VALENTINA MAGRI

Dottoressa di ricerca

ciclo: XXXIV


supervisore: Prof Vito D'Andrea
relatore: Prof Vito D'Andrea

Titolo della tesi: Tecnologia Avanzata SeRAD: Selective Radioassisted Axillary Dissection nelle pazienti operate per carcinoma della mammella localmente avanzato in risposta dopo trattamento neoadiuvante.

OBJECTIVES: Single-center retrospective analysis with a long follow-up to evaluate rates of axillary recurrence, Disease Free Survival (DFS), complications and re-interventions in clinically lymph node positive breast cancer patients who underwent innovative Selective Radioassisted Axillary Dissection (SeRAD) or Sentinel lymph node biopsy (SLNB) or complete axillary lymph node dissection (ALND) after neoadjuvant treatment. METHODS: we retrospectively enrolled locally advanced breast cancer patients submitted to neoadjuvant chemotherapy followed by surgery. Main inclusion criteria were age ≥ 18 years, histologically confirmed breast cancer with clinically positive axillary lymph nodes; no distant lesions, no previous radiation on chest and axilla, no previous surgery on axilla. SLNB removed sentinel and parasentinel lymph nodes (maximum three nodes) capturing the radioactive tracer. SeRAD consisted of the removal of at least four up to a maximum of nine lymph nodes, capturing the radioactive tracer. ALND included removal of at least ten axillary lymph nodes (levels I-II). RESULTS: 114 patients were included in the analysis. At the axillary level, 52 patients (46%) were treated with ALND, 42 patients (37%) were treated with SeRAD and finally 20 patients (17%) with SNLB. At a mean follow-up of 66 months (range 25-107 months), relapse of disease was observed in 28 patients: 5 in the group who received SNLB, 8 in the SeRAD group and finally 15 in the group treated with ALND. 7 patients had an axillary recurrence, all these patients have previously received ALND. At 5 years, 70% (p-value = 0.12) of patients in the SNLB group, 84% (p-value = 0.05) in the SeRAD group and 87% (p-value = 0.05) in ALND group are disease-free. The DFS is positively influenced by the achievement of the pRC (p-value = 0.032). 15 patients presented post-surgery complications: 13 patients belonging to ALND group, 1 patient who received SeRAD technique and finally 1 patient from the SNLB group. This difference is statistically significant (p-value = 0.003). Lymphedema appeared in 13 patients (11.4% of the entire sample), 12 belonged to the group treated with ALND and 1 to the SeRAD group (p-value = 0.02). CONCLUSIONS: In our analysis, SeRAD is a feasible and safe procedure in patients affected by locally advanced breast cancer who underwent neoadjuvant treatment with clinically positive axillary nodes at diagnosis. These results, albeit initial and limited, represent an opportunity for an evolution in the field of cancer surgery, further studies can confirm this new strategy. This technique aims to reduce the extent of surgery at axillary level and the risk of postoperative complications, while preserving excellent oncological results in terms of disease-free survival and long-term quality of life.

