)
CONENNA
- The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I;Poster presentation; MOLECULAR PATHOLOGY: FROM BENCH TO BEDSIDESIPMeT Young Scientist Meeting, Perugia (Italy), 12/2021
- THE CYTOSKELETON REGULATOR INVERTED FORMIN INF2 REGULATES THE SHH PATHWAY AND IS IMPLICATED IN MEDULLOBLASTOMA TUMORIGENESIS. Poster Presentation, MOLECULAR PATHOLOGY: FROM BENCH TO BEDSIDESIPMeT Young Scientist Meeting, Ancona (Italy), 09/2022
- The role of the cytoskeleton regulator inverted formin 2 INF2 in medulloblastoma tumorigenesis; Poster Presentation and Chairwoman:, 5th Brain Storming Research Assembly For Young Neuroscientists (BraYn), Roma (Italy), 09/2022
CUCINOTTA
- "The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I Poster presentation; MOLECULAR PATHOLOGY: FROM BENCH TO BEDSIDE - SIPMeT Young Scientist Meeting 2021 - Perugia, 10-11 Dicembre 2021 A.
- Blocking the Hedgehog-dependent tumor growth by a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor. Poster presentation; PRECISION MEDICINE IN THE ERA OF INTEGRATED OMICS – SIRTEPS – Favignana, 18-19 Maggio 2023 A.
- Blocking the Hedgehog-dependent tumor growth by a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor. Poster presentation; GENERAL PATHOLOGY: THE TRUNK OF THE TREE OF MEDICINE - SIPMeT Young Scientist Meeting 2023 – Parma, 22-23 Settembre 2023.
- Blocking the Hedgehog-dependent tumor growth by a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor. Flash Oral presentation; ABCD National Ph.D. Meeting 2022 – Salerno 24/26 marzo 2022
- Blocking the Hedgehog-dependent tumor growth by a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor; Oral presentation; FISV Congress "3R: Research, Resilience, Reprise" – Portici 14/16 settembre 2022 A.
- Blocking the Hedgehog-dependent tumor growth by a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor. Oral presentation; BraYn 5th Brainstorming Research Assembly for Young Neuroscientists – 28/30 Settembre 2022.
- MEX3A/RIG-I axis as a therapeutic target for new options in the treatment of glioblastoma; Oral presentation; "PRECISION MEDICINE IN THE ERA OF INTEGRATED OMICS” – SIRTEPS – Favignana, 18-19 Maggio 2023.
DE CAROLIS
- "Jagged1, a novel non-canonical player in pancreatic ductal adenocarcinoma; Poster presentation; 3° Congresso Nazionale SIRTEPS, "Precision Medicine in the era of Integrated Omics", Favignana (TP), 18-19 maggio 2023;
- "Jagged1, a novel non-canonical player in pancreatic ductal adenocarcinoma; Poster presentation; Congresso SIPMET 2023, "Young Scientist Meeting 2023. General Pathology: the trunk of the tree of medicine", Parma (PR) 22-23 settembre 2023.
DE RENZI
- Liquid biopsy to track KRAS G12C mutation at progressive disease in patients with advanced non-small cell lung cancer (NSCLC) (poster presentation); ESMO Congress 2021, Virtual congress, 16-21 September 2021.
- RAS Mutation Conversion in Bevacizumab-Treated Metastatic Colorectal Cancer Patients: A Liquid Biopsy Based Study (poster presentation); EACR Conference, Liquid Biopsies, 24-26 May 2022, Bergamo, Italy.
De Renzi G, Emili F, De Meo M, Belardinilli F, Magri M, Gazzaniga P, Nicolazzo C.
- Prognostic role of circulating tumor cell trajectories in metastatic colorectal cancer (poster presentation); 6th Advances in Circulating Tumor Cells: “Liquid Biopsy and Precision Oncology: Where do we stand now?", 20-23 September 2023, Skiathos, Greece.
IVY
Investigation into the validity of the MYC internal ribosome entry site and its role in resistance to stress. Oral presentation. 26th International Symposium on Molecular Medicine. Tivoli, Italy, November 4 2023.
MAIOLA
- Il trattamento dei meningiomi craniospinali. Presentazione orale. Vincenza Maiola, Giancarlo D’Andrea. XVII Congresso nazionale SIB. Ancona 26-27/10/2023
- PDTA e trattamento delle metastasi cerebrali. Presentazione orale. Vincenza Maiola. Il trattamento delle metastasi cerebrali e degli aneurismi cerebrali. Impatto sul territorio della ASL Frosinone dal ricovero alla riabilitazione fino al rientro sul territorio. Frosinone 22-23/09/2023
- IV SESSIONE: TRAUMI CRANICI E SPINALI. Presentazione orale. Vincenza Maiola Emergenze in Neurologia: dalle linee guida alla pratica clinica. Ferentino 29/10/22
- Malattia oligometastatica: sempre la chirurgia? Presentazione orale.Vincenza Maiola.Trattamento multidisciplinare delle metastasi cerebrali 7 maggio 2022 Isola del Liri (Frr)
- Organizzazione di chirurgia da sveglio con monitoraggio neurofisiologico intraoperatorio in una uoc nch di nuova istituzione. Presentazione orale. V. Maiola, V. Picotti, P. Bruzzaniti, F. Bambina, M. Castiglione, G. D’Andrea. Comunicazione Orale: SiNch 70° Congresso Nazionale Milano 14-16 Ottobre 2021.
- Ultra early surgery nell’emorragia subaracnoidea da aneurisma rotto. ruolo prognostico del trattamento precoce su vasospasmo e idrocefalo. studio bicentrico. Risultati preliminari. Presentazione orale. M. Castiglione, V. Picotti, V. Maiola, P. Bruzzaniti, F. Bambina, G. D’Andrea. SiNch 70° Congresso Nazionale Milano 14-16 Ottobre 2021
- Fratture vertebrali della giunzione toracolombare: studio retrospettivo randomizzato su due popolazioni di pazienti trattati con stabilizzazione “breve” (non oltre i 3 segmenti) o “lunga” (oltre i 4 segmenti) Presentazione orale. F. Bambina, P. Bruzzaniti, V. Maiola, V. Picotti, M. Castiglione, G. D’Andrea. SiNch 70° Congresso Nazionale Milano 14-16 Ottobre 2021.
MERLINO
-Casi clinici di patologia vulvare: tossicità vulvo-vaginale dei trattamenti antiblastici in pazienti BCS sotto i 40 anni di età. "Oral presentation" in XXXVI S.I.C.P.C.V. XXXVI congresso nazionale, dal 29.09.2022 al 1.10.2022, Cagliari.
- Urinary incontinence management in women with genitourinary syndrome: long-term effect of vaginal fractional CO2 laser treatment versus pelvic floor muscle training, mono central perspective study. "Oral Presentation", SIGO 15-18 Dicembre 2022 , Milano.
- "Il dolore nella patologia vulvare". "Oral presentation" in il dolore pelvico cronico nella donna. La terra di nessuno. 13.01.2023, Roma.
- Casi clinici di patologia vulvare: tossicità vulvo-vaginale dei trattamenti antiblastici in pazienti BCS sotto i 40 anni di età. "Oral presentation" in 2° corso di colposcopia e patologia del tratto genitale inferiore. Dal 13.04.2023 al 15.04.2023, Roma.
- "Long-term effect of fractional CO2 Laser Therapy for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: mono-central perspective study"."Poster and oral presentation" in 2nd world congress of integrative medicine and health, 20-23.09.2023, Roma.
- "Sexual health and intimacy coping with early-onset breast cancer: a qualitative investigation with patients and their partners"; "Poster" in 2nd world congress of integrative medicine and health, 20-23.09.2023, Roma.
- "Oncological drugs and vulvovaginal toxicity: which strategies" "oral presentation and abstract" in SIME, 19-21.05.2023, Roma.
- "Opzioni terapeutiche nelle BCS survivors", "Oral presentation" in The Vulva Unmasked, dal 13 al 14.10.2023, Roma.
RUTIGLIANO
- -Delivery of Methotrexate by thiols functionalised gold nanoparticles in neuroblastoma: therapeutic effects and structural studies; Oral presentation. International Conference on Advanced Molecular Medicine, 09-09-2022, Tivoli (Rome).
- Cytotoxic effects of magnetic nanohybrids on colorectal adenocarcinoma cell models. Poster presentation. 26th International Symposium on Molecular Medicine, 02-04/11/2023, Tivoli (Rome).
