MORPHOGENESIS AND TISSUE ENGINEERING

Call for application 41st cycle

Bando ordinario

Educational goals and objectives

The Ph.D. program in Morphogenesis and Tissue Engineering is part of the School of Doctorate in Biology and Molecular Medicine. The overall aim of the Ph.D. program is to provide cultural, analytical and methodological tools and analytical tools to perform high level-, basic- or traslational- or applied-, research in the biomedical and biotechnological fields. For this purpose, the courses are aimed to teach the students not only notions (rapidly changing and evolving) but also to acquire evaluation criteria to innovatively pinpoint unresolved issues, in specific fields and to design experimental strategies which address these issues. The educational aims of the Ph.D. program are developed through research guidelines regarding the study of the mechanisms regulating cell differentiation, tissue homeostasis, regeneration and the physiopathology of different tissues.
In particular, the research interests are distributed in three main curricula:
Curriculum in Morphogenetic and Cytological Sciences:
Progression and maintenance of the differentiated state, through interaction between muscle cells and factors regulating histogenesis, homeostasis and tissue regeneration; Identification of molecular mechanisms of cell differentiation; Tissue engineering to mimic neo-organogenesis to produce ex vivo living tissue and to study cell–cell interactions, stem cell–matrix interactions and the role of tissue niche on stem cells behavior; Molecular mechanisms of tissue remodeling and homeostasis Stem cells and regenerative medicine Curriculum in Cell Sciences and Technologies:
The main areas of training for this curriculum are: Mechanisms controlling cell cycle and death, a primary interest being devoted to the study of molecular regulators of the intrinsic and extrinsic apoptosis pathways. isolation and characterization of mammalian germline stem cells, prerequisite for their potential use in medical therapy of infertility and of testis germ cell tumors. Tissue homeostasis and malignant transformation: interplay between tissue homeostasis changes induced by inflammatory agents and carcinogenesis or tumor progression in hyperplasic and carcinoma cells and in "in vivo" mouse models of orthotopic- and xenotransplants; cross talk between signal pathways activated by receptors of innate immunity and oncogenes in the onset of transformed phenotype; immunosuppressive mechanisms developed by tumour cells and strategies to restore anti-tumour immunosurveillance.
Curriculum in Cell and Tissue Biophysics focus in the following fields: mathematical modeling, multivariate statistics and biophysical chemistry; spectroscopical methods; human biology, molecular genetics and brain metabolism; dynamical simulations and modeling of biosystems at different dimensional scale.

Specifiche economiche

Sapienza Scholarships	Other Scholarships	Departments	Without scholarship
7	2 (+1*)	0	3* Dopo la pubblicazione del bando è stata finanziata una borsa da parte di Thales Alenia Spa

Annotazioni

Themes, curriculum and specific competence

Borse ENTI TERZI, PARTENARIATI ESTESI, ECCELLENZA

Tematica: FIS2 - Caratterizzazione neuro-fisiologica del comportamento umano alla guida - 41° ciclo a.a. 2025/2026 Finanziato dal Fondo italiano per la scienza – Bando FIS 2 2023 - nell’ambito del progetto dal titolo: “Psychophysiological modelling of user’s perception and experience in car simulators for their effective deployment in driving education and road safety programmes” SIMU2DRIVE
Sul curriculum: BIOFISICA CELLULARE E TISSUTALE

Ente finanziatore: DIPARTIMENTO DI MEDICINA MOLECOLARE
Competenze richieste: nessuna competenza specifica richiesta

Admission Procedure

Qualifications assessment	The qualifications are estimated according to the evaluation criteria defined by the Doctoral Teaching Council (the evaluation grid is available in the call for applications): 1. Academic titles (graduation date and score, detailed exams and related grades). 2. Curriculum vitae. Please clearly indicate research experience, acquired technical skills, publications, and other qualifications that the candidate may consider useful for the purposes of evaluation, scholarships, research training courses, research collaboration contracts. 3. Letter of motivation. The candidate must indicate the reasons for the choice to apply to the MIT PhD program, must briefly describe the previous research experience, the acquired technical competences / skills and future scientific interests. 4. Letter(s) of recommendation supporting the candidate. It should be clear from the letter why the reviewer is able to evaluate the candidate. N.B.: 1) Candidates do not require a minimum score to be admitted to the oral part of the examination. 2) Language used for the examination: ITALIAN / ENGLISH

