The scientific activity in the academic year 2024-2025 concerned all topics related to the PhD themes. Many of the results obtained by the PhD students have been presented at various national and international congresses (see PhD students). Furthermore, the PhD students produced numerous publications in international journals. The reports on the research activity carried out by the PhD students, countersigned by the Guide / Tutor Lecturers, and their publications are on the website of the Department of Experimental Medicine, under the PhD in Experimental Medicine, at the following link:
https://phd.uniroma1.it/web/ANNUAL-REPORT-EXPERIMENTAL-MEDICINE_nL3522_EN.aspx
Research activity report for doctoral students enrolled in the 39th cycle: The research topics developed by the first year students concerned:
-In vitro studies on multi-resistant bacteria;
-Exploring epigenetic modifications to target oncogenic molecules, such as mup53 and STAT3;
-Cross-talk between autophagy and cell cycle in the regulation of development and cancer;
-Innate Immune Responses to Respiratory Virus Infection and its Regulation;
-Cross-sectional and Correlation Study in Pediatric Atopic Dermatitis: Microbiota, Oncogenic Viruses, Systemic and Local Inflammatory Biomarkers;
-In vitro peptide-based strategies to overcome antibiotic resistance;
-A personalized cellular system for Cystic Fibrosis precision Therapy;
-Nutraceutical activity of bioactive molecules obtained from plant compounds;
-Analysis of Key Markers of Autophagy and Related Signal Transduction Mechanisms in Platelets and EPCs of Patients with Coronary Artery Disease: Correlation with Disease Severity, Endothelial Dysfunction, and Oxidative Stress;
Research Report for Doctoral Students Enrolled in the 38th Cycle: The research topics developed by second-year students included:
- Study of the neuroprotective mechanisms of mitochondria-associated neuroglobin;
- Evaluation of the differentiation potential of dental pulp-derived mesenchymal stem cells following hypoxic stimulation;
- Role of microbial co-infections and immune response in the persistence of human papillomavirus mucosal infections;
- Characterization of epimetabolic cross-talk contributing to pancreatic ductal adenocarcinoma onset and progression;
- Evaluation of the efficacy of PIVKA-II in the diagnosis of pancreatic cancer: biomarker expression at the circulating, tissue, and cellular levels;
- The role of autonomic dysfunction and inflammation in patients with acute coronary syndrome with normal coronary arteries: a complex relationship with potential therapeutic implications;
- Correlation of circulating MST1 and MST1-P levels in platelets and EPCs of patients with the presence and severity of coronary artery disease, endothelial dysfunction, and oxidative stress;
- Effects of the hypoxic microenvironment and the role of polysialic acid in glioblastoma.
Research Report for Doctoral Students Enrolled in the 37th Cycle: The research topics developed by third-year students included:
- Potential for UPR manipulation in the treatment of colon cancer;
- Characterization of the interferon response during SARS-CoV-2 infection and of the host factors determining COVID-19 severity; - Study of the response to SARS-CoV-2 vaccination in "fragile" populations;
- Bioenergetics in Amyotrophic Lateral Sclerosis: New Experimental Approaches and Potential Therapeutics;
- Cardiac Fibrosis in Atrial Fibrillation;
- Correlation between Aortic Wall Shrinkage and the Inflammatory Response after EVAR;
- Extracellular Vesicles in Liquid Biopsy and Tissue Samples in Adult Diffuse Gliomas: Possible Role of H3F3A p.Tyr55f;
- Intervertebral Disc Degeneration: Study of the Mechanisms Underlying Degeneration in an In Vitro Model.