VIRGINIA CIPOLLINI

Dottoressa di ricerca

ciclo: XXXIV



Titolo della tesi: Approaching the early stages of Alzheimer's Disease: evaluating the relationship with telomere length shortening and the diagnostic potential of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (Angio-OCT)

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. In recent years, thanks to the development of specific biomarkers that identify the molecular pathology of AD, it has become clear that AD dementia is a chronic condition that develops silently for more than 10 years before the onset of the first symptoms. The pathological-clinical “continuum of AD” encompasses the time between the initial neuropathological changes and symptoms of advanced disease. Timely detection of the disease would therefore recognize patients that are at risk for future cognitive deterioration and provide a time window for prevention and novel therapeutic interventions. The scopes of this thesis are focused on the evaluation of the role of telomere length, which has been proposed as a candidate biomarker of aging, on AD development, analyzing leukocyte telomere length (LTL) in a sample of Mild cognitive impairment (MCI) and AD patients compared to healthy controls, with cross-sectional and longitudinal analyses (1-year follow-up), observing that LTL may in some way influence the clinical course of patients with AD and suggesting that shorter LTL is associated with worse progression of AD (Study I). Moreover, we evaluated the diagnostic potential of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA), in the prodromal phases of AD, observing changes in retinal layer thickness and volumes compared to healthy controls but only poor relationship with cognitive functioning (Study II) and analyzing the characteristics of the retinal and choriocapillaris vascular structure, founding only a significant reduction in the flow area of choriocapillaris in patients with early AD versus the age-matched control group (Study III). In general, the results of these studies invite further clinical validation of other biomarkers in the context of early AD diagnosis, prognosis, and treatment monitoring in individual patients.

Produzione scientifica

11573/1688638 - 2023 - Retinal and Choriocapillaris Vascular Changes in Early Alzheimer Disease Patients Using Optical Coherence Tomography Angiography
Di Pippo, Mariachiara; Cipollini, Virginia; Giubilei, Franco; Scuderi, Gianluca; Abdolrahimzadeh, Solmaz - 01a Articolo in rivista
rivista: JOURNAL OF NEURO-OPHTHALMOLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 1-6 - issn: 1070-8022 - wos: (0) - scopus: (0)

11573/1634350 - 2022 - Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases.
Babiloni, Claudio; Lorenzo, Ivan; Lizio, Roberta; Lopez, Susanna; Tucci, Federico; Ferri, Raffaele; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Onofrj, Marco; Stocchi, Fabrizio; Vacca, Laura; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Marizzoni, Moira; D'antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lutfu; Yener, Görsev; Hünerli Gündüz, Duygu; Paul Taylor, John; Schumacher, Julia; Mckeith, Ian; B Frisoni, Giovanni; Francesca De Pandis, Maria; Bonanni, Laura; Del Percio, Claudio; Noce, Giuseppe - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF AGING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 88-108 - issn: 0197-4580 - wos: WOS:000800025900003 (11) - scopus: 2-s2.0-85129683296 (11)

11573/1672742 - 2022 - Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study
Babiloni, Claudio; Noce, Giuseppe; Ferri, Raffaele; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Zurrón, Montserrat; Díaz, Fernando; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lutfu; Yener, Görsev; Gündüz, Duygu Hünerli; Onorati, Paolo; Stocchi, Fabrizio; Vacca, Laura; Maestú, Fernando; Frisoni, Giovanni B; Del Percio, Claudio - 01a Articolo in rivista
rivista: CEREBRAL CORTEX (New York, NY : Oxford University Press, c1991-) pp. 2197-2215 - issn: 1047-3211 - wos: WOS:000789377200001 (9) - scopus: 2-s2.0-85128377064 (7)