Oral interview	The oral test consists: a) A 12- to 15-minute presentation, in front of the Commission, related to the experimental work conducted during the preparation of the thesis, or other experimental work, or of a research project selected by the candidate among the topics of the MIT PhD program. The evaluation will consider the clarity and completeness of the presentation, the way in which the various sections are balanced (identification of scientific problem and state of the art, experimental methodology, results, conclusions). In the case a research project is presented, the Commission will assess its originality and feasibility, the clarity and completeness of the aims presented, of the methodologies and of the potential results. b) Discussion of the contents of the presentation. c) Other topics selected by the Commission from among those that are inherent to the cultural topic of the PhD course. d) Assessment of level of English. The schedule of the oral exam will be published on the PhD course website: https://phd.uniroma1.it/web/MORPHOGENESIS-AND-TISSUE-ENGINEERING_nD3525_EN.aspx N.B.: 1) The candidate must be awarded a score of at least 36/70 to pass the examination. 2) Language used for the examination: ITALIAN / ENGLISH 3) The schedule of oral test will be indicated on the PhD course web site: https://phd.uniroma1.it/web/MORFOGENESI-E-INGEGNERIA-TISSUTALE_nD3525_IT.aspx
language	INGLESE ITALIANO

contacts and info	Per informazioni: dottoratomit.saimlal@uniroma1.it
more info	Evaluation criteria are those detailed in the call and website

Curriculum studiorum

Graduation date and grade of the Master's degree
detailed list of exams including completion dates and scores of Masters's degree
Graduation date and grade of the Bachelor’s degree
detailed list of exams including completion dates and scores of Bachelor's degree
History of Scholarships, Research Grants (or similar)
Certificates of Foreign Languages
Certificates of participation in post-graduate university courses
certificates of Participation in research groups
certificates of Participation in internships
Other University Awards/Degrees (e.g.: awards in competition, second degree)
Computer skills

Required documentation

§ degree thesis abstract

mandatory
The candidate must provide a page abstract of its thesis organized in the following points:
- RATIONALE
- PRELIMINARY DATA
- BROAD OBJECTIVES
- PROJECT DESIGN AND METHODS
- EXPECTED RESULTS, the file must be uploaded within le ore 23:59 del 19/06/2025

§ first letter of introduction (by a teacher)

optional, the letter must be uploaded by the candidate
Recommendation letters should be provided ONLY in the format present on the PhD website (File name
RECOMMENDATION LETTER)., the file must be uploaded within le ore 23:59 del 19/06/2025
download the attachement

§ letter of motivation (by the candidate)

mandatory
The cover letter should include the following points:
- Explain the reasons that prompted you to apply for this PhD program
- What are your career plans and what do you plan to do right after your PhD?, the file must be uploaded within le ore 23:59 del 19/06/2025

§ degree thesis (complete)

mandatory
Provide the PDF of master thesis

The candidates that will obtain the degree later on, can upload a PDF file (minimum 2-3 pages), containing the following information:
Title of the thesis
Aim of the study
Results, the file must be uploaded within le ore 23:59 del 19/06/2025

§ Curriculum Vitae et Studiorum

mandatory
Clearly indicate the professional training (only relevant activities), research experience, acquired technical skills,
publications and other qualifications that the candidate considers useful for the purposes of evaluation,
scholarships, research training courses, research collaboration contracts, etc,, the file must be uploaded within le ore 23:59 del 19/06/2025

Language Skills

the candidate must know the following languages

ENGLISH

ITALIANO

Exam Schedule

Qualifications assessment

day	26/06/2025
notes	none
publication on notice board	NO
publication on the web site	Yes
web site	https://phd.uniroma1.it/web/MORFOGENESI-E-INGEGNERIA-TISSUTALE_nD3525_IT.aspx
date of publication	08/07/2025
contacts	dottoratomit.saimlal@uniroma1.it

Oral interview

day	11/07/2025
notes	none
time	09:00
classroom	Aula Monesi
address	Via A. Scarpa 14/16; RM015 Roma
publication on notice board	NO
publication on the web site	Yes
web site	https://phd.uniroma1.it/web/MORFOGENESI-E-INGEGNERIA-TISSUTALE_nD3525_IT.aspx
date of publication	11/07/2025
contacts	dottoratomit.saimlal@uniroma1.it

Evaluation scale

Qualifications assessment

Valutazione titoli

Punteggio massimo complessivo per la prova/overall max score: 30

1.1 Voto di laurea (magistrale, specialistica o a ciclo unico – max 5 punti)
1.1 Master degree final mark (max. 5 points)

Punteggio massimo/max score: 5

110, 110 e lode 110, 110 cum laude	5,0
109 -107 109 -107	4,0
106 -104 106 -104	3,0
103 -101 103 -101	2,0
100 - 98 100 - 98	1,0
<98 <98	0,0

Per gli studenti che discuteranno la tesi dopo la valutazione dei titoli ma prima del 31 ottobre 2025 la griglia al punto 1.1 è sostituita dalla seguente
Or, for students attaining their degree within October 31st 2025

