VALENTINA FERRARO

Dottoressa di ricerca

ciclo: XXXIV



Titolo della tesi: Trattamento mininvasivo delle metastasi epatiche da carcinoma del colon retto. Studio Multicentrico degli outcomes della Chirurgia Robotica vs la Chirurgia Laparoscopica

Background: The liver is the most common site of metastatic spread of colorectal cancer (CRC). Approximately 15–25% of patients with CRC will have distant metastases at the time of primary diagnosis and about 50% of them will develop recurrences within the first 2 years after surgery. Liver resection is the standard of treatment for colorectal Liver Metastases (CRLM). Parenchyma-sparing approach should be preferred whenever suitable in order to allow future re-do hepatectomy and to garantee preserving future liver remnant (FLR). Interest in minimally invasive liver surgery (MILS) has increased over the last decades due to the possibility of reducing postoperative pain and disability, shortening the hospital stay and the time required for functional recovery. Nevertheless the role of robotic liver surgery is still under debate, especially with regard to oncological outcomes. The aim of our study was to evaluate the short- and longterm outcomes of laparoscopic liver resections (LLR ) versus robotic liver resection (RLR) for the treatment of CRLM. Matherials and methods: we retrospectively analyzed 406 consecutive patients with CRLM who underwent LLR (328) vs RLR (78). Patients were divided into LLR and RLR groups and then, perioperative, postoperative and oncological outcomes were analyzed. Propensity score-matched analysis was used to match groups for preoperative characteristics, liver functions tests, metastases postions and surgical procedure. Results: After propensity score matching, 116 patients were enrolled, 58 in the LLR group and 58 in the RLR group. There were no significant differences between the two groups in terms of complications, hospital stay, post-operative mortality, oncological outcomes, recurrence and overall survival. Conclusions: our study and available evidences suggest that oncologic results after robotic liver resection are comparable to laparoscopic approaches when performed in experienced centers, robotic assisted surgery is accurate in terms of R0 rates and disease-free surgical margins. Laparoscopic and robotic-assisted hepatectomies are both technically demanding but safe and feasible. Despite high cost and the lack of diffusion between many hepatobiliary surgeons, robotic liver surgery continues evolving and our results support the constant implementation of robotic programs.

Produzione scientifica

11573/1582777 - 2021 - The role of laparoscopic surgery in localized pancreatic neuroendocrine tumours
Ferraro, Valentina; Tedeschi, Michele; Laera, Letizia; Ammendola, Michele; Riccelli, Umberto; Silvestris, Nicola; Fiorentino, Alba; Surico, Giammarco; Inchingolo, Riccardo; Decembrino, Francesco; De Angelis, Nicola; Memeo, Riccardo - 01g Articolo di rassegna (Review)
rivista: CURRENT TREATMENT OPTIONS IN ONCOLOGY ([Philadelphia, Pa.] : Current Science, c2001-) pp. - - issn: 1534-6277 - wos: WOS:000624583800001 (3) - scopus: 2-s2.0-85102017463 (4)

11573/1499751 - 2021 - Laparoscopic R1 vascular hepatectomy for hepatocellular carcinoma (with video)
Libia, Annarita; Ferraro, Valentina; Tedeschi, Michele; De'angelis, Nicola; Torzilli, Guido; Aldrighetti, Luca; Pessaux, Patrick; Cherqui, Daniel; Memeo, Riccardo - 01a Articolo in rivista
rivista: ANNALS OF SURGICAL ONCOLOGY (New York: Springer Philadelphia, PA: Lippincott, Williams & Wilkins) pp. - - issn: 1068-9265 - wos: WOS:000615125400001 (1) - scopus: 2-s2.0-85100592310 (1)

11573/1496162 - 2021 - Effect of thyroidectomy on circulating angiogenic cytokines in papillary thyroid carcinoma and benign goiter: Potential for new biomarkers?
Ria, R.; Prete, F.; Melaccio, A.; Di Meo, G.; Saltarella, I.; Solimando, A. G.; Gurrado, A.; Ferraro, V.; Pasculli, A.; Sgaramella, L. I.; Racanelli, V.; Vacca, A.; Testini, M. - 01a Articolo in rivista
rivista: SURGERY (New York: Elsevier. Orlando, FL: Mosby Year Book Incorporated) pp. 27-33 - issn: 0039-6060 - wos: WOS:000600403200006 (5) - scopus: 2-s2.0-85085601579 (5)

11573/1498987 - 2020 - Robotic or three-dimensional (3D) laparoscopy for right colectomy with complete mesocolic excision (CME) and intracorporeal anastomosis? A propensity score-matching study comparison
Ceccarelli, G.; Costa, G.; Ferraro, V.; De Rosa, M.; Rondelli, F.; Bugiantella, W. - 01a Articolo in rivista
rivista: SURGICAL ENDOSCOPY (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. - - issn: 0930-2794 - wos: WOS:000530606500001 (26) - scopus: 2-s2.0-85085100145 (23)