PAPERS INVOLVING COLLABORATION BETWEEN PHD STUDENTS AND /OR WITH IF≥8
- D'ONOFRIO L, Fogolari M, AMENDOLARA R, Siena A, De Fata R, Davini F, Coraggio L, MIGNOGNA C, Moretti C, Maddaloni E, Angeletti S, Buzzetti R. Reduced early response to SARS-CoV2 vaccination in people with type 1 and type 2 diabetes, a 6 months follow-up study: The CoVaDiab study I. Diabetes Metab Res Rev. 2023 Mar;39(3):e3601. doi: 10.1002/dmrr.3601
- D'ONOFRIO L, AMENDOLARA R, MIGNOGNA C, Leto G, Tartaglione L, Mazzaferro S, Maddaloni E, Buzzetti R. Lack of Association between Serum Chitotriosidase Activity and Arterial Stiffness in Type 2 Diabetes without Cardiovascular Complications. Int J Mol Sci. 2023 Oct 31;24(21):15809. doi: 10.3390/ijms242115809
- Leto G, Tartaglione L, Rotondi S, Pasquali M, Maddaloni E, MIGNOGNA C, D'ONOFRIO L, Zampetti S, Carlone A, Muci ML, Mastroluca D, Fassino V, Buzzetti R, Mazzaferro S. Diastolic Pressure and ACR are Modifiable Risk Factors are Arterial Stiffness in T2DM Without Cardiovascular Disease. J Clin Endocrinol Metab. 2022 Aug 18;107(9):e3857-e3865. doi: 10.1210/clinem/dgac291
- MIGNOGNA C, Maddaloni E, D'ONOFRIO L, Buzzetti R. Investigational therapies targeting CD3 for prevention and treatment of type 1 diabetes. Expert Opin Investig Drugs. 2021 Dec;30(12):1209-1219. doi: 10.1080/13543784.2022.2022119
- Maddaloni E, D'Onofrio L, Siena A, Luordi C, MIGNOGNA C, AMENDOLARA R, Cavallari I, Grigioni F, Buzzetti R. Impact of cardiovascular disease on clinical outcomes in hospitalized patients with Covid-19: a systematic review and meta-analysis. Intern Emerg Med. 2021 Oct;16(7):1975-1985. doi: 10.1007/s11739-021-02804-x.
- D'ONOFRIO L, Pieralice S, Maddaloni E, MIGNOGNA C, Sterpetti S, Coraggio L, Luordi C, Guarisco G, Leto G, Leonetti F, Manfrini S, Buzzetti R. Effects of the COVID -19 lockdown on glycemic control in subjects with type 2 diabetes: the glycalock study. Diabetes Obes Metab. 2021 Jul;23(7):1624-1630. doi: 10.1111/dom.14380.
- Mantovani A, Morieri ML, Palmisano L, Masulli M, Cossu E, Baroni MG, Bonomo K, Cimini FA, Cavallo G, Buzzetti R, MIGNOGNA C, Leonetti F, Bacci S, Trevisan R, Pollis RM, Aldigeri R, Cas AD, de Kreutzenberg SV, Targher G. Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adult with type 1 diabetes mellitus. Cardiovasc Diabetol. 2023 Aug 10;22(1):204. doi: 10.1186/s12933-023-01945-x.
- D'Onofrio L, Fogolari M, AMENDOLARA R, Siena A, De Fata R, Davini F, Coraggio L, MIGNOGNA C, Moretti C, Maddaloni E, Angeletti S, Buzzetti R. Reduced early response to SARS-CoV2 vaccination in people with type 1 and type 2 diabetes, a 6 months follow-up study: The CoVaDiab study I. Diabetes Metab Res Rev. 2023 Mar;39(3):e3601. doi: 10.1002/dmrr.3601
- Alhamar G, Maddaloni E, Al Shukry A, Al-Sabah S, Al-Haddad M, Al-Youha S, Jamal M, Almazeedi S, Al-Shammari AA, Abu-Farha M, Abubaker J, Alattar AT, AlOzairi E, Alessandri F, D'Onofrio L, Leto G, Mastroianni CM, MIGNOGNA C, Pascarella G, Pugliese F, Ali H, Al Mulla F, Buzzetti R, Pozzilli P. Development of clinical risk score to predict death in patients with COVID-19. Diabetes Metab Res Rev. 2022 Jul;38(5):e3526. doi: 10.1002/dmrr.3526.
- D'Onofrio L, Coraggio L, Zurru A, Carlone A, MIGNOGNA C, Moretti C, Maddaloni E, Buzzetti R. Short term safety profile of Sars-Cov 2 vaccination on glucose control: Continuous glucose monitoring data in people with autoimmune diabetes. Diabetes Res Clin Pract. 2021 Sep;179:109022. doi: 10.1016/j.diabres.2021.109022.