29 - 30	5,0
28 – 28.99	4,0
27 - 27.99	3,0
26 - 26.99	2,0
25 - 25.99	1,0
<25	0,0

1.2 Tesi di laurea (max 10 punti)
1.2 Degree thesis (to be submitted in PDF format), (max. 10 points)

Punteggio massimo/max score: 10

struttura structure	2,0
chiarezza clarity	2,0
completezza completeness	2,0
originalità originality	4,0

1.3 Curriculum - Esperienze di ricerca (max 9 punti)
1.3 Curriculum studiorum, Research experience (max 9 points)

Punteggio massimo/max score: 9

Percorso formativo (solo attività pertinenti) Training (relevant activities only)	3,0
Esperienze nel campo della ricerca Research experience	3,0
Corsi di formazione alla ricerca Training coursesfor researchers	3,0

1.4 Pubblicazioni (e altri titoli max 6 punti)
1.4 Publications (max. 6 points)

Punteggio massimo/max score: 6

Pubblicazione PubMed / ISI / Scopus (primo / ultimo autore) PubMed / ISI / Scopus publications (first/last author)	3,0
Pubblicazione PubMed / ISI / Scopus (co-autore) indexed publications (co-author)	2,0
Comunicazione / contributo a convegno Meeting abstracts	1,0

Oral interview

Prova orale

Punteggio massimo complessivo per la prova/overall max score: 70

Prova orale
Oral test

Punteggio massimo/max score: 70
2. Prova orale (max 70 punti) La prova orale consiste in: a) Esposizione alla Commissione, da parte del candidato, di una presentazione di 12–15 min. relativa al lavoro sperimentale svolto per la tesi di laurea, di altro lavoro sperimentale o, in alternativa, ad un progetto di ricerca proposto dal candidato tra le tematiche del Dottorato di ricerca in MIT. Per la valutazione si terrà conto della chiarezza e completezza della presentazione, dell'equilibrio tra le varie parti (individuazione del problema scientifico e stato dell'arte, metodologia sperimentale, risultati, conclusioni); nel caso di progetto di ricerca, la Commissione ne valuterà l'originalità e la fattibilità, la chiarezza e completezza nell'esposizione degli obiettivi, delle metodologie e dei potenziali risultati. b) Discussione dei contenuti della presentazione stessa. c) Altri argomenti a scelta della Commissione, tra quelli inerenti alle tematiche culturali proprie del Dottorato. d) Verifica della conoscenza della lingua inglese. Gli elementi presi in esame ai fini della valutazione globale sono: la conoscenza della materia, l'impiego di un linguaggio appropriato, la capacità di ragionamento. Inoltre, il/la candidato/a deve dimostrare di avere padronanza degli argomenti della disciplina, evitando il semplice nozionismo e dimostrando una più articolata integrazione delle conoscenze. N.B.: 1) Per il superamento della prova orale il candidato deve ottenere un punteggio di almeno 36/70. 2) Lingua della prova: ITALIANO / INGLESE 3) Il calendario della prova orale verrà pubblicato sul sito del corso di dottorato: https://phd.uniroma1.it/web/MORFOGENESI-E-INGEGNERIA-TISSUTALE_nD3525_IT.aspx
2. Oral examination (max. 70 points) Oral examination consists in: a) A 12- to 15-minute presentation, in front of the Commission, related to the experimental work conducted during the preparation of the thesis, or other experimental work, or of a research project selected by the candidate among the topics of the MIT PhD program. The evaluation will consider the clarity and completeness of the presentation, the way in which the various sections are balanced (identification of scientific problem and state of the art, experimental methodology, results, conclusions). In the case a research project is presented, the Commission will assess its originality and feasibility, the clarity and completeness of the aims presented, of the methodologies and of the potential results. b) Discussion of the contents of the presentation. c) Other topics selected by the Commission from among those that are inherent to the cultural topic of the PhD course. d) Assessment of level of English. Overall, the elements taken into consideration for the evaluation are: knowledge of the subject, the use of an appropriate language, the ability of reasoning demonstrated during the exam. Furthermore, the student must demonstrate that he / she has mastered the topics of the discipline, avoiding the simple notions and demonstrating a more articulated integration of the knowledge. N.B.: 1) The candidate must be awarded a score of at least 36/70 to pass the examination. 2) Language used for the examination: ITALIAN / ENGLISH 3) The schedule of oral test will be indicated on the PhD course web site: https://phd.uniroma1.it/web/MORFOGENESI-E-INGEGNERIA-TISSUTALE_nD3525_IT.aspx

Finanziato dal Fondo italiano per la scienza - Bando FIS