THERAPY OF MALE INFERTILITY
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Lucio Gnessi – Position: Professor
Program: Definition, epidemiology, and psychosocial impact. Diagnostic evaluation: medical history, physical examination, semen analysis. Genetic, endocrine, environmental, and lifestyle-related causes. Hormonal treatments (gonadotropins, anti-estrogens, testosterone). Assisted reproductive technologies (IUI, IVF, ICSI). Management of varicocele, infections, and obstructions. Surgery: varicocele repair, TESE/microTESE. Complementary approaches: lifestyle, supplementation, stress reduction. Psychological support and couple counselling. Research and future developments: novel treatments, gene therapy, regenerative medicine.
Final assessment: Oral examination
Date: Wednesday, 11/12/2024
KLINEFELTER SYNDROME AND FERTILITY
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Matteo Spaziani – Position: Professor
Program: Genetic features and clinical presentation. Impact on testicular function and fertility. Pathophysiology of testicular dysfunction. Diagnostic approach: karyotype, hormones, semen analysis. Fertility preservation in young patients. Therapeutic strategies (TESE, ICSI). Endocrine aspects: hypogonadism and hormone replacement therapy. Genetic counselling and psychological support. Research perspectives and future directions. Social implications and quality of life.
Final assessment: Oral examination
Date: Wednesday, 15/01/2025
CRYOPRESERVATION OF GAMETES AND EMBRYOS
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Donatella Paoli – Position: Professor
Program: Principles and historical background. Techniques for sperm and oocyte cryopreservation; success indicators. Embryo cryopreservation: protocols, cryoprotectants, survival rates. Clinical applications: IVF, gamete donation, fertility preservation. Advanced technologies. Impact on quality and morphological/genetic assessment. Legal and ethical aspects: storage and use. Reproductive outcomes: implantation, pregnancy, neonatal outcomes. Technical challenges and innovations. Psychosocial aspects.
Final assessment: Oral examination
Date: Wednesday, 05/02/2025
WHO MANUAL 2010 – GUIDELINES FOR SEMEN ANALYSIS
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Donatella Paoli – Position: Professor
Program: Purpose, relevance, and clinical applications. Updates compared to previous editions. Standard parameters (volume, concentration, motility, morphology). Sample collection and analysis. Morphological criteria according to WHO 2010. Role in infertility diagnostics. Interpretation of results and reference ranges. Application in clinical and research laboratories. Limitations and critical issues. Future perspectives and integration with advanced technologies.
Final assessment: Oral examination
Date: Wednesday, 05/03/2025
ASSISTED REPRODUCTION AND CRYOBANKS
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Donatella Paoli – Position: Professor
Program: Types and indications of assisted reproductive technologies. Role and regulation of cryobanks. Gamete and embryo preservation: protocols and safety. Legal and ethical aspects: consent, duration, destination. Clinical use in ART and success rates. Accreditation and quality management. Psychosocial aspects. Role in research and regenerative medicine. Innovations and future perspectives.
Final assessment: Oral examination
Date: Wednesday, 09/04/2025
TESTICULAR TUMORS
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 2
Instructor: Carlotta Pozza – Position: Professor
Program: Epidemiology, types, and risk factors. Histological classification and morphology. Immunohistochemistry: markers and prognostic role. Molecular alterations and expression profiles. Multiparametric ultrasonography: technique, advantages, limitations. Benign vs malignant differentiation and clinicopathological correlation. Clinical management: therapy, monitoring, adjuvant treatments. Biopsy and advanced imaging. Follow-up and surveillance. Future perspectives and personalized therapies.
Final assessment: Oral examination
Date: Wednesday, 23/04/2025
TESTICULAR CANCER AND SPERM DNA METHYLATION
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Daniele Gianfrilli – Position: Professor
Program: Testicular cancer: epidemiology, types, and risk factors. Biology and pathogenesis; impact on testicular function and spermatogenesis. Sperm DNA methylation: principles and gene regulation. Epigenetic alterations in cancer patients. Analytical techniques (bisulfite sequencing, NGS). Correlation with semen parameters. Effects of cancer treatments. Role in fertility and ART. Research perspectives.
Final assessment: Oral examination
Date: Wednesday, 07/05/2025
ERECTILE DYSFUNCTION
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 2
Instructor: Daniele Gianfrilli – Position: Professor
Program: Definition, prevalence, and clinical relevance. Physiology of erection (neurovascular and hormonal mechanisms). Psychological and organic causes. Association with cardiovascular disease, diabetes, and obesity. Diagnostic evaluation. Therapies: PDE5 inhibitors, hormonal therapy, devices, psychotherapy. Innovative treatments. Impact on quality of life and relationships. Prevention and lifestyle. Future developments.
Final assessment: Oral examination
Date: Wednesday, 28/05/2025
PREMATURE EJACULATION
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Emmanuele A. Jannini – Position: Professor
Program: Definition, prevalence, and psychosocial impact. Physiology and neuroendocrine mechanisms. Classification: lifelong, acquired, situational. Risk factors. Diagnostic assessment. Behavioral and couple therapy. Pharmacological treatments (SSRIs, topical anesthetics). Combined therapy. Impact on quality of life and relationships. Research and future perspectives.
