XXXVII ciclo - Inglese
Giovanni Manfredi Assanto studied the incidence of EZH2 mutations by digital droplet PCR in advanced and localized follicular lymphoma, its prognostic impact and potential role in minimal residual disease.
Marco Beldinanzi studied the incidence of IG/TR and BCR/ABL gene mutations by digital droplet PCR in Philadelphia-positive acute lymphoblastic leukemia patients
Giorgia Buoncuore identified and characterized circulating chondroprogenitor cells in Osteoarthritis patients through immunofluorescence and FACS analysis and in vitro assays.
Alessandra Ida Celia studied the role of immature neutrophil populations and IL-16 in lupus nephritis through multiomic approach.
Bianca Cinicola studied both humoral and cellular immune response to two different SARS-CoV-2 vaccines (i.e: Wuhan strain and the Omicron variant) in children of 5 to 11 years of age.
Cecilia Ciancaglini studied the cross-talk between human macrophages and type 2 innate lymphoid cells (ILC2) by performing in vitro co-cultures.
Luciapia Farina studied pro nerve growth factor and its receptor in the synovium of chronic arthritis patients.
Marta Kaciulis investigated the role of ADAR1 in the progression and in immune evasion of cervical cancer through the suppression of type I interferons.
Gianfranco La Pietra investigated chromosomal abnormalities in newly diagnosed Multiple Myeloma patients and evaluated potential correlations with the prognosis, including the response to the front-line therapy with latest generation drugs.
Lorenzo Lucantonio investigated the potential role of TAM family receptors in the regulation of innate lymphoid cell functions in physiological and pathologic conditions.
Francesco Natalucci studied nectosis associated-autoantigens in the synovial fluid of Systemic Lupus Erythematosus patients having joint erosive damage.
Erisa Putro investigated the molecular players able to modulate mastocyte phenotype and functions during progression from chronic intestinal inflammation to colorectal cancer.
Giovanni Zucchi investigated the potential interaction between CCRL2 and members of the TLR family and its functional outcomes in BMDM and dendritic cells by taking advantage of WT and CCRL2 KO mice.
XXXVI ciclo - Inglese
Deborah CardinaIi studied the risk relapse categories of acute lymphoblastic leukemia (Ph-like) patients based on their genomic features in combination with minimal residual disease status.
Marina Cerreto studied the role of sialylation in chronic lymphocytic leukemia migration and dissemination.
Mattia CoIa performed next-generation sequencing on cell-free DNA in chronic lymphocytic leukemia to identify predictive markers of efficacy/resistance to Venetoclax-based therapy.
Lorenzo D'Ambrosio performed transcriptomic studies on samples derived from NSCLC (Non-Small Cell Lung Cancer) patients focusing on the correlation between the number of mutations in the tumor and the response to immunocheckpoint therapy. Moreover, He characterized also tumor infiltrating T lymphocytes populations
Davide De Federicis studied the role of CD16 in the modulation of nutrient transporters expression such as CD98, CD71 and GLUT1 in conventional and memory NK cells.
Cristina Garufi investigated the phenotype and functions of circulating monocytes subpopulations in Rheumatoid Arthritis patients treated with JAK family kinase inhibitors.
Giulia Garzi carried out a prospective study on a cohort of 471 adult patients infected with SARS-CoV-2 in the first two years of the pandemic evaluating the disease severity and the patient mortality rate.
Chiara Gioia studied the effects of anti-TNF therapy in Rheumatoid Arthritis and Spondylarthritis patients analyzing the level of lymphocytosis and evaluating risk and predictive factors and potential association with lymphoproliferative diseases.
SiIvia Gitto studied the effect of anti-PD1/PDL1 therapy on the cell cycle regulation in effector and memory T cells in mouse models and in peripheral blood of patients with solid tumors.
RaffaeIIa Izzo studied the association of signaling pathways activated by interleukin-1 with autoimmune epithelitis induced in Sjögren's syndrome patients.
Arianna Piserà studied the effects of the single nucleotide polymorphism of the CCRL2 receptor on the binding to its ligand chemerin using CCRL2 mutated HEK293 transfectants and analyzing the association with SARS-CoV2 infection.
SiIvia Ruggeri investigated the phenotypic and functional alterations of NK cell compartment in severe SARS-CoV-2 infected adult and elderly patients showing no comorbidities at hospital admission, but both requiring mechanical ventilation.
EIeonora Russo studied the phenotype and functions of hepatic innate lymphoid cells in the regulation of liver metastases growth in a colorectal cancer mouse model.
XXXV ciclo - Inglese
MagdaIini AIexandrini studied the role of Dengue virus infection on the oxidative stress response and the regulation of cellular metaboIism.
MicheIa AnsuineIIi evaluated the cytokine release syndrome (CRS) after haploidentical hematopoietic stem cell transplantation in a cohort of 169 patients.
Claudia Manuela Arnone studied new gene therapy approaches for the treatment of gliomas in children.
Luciana Cafforio applied NGS techniques to identify patients with chronic lymphoid leukemia suitable for Venetoclax therapy.
Chiara Di Censo analyzed subpopulations of type 1 innate lymphoid cells (ILC1) in the murine liver, and identified cytotoxic cell populations potentially effective in the response to liver infections or neoplasms.
Francesca Fazio applied NGS techniques to analyze the sequence of κ and λ light chains focusing on potential glycosylation sites in patients with plasma cell dyscrasias.
Luisa Loconte investigated the immunomoduIatory properties of extraceIlular vesicles derived from multiple myeloma cell lines or from clinical samples focusing on the NKG2D receptor and its ligands.
JuIija Mazej used transcriptomic and cytometric approaches to study the mechanisms of regulation of NK cell and innate lymphoid type 1 (ILC1) cell functions through interleukin-12 and type I interferons.
VaIeria Orefice studied the effects of caffeine on endothelial cells derived from patients affected by Systemic Lupus Erythematosus by setting up in vitro cultures.
Sara Pepe studied through NGS driver and non-driver mutations in patients affected by myelofibrosis
Giuseppe PietropaoIo studied the in vitro and in vivo role of the induction of immunocheckpoints on type 2 innate lymphoid cells (ILC2) and the possible regulatory mechanisms.
CarmeIo Pirone studied the onset of small fiber neuropathies in patients affected by Systemic Lupus Erythematosus and its correlation with the expression of proinflammatory cytokines.
GiuIia Radice studied immunocompetent populations following treatment with CAR-T cells in patients affected by acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
Roberta Soscia studied tumor cirIcular DNA (ctDNA) and developed purification and enrichment techniques to study the rearrangement of the immunoglobulin heavy chain in patients with diffuse large cell lymphoma.