VALERIA TERESA BARLETTA

Dottoressa di ricerca

ciclo: XXXIII



Titolo della tesi: In vivo analyses of the correlates of cortical and white matter pathology in patients with multiple sclerosis by quantitative 7 Tesla and 3 Tesla MRI and molecular imaging

This thesis is divided in two sections. The first reports the results from a project regarding the application of ultra-high-field quantitative MRI for the study of cortical grey matter pathology in patients with early multiple sclerosis (MS). Applying a Combined Myelin Estimation method, obtained by 7 Tesla magnetic resonance imaging, we aimed at characterizing cortical microstructural abnormalities related to myelin content in cortical lesions and normal-appearing cortex, to assess their evolution at 1-year follow-up and to relate cortical myelin changes to clinical and radiological disease burden. Data obtained from 25 patients with early MS and 19 healthy volunteers showed overall abnormally low myelin content in cortical lesions and several areas of normal-appearing cortex. Myelin content along the cortex correlated with neurological impairment. Individual cortical lesion analysis revealed heterogenous patterns, ranging from extensive to partial demyelination, or even measurements comparable to the healthy group. At 1-year follow-up, cortical myelin was overall decreased in cortical lesions and scattered areas in the normal-appearing cortex. Diffusion metrics obtained in the same regions did not show the presence of cortical neural loss accompanying early demyelination. The second section reports results from a study in which we combined 11C-PBR28 positron-emission tomography, marking activated microglia, with the more recently validated synthetic magnetic resonance imaging for myelin content assessment, aiming at researching the presence of correlates of pathology in the white matter of patients with multiple sclerosis at different disease stages, and assessing the interplay between neuroinflammation and demyelination. We found abnormal increase of microglia activation in MS patients compared to healthy volunteers in several areas across the white matter, correlating with clinical and radiological disease burden. An individual analysis of white matter lesions showed the presence of active lesions in the early phases of the disease, evolving in inactive or peripherally active lesions in the late disease phases, the latter correlating with clinical disability. Myelin content in the normal-appearing white matter of MS patients correlated with neurological impairment and lesion load. Higher microglia activation in the white matter lesions was related to lower myelin content in the non-lesioned white matter.

Produzione scientifica

11573/1489939 - 2021 - The relevance of multiple sclerosis cortical lesions on cortical thinning and their clinical impact as assessed by 7.0-T MRI.
Treaba, Ca; Mercaldo, N; Herranz, E; Barletta, V; Mehndiratta, A; Ouelette, R; Sloane, J; Klawiter, E; Kinkel, R; Mainero, C. - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:000613597200001 (1) - scopus: 2-s2.0-85100136524 (1)

11573/1344657 - 2020 - Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by 11 C-PBR28 MR-PET
Barletta, Valeria Teresa; Herranz, E.; Treaba, C. A.; Ouellette, R.; Mehndiratta, A.; Loggia, M.; Klawiter, E. C.; Ionete, C.; Jacob, S. A.; Mainero, C. - 01a Articolo in rivista
rivista: MULTIPLE SCLEROSIS (Basingstoke: Stocktom, 1995-. United Kingdom: Arnold) pp. 668-678 - issn: 1352-4585 - wos: WOS:000533125500008 (15) - scopus: 2-s2.0-85064563754 (15)

11573/1489933 - 2020 - Ultra-high field 7 T imaging in multiple sclerosis.
Louapre, C; Treaba, Ca; Barletta, V; Mainero, C. - 01a Articolo in rivista
rivista: CURRENT OPINION IN NEUROLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. - - issn: 1350-7540 - wos: WOS:000561276800002 (5) - scopus: 2-s2.0-85088487372 (5)

11573/1489937 - 2020 - Characterization of thalamic lesions and their correlates in multiple sclerosis by ultra-high-field MRI.
Mehndiratta, A; Treaba, Ca; Barletta, V; Herranz, E; Ouellette, R; Jacob, A Sloane Ja; Klawiter, Ec; Kinkel, Rp; Mainero, C. - 01a Articolo in rivista
rivista: MULTIPLE SCLEROSIS (Basingstoke: Stocktom, 1995-. United Kingdom: Arnold) pp. - - issn: 1352-4585 - wos: WOS:000630775700007 (9) - scopus: 2-s2.0-85086853065 (8)

11573/1489929 - 2020 - 7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis.
Ouellette, R; Treaba, Ca; Granberg, T; Herranz, E; Barletta, V; Mehndiratta, A; De Leener, B; Tauhid, S; Yousuf, F; Dupont, Sm; Klawiter, Ec; Sloane, Ja; Bakshi, R; Cohen-Adad, J; Mainero, C. - 01a Articolo in rivista
rivista: BRAIN (-Oxford: Oxford University Press -Oxford: Clarendon Press -London: Macmillan -London: Butterworths Scientific Publications, 1878-) pp. - - issn: 0006-8950 - wos: WOS:000607101500022 (12) - scopus: 2-s2.0-85094685280 (9)