Final assessment: Oral examination
Date: Wednesday, 25/06/2025
BIOLOGY, PATHOPHYSIOLOGY AND CLINICAL ASPECTS OF ADIPOSE TISSUE
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Carla Lubrano – Position: Professor
Program: Types and distribution of adipose tissue and biological functions. Adipogenesis, cellular structure, endocrine activity. Role in energy metabolism and glucose homeostasis. Adipose dysfunction, inflammation, and obesity. Relationship with diabetes, metabolic syndrome, and insulin resistance. Cardiovascular risk. Investigative techniques. Obesity treatment: diet, exercise, bariatric surgery. Emerging pharmacological therapies. Future perspectives: adipokine modulation and personalized medicine.
Final assessment: Oral examination
Date: Wednesday, 02/07/2025
OBESITY AND DIABETES: NEW EVIDENCE
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Gisella Cavallo – Position: Professor
Program: Definitions, epidemiology, and associations. Novel pathogenetic mechanisms. Transition from obesity to type 2 diabetes. Impact on glycaemic control and complications. Evidence-based lifestyle interventions. Pharmacological therapies. Bariatric surgery and diabetes outcomes. Technological innovations (CGM, automated systems). Prevention strategies. Emerging targets and microbiome research.
Final assessment: Oral examination
Date: Wednesday, 16/07/2025
INSULIN THERAPY
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Ilaria Barchetta – Position: Professor
Program: History and types of insulin. Mechanisms of action. Indications (T1D, T2D, others). Basal-bolus regimens, MDI, insulin pumps. Glucose monitoring and dose adjustment. Management of side effects. Integration with lifestyle and other drugs. Technological innovations. Education and adherence. Future perspectives.
Final assessment: Oral examination
Date: Wednesday, 03/09/2025
METABOLISM AND AGEING
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Carla Lubrano – Position: Professor
Program: Metabolic mechanisms of ageing: telomeres, oxidative stress, inflammation. Age-related metabolic changes. Interventions: diet, exercise, anti-ageing drugs. Caloric restriction and longevity. Future research: biomarkers and anti-ageing strategies.
Final assessment: Not specified
Date: Wednesday, 17/09/2025
THYROID CANCER
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Elisa Giannetta – Position: Professor
Program: Epidemiology and risk factors. Thyroid anatomy and physiology. Differentiated thyroid cancer. Medullary thyroid carcinoma. Anaplastic carcinoma. Diagnostic tools. Surgical and medical treatment. Targeted therapies and immunotherapy. Follow-up and complications. Future perspectives.
Final assessment: Oral examination
Date: Wednesday, 08/10/2025
SCIENTIFIC DATA COMMUNICATION TECHNIQUES
Type: Part of the educational programme
Delivery mode: Seminar
Hours: 3
Instructor: Elisabetta Ferretti – Position: Professor
Program: Principles of scientific communication. Presentation structure. Data visualization. Scientific writing. Communication for non-specialists. Publication process. Peer review. Scientific integrity and ethics. Public communication and digital platforms.
Final assessment: Oral examination
Date: Wednesday, 22/10/2025
Seminars
• 10/01/2025 – Davide Masi, PhD Microbiota and immunity: new frontiers in obesity research
• 31/01/2025 – Luiza Diniz Ferreira Borges, PhD student Epigenetic modulation of amyloid clearance: insights from LRP1 and PICALM
• 07/02/2025 – Giovanna Blaconà, Research Fellow CFTR expression variability and personalized therapy in cystic fibrosis
• 24/02/2025 – Michele Aventaggiato, RTDA Effects of novel activators of mitochondrial sirtuin SIRT3 on cancer cells
• 07/03/2025 – Valeria Hasenmajer, RTDA Circadian clock disruption and immune dysregulation in chronic hypercortisolism
• 13/03/2025 – Prof. Geltrude Mingrone Definition and diagnostic criteria of clinical obesity
• 24/03/2025 – Federica Barreca, Research Fellow Effects of SIRT3/SIRT5 modulation on metabolism and mitophagy
• 04/04/2025 – Claudia Varricchio, PhD student Notch-dependent mechanisms in T-cell acute lymphoblastic leukemia
• 09/04/2025 – Marc Sim, PhD Abdominal aortic calcification and healthy ageing
• 11/04/2025 – Mario Cristina, PhD student Molecular characterization of breast cancer spheroids after mitochondrial modulation
• 09/05/2025 – Katsiaryna Karpach, Research Fellow DNA methylation alterations and ageing-related diseases
• 23/05/2025 – Elena Splendiani, PhD 3D spatial transcriptomics for precision medicine
• 30/05/2025 – Claudia Piciocchi, PhD student Functional parameters in eating disorders
• 13/06/2025 – Daniela Caissutti Neuroglobin in neuroprotection: molecular mechanisms
• 19/06/2025 – Prof. Stefania Mardente & Prof. Silvia Marinozzi History, art, law and society: understanding and preventing gender-based violence
• 27/06/2025 – Rocco Amendolara, Research Fellow Retention of β-cell function in autoimmune diabetes
• 11/09/2025 – Pasqualino Loi, Luca Palazzese, Alessandra Bonacquisto Sperm lyophilization: present and future