Call for application 40th cycle

Bando ordinario

Educational goals and objectives

The Ph.D. program in Morphogenesis and Tissue Engineering is part of the School of Doctorate in Biology and Molecular Medicine. The overall aim of the Ph.D. program is to provide cultural, analytical and methodological tools and analytical tools to perform high level-, basic- or traslational- or applied-, research in the biomedical and biotechnological fields. For this purpose, the courses are aimed to teach the students not only notions (rapidly changing and evolving) but also to acquire evaluation criteria to innovatively pinpoint unresolved issues, in specific fields and to design experimental strategies which address these issues. The educational aims of the Ph.D. program are developed through research guidelines regarding the study of the mechanisms regulating cell differentiation, tissue homeostasis, regeneration and the physiopathology of different tissues.
In particular, the research interests are distributed in three main curricula:
Curriculum in Morphogenetic and Cytological Sciences:
Progression and maintenance of the differentiated state, through interaction between muscle cells and factors regulating histogenesis, homeostasis and tissue regeneration; Identification of molecular mechanisms of cell differentiation; Tissue engineering to mimic neo-organogenesis to produce ex vivo living tissue and to study cell–cell interactions, stem cell–matrix interactions and the role of tissue niche on stem cells behavior; Molecular mechanisms of tissue remodeling and homeostasis Stem cells and regenerative medicine Curriculum in Cell Sciences and Technologies:
The main areas of training for this curriculum are: Mechanisms controlling cell cycle and death, a primary interest being devoted to the study of molecular regulators of the intrinsic and extrinsic apoptosis pathways. isolation and characterization of mammalian germline stem cells, prerequisite for their potential use in medical therapy of infertility and of testis germ cell tumors. Tissue homeostasis and malignant transformation: interplay between tissue homeostasis changes induced by inflammatory agents and carcinogenesis or tumor progression in hyperplasic and carcinoma cells and in "in vivo" mouse models of orthotopic- and xenotransplants; cross talk between signal pathways activated by receptors of innate immunity and oncogenes in the onset of transformed phenotype; immunosuppressive mechanisms developed by tumour cells and strategies to restore anti-tumour immunosurveillance.
Curriculum in Cell and Tissue Biophysics focus in the following fields: mathematical modeling, multivariate statistics and biophysical chemistry; spectroscopical methods; human biology, molecular genetics and brain metabolism; dynamical simulations and modeling of biosystems at different dimensional scale.

Specifiche economiche

Tipologia 1: DM629
Transizione digitale Generiche Pubblica Amministrazione Patrimonio culturale
0 0 0 0

Tipologia 2: DM630 Tipologia 3: Partenariati estesi Tipologia 4: Enti terzi ed Eccellenza Tipologia 5: Sapienza
1 0 2 9

Senza borsa

Themes, curriculum and specific competence

Borse ex D.M. 630: 1


Tematica: Impiego di specifici PROTACs quale possibile strategia terapeutica per il trattamento del melanoma
Competenze richieste: Tecniche di biologia cellulare e molecolare applicate in campo oncologico
- Use of specific PROTACs as a possible therapeutic strategy for the treatment of melanoma
Required skills: Cellular and molecular biology techniques applied in the oncology field.

Tematica: Biomonitoraggio di contaminanti ambientali presenti nel latte bovino e valutazione tossicologica in vitro su line cellulari di origine umana
Competenze richieste: Si richiedono eventuali precedenti conoscenze di biologia cellulare e di saggi di tossicologia in vitro, per esempio mantenimento di colture cellulari in sistemi bi- e/o tri-dimensionali, esecuzione di saggi di proliferazione, apoptosi, necrosi, migrazione e determinazione di saggi di secrezione proteica mediante saggi ELISA e/o AlphaLISA.
- Biomonitoring of bovine milk environmental contaminants and their in vitro toxicological evaluation on human-derived cell lines.
Required skills: Any previous knowledge of cell biology and in vitro toxicology assays is required, such as maintenance of cell cultures, execution of proliferation, apoptosis, necrosis, migration assays and protein secretion measurements by ELISA and/or AlphaLISA assays.

