Phd in NETWORK ONCOLOGY AND PRECISION MEDICINE

Research: Multiomic spatial profiling of the tumor microenvironment in EBV-associated hematological malignancies

Education and Training
2025 – Residency in Anatomic Pathology at Sapienza University of Rome, with a final grade of 70/70 with honors. Experimental thesis in Hematopathology entitled: “LEF-1 Expression in CLL/SLL: A Multicenter Retrospective Study of Clinicopathological and Molecular Correlations.”
2024 – Enrollment in the PhD program in “Network Oncology and Precision Medicine” (40th cycle) at Sapienza University of Rome. Currently ongoing (2nd year).
2020 – Medical licensure (according to Italian Decree Law 17/03/2020 No.18) and registration with the Medical Board of Rome.
2019 – MD degree in Medicine and Surgery at Sapienza University of Rome, with a final grade of 110/110 with honors. Experimental thesis in Anatomic Pathology and Clinicopathological Correlations entitled: “2-[18F] Fluoro-2-deoxy-D-glucose Positron Emission Tomography (FDG-PET/CT) in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Significance and correlation of standardized uptake value (SUV) with the histological and immunohistochemical features of the disease.”

Professional Experience
January 2025 – Authorization to participate in clinical activities as a PhD physician at the UOC Anatomia e Istologia Patologica presso Policlinico Umberto I
July 2024 – November 2024 Specialist training period outside the residency network at the Hematopathology Unit, IRCCS Policlinico Sant’Orsola Hospital, Bologna.
January 2021 – January 2025 – Resident Physician (Specialty Training) at UOC Anatomia e Istologia Patologica presso Policlinico Umberto I.
July 2021 Author of the AIMS Preclinical Manual – 8th edition (2022), with particular contribution to the section on Clinical Immunology and Allergology.
February 2021 Reviewer for the lecture “Focus on Immuno-hematological Clinical Cases” – AIMS S.R.L. online course.
October 2020 – July 2021 Question development for the AIMS S.R.L. online simulator, covering the following subjects: Anatomy, Anatomic Pathology, Clinical Immunology and Allergology, Biology and Clinical Biochemistry, Pharmacology and Toxicology, Medical Genetics
December 2020 Reviewer for the Immunology lecture – AIMS S.R.L. online course. November 2020 Reviewer for the Preclinical lecture – AIMS S.R.L. online course.
July 2019 – August 2019 Practical internship required for medical licensure at the Vascular Surgery Unit, Department of Surgery “Pietro Valdoni”, Policlinico Umberto I, Rome.
August 2019 – September 2019 Practical internship required for medical licensure at: Radiology Service, Department of Radiological, Oncological and Pathological Sciences and Emergency Medicine Unit, Policlinico Umberto I, Rome.
December 2017 – February 2020 Internship at the Institute of Anatomic Pathology, Policlinico Umberto I, Rome. Activities included: • Macroscopic diagnostic evaluation and specimen grossing • Light microscopy study of major pathological conditions (oncologic and non-oncologic) involving gastrointestinal tract, urogenital system, hematopoietic system, head and neck region, central nervous system • Participation in intraoperative frozen section diagnostics • Autopsy examinations
July 2016 Internship at the Parasitology Laboratory, Department of Public Health and Infectious Diseases, Policlinico Umberto I, Rome. Activities included: • Morphological study of major parasitic species by light microscopy on histological preparations and blood/stool samples • Malaria diagnosis on thin and thick blood smears
July 2015 Internship at the Virology Laboratory, Department of Molecular Medicine, Policlinico Umberto I, Rome. Activities included: • Diagnosis of HIV infection in blood and cerebrospinal fluid samples by Real-Time PCR and evaluation of antiretroviral drug resistance by sequencing • Diagnosis of Echovirus and Coxsackievirus infections • Cell culture maintenance with evaluation by light microscopy Research project • Spatial multi-omic profiling of the tumor microenvironment in EBV-related hematologic malignancies – Part I: how EBNA2 regulates miR-155. Identification, selection, and review of EBV-positive DLBCL cases with latency II and III, and creation of a database including semiquantitative morphological and immunohistochemical features. Analysis of the expression patterns of viral latency proteins (LMP1, EBNA2), highlighting the coexistence of different viral latency states within the same neoplastic proliferation. RNA extraction from tissue samples and quantification of miR-155 by RT-qPCR, with parallel investigations performed on in vitro models.
Data analysis and interpretation with a focus on microRNA regulatory mechanisms, particularly the role of the ZFP36L1 protein, and initiation of its immunohistochemical evaluation in tissue samples. • LEF-1 expression in CLL/SLL: multicenter clinicopathological and molecular study. Development and expansion of a retrospective multicenter study aimed at evaluating LEF-1 expression in CLL/SLL and correlating it with clinical, pathological, and molecular features. Collection and review of cases from multiple centers and establishment of a bicentric research project. • Molecular characterization of splenic B-cell leukemias/lymphomas with prominent nucleoli. Collection of cases of splenic-derived B-cell leukemia/lymphoma with prominent nucleoli and initiation of a molecular characterization project using exome sequencing, bulk RNA-seq, and potentially in situ transcriptomics. • Establishment of a lymph node tissue biobank. Development of a protocol for the collection of fresh material from excisional lymph node biopsies with the aim of creating a frozen tissue archive to support diagnostic and research activities.