11573/1344668 - 2019 - In vivo characterization of cortical lesion demyelination and remyelination in early multiple sclerosis by quantitative 7 Tesla MRI
Barletta, V.; Herranz, E.; Treaba, A.; Mehndiratta, A.; Ouellette, R.; Mangeat, G.; Sloane, J.; Mercaldo, N.; Cohen-Adad, J.; Mainero, C. - 04d Abstract in atti di convegno
congresso: ECTRIMS 2019 (Stoccolma)
libro: ECTRIMS Online Library - ()

11573/1344667 - 2019 - Whole brain in vivo axonal diameter mapping in multiple sclerosis
De Santis, Silvia; Herranz, Elena; Treaba, Constantina A.; Barletta, Valeria Teresa; Mehndiratta, Ambica; Mainero, Caterina; Toschi, Nicola - 04d Abstract in atti di convegno
congresso: Engineering in Medicine and Biology Society (EMBC), Annual International Conference of the IEEE (Berlino)
libro: IEEE - ()

11573/1344663 - 2019 - Profiles of cortical and white matter lesion inflammation in multiple sclerosis by combined 11C-PBR28 and 7 T imaging
Herranz, E.; Barletta, V.; Treaba, C. A.; Mehndiratta, A.; Ouellette, R.; Loggia, M.; Klawiter, E.; Sloane, J.; Mainero., C. - 04f Poster
congresso: ECTRIMS 2019 (Stoccolma)
libro: ECTRIMS online library - ()

11573/1344665 - 2019 - Thalamic atrophy and its substrates in multiple sclerosis by ultra-high field MRI
Mehndiratta, A.; Treaba, C. A.; Barletta, V.; Herranz, E.; Ouellette, R.; Sloane, J.; Klawiter, E.; Mainero, C. - 04f Poster
congresso: ECTRIMS 2019 (Stoccolma)
libro: ECTRIMS online library - ()

11573/1344666 - 2019 - Characterization of outer and inner spinal cord pathology in multiple sclerosis by 7 Tesla imaging. ECTRIMS 2019
Ouellette, R.; Treaba, C. A.; Granberg, T.; Herranz, E.; Barletta, Valeria Teresa; Mehndiratta, A.; De Leener, B.; Tauhid, S.; Yousuf, F.; Dupont, S.; Klawiter, E. C.; Sloane, J. A.; Bakshi, R.; Cohen-Adad, J.; Mainero, C. - 04f Poster
congresso: ECTRIMS 2019 (Stoccolma)
libro: ECTRIMS online library - ()

11573/1344664 - 2019 - The relevance of 7-Tesla paramagnetic rim lesions in patients with multiple sclerosis
Treaba, C.; Granberg, T.; Herranz, E.; Mercaldo, N.; Barletta, V.; Mehndiratta, A.; Ouellette, R.; Sloane, J.; Kinkel, R.; Mainero, C. - 04f Poster
congresso: ECTRIMS 2019 (Stoccolma)
libro: ECTRIMS Online Library - ()

11573/1173024 - 2018 - In vivo characterization of cerebellar microglia activation in multiple sclerosis by combined 11C-PBR28 MR-PET and 7 Tesla MRI.
Barletta, V.; Herranz, E.; Treaba, C. A.; Ouellette, R.; Mehndiratta, A.; Loggia, M.; Klawiter, E.; Ionete, C.; Sloane, J.; Mainero, C. - 04f Poster
congresso: ISMRM (Paris)
libro: ISMRM - ()

11573/1173015 - 2018 - Microglia activation in cerebellum increases with proximity to the fourth ventricle in progressive MS.
Barletta, V; Herranz, E; Treaba, Ca; Ouellette, R; Mehndiratta, A; Loggia, M; Klawiter, E; Ionete, C; Sloane, J; Mainero, C. - 04f Poster
congresso: ECTRIMS (Berlin)
libro: MS Journal - ()

11573/957368 - 2017 - Effect on cognition of estroprogestins combined with Interferon Beta in multiple sclerosis: analysis of secondary outcomes from a randomised controlled trial
De Giglio, Laura; Marinelli, Fabiana; Barletta, Valeria Teresa; Pagano, Veronica A.; De Angelis, Floriana; Fanelli, Fulvia; Petsas, Nikolaos; Pantano, Patrizia; Tomassini, Valentina; Pozzilli, Carlo - 01a Articolo in rivista
rivista: CNS DRUGS (Adis International Limited:Private Bag 65901, Mairangi Bay, Auckland 1311 New Zealand:011 64 9 4770741, EMAIL: subs@adis.com, david.herrick@adis.co.nz, INTERNET: http://www.adis.com, Fax: 011 64 9 4770766) pp. 161-168 - issn: 1172-7047 - wos: WOS:000394150600006 (23) - scopus: 2-s2.0-85006516172 (28)