- D'ONOFRIO L, MIGNOGNA C, Carlone A, Bellizzi E, Di Guida M, Moretti C, Zampetti S, Leto G, Maddaloni E, Buzzetti R. Decrease of coronary heart disease risk with GLP1-receptor agonists or SGLT2 inhibitors therapy in patients with type 2 diabetes in primary cardiovascular prevention: A 24 months follow-up study. Diabetes Res Clin Pract. 2021 Mar;173:108681. doi: 10.1016/j.diabres.2021.108681.
- Maddaloni E, D'ONOFRIO L, Alessandri F, MIGNOGNA C, Leto G, Coraggio L, Sterpetti S, Pascarella G, Mezzaroma I, Lichtner M, Pozzilli P, Agrò FE, Rocco M, Pugliese F, Mastroianni CM, Buzzetti R; CoViDiab Study group. Clinical features of patients with type 2 diabetes and without Covid-19: a case control study (CoViDiab I). Diabetes Res Clin Pract. 2020 Nov;169:108454. doi:10.1016/j.diabres.2020.108454.
-Canonico F, CHIRIVI M, Maiullari F, Milan M, Rizzi R, Arcudi A, Galli M, Pane M, Gowran A, Pompilio G, Mercuri E, Crea F, Bearzi C, D'Amario D. Focus on the road to modelling cardiomyopathy in muscular dystrophy. Cardiovasc Res. 2022 Jun 29;118(8):1872-1884. doi: 10.1093/cvr/cvab232.
-Bordin A, CHIRIVÌ M, Pagano F, Milan M, Iuliano M, Scaccia E, Fortunato O, Mangino G, Dhori X, De Marinis E, D'Amico A, Miglietta S, Picchio V, Rizzi R, Romeo G, Pulcinelli F, Chimenti I, Frati G, De Falco E. Human platelet lysate-derived extracellular vesicles enhance angiogenesis through miR-126. Cell Prolif. 2022 Nov;55(11):e13312. doi: 10.1111/cpr.13312.
-Maiullari F, CHIRIVÌ M, Costantini M, Ferretti AM, Recchia S, Maiullari S, Milan M, Presutti D, Pace V, Raspa M, Scavizzi F, Massetti M, Petrella L, Fanelli M, Rizzi M, Fortunato O, Moretti F, Caradonna E, Bearzi C, Rizzi R. In vivoorganized neovascularization induced by 3D bioprinted endothelial-derived extracellular vesicles. Biofabrication. 2021 Apr 7;13(3). doi: 10.1088/1758-5090/abdacf.
-Milan M, Pace V, Maiullari F, CHIRIVÌ M, Baci D, Maiullari S, Madaro L, Maccari S, Stati T, Marano G, Frati G, Puri PL, De Falco E, Bearzi C, Rizzi R. Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation. Cell Death Dis. 2018 Jan 25;9(2):108. doi: 10.1038/s41419-017-0174-5.
- Ludovica Lospinoso Severini, Elena Loricchio, SHIRIN NAVACCI, Irene Basili, Romina Alfonsi, Flavia Bernardi, Marta Moretti, MARILISA CONENNA, ANTONINO CUCINOTTA, Sonia Coni, Marialaura Petroni, Enrico De Smaele, Giuseppe Giannini, Marella Maroder, Gianluca Canettieri, Angela Mastronuzzi, Daniele Guardavaccaro, Olivier Ayrault, Paola Infante, Francesca Bufalieri, Lucia Di Marcotullio, “SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma”, 2023 Dec 7, Cell Death and Differentiation. doi: 10.1038/s41418-023-01246-6
- Magri, V., Marino, L., Nicolazzo, C., Gradilone, A., DE RENZI, G., DE MEO, M., Gandini, O., Sabatini, A., Santini, D., Cortesi, E. and Gazzaniga, P., 2023. Prognostic Role of Circulating Tumor Cell Trajectories in Metastatic Colorectal Cancer. Cells, 12(8), p.1172. DOI: 10.3390/cells12081172
- Nicolazzo, C., Magri, V., Marino, L., Belardinilli, F., Di Nicolantonio, F., DE RENZI, G., Caponnetto, S., DE MEO, M., Giannini, G., Santini, D. and Cortesi, E., 2023. Genomic landscape and survival analysis of ctDNA “neo-RAS wild-type” patients with originally RAS mutant metastatic colorectal cancer. Frontiers in Oncology, 13, p.1160673. DOI: 10.3389/fonc.2023.1160673
- Nicolazzo, C., Barault, L., Caponnetto, S., DE RENZI, G., Belardinilli, F., Bottillo, I., Bargiacchi, S., Macagno, M., Grammatico, P., Giannini, G. and Cortesi, E., 2021. True conversions from RAS mutant to RAS wild-type in circulating tumor DNA from metastatic colorectal cancer patients as assessed by methylation and mutational signature. Cancer Letters, 507, pp.89-96. DOI: 10.1016/j.canlet.2021.03.014
- Grazioli P, Orlando A, Giordano N, Noce C, Peruzzi G, ABDOLLAHZADEH B, Screpanti I, Campese AF. Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia. Front Immunol. 2022 Apr 4; 13:809261. doi: 10.3389/fimmu.2022.809261.
- Rino Ragno, Anna Minarini, Eleonora Proia, Antonini Lorenzo, Andrea Milelli, Vincenzo Tumiatti,
Marco Fiore, Pasquale Fino, LAVINIA RUTIGLIANO, Rossella Fioravanti, TOMOAKI TAHARA, Elena Pacella,
Antonio Greco, Gianluca Canettieri, Maria Luisa Di Paolo, and Enzo Agostinelli/Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies/ J. Chem. Inf. Model. (2022), 62, 3910−3927. doi: 10.1021/acs.jcim.2c00559
- Tommaso A. Salamone , LAVINIA RUTIGLIANO , Beatrice Pennacchi , Sara Cerra , Roberto Matassa , Stefania Nottola , Fabio Sciubba , Chiara Battocchio , Martina Marsotto , Alessandra Del Giudice , Andrei Chumakov , Anton Davydok , Souren Grigorian , Gianluca Canettieri , Enzo Agostinelli , Ilaria Fratoddi/ Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment: From synthesis to in vitro studies on neuroblastoma cell lines/ J. Colloid and Interface Science 649 (2023) 264–278.
doi: 10.1016/j.jcis.2023.06.078
- Coni S, Bordone R, IVY DM, Yurtsever ZN, Di Magno L, D'AMICO R, Cesaro B, Fatica A, Belardinilli F, Bufalieri F, Maroder M, De Smaele E, Di Marcotullio L, Giannini G, Agostinelli E, Canettieri G.
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation. Cancer Lett. 2023 Apr 10;559:216120. doi: 10.1016/j.canlet.2023.216120.
NOTE
Questi progetti hanno già dato adito a delle pubblicazioni su riviste internazionali indexate, come evidenziabile nelle schede di rendicontazione dei Dottorandi. Sono state riportate qui alcune pubblicazioni selezione o perché scaturite dalla collaborazione di più dottorandi o perché di particolare rilievo scientifico (IF≥8). Inoltre, alcuni Dottorandi hanno presentato i risultati delle loro ricerche come posters o presentazioni orali in Congressi Nazionali e/o Internazionali (vedi sopra).
Diversi Dottorandi hanno inoltre frequentato laboratori di ricerca sulla base di specifici accordi con componenti stranieri del collegio dei docenti o con altri colleghi stranieri con cui esistono accordi di collaborazione:
Some of these projects gave rise to publications in indexed international journals, as highlighted in the PhD students' reporting forms. Some selected publications have been reported here either because they resulted from the collaboration of several PhD students or because they are of particular scientific relevance (IF≥8). Furthermore, some PhD students have presented their results as posters or oral presentations at National and/or International Conferences (see above).
Several PhD students have also attended research laboratories on the basis of specific agreements with foreign members of the teaching board or with other foreign colleagues with whom collaboration agreements exist:
Dott. Behnaz Abdollahzadeh -36 ciclo, presso Weill Cornell Medical College, New York, USA (sotto la tutela Prof. Roberta Zappasodi) dal 01/04/2023 al 31/08/2023.
Dott. Marilisa Conenna -36 ciclo, presso Columbia University, New York, USA (sotto la tutela della Prof. Francesca Bartolini) dal 10/3/23 al 9/3/24
Dott. Giulia Conti -37 ciclo, presso University of Aberdeen, UK (sotto la tutela della Professor Valerie Speirs) dal 3/7/23 al 6/10/23
Dott. Mohamed El Hachmi (38 ciclo) presso, Università Paris Cité (Prof. Karim Wahbi – Prof. Pier-Yves Boelle) dal 1/10/23 al 31/8/24 (Accordo Co-tutela interna)