11573/1646140 - 2022 - Circulating U13 Small Nucleolar RNA as a Potential Biomarker in Huntington’s Disease: A Pilot Study
Romano, Silvia; Romano, Carmela; Peconi, Martina; Fiore, Alessia; Bellucci, Gianmarco; Morena, Emanuele; Troili, Fernanda; Cipollini, Virginia; Annibali, Viviana; Giglio, Simona; Mechelli, Rosella; Ferraldeschi, Michela; Veneziano, Liana; Mantuano, Elide; Sani, Gabriele; Vecchione, Andrea; Umeton, Renato; Giubilei, Franco; Salvetti, Marco; Corbo, Rosa Maria; Scarabino, Daniela; Ristori, Giovanni - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 12440- - issn: 1661-6596 - wos: WOS:000873041100001 (1) - scopus: 2-s2.0-85140829236 (2)

11573/1693891 - 2022 - Circulating U13 small nucleolar RNA as a candidate biomarker for Huntington's disease: A Pilot Study
Romano, Silvia; Romano, Carmela; Peconi, Martina; Fiore, Alessia; Bellucci, Gianmarco; Morena, Emanuele; Troili, Fernanda; Cipollini, Virginia; Annibali, Viviana; Giglio, Simona; Mechelli, Rosella; Ferraldeschi, Michela; Veneziano, Liana; Mantuano, Elide; Sani, Gabriele; Vecchione, Andrea; Umeton, Renato; Giubilei, Franco; Salvetti, Marco; Corbo, Rosa Maria; Scarabino, Daniela; Ristori, Giovanni - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: (0) - scopus: (0)

11573/1571343 - 2021 - Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment
Babiloni, C.; Ferri, R.; Noce, G.; Lizio, R.; Lopez, S.; Lorenzo, I.; Tucci, F.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Fama, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Cipollini, V.; Marizzoni, M.; Guntekin, B.; Akturk, T.; Hanoglu, L.; Yener, G.; Ozbek, Y.; Stocchi, F.; Vacca, L.; Frisoni, G. B.; Del Percio, C. - 01a Articolo in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. 1085-1114 - issn: 1387-2877 - wos: WOS:000683026700019 (7) - scopus: 2-s2.0-85112072065 (8)

11573/1497233 - 2021 - Abnormalities of cortical sources of resting state alpha electroencephalographic rhythms are related to education attainment in cognitively unimpaired seniors and patients with Alzheimer's disease and amnesic Mild cognitive impairment
Babiloni, Claudio; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Panzavolta, Andrea; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hanoğlu, Lutfu; Yener, Görsev; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B; Del Percio, Claudio - 01a Articolo in rivista
rivista: CEREBRAL CORTEX (Oxford: Oxford University Press.) pp. - - issn: 1460-2199 - wos: WOS:000637029100025 (9) - scopus: 2-s2.0-85102910430 (14)

11573/1578470 - 2021 - Exploring the association of early life physical activity and risk of dementia: a systematic review
Della Gatta, Francesco; Lacorte, Eleonora; Fabrizi, Elisa; Remoli, Giulia; Cipollini, Virginia; Troili, Fernanda; Vanacore, Nicola; Giubilei, Franco - 01g Articolo di rassegna (Review)
rivista: MINERVA MEDICA (Edizioni Minerva Medica:Corso Bramante 83-85, 10126 Turin Italy:011 39 011 678282318, EMAIL: journals.dept@minervamedica.it, INTERNET: http://www.minervamedica.it, Fax: 011 39 011 674502) pp. 448-455 - issn: 0026-4806 - wos: WOS:000674340400004 (4) - scopus: 2-s2.0-85111505392 (3)

11573/1497209 - 2020 - Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia
Babiloni, C.; Ferri, R.; Noce, G.; Lizio, R.; Lopez, S.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Fama, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Cipollini, V.; Marizzoni, M.; Guntekin, B.; Akturk, T.; Hanoglu, L.; Yener, G.; Emek-Savas, D. D.; Stocchi, F.; Vacca, L.; Frisoni, G. B.; Del Percio, C. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 259-270 - issn: 0167-8760 - wos: WOS:000599762000001 (15) - scopus: 2-s2.0-85094903103 (15)