Admission Procedure

Qualifications assessment The qualifications are estimated according to the evaluation criteria defined by the Doctoral Teaching Board (the evaluation grid is available in the call for applications):
1. Academic titles (graduation date and score, detailed exams and related grades).
2. Curriculum vitae. Please clearly indicate research experience, acquired technical skills, publications, and other qualifications that the candidate may consider useful for the purposes of evaluation, scholarships, research training courses, research collaboration contracts.
3. Letter of motivation. The candidate must indicate the reasons for the choice to apply to the MIT PhD program, must briefly describe the previous research experience, the acquired technical competences / skills and future scientific interests.
4. Letter(s) of recommendation supporting the candidate. It should be clear from the letter why the reviewer is able to evaluate the candidate.

Oral interview The oral test consists:
a) A 12- to 15-minute presentation, in front of the Commission, related to the experimental work conducted during the preparation of the thesis, or other experimental work, or of a research project selected by the candidate among the topics of the MIT PhD program. The
evaluation will consider the clarity and completeness of the presentation, the way in which the various sections are balanced (identification of scientific problem and state of the art, experimental methodology, results, conclusions). In the case a research project is presented, the Commission will assess its originality and feasibility, the clarity and completeness of
the aims presented, of the methodologies and of the potential results.
b) Discussion of the contents of the presentation.
c) Other topics selected by the Commission from among those that are inherent to the cultural topic of the PhD course.
d) Assessment of level of English.

The schedule of the oral exam will be published on the PhD course website:
language ITALIANO

contacts and info Per informazioni: sito web:
more info Evaluation criteria are those detailed in the call and website

Curriculum studiorum

Graduation date and grade of the Master's degree
detailed list of exams including completion dates and scores of Masters's degree
Graduation date and grade of the Bachelor’s degree
History of Scholarships, Research Grants (or similar)
Certificates of Foreign Languages
Certificates of participation in post-graduate university courses
certificates of Participation in research groups
certificates of Participation in internships
Other University Awards/Degrees (e.g.: awards in competition, second degree)
Computer skills

Required documentation

§ degree thesis abstract
The candidate must provide a page abstract of its thesis organized in the following points:
, the file must be uploaded within le ore 23:59 del 20/06/2024

§ first letter of introduction (by a teacher)
mandatory, the letter must be uploaded by the referee by il le ore 23:59 del 20/06/2024
Recommendation letters should be provided ONLY in the format present on the PhD website (TEMPLATE RECOMMENDATION LETTER).

§ List of publications
The candidate can submit the list of indexed publications on PubMed/ISI/Scopus, the file must be uploaded within le ore 23:59 del 20/06/2024

§ letter of motivation (by the candidate)
The cover letter should include the following points:
- Explain the reasons that prompted you to apply for this PhD program
- What are your career plans and what do you plan to do right after your PhD?,
, the file must be uploaded within le ore 23:59 del 20/06/2024

§ degree thesis (complete)
Provide the PDF of master thesis, the file must be uploaded within le ore 23:59 del 20/06/2024

§ Curriculum Vitae et Studiorum
Clearly indicate the professional training (only relevant activities), research experience, acquired technical skills,
publications and other qualifications that the candidate considers useful for the purposes of evaluation,
scholarships, research training courses, research collaboration contracts, etc
, the file must be uploaded within le ore 23:59 del 20/06/2024

Language Skills

the candidate must know the following languages

Exam Schedule

Qualifications assessment
publication on notice boardNO
publication on the web siteYes
web site
date of publication04/07/2024

Oral interview
classroomAula Monesi
addressSezione di istologia ed Embriologia Medica; Via A. Scarpa 14
publication on notice boardNO
publication on the web siteYes
web site
date of publication23/07/2024

Day of publication of the final outcome: 23/07/2024

Evaluation scale

Qualifications assessment english version

Oral interview english version

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