Produzione scientifica

  • 11573/502026 - 2013 - Multimodality Treatment of Gynecomastia in Patients Receiving Antiandrogen Therapy for Prostate Cancer in the Era of Abiraterone Acetate and New Antiandrogen Molecules (01a Articolo in rivista)
    ALESINI, DANIELE; IACOVELLI, ROBERTO; PALAZZO, ANTONELLA; ALTAVILLA, AMELIA; RISI, EMANUELA; URBANO, FEDERICA; MANAI, CHIARA; PASSARO, ANTONIO; MAGRI, VALENTINA; CORTESI, ENRICO
  • 11573/935217 - 2016 - Safety analysis, association with response and previous treatments of everolimus and exemestane in 181 metastatic breast cancer patients. A multicenter Italian experience (01a Articolo in rivista)
    CORTESI, ENRICO; MARCHETTI, PAOLO; SANTINI, DANIELE; PIZZUTI, LAURA; FABBRI, MARIA AGNESE; MAGRI, VALENTINA; SINI, VALENTINA; MENTUCCIA, LUCIA
  • 11573/966321 - 2017 - EpCAM expressing circulating tumor cells in colorectal cancer (01a Articolo in rivista)
    NICOLAZZO, CHIARA; RAIMONDI, CRISTINA; CECCARELLI, SIMONA; MAGRI, VALENTINA; MARCHESE, CINZIA; GRADILONE, ANGELA; GAZZANIGA, PAOLA
  • 11573/1118454 - 2016 - Eribulin in male patients with breast cancer: The first report of clinical outcomes (01a Articolo in rivista)
    GIORDANO, GUIDO; MAGRI, VALENTINA; TEDESCHI, MARIA
  • 11573/1118444 - 2018 - Automated classification of focal breast lesions according to S-detect: validation and role as a clinical and teaching tool (01a Articolo in rivista)
    DI SEGNI, MATTIA; DE SOCCIO, VALERIA; CANTISANI, VITO; BONITO, GIACOMO; RUBINI, ANTONELLO; LAMORTE, SVEVA; MAGRI, VALENTINA; DE VITO, CORRADO; MIGLIARA, GIUSEPPE; METERE, ALESSIO; GIACOMELLI, LAURA; DE FELICE, CARLO; D'AMBROSIO, FERDINANDO
  • 11573/1677825 - 2023 - Prognostic role of circulating tumor cell trajectories in metastatic colorectal cancer (01a Articolo in rivista)
    MAGRI, VALENTINA; MARINO, LUCA; NICOLAZZO, CHIARA; GRADILONE, ANGELA; DE RENZI, GIANLUIGI; DE MEO, MICHELA; GANDINI, ORIETTA; SABATINI, ARIANNA; SANTINI, DANIELE; CORTESI, ENRICO; GAZZANIGA, PAOLA
  • 11573/1676520 - 2023 - Genomic landscape and survival analysis of ctDNA “neo-RAS wild-type” patients with originally RAS mutant metastatic colorectal cancer (01a Articolo in rivista)
    NICOLAZZO, CHIARA; MAGRI, VALENTINA; MARINO, LUCA; BELARDINILLI, FRANCESCA; DE RENZI, GIANLUIGI; CAPONNETTO, SALVATORE; DE MEO, MICHELA; GIANNINI, GIUSEPPE; SANTINI, DANIELE; CORTESI, ENRICO; GAZZANIGA, PAOLA
  • 11573/1187945 - 2019 - A multicenter REtrospective observational study of first-line treatment with PERtuzumab, trastuzumab and taxanes for advanced HER2 positive breast cancer patients. RePer Study (01a Articolo in rivista)
    PIZZUTI, LAURA; MENTUCCIA, LUCIA; SPERDUTI, ISABELLA; BARBA, MADDALENA; BARCHIESI, GIACOMO; MAGRI, VALENTINA; BOTTICELLI, ANDREA; FABBRI, MARIA AGNESE; MAZZOTTA, MARCO; SANTINI, DANIELE; MARCHETTI, PAOLO; TOMAO, SILVERIO
  • 11573/1224164 - 2019 - A simplified genomic profiling approach predicts outcome in metastatic colorectal cancer (01a Articolo in rivista)
    CAPALBO, CARLO; BELARDINILLI, FRANCESCA; RAIMONDO, DOMENICO; MILANETTI, EDOARDO; MAGRI, VALENTINA; PRETE, ALESSANDRA ANNA; PECORARI, SILVIA; COPPA, ANNA; NICOLUSSI, ARIANNA; VALENTINI, VIRGINIA; CARDINALI, BEATRICE; PETRONI, MARIALAURA; INFANTE, PAOLA; FILETTI, MARCO; COLICCHIA, VALERIA; PACI, PAOLA; MEZI, SILVIA; CORTESI, ENRICO; MARCHETTI, PAOLO; BELLAVIA, DIANA; CANETTIERI, GIANLUCA; GIANNINI, GIUSEPPE
  • 11573/1686009 - 2023 - Is cancer an intelligent species? (01g Articolo di rassegna (Review))
