Baglioni Valentina

Dottoressa di ricerca

ciclo: XXXIII



Titolo della tesi: Neuroimmunity in Neurodevelopmental Disorders: Antibodies detection to neuronal surface antigens in Chronic Tic Disorders

Summary The role of immunological processes in the etiopathogenesis of neurodevelopmental disorders is of increasing scientific interest, with recent data amount. Indeed, a multifactorial model has been postulated, in which both polygenic vulnerability and environmental factors are involved in these disorders, including immunologic changes. According to the “immune theory” of neurodevelopmental disorders, an immune system trigger (i.e. toxins, infections or maternal immune molecules), acting in different stages of growth (from prenatal to postnatal periods) will transfer in a genetic vulnerable individual, causing alterations in neural circuits that lead to the neurodevelopmental disorder. Several antigenic targets in the central nervous system (CNS), as CASPR2, LGI1 and NMDAR, have been candidates as antibody-mediated neurodevelopment disorder, given their relevance in normal brain development. Tourette Syndrome (TS) represents a valid model for the study of neurodevelopmental disorders because of clinic and pathophysiological overlaps with other neurodevelopment conditions (i.e. autism; adhd; obsessive-compulsive disorders). In TS a role for autoantibodies directed against neuronal proteins has long been suspected, particularly involving deregulations in the dopamine system, but so far results are still inconsistent. This doctoral thesis is divided into two parts. In the first part I have reviewed the state of the art of neurodevelopmental disorders (Austism; ADHD; OCD; Tourette/tic diosrders) associated with neuro-immune alterations (cytokines; microglia activation, surface-antibodies), and the role of the most relevant antigenic targets in the CNS, as CASPR2, LGI1 and NMDAR, during several stage of the neurodevelopment. The second part is constituted by two-experimental studies, aimed to look for antibodies to specific or undefined neuronal proteins that could be involved in the aetiology of TS/Tic disorders (TDs), as part of the EMTICS project, a prospective European longitudinal observational study for tic disorders in children. The results of these studies have been published (Addabbo F et al., 2020; Baglioni V. et al., 2019). The first experimental research was focused on D2DR antibodies (D2DR-Ab) detection in 137 patients during symptoms exacerbation, carried on in collaboration with the University of Bari, under the supervision of Professor Davide Martino and Maura Buttiglione. The second experimental research was on 218 EMTICS participants sera, resulted D2DR-Ab negative, looking for those antibodies that had already been described in autoimmune neurological diseases (NMDAR; CASPR2; LGI1, AMPAR, GABAAR), and aimed to search for evidence of possible unknown antibodies in TS/TD in different disease stages (preclinic; clinic; chronic). I personally led on the second study and laboratory examinations during one-year internship period in the Nuffield Department of Clinical Neuroscience of Oxford University, under the supervision of professor Angela Vincent. Serum anti-D2R antibodies were evaluated using a cell-based assay, as for the presence of specific antibodies to NMDAR, CASPR2, LGI1, AMPAR and GABAAR. Presence of antibodies binding to rodent brain tissue was assessed by immunohistology on rat brain sections and by immunofluorescent staining of live hippocampal neurons. In the D2R antibodies study, 11 (8%) participants became anti-D2R-positive at exacerbation (‘early peri- exacerbation seroconverters’), and nine (6.6%) became anti-D2R-positive at post-exacerbation (‘late peri-exacerbation seroconverters’). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar’s odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs. In the second study, for the research of know and unknown surface-neuroantibodies, in D2R-antibodies negative participants, immunohistology indicated evidence of antibodies reactive with brain tissue, binding mainly to the hippocampus, the basal ganglia or the cerebellum in 26/218 (12%), with 8% of the preclinical or onset sera binding to the dentate gyrus/CA3 region or cerebellum. Only two individuals (one pre-clinical, one chronic) had antibodies binding the NMDAR and the binding was only weakly positive. No other specific antibodies were detected. There is a potential association between immune mechanisms and the severity course of tics in adolescents with TS/TDs. To the best of our knowledge, this is the first study exploring the association between anti-D2R antibodies and the clinical course of chronic TDs. The observed association between anti-D2R antibodies and tic exacerbations remains an important finding with potential, albeit still to verify, pathophysiological implications, regardless of the relative frequency of these antibodies in the tic disorder population. Findings cannot support the use of these antibodies as a novel clinical biomarker, but expand the existing evidence of immune dysregulation in these conditions, supported also by the reported neuronal reactivity towards rodent brain tissue sections in a limited number of samples.

