Heritage science is an interdisciplinary research area based on different disciplinary skills: humanities (archaeology, philosophy, philology, geography, art history), social sciences (economics, sociology), hard sciences (chemistry, physics, geology, mathematics), architecture, computer science and engineering. The research and innovation activities of the PhD in Heritage Science (PhD-HS) aim at improving understanding and interpretation, conservation and protection, management and sustainable use of tangible and intangible natural and cultural heritage. PhD-HS is built, with strong international connotation, on the models of national PhD already started, in particular the one in Sustainable Development and Climate Change. The coordination is of Sapienza University of Rome. Universities contribute by coordinating and/or participating in one of the planned curricula (11 from archaeology to artificial intelligence, from art history to applied physics to the study of matter, from museology to environmental sciences). In addition to the participation of public bodies (CNR and INFN), PhD-HS sees the involvement of institutions belonging to the Ministry of Culture in order to better link research to real needs and address current needs and future challenges. It will be compulsory for PhD students to take courses and conduct research abroad (secondment) for a period of not less than 6 months and for a maximum of 12 months at universities, institutions, cultural institutions, in particular in the laboratories and the Central and Peripheral Institutes of the Ministry of Education, Research and Cultural Institutions. PhD-HS aims at fostering coordination, overcoming the fragmentation of the higher education system in the field of research applied to cultural heritage and creating a new generation of researchers and professionals working in the field, able to collaborate and compete in the context of the most prestigious European and international initiatives. For this reason, PhD-HS provides for the mobility of PhD students and teachers between the different locations within the same curriculum and, when possible, between multiple curricula. European research infrastructures are the ideal place to train new generations in a highly interdisciplinary and excellence-driven environment. The use of the facilities of the research infrastructures by PhD students and their involvement in their activities will be promoted. The sector operates an ecosystem of research infrastructures recognised at European and global level and included in the ESFRI Roadmap (European Strategy Forum on Research Infrastructures) such as: E-RIHS (European Research Infrastructure for Heritage Science, http://www.e-rihs.it) and DARIAH ERIC (Digital Research Infrastrutcture for the Arts and Humanities European Research Infrastructure Consortium, https://www.dariah.eu).