    NICOLAZZO, CHIARA; MAGRI, VALENTINA; GAZZANIGA, PAOLA
  • 11573/1280087 - 2016 - Prolactin as a potential negative predictive factor in metastatic non-small cell lung cancers (NSCLC) patients in treatment with Nivolumab (NIVO) (01h Abstract in rivista)
    CAPONNETTO, SALVATORE; MANCINI, MARIALAURA; MANAI, CHIARA; MAGRI, VALENTINA; PELLEGRINO, DENISE; MOSILLO, CLAUDIA; PIESCO, GABRIELE; POMATI, GIULIA; SCAGNOLI, SIMONE; URBANO, FEDERICA; BARCHIESI, GIACOMO; ZANCLA, SERENA; CORTESI, ENRICO
  • 11573/1669080 - 2023 - Pregnancy-associated breast cancer: a diagnostic and therapeutic challenge (01g Articolo di rassegna (Review))
    GALATI, FRANCESCA; MAGRI, VALENTINA; MOFFA, GIULIANA; RIZZO, VERONICA; PASCULLI, MARCELLA; BOTTICELLI, ANDREA; PEDICONI, FEDERICA
  • 11573/1307277 - 2020 - Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti-HER2 agents in the real world setting (01a Articolo in rivista)
    PIZZUTI, LAURA; BARCHIESI, GIACOMO; MARCHETTI, PAOLO; MAZZOTTA, MARCO; GIUSTI, RAFFAELE; BOTTICELLI, ANDREA; TOMAO, SILVERIO; TOMAO, FEDERICA; SANTINI, DANIELE; MENTUCCIA, LUCIA; MAGRI, VALENTINA; CORTESI, ENRICO; FABBRI, MARIA AGNESE; D'AURIA, GIULIANA; SINI, VALENTINA; LIVI, LORENZO; DE MARIA MARCHIANO, RUGGERO; RISI, EMANUELA; SPERDUTI, ISABELLA; BARBA, MADDALENA
  • 11573/1352290 - 2019 - Correlation of body composition by computerized tomography and metabolic parameters with survival of nivolumab-treated lung cancer patients (01a Articolo in rivista)
    MAGRI, VALENTINA; DI SEGNI, MATTIA
  • 11573/1408005 - 2020 - T-DM1 Efficacy in patients with HER2-positive metastatic breast cancer progressing after a Taxane Plus Pertuzumab and Trastuzumab. An italian multicenter observational study (01a Articolo in rivista)
    MAGRI, VALENTINA; NASO, GIUSEPPE
  • 11573/1399216 - 2020 - Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer (01a Articolo in rivista)
    BELARDINILLI, FRANCESCA; CAPALBO, CARLO; RAIMONDO, DOMENICO; MILANETTI, EDOARDO; MAHDAVIAN, YASAMAN; PACI, PAOLA; SIBILIO, PASQUALE; MEZI, SILVIA; MAGRI, VALENTINA; COPPA, ANNA; NICOLUSSI, ARIANNA; GRADILONE, ANGELA; PETRONI, MARIALAURA; DI GIULIO, STEFANO; FABRETTI, FRANCESCA; INFANTE, PAOLA; CONI, SONIA; CANETTIERI, GIANLUCA; GIANNINI, GIUSEPPE
  • 11573/1455319 - 2020 - Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer (01a Articolo in rivista)
    NICOLAZZO, CHIARA; LORENI, FLAVIA; CAPONNETTO, SALVATORE; MAGRI, VALENTINA; VESTRI, ANNA RITA; GRADILONE, ANGELA; CORTESI, ENRICO; GAZZANIGA, PAOLA
  • 11573/1339976 - 2019 - Circulating tumor cells in right-and left-sided colorectal cancer (01a Articolo in rivista)
    NICOLAZZO, CHIARA; RAIMONDI, CRISTINA; GRADILONE, ANGELA; EMILIANI, ALESSANDRA; FRANCESCANGELI, FEDERICA; BELARDINILLI, FRANCESCA; SEMINARA, PATRIZIA; LORENI, FLAVIA; MAGRI, VALENTINA; TOMAO, SILVERIO; GAZZANIGA, PAOLA
  • 11573/1118468 - 2015 - The promise of liquid biopsy in cancer: a clinical perspective (01i Case report)
    CORTESI, ENRICO; PALLESCHI, MICHELA; MAGRI, VALENTINA; NASO, GIUSEPPE
  • 11573/1554118 - 2020 - Palbociclib plus fulvestrant or everolimus plus exemestane for pretreated advanced breast cancer with lobular histotype in ER+/HERr2− patients: A propensity score-matched analysis of a multicenter retrospective patient series (01a Articolo in rivista)
    BOTTICELLI, ANDREA; PALAZZO, ANTONELLA; ALESINI, DANIELE; MAGRI, VALENTINA; NASO, GIUSEPPE; MARCHETTI, PAOLO