Produzione scientifica

11573/1701266 - 2024 - Comorbidities and Disease Duration in Tourette Syndrome: Impact on Cognition and Quality of Life of Children
Conte, Giulia; Costanza, Carola; Novelli, Maria; Scarselli, Veronica; Arigliani, Elena; Valente, Francesca; Baglioni, Valentina; Terrinoni, Arianna; Chiarotti, Flavia; Cardona, Francesco - 01a Articolo in rivista
rivista: CHILDREN (Basel: MDPI AG, 2014-) pp. - - issn: 2227-9067 - wos: (0) - scopus: (0)

11573/1701961 - 2023 - Functional Motor Disorders in pediatrics: clinical motor correlates and neuropsychiatric profiles
Baglioni, V.; Conte, G.; Cardona, F. - 04f Poster
congresso: 15th European Conference on Tourette Syndrome & Tic Disorders (Brussels)
libro: Congress book of the 15th European Conference on Tourette Syndrome & Tic Disorder - ()

11573/1681320 - 2023 - Tension-Type Headache in Children and Adolescents.
Baglioni, V; Orecchio, S; Esposito, D; Faedda, N; Natalucci, G; Guidetti, V - 01g Articolo di rassegna (Review)
rivista: LIFE (Basel: MDPI) pp. - - issn: 2075-1729 - wos: WOS:000958792100001 (0) - scopus: 2-s2.0-85151361601 (0)

11573/1671373 - 2023 - Psychogenic non-epileptic seizures and functional motor disorders in developmental age: A comparison of clinical and psychopathological features
Gigliotti, F.; Di Santo, F.; Cesario, S.; Esposito, D.; Manti, F.; Galosi, S.; Ferrara, M.; Leuzzi, V.; Baglioni, V. - 01a Articolo in rivista
rivista: EPILEPSY & BEHAVIOR ([San Diego, CA] : Elsevier B.V., c2000- San Diego, CA : Academic Press, c2000-) pp. - - issn: 1525-5050 - wos: WOS:000992885000001 (1) - scopus: 2-s2.0-85148345451 (2)

11573/1681902 - 2023 - Genome-wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome.
Tsetsos, F; Topaloudi, A; Jain, P; Yang, Z; Yu, D; Kolovos, P; Tumer, Z; Rizzo, R; Hartmann, A; Depienne, C; Worbe, Y; Müller-Vahl, Kr; Cath, Dc; Boomsma, Di; Wolanczyk, T; Zekanowski, C; Barta, C; Nemoda, Z; Tarnok, Z; Padmanabhuni, Ss; Buxbaum, Jd; Grice, D; Glennon, J; Stefansson, H; Hengerer, B; Yannaki, E; Stamatoyannopoulos, Ja; Benaroya-Milshtein, N; Cardona, F; Hedderly, T; Heyman, I; Huyser, C; Mir, P; Morer, A; Mueller, N; Munchau, A; Plessen, Kj; Porcelli, C; Roessner, V; Walitza, S; Schrag, A; Martino, D; Openneer, Ha€Ira J. C.; Chaim, Huyser; Martino, Davide; Anette, Schrag; Alan, Apter; Baglioni, Valentina; Juliane, Ball; Noa, Benaroya-Milshtein; Emese, Bognar; Bianka, Burger; Judith, Buse; Francesco, Cardona; Marta Correa Vela, ; Nanette, M Debes; Andrea, Dietrich; Maria Cristina Ferro, ; Carolin, Fremer; Blanca, Garcia-Delgar; Mariangela, Gulisano; Annelieke, Hagen; Julie, Hagstrøm; Tammy, J Hedderly; Isobel, Heyman; Chaim, Huyser; Marcos, Madruga-Garrido; Pablo, Mir; Norbert, Müller; Peter, Nagy; Neri, Valeria; Thaïra J, C Openneer; Pellico, Alessandra; Kerstin, J Plessen; Cesare, Porcelli; Renata, Rizzo; Daphna, Ruhrman; Jaana M, L Schnell; Silvestri, Paola Rosaria; Liselotte, Skov; Tamar, Steinberg; Friederike Tagwerker Gloor, ; Zsanett, Tarnok; Susanne, Walitza; Elif, Weidinger - 01a Articolo in rivista
rivista: BIOLOGICAL PSYCHIATRY (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. - - issn: 0006-3223 - wos: (0) - scopus: 2-s2.0-85151260500 (0)

11573/1678273 - 2022 - Functional Motor Disorders in childhood and adolescence: clinical correlates of an emerging diagnostic challenge.
Baglioni, V.; Conte, G.; Valente, F.; Cardona, F. - 04f Poster
congresso: 14th European Conference on Tourette Syndrome and Tic Disorders (Lausanne, Switzerland)
libro: ESSTS Book of Abstracts - ()

11573/1663020 - 2022 - Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study
Bond, Molly; Moll, Natalie; Rosello, Alicia; Bond, Rod; Schnell, Jaana; Burger, Bianka; J Hoekstra, Pieter; Dietrich, Andrea; Schrag, Anette; Kocovska, Eva; Martino, Davide; Mueller, Norbert; Schwarz, Markus; Meier, Ute-Christiane; Collaborative Group: Alan Apter, Emtics; Baglioni, Valentina; Ball, Juliane; Benaroya-Milshtein, Noa; Bodmer, Benjamin; Bognar, Emese; Burger, Bianka; Buse, Judith; Cardona, Francesco Carmelo Giovanni; Correa Vela, Marta; M Debes, Nanette; Dietrich, Andrea; Cristina Ferro, Maria; Fremer, Carolin; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; J Hedderly, Tammy; Heyman, Isobel; J Hoekstra, Pieter; Huyser, Chaim; Madruga-Garrido, Marcos; Marotta, Anna; Martino, Davide; Mir, Pablo; Morer, Astrid; Müller, Norbert; R Müller-Vahl, Kirsten; Münchau, Alexander; Nagy, Peter; Neri, Valeria; Jc Openneer, Thaïra; Pellico, Alessandra; Periañez Vasco, Ángela; J Plessen, Kerstin; Porcelli, Cesare; Redondo, Marina; Rizzo, Renata; Roessner, Veit; Ruhrman, Daphna; Ml Schnell, Jaana; Schrag, Anette; Silvestri, Paola Rosaria; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Tarnok, Zsanett; Tübing, Jennifer; L Turner, Victoria; Walitza, Susanne; Weidinger, Elif - 01a Articolo in rivista
rivista: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (Berlin: Springer, 1992- Seattle Wash.; Bern; Göttingen: Hogrefe & Huber Darmstadt: Steinkopff Verlag Heidelberg: Steinkopff Verlag) pp. - - issn: 1018-8827 - wos: WOS:000639793900001 (10) - scopus: 2-s2.0-85135420040 (10)

11573/1643100 - 2022 - Suggestive Seizure Induction technique in a pediatric PNES population related to neurocognitive and psychological profile: a pilot study.
Cesario, Serena; Esposito, Dario; Gigliotti, Federica; Baglioni, Valentina; Di Santo, Federica; Mastrangelo, Mario - 04d Abstract in atti di convegno
congresso: 14th European Pediatric Neurology Society Congress (Glasgow)
libro: 14th European Paediatric Neurology Society Congress - (978-3-00-072065-9)

11573/1663019 - 2022 - Tic disorders in children and adolescents: does the clinical presentation differ in males and females? A report by the EMTICS group
Garcia‐Delgar, Blanca; Servera, Mateu; Coffey, Barbara J.; Lázaro, Luisa; Openneer, Thaïra; Benaroya‐Milshtein, Noa; Steinberg, Tami; Hoekstra, Pieter J.; Dietrich, Andrea; Morer Emtics Collaborative Group Alan Apter, Astrid; Baglioni, Valentina; Ball, Juliane; Benaroya-Milshtein, Noa; Bognar, Emese; Burger, Bianka; Buse, Judith; Cardona, Francesco Carmelo Giovanni; Correa Vela, Marta; Debes, Nanette M.; Dietrich, Andrea; Cristina Ferro, Maria; Fremer, Carolin; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; Hedderly, Tammy J.; Heyman, Isobel; Hoekstra, Pieter J.; Huyser, Chaim; Madruga-Garrido, Marcos; Marotta, Anna; Martino, Davide; Mir, Pablo; Morer, Astrid; Müller, Norbert; Müller-Vahl, Kirsten; Münchau, Alexander; Nagy, Peter; Neri, Valeria; Openneer, Thaïra J. C.; Pellico, Alessandra; Plessen, Kerstin J.; Porcelli, Cesare; Rizzo, Renata; Roessner, Veit; Ruhrman, Daphna; Schnell, Jaana M. L.; Silvestri, Paola Rosaria; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Tarnok, Zsanett; Walitza &Amp;, Susanne; Weidinger, Elif - 01a Articolo in rivista
rivista: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (Berlin: Springer, 1992- Seattle Wash.; Bern; Göttingen: Hogrefe & Huber Darmstadt: Steinkopff Verlag Heidelberg: Steinkopff Verlag) pp. - - issn: 1018-8827 - wos: WOS:000647087000001 (19) - scopus: 2-s2.0-85105525247 (20)

11573/1663022 - 2022 - Clinical precursors of tics: an EMTICS study
Openneer, Tha€Ira J. C.; Huyser, Chaim; Martino, Davide; Schrag, Anette; Apter, Alan; Baglioni, Valentina; Ball, Juliane; Benaroya-Milshtein, Noa; Bognar, Emese; Burger, Bianka; Buse, Judith; Cardona, Francesco Carmelo Giovanni; Correa Vela, Marta; M Debes, Nanette; Dietrich, Andrea; Cristina Ferro, Maria; Fremer, Carolin; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; J Hedderly, Tammy; Heyman, Isobel; Huyser, Chaim; Madruga-Garrido, Marcos; Mir, Pablo; Morer, Astrid; Müller, Norbert; Müller-Vahl, Kirsten; Münchau, Alexander; Nagy, Peter; Neri, Valeria; C Openneer, Thaïra J; Pellico, Alessandra; J Plessen, Kerstin; Porcelli, Cesare; Rizzo, Renata; Roessner, Veit; Ruhrman, Daphna; L Schnell, Jaana M; Silvestri, Paola Rosaria; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Tarnok, Zsanett; Walitza, Susanne; Weidinger, Elif; Hoekstra, Pieter J.; Dietrich, Andrea - 01a Articolo in rivista
rivista: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0021-9630 - wos: WOS:000665827000001 (7) - scopus: 2-s2.0-85109003617 (12)

11573/1681900 - 2022 - Lack of Association of Group A Streptococcal Infections and Onset of Tics: European Multicenter Tics in Children Study
Schrag, Anette-Eleonore; Martino, Davide; Wang, Hanyuying; Ambler, Gareth; Benaroya-Milstein, Noa; Buttiglione, Maura; Cardona, Francesco Carmelo Giovanni; Creti, Roberta; Efstratiou, Androulla; Hedderly, Tammy; Heyman, Isobel; Huyser, Chaim; Mir, Pablo; Morer, Astrid; Moll, Natalie; E Müller, Norbert; R Müller-Vahl, Kirsten; J Plessen, Kerstin; Porcelli, Cesare; Rizzo, Renata; Roessner, Veit; Schwarz, Markus; Tarnok, Zsanett; Walitza, Susanne; Dietrich, Andrea; J Hoekstra Alan Apter, Pieter; Baglioni, Valentina; Ball, Juliane; Benaroya-Milshtein, Noa; Bodmer, Benjamin; Bognar, Emese; Burger, Bianka; Buse, Judith; Cardona, Francesco Carmelo Giovanni; Correa Vela, Marta; M Debes, Nanette; Dietrich, Andrea; Cristina Ferro, Maria; Fremer, Carolin; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; J Hedderly, Tammy; Heyman, Isobel; J Hoekstra, Pieter; Huyser, Chaim; Madruga-Garrido, Marcos; Marotta, Anna; Martino, Davide; Mir, Pablo; Morer, Astrid; Müller, Norbert; R Müller-Vahl, Kirsten; Münchau, Alexander; Nagy, Peter; Neri, Valeria; Jc Openneer, Thaïra; Pellico, Alessandra; Periañez Vasco, Ángela; J Plessen, Kerstin; Porcelli, Cesare; Redondo, Marina; Rizzo, Renata; Roessner, Veit; Ruhrman, Daphna; Ml Schnell, Jaana; Schrag, Anette; Silvestri, Paola Rosaria; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Tarnok, Zsanett; Tübing, Jennifer; L Turner, Victoria; Walitza, Susanne; Weidinger, Elif - 01a Articolo in rivista
rivista: NEUROLOGY (Wolters Kluwer Hagerstown MD: Lippincott Williams & Wilkins Cleveland Ohio: Advanstar Communications) pp. - - issn: 0028-3878 - wos: WOS:000767503200021 (11) - scopus: 2-s2.0-85138147476 (0)

11573/1614156 - 2021 - Functional neurological disorders in childhood and adolescence: Epidemiology and phenomenology of an emerging diagnostic and clinical challenge
Baglioni, V.; Cesario, S.; Gigliotti, F.; Galosi, S.; Di Maggio, C.; Ferrara, M.; Leuzzi, V.; Di Santo, F. - 01h Abstract in rivista
rivista: EUROPEAN PSYCHIATRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. S247-S248 - issn: 0924-9338 - wos: WOS:000693667600216 (0) - scopus: (0)

11573/1663018 - 2021 - Hair cortisol-a stress marker in children and adolescents with chronic tic disorders? A large European cross-sectional study
Buse, Judith; Rothe, Josefine; Uhlmann, Anne; Bodmer, Benjamin; Kirschbaum, Clemens; Hoekstra, Pieter J.; Dietrich, Andrea; Roessner, Veit; Collaborative Group: Alan Apter, Emtics; Baglioni, Valentina; Ball, Juliane; Benaroya-Milshtein, Noa; Bodmer, Benjamin; Bognar, Emese; Burger, Bianka; Buse, Judith; Cardona, Francesco Carmelo Giovanni; Correa Vela, Marta; Dietrich, Andrea; Cristina Ferro, Maria; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; Hedderly, Tammy J.; Heyman, Isobel; Hoekstra, Pieter J.; Huyser, Chaim; Madruga-Garrido, Marcos; Martino, Davide; Mir, Pablo; Morer, Astrid; Müller-Vahl, Kirsten; Münchau, Alexander; Nagy, Peter; Neri, Valeria; Openneer, Thaïra J. C.; Pellico, Alessandra; Plessen, Kerstin J.; Porcelli, Cesare; Rizzo, Renata; Roessner, Veit; Ruhrman, Daphna; Schnell, Jaana M. L.; Schrag, Anette; Silvestri, Paola Rosaria; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Tarnok &Amp;, Zsanett; Weidinger, Elif - 01a Articolo in rivista
rivista: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (Berlin: Springer, 1992- Seattle Wash.; Bern; Göttingen: Hogrefe & Huber Darmstadt: Steinkopff Verlag Heidelberg: Steinkopff Verlag) pp. - - issn: 1018-8827 - wos: WOS:000609089700002 (4) - scopus: 2-s2.0-85131108208 (4)

11573/1560631 - 2021 - Link Between Topographic Memory and the Combined Presentation of ADHD (ADHD-C): A Pilot Study
Faedda, Noemi; Guariglia, Cecilia; Piccardi, Laura; Natalucci, Giulia; Rossetti, Serena; Baglioni, Valentina; Alunni Fegatelli, Danilo; Romani, Maria; Vigliante, Miriam; Guidetti, Vincenzo - 01a Articolo in rivista
rivista: FRONTIERS IN PSYCHIATRY (Lausanne, Switzerland: Frontiers Media S.A. All Rights Reserved) pp. 647243- - issn: 1664-0640 - wos: WOS:000668338900001 (3) - scopus: 2-s2.0-85109146758 (3)

11573/1663021 - 2021 - Yale Global Tic Severity Scale (YGTSS): Psychometric Quality of the Gold Standard for Tic Assessment Based on the Large-Scale EMTICS Study
Haas, Martina; Jakubovski, Ewgeni; Fremer, Carolin; Dietrich, Andrea; Hoekstra, Pieter J.; Jäger, Burkard; Müller-Vahl Alan Apter, Kirsten R.; Baglioni, Valentina; Ball, Juliane; Benaroya-Milshtein, Noa; Bodmer, Benjamin; Bognar, Emese; Burger, Bianka; Buse, Judith; Cardona, Francesco Carmelo Giovanni; Correa Vela, Marta; Debes, Nanette M.; Dietrich, Andrea; Cristina Ferro, Maria; Fremer, Carolin; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; Hedderly, Tammy J.; Heyman, Isobel; Hoekstra, Pieter J.; Huyser, Chaim; Madruga-Garrido, Marcos; Marotta, Anna; Martino, Davide; Mir, Pablo; Morer, Astrid; Müller, Norbert; Müller-Vahl, Kirsten R.; Münchau, Alexander; Nagy, Peter; Neri, Valeria; Openneer, Thaïra J. C.; Pellico, Alessandra; Periañez Vasco, Ángela; Plessen, Kerstin J.; Porcelli, Cesare; Redondo, Marina; Rizzo, Renata; Roessner, Veit; Ruhrman, Daphna; Schnell, Jaana M. L.; Schrag, Anette; Silvestri, Paola Rosaria; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Tarnok, Zsanett; Tübing, Jennifer; Turner, Victoria L.; Walitza, Susanne; Elif Weidinger, And - 01a Articolo in rivista
rivista: FRONTIERS IN PSYCHIATRY (Lausanne, Switzerland: Frontiers Media S.A. All Rights Reserved) pp. - - issn: 1664-0640 - wos: WOS:000627426700001 (25) - scopus: 2-s2.0-85102468310 (27)

11573/1663024 - 2021 - Association of Group A Streptococcus Exposure and Exacerbations of Chronic Tic Disorders
Martino, Davide; Schrag, Anette; Anastasiou, Zacharias; Apter, Alan; Benaroya-Milstein, Noa; Buttiglione, Maura; Cardona, Francesco Carmelo Giovanni; Creti, Roberta; Efstratiou, Androulla; Hedderly, Tammy; Heyman, Isobel; Huyser, Chaim; Madruga, Marcos; Mir, Pablo; Morer, Astrid; Mol Debes, Nanette; Moll, Natalie; Mu ̈Ller, Norbert; Mu ̈Ller-Vahl, Kirsten; Munchau, Alexander; Nagy, Peter; Jessica Plessen, Kerstin; Porcelli, Cesare; Rizzo, Renata; Roessner, Veit; Schnell, Jaana; Schwarz, Markus; Skov, Liselotte; Steinberg, Tamar; Tarnok, Zsanett; Walitza, Susanne; Dietrich, Andrea; Hoekstra, Pieter J.; Baglioni, Valentina; Ball, Juliane; Bognar, Emese; Burger, Bianka; Buse, Judith; Correa Vela, Marta; Cristina Ferro, Maria; Fremer, Carolin; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; Huyser, Chaim; Marotta, Anna; Neri, Valeria; C Openneer, Thaïra J; Pellico, Alessandra; J Plessen, Kerstin; Roessner, Veit; Ruhrman, Daphna; L Schnell, Jaana M; Silvestri, Paola Rosaria; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Elif Weidinger, Susanne Walitza - 01a Articolo in rivista
rivista: NEUROLOGY (Wolters Kluwer Hagerstown MD: Lippincott Williams & Wilkins Cleveland Ohio: Advanstar Communications) pp. - - issn: 0028-3878 - wos: WOS:000656633700023 (19) - scopus: 2-s2.0-85103474236 (21)

11573/1568954 - 2021 - Management of Neurological Emergencies in Children: An Updated Overview
Mastrangelo, M.; Baglioni, V. - 01g Articolo di rassegna (Review)
rivista: NEUROPEDIATRICS (Hippokrates Verlag GmbH:Postfach 300504, D-70445 Stuttgart Germany:011 49 711 89310, Fax: 011 49 711 8931706) pp. 242-251 - issn: 0174-304X - wos: WOS:000668314200005 (4) - scopus: 2-s2.0-85110260068 (4)

11573/1617361 - 2021 - Clinical variability at the mild end of BRAT1‐related spectrum:evidence from two families with genotