Annual report

All the PhD students of the PhD in Molecular Medicine have carried out an intense research activity on various project lines listed below.

In some cases some PhD students have also presented the results of their research as posters or oral presentations in National and/or International Congresses held online, as shown by the individual files.

Scientific Projects - 1st year PhD students
- Immuno-metabolic and phenotypic characterization of autoimmune diabetes and its consequences.
- Targeted therapies for malignant mesothelioma.
- Role of KCash2 in neurogenesis in central nervous system.
- Role of NBS1 in cerebellar development and carcinogenesis.
- Using Crispr-Cas9 technology to investigate the role of NBS1 mutations on ciliogenesis as a model for the Nijmegen Breakage Syndrome.
- Matched germline and tumor profiling in male breast cancer patients
- Morphological and molecular characterization of breast cancer organoids following treatment with sirtuin modulators.
- Molecular dissection of Notch3-Pin1 cross-talk to overcome platinum resistance in ovarian cancer.
- Dissecting the role of the Cullin3-Ren/Kctd11 E3 ubiquitin ligase complex in the control of the hedgehog pathway and medulloblastoma tumorigenesis. - Characterization of Pik3γ inhibition in macrophages and tumor immune infiltrate mediated by Men1611.
- New strategies to reprogram immunosenescence.
- Targeting redox alterations and sensors in colorectal cancer.
- Identification of new strategies for thymic regeneration.
- The role of cGas/Sting pathway in MYCN-driven neuroblastoma.
- The role of the microRNAs in Cxcr4-dependent maturation of thymocytes in a Notch3-induced acute lymphoblastic leukemia.

Scientific Projects – 2 year PhD students
- MDSC/NK cell cross-talk in notch-dependent t-cell acute lymphoblastic leukemia: the possible role of the PD-1/PD-L1 pathway.
- Role of HECT-E3 Ubiquitin Ligases SMURFs in the modulation of the Hedgehog pathway.
- Role of the extracellular matrix in human pathophysiology.
- The role of the cytoskeleton regulator inverted formin 2 (INF2) in medulloblastoma.
- Blocking the Hedgehog-dependent tumor growth by a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor.
- Jagged1, a novel non-canonical player in pancreatic cancer. Identification of novel target drugs.
- Liquid biopsy in precision oncology through the use of unconventional body fluids.
- Translational mechanisms of MYC-related metastasis.
- Pathological and molecular aspects of cerebral meningiomas: analysis of prognostic factors
- Comparison of Immunohistochemical and histopathological findings between patients with diabetic and idiopathic carpal tunnel syndrome
- Phenotypic characterization in patients with BRCA-related breast cancer and possible treatment options for genitourinary syndrome of menopause in survivors: comparison of triple negative and luminal in a cohort of 171 women.
- Pharmacological intervention to target the pro-calcific phenotypic drift of myeloid cells: a pilot study
- The consequences of aromatase inhibitors in the treatment of breast cancer: a "new" form of carpal tunnel syndrome? Aromatase inhibitor consequences in breast cancer treatment: a “new” form of carpal tunnel syndrome?
- Role of gut microbiome and TMAO microbial metabolite in plaque instability.
- Drug delivery in anti-cancer therapy
- The role of MEX3A in glioblastoma development as a biomarker and prognostic marker
- Mechanism of the anticancer effect of polyamines

Scientific Projects – 3 year PhD students
- The role of antiphospholipid antibody pattern in the recurrence of thrombosis in patients with Antiphospholipid Syndrome
- Glutaminase role in cancer cell
- Deciphering the role of the pro-autophagy factor AMBRA1 in the control of the Hedgehog signaling pathway and in the tumorigenesis of medulloblastoma
- Characterization of the mechanisms involved in the regulation of KCASH tumor suppressors
- COVID-19 and diabetes: effects of a dangerous relationship, from clinical manifestation to vaccine efficacy
- The histone methyltransferase EZH2 represses Notch oncosuppressive program in cervical cancer and acute myeloid leukemia
- Molecular dissection of Notch3-Pin1 cross-talk to overcome Platinum resistance in Ovarian Cancer
- Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes in T-ALL progression.
- Intraveolar dissemination (STAS): a pathogenetic mechanism for synchronous pulmonary adenocarcinomas?
- The predictive role of immune profile in patients with solid tumors in treatment with immunotherapy: a network analysis of efficacy and toxicity
- A novel microRNA signature for the detection of melanoma by liquid biopsy
- Overcoming drug resistance in prostate cancer: novel biomarkers and treatment strategies
- Role of SIRT1 in the regulation of adipose tissue and metabolism: implications with the ketogenic diet.
- MicroRNAs as diagnostic biomarkers and identification of molecular escape mechanism to tyrosine kinase inhibitors (TKI) in Medullary Thyroid Carcinoma
- Loss of ATP2C1 function promotes trafficking and degradation of NOTCH1: implications for Hailey-Hailey disease.
- New frontiers in the immunophenotypic characterization and diagnostics of neuroendocrine neoplasms

In some case, the outcomes of these projects gave rise to publications in indexed international journals, as can be seen in the report cards of the PhD students. Furthermore, some PhD students have presented the results of their research as posters or oral presentations in National and/or International Congresses, as shown by the individual files.

Several PhD students have also attended research laboratories on the basis of specific agreements with foreign members of the teaching staff or with other foreign colleagues with whom we share collaboration agreements:
Dott. Elena Splendiani, 35 ciclo, presso il Max-Delbrück-Center (MDC) for Molecular Medicine Institute di Berlino-Germania, Lab Systems Biology of Gene Regulatory Elements., dal 15 Gennaio 2022 al 30 Settembre 2022, sotto tutela del Dott. N. Rajewsky
Dott. Irene Basili, 35 ciclo, presso Istituto “Marie Curie” di Orsay (Francia) dal 17 luglio 2022 fino al 31 Gennaio 2023, sotto tutela Dr. Olivier Ayrault, membro non docente del Collegio del nostro Dottorato.
Dott. Rossella Tozzi, 35 ciclo, presso l’Instituto Universitario de Investigaciones Biomédicas y Sanitarias, unità di Diabetes and Applied Endocrinology, Universidad de Las Palmas de Gran Canaria, Islas Canarias, Spain, dal 1 giugno al 1 ottobre 2022 sotto la guida della dott.ssa Wagner
Dott. Elisabetta Tortorella, 35 ciclo, MOLECULAR ENDOCRINOLOGY LABORATORY BIOMEDICAL SCIENCES KU LEUVEN, dal Ottobre 2021-Marzo 2022
Dott. Giuseppe Barilaro, 35 ciclo, cotutela presso Università di Barcellona, Dip. Di Medicina, Tutor Prof. Ricard Cervera Segura. (vedi accordi di cotutela)

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