  • 11573/1585341 - 2021 - Role of chemotherapy in vulvar cancers: time to rethink standard of care? (01g Articolo di rassegna (Review))
    MAZZOTTA, MARCO; PIZZUTI, LAURA; DI LISA, FRANCESCA SOFIA; TOMAO, SILVERIO; MARCHETTI, LUCA; BOTTICELLI, ANDREA; MARCHETTI, PAOLO; MAGRI, VALENTINA; PISEGNA, SIMONA; BUZZACCHINO, FEDERICA
  • 11573/1601268 - 2021 - Sequential isolation and characterization of single CTCs and large CTC clusters in metastatic colorectal cancer patients (01a Articolo in rivista)
    MAGRI, VALENTINA; DE RENZI, GIANLUIGI; GANDINI, ORIETTA; GAZZANIGA, PAOLA; NICOLAZZO, CHIARA
  • 11573/1617992 - 2020 - Oncotype DX predictive nomogram for recurrence score output: the novel system ADAPTED01 based on quantitative immunochemistry analysis (01a Articolo in rivista)
    MAGRI, VALENTINA; SANTORO, ANTONIO; NASO, GIUSEPPE; TOMAO, SILVERIO
  • 11573/1616972 - 2022 - An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile (01a Articolo in rivista)
    NICOLAZZO, CHIARA; COLACE, LIDIA; MAGRI, VALENTINA; CIARDI, ANTONIO; SCAROLA, FRANCESCO; LA TORRE, FILIPPO; GAZZANIGA, PAOLA
  • 11573/1616979 - 2022 - RAS mutation conversion in bevacizumab-treated metastatic colorectal cancer patients: a liquid biopsy based study (01a Articolo in rivista)
    NICOLAZZO, CHIARA; BELARDINILLI, FRANCESCA; VESTRI, ANNA RITA; MAGRI, VALENTINA; DE RENZI, GIANLUIGI; DE MEO, MICHELA; CAPONNETTO, SALVATORE; CORTESI, ENRICO; GIANNINI, GIUSEPPE; GAZZANIGA, PAOLA
  • 11573/1650247 - 2017 - Comparative effects of Folfirinox and Gemcitabine/nab-paclitaxel as first and second line chemotherapy for metastatic pancreatic cancer: single choice or sequence (01h Abstract in rivista)
    CAPONNETTO, SALVATORE; MAGRI, VALENTINA; SCAGNOLI, SIMONE; POMATI, GIULIA; PIESCO, GABRIELE; PISEGNA, SIMONA; SIRGIOVANNI, GRAZIA; NAPOLI, VALERIO MARIA; BUSCICCHIO, DARIO; MARINELLI, DANIELE; MAMMONE, GIULIA; ASTORINO, VINCENZO; CORTESI, ENRICO
  • 11573/1658907 - 2022 - Precision medicine in breast cancer: do MRI biomarkers identify patients who truly benefit from the Oncotype DX Recurrence Score® Test? (01a Articolo in rivista)
    GALATI, FRANCESCA; MAGRI, VALENTINA; MOFFA, GIULIANA; RIZZO, VERONICA; BOTTICELLI, ANDREA; CORTESI, ENRICO; PEDICONI, FEDERICA
  • 11573/1275290 - 2019 - Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: a real-world experience (01a Articolo in rivista)
    MENTUCCIA, LUCIA; BARBA, MADDALENA; MARCHETTI, PAOLO; TOMAO, SILVERIO; SERGI, DOMENICO; SANTINI, DANIELE; SINI, VALENTINA; BOTTICELLI, ANDREA; CORTESI, ENRICO; MAGRI, VALENTINA; POMATI, GIULIA; SCAGNOLI, SIMONE; SEMINARA, PATRIZIA
  • 11573/969802 - 2017 - Prolactin as a Potential Early Predictive Factor in Metastatic Non-Small Cell Lung Cancer Patients Treated with Nivolumab (01a Articolo in rivista)
    CAPONNETTO, SALVATORE; BARCHIESI, GIACOMO; MAGRI, VALENTINA; CORTESI, ENRICO
  • 11573/1363903 - 2020 - Impact of BMI on HER2+ metastatic breast cancer patients treated with pertuzumab and/or trastuzumab emtansine. Real-world evidence (01a Articolo in rivista)
    PIZZUTI, LAURA; BARCHIESI, GIACOMO; MARCHETTI, PAOLO; BOTTICELLI, ANDREA; MARINELLI, DANIELE; TOMAO, SILVERIO; MAGRI, VALENTINA; CORTESI, ENRICO; SANTINI, DANIELE
  • 11573/1554099 - 2021 - Eribulin in brain metastases of breast cancer. outcomes of the EBRAIM prospective observational trial (01a Articolo in rivista)
    MAGRI, VALENTINA; PALLESCHI, MICHELA; COGNETTI, FRANCESCO

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