11573/794845 - 2015 - Relationship between prolactin plasma levels and white matter volume in women with multiple sclerosis
De Giglio, Laura; Marinelli, Fabiana; Prosperini, Luca; Contessa, Gian Marco; Gurreri, F.; Piattella, Maria Cristina; De Angelis, Floriana; Barletta, Valeria Teresa; Tomassini, Valentina; Pantano, Patrizia; Pozzilli, Carlo - 01a Articolo in rivista
rivista: MEDIATORS OF INFLAMMATION (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245 Oxford: Rapid Communications.) pp. - - issn: 0962-9351 - wos: WOS:000358238900001 (15) - scopus: 2-s2.0-84937775635 (16)

11573/1174155 - 2015 - Two determinants of late disability progression in multiple sclerosis: early inflammatory disease and old age in damaged brain.
Fanelli, F.; Danni, M.; Cavalla, P.; Binello, E.; Barletta, V.; Prosperini, L.; Pinessi, L.; Provinciali, L.; Pozzilli, C. - 04f Poster
congresso: ECTRIMS (Bercellona)
libro: MS Journal - ()

11573/1081799 - 2015 - Oral contraceptives combined with interferon β in multiple sclerosis
Pozzilli, Carlo; De Giglio, Laura; Barletta, Valeria T.; De Angelis, Floriana; Gallo, Valentina; Pagano, Veronica A.; Marini, Stefano; Piattella, Maria C.; Tomassini, Valentina; Pantano, Patrizia; Marinelli, Fabiana - 01a Articolo in rivista
rivista: NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION (Baltimore, MD : Wolters Kluwer Health/Lippincott Williams & Wilkins [2014]-) pp. - - issn: 2332-7812 - wos: WOS:000218627600007 (63) - scopus: 2-s2.0-84991473651 (67)

11573/762924 - 2014 - Interferon-beta-1a treatment has a positive effect on quality of life of relapsing-remitting multiple sclerosis: results from a longitudinal study. J Neurol Sci. 2014 Feb 15;337(1-2):180-5. doi: 10.1016/j.jns.2013.12.006. Epub 2013 Dec 26.
Patti, F; Pappalardo, A; Montanari, E; Pesci, I; Barletta, V; Pozzilli, Carlo - 01a Articolo in rivista
rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0022-510X - wos: (0) - scopus: (0)

11573/543171 - 2013 - Mood and coping in clinically isolated syndrome and multiple sclerosis.
Bianchi, Valentina; De Giglio, Laura; Prosperini, Luca; Mancinelli, C; De Angelis, Floriana; Barletta, Valeria Teresa; Pozzilli, Carlo - 01a Articolo in rivista
rivista: ACTA NEUROLOGICA SCANDINAVICA (Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377) pp. - - issn: 0001-6314 - wos: WOS:000333851500004 (19) - scopus: (0)

11573/543139 - 2013 - Interferon beta failure predicted by EMA criteria or isolated MRI activity in multiple sclerosis.
Prosperini, Luca; Mancinelli, Cr; De Giglio, Laura; De Angelis, Floriana; Barletta, Valeria Teresa; Pozzilli, Carlo - 01a Articolo in rivista
rivista: MULTIPLE SCLEROSIS (Basingstoke: Stocktom, 1995-. United Kingdom: Arnold) pp. -... - issn: 1352-4585 - wos: WOS:000333690400010 (41) - scopus: 2-s2.0-84899115698 (44)

11573/762954 - 2012 - Predictors of freedom from disease activity in natalizumab treated-patients with multiple sclerosis. J Neurol Sci. 2012 Dec 15;323(1-2):104-12. doi: 10.1016/j.jns.2012.08.027. Epub 2012 Sep 21.
Prosperini, Luca; Gianni', Costanza; Barletta, V; Mancinelli, C; Fubelli, F; Borriello, Giovanna; Pozzilli, Carlo - 01a Articolo in rivista
rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0022-510X - wos: (0) - scopus: (0)

11573/866371 - 2012 - Predictors of freedom from disease activity in natalizumab treated-patients with multiple sclerosis
Prosperini, Luca; Gianni', Costanza; Barletta, Valeria Teresa; Mancinelli, Chiara; Fubelli, Federica; Borriello, Giovanna; Pozzilli, Carlo - 01a Articolo in rivista
rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 104-112 - issn: 0022-510X - wos: WOS:000311132700018 (41) - scopus: 2-s2.0-84867849114 (45)

11573/380525 - 2011 - Management of breakthrough disease in patients with multiple sclerosis: when an increasing of Interferon beta dose should be effective?
Prosperini, Luca; Giovanna, Borriello; Laura De Giglio, ; Laura, Leonardi; Barletta, Valeria Teresa; Pozzilli, Carlo - 01a Articolo in rivista
rivista: BMC NEUROLOGY ([London]: BioMed Central.) pp. - - issn: 1471-2377 - wos: WOS:000288383900001 (17) - scopus: 2-s2.0-79951945249 (19)

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