11573/1498971 - 2020 - Performance of comprehensive complication index and clavien‐dindo complication scoring system in liver surgery for hepatocellular carcinoma
Giani, A.; Cipriani, F.; Famularo, S.; Donadon, M.; Bernasconi, D. P.; Ardito, F.; Fazio, F.; Nicolini, D.; Perri, P.; Giuffrida, M.; Pontarolo, N.; Zanello, M.; Lai, Q.; Conci, S.; Molfino, S.; Germani, P.; Pinotti, E.; Romano, M.; La Barba, G.; Ferrari, C.; Patauner, S.; Manzoni, A.; Sciannamea, I.; Fumagalli, L.; Troci, A.; Ferraro, V.; Floridi, A.; Memeo, R.; Crespi, M.; Chiarelli, M.; Antonucci, A.; Zimmitti, G.; Frena, A.; Percivale, A.; Ercolani, G.; Zanus, G.; Zago, M.; Tarchi, P.; Baiocchi, G. L.; Ruzzenente, A.; Rossi, M.; Jovine, E.; Maestri, M.; Valle, R. D.; Grazi, G. L.; Vivarelli, M.; Ferrero, A.; Giuliante, F.; Torzilli, G.; Aldrighetti, L.; Gianotti, L.; Romano, F.; Ciulli, C.; Braga, M.; Ratti, F.; Costa, G.; Razionale, F.; Russolillo, N.; Marinelli, L.; De Peppo, V.; Cremaschi, E.; Calabrese, F.; Laureiro, Z. L.; Lazzari, G.; Cosola, D.; Montuori, M.; Salvador, L.; Cucchetti, A.; Franceschi, A.; Ciola, M.; Sega, V.; Calcagno, P.; Pennacchi, L.; Tedeschi, M. - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. 1-15 - issn: 2072-6694 - wos: WOS:000601849900001 (12) - scopus: 2-s2.0-85098266824 (15)

11573/1498978 - 2020 - Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes
Pasculli, A.; Gurrado, A.; De Luca, G. M.; Mele, A.; Marzullo, A.; Mangone, A.; Cellamare, S.; Ferraro, V.; Maqoud, F.; Caggiani, M. C.; Rana, F.; Cavallaro, G.; Prete, F. P.; Tricarico, D.; Altomare, C. D.; Testini, M. - 01a Articolo in rivista
rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 1-12 - issn: 2045-2322 - wos: WOS:000559768000002 (2) - scopus: 2-s2.0-85083839871 (2)

11573/1495908 - 2020 - The critical view of safety during laparoscopic cholecystectomy: Strasberg Yes or No? An Italian Multicentre study
Sgaramella, L. I.; Gurrado, A.; Pasculli, A.; De Angelis, N.; Memeo, R.; Prete, F. P.; Berti, S.; Ceccarelli, G.; Rigamonti, M.; Badessi, F. G. A.; Solari, N.; Milone, M.; Catena, F.; Scabini, S.; Vittore, F.; Perrone, G.; De Werra, C.; Cafiero, F.; Testini, M.; Baiocchi, G. L.; Baldazzi, G.; Battocletti, M.; Bertoglio, S.; Bianco, P.; Bugiantella, W.; Ciaccio, G.; Cobianchi, L.; Conzo, G.; Crespi, M.; De Rosa, M.; Di Meo, G.; Docimo, L.; Fabris, L.; Feleppa, C.; Ferraro, V.; Fontana, T.; Gambardella, C.; Gennai, A.; Guida, F.; Invernizzi, L.; Massobrio, A.; Medas, F.; Monaco, L.; Muntoni, G.; Musella, M.; Palombo, D.; Perinotti, R.; Pertile, D.; Pezzolla, A.; Piccirillo, G.; Polastri, R.; Ruggiero, R.; Scatizzi, M.; Somaglino, C.; Tolone, S.; Traverso, E.; Tutino, R.; Valduga, C.; Zuolo, M. - 01a Articolo in rivista
rivista: SURGICAL ENDOSCOPY (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. - - issn: 0930-2794 - wos: WOS:000559630200004 (29) - scopus: 2-s2.0-85089247013 (31)

11573/1350065 - 2019 - Current concepts in parathyroid carcinoma. A single Centre experience
Ferraro, V.; Sgaramella, L. I.; Di Meo, G.; Prete, F. P.; Logoluso, F.; Minerva, F.; Noviello, M.; Renzulli, G.; Gurrado, A.; Testini, M. - 01a Articolo in rivista
rivista: BMC ENDOCRINE DISORDERS (London: BioMed Central.) pp. 46- - issn: 1472-6823 - wos: WOS:000469457000002 (52) - scopus: 2-s2.0-85066935876 (56)

11573/1349721 - 2018 - Parathyroid carcinoma in multiple endocrine neoplasm type 1 syndrome: case report and systematic literature review
Di Meo, G.; Sgaramella, L. I.; Ferraro, V.; Prete, F. P.; Gurrado, A.; Testini, M. - 01g Articolo di rassegna (Review)
rivista: CLINICAL AND EXPERIMENTAL MEDICINE (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 585-593 - issn: 1591-8890 - wos: WOS:000451750300016 (16) - scopus: 2-s2.0-85048805813 (18)

11573/1496772 - 2017 - Patologia litiasica della colecisti e delle vie biliari. Testo di “Chirurgia Generale” a cura di Minni F. Edizioni CEA. Zanichelli 2019.
Gurrado, A; Sgaramella, Li; Di Meo, G; Catalano, G; Ferraro, V; Testini, M. - 02a Capitolo o Articolo
libro: Chirurgia Generale - ()

11573/1350050 - 2016 - Advanced vessel sealing devices in total thyroidectomy for substernal goitre: A retrospective cohort study
Testini, M.; Pasculli, A.; Di Meo, G.; Ferraro, V.; Logoluso, F.; Minerva, F.; Pezzolla, A.; Gurrado, A. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF SURGERY (London : Surgical Associates, 2004-) pp. 160-164 - issn: 1743-9191 - wos: WOS:000386903200026 (7) - scopus: 2-s2.0-84990931872 (7)

11573/1350674 - 2014 - Analysis of Surgical Risk Factors in Tailoring Digestive Anastomosis
Testini, Mario; Franco, Ilaria Fabiola; Ferraro, Valentina; Gurrado, Angela; Lissidini, Germana - 02a Capitolo o Articolo
libro: Endoscopic Follow-up of Digestive Anastomosis - (978-88-470-5369-4; 978-88-470-5370-0)

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