11573/1407361 - 2020 - Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study
Babiloni, C.; Pascarelli, M. T.; Lizio, R.; Noce, G.; Lopez, S.; Rizzo, M.; Ferri, R.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Fama, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Salvetti, M.; Cipollini, V.; Bonanni, L.; Franciotti, R.; Onofrj, M.; Stirpe, P.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Aarsland, D.; Parnetti, L.; Farotti, L.; Marizzoni, M.; D'antonio, F.; De Lena, C.; Guntekin, B.; Hanoglu, L.; Yener, G.; Emek-Savas, D. D.; Triggiani, A. I.; Taylor, J. P.; Mckeith, I.; Stocchi, F.; Vacca, L.; Hampel, H.; Frisoni, G. B.; De Pandis, M. F.; Del Percio, C. - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF AGING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 88-111 - issn: 0197-4580 - wos: WOS:000534538900012 (19) - scopus: 2-s2.0-85082532046 (22)

11573/1307828 - 2020 - Neurocognitive assessment and retinal thickness alterations in Alzheimer disease: is there a correlation?
Cipollini, Virginia; Abdolrahimzadeh, Solmaz; Troili, Fernanda; De Carolis, Antonella; Calafiore, Silvia; Scuderi, Luca; Giubilei, Franco; Scuderi, Gianluca - 01a Articolo in rivista
rivista: JOURNAL OF NEURO-OPHTHALMOLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 370-377 - issn: 1070-8022 - wos: WOS:000571163200020 (21) - scopus: 2-s2.0-85089613790 (23)

11573/1477827 - 2020 - Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms
Pascarelli, M. T.; Del Percio, C.; De Pandis, M. F.; Ferri, R.; Lizio, R.; Noce, G.; Lopez, S.; Rizzo, M.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Fama, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Salvetti, M.; Cipollini, V.; Franciotti, R.; Onofri, M.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Aarsland, D.; Parnetti, L.; Farotti, L.; Marizzoni, M.; D'antonio, F.; De Lena, C.; Guntekin, B.; Hanoglu, L.; Yener, G.; Emek-Savas, D. D.; Ivano Triggiani, A.; Paul Taylor, J.; Mckeith, I.; Stocchi, F.; Vacca, L.; Hampel, H.; Frisoni, G. B.; Bonanni, L.; Babiloni, C. - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 2716-2731 - issn: 1388-2457 - wos: WOS:000580661200024 (11) - scopus: 2-s2.0-85092140716 (12)

11573/1477823 - 2020 - Corrigendum: Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System (Frontiers in Neuroanatomy, (2020), 14, 10.3389/fnana.2020.00017)
Troili, F.; Cipollini, V.; Moci, M.; Morena, E.; Palotai, M.; Rinaldi, V.; Romano, C.; Ristori, G.; Giubilei, F.; Salvetti, M.; Orzi, F.; Guttmann, C. R. G.; Cavallari, M. - 01b Commento, Erratum, Replica e simili
rivista: FRONTIERS IN NEUROANATOMY (Lausanne : Frontiers Research Foundation, 2007-) pp. 51- - issn: 1662-5129 - wos: WOS:000576084100001 (0) - scopus: 2-s2.0-85091770391 (7)

11573/1574278 - 2020 - Perivascular unit: this must be the place. The anatomical crossroad between the immune, vascular and nervous system
Troili, F; Cipollini, V; Moci, M; Morena, E; Palotai, M; Rinaldi, V; Romano, C; Ristori, G; Giubilei, F; Salvetti, M; Orzi, F; Guttmann, Crg; Cavallari, M - 01g Articolo di rassegna (Review)
rivista: FRONTIERS IN NEUROANATOMY (Lausanne : Frontiers Research Foundation, 2007-) pp. 14-17 - issn: 1662-5129 - wos: WOS:000531196200001 (47) - scopus: 2-s2.0-85084082947 (41)

11573/1246711 - 2019 - Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases
Babiloni, Claudio; Del Percio, Claudio; Pascarelli, Maria Teresa; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Rizzo, Marco; Ferri, Raffaele; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Salvetti, Marco; Cipollini, Virginia; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Farotti, Lucia; Marizzoni, Moira; D'antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; Mckeith, Ian; Stocchi, Fabrizio; Vacca, Laura; Hampel, Harald; Frisoni, Giovanni B.; De Pandis, Maria Francesca; Bonanni, Laura - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF AGING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 112-127 - issn: 0197-4580 - wos: WOS:000465302200012 (28) - scopus: 2-s2.0-85061751338 (32)

11573/1348179 - 2019 - Emerging biomarkers in vascular cognitive impairment and dementia. From pathophysiological pathways to clinical application
Cipollini, V.; Troili, F.; Giubilei, F. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-27 - issn: 1661-6596 - wos: WOS:000472634100206 (55) - scopus: 2-s2.0-85067808754 (61)

11573/1336007 - 2019 - Th17 and Cognitive Impairmen. Possible Mechanisms of Action
Cipollini, V; Anrather, J; Orzi, F; Iadecola, C. - 01g Articolo di rassegna (Review)
rivista: FRONTIERS IN NEUROANATOMY (Lausanne : Frontiers Research Foundation, 2007-) pp. 1-12 - issn: 1662-5129 - wos: WOS:000501211700001 (74) - scopus: 2-s2.0-85076710701 (81)

11573/1336011 - 2019 - Neurovascular Dysfunction in Alzheimer Disease. Assessment of Cerebral Vasoreactivity by Ultrasound Techniques and Evaluation of Circulating Progenitor Cells and Inflammatory Markers
Cipollini, Virginia; Sette, G.; Bossu, P.; Ciaramella, A.; Salani, F.; De Carolis, A.; Troili, F.; Orzi, F.; Giubilei, F. - 01a Articolo in rivista
rivista: ALZHEIMER DISEASE & ASSOCIATED DISORDERS (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 212-219 - issn: 0893-0341 - wos: WOS:000486156400006 (6) - scopus: 2-s2.0-85069647712 (7)

11573/982231 - 2017 - Cognitive profiles in degenerative dementia without evidence of small vessel pathology and small vessel vascular dementia
De Carolis, Antonella; Cipollini, Virginia; Donato, Nicole; Sepe Monti, Micaela; Orzi, Francesco; Giubilei, Franco - 01a Articolo in rivista
rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 101-107 - issn: 1590-1874 - wos: WOS:000394217500013 (3) - scopus: 2-s2.0-84988659985 (4)

11573/1311784 - 2016 - Evaluation of retinal thickness in Alzheimer's disease
Troili, F; Orlando, Biagio; Calafi, S; Cipollini, V; Pranna, F; De Carolis, A; Scuderi, G; Giubilei, F - 01h Abstract in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. S55-S55 - issn: 1387-2877 - wos: WOS:000377138200081 (0) - scopus: (0)

11573/778160 - 2015 - Anosognosia in people with cognitive impairment: association with cognitive deficits and behavioral disturbances
Carolis, A. D.; Cipollini, Virginia; Corigliano, V.; Comparelli, A.; Sepe Monti, M.; Orzi, F.; Ferracuti, Stefano; Giubilei, Franco - 01a Articolo in rivista
rivista: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. EXTRA (Basel: S. Karger, 2011-) pp. 42-50 - issn: 1664-5464 - wos: WOS:000367323400005 (21) - scopus: 2-s2.0-84931435717 (22)

11573/513857 - 2012 - Neuropsychological patterns underlying anosognosia in people with cognitive impairment.
Decarolis, A.; Corigliano, V.; Comparelli, A.; Sepe Monti, M.; Cipollini, V.; Orzi, Francesco; Ferracuti, Stefano; Giubilei, Franco - 01a Articolo in rivista
rivista: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (S Karger AG:Allschwilerstrasse 10, CH-4009 Basel Switzerland:011 41 61 3061111, EMAIL: orders@karger.ch, INTERNET: http://www.karger.com, Fax: 011 41 61 3061234) pp. 216-223 - issn: 1420-8008 - wos: WOS:000312897800010 (6) - scopus: 2-s2.0-84868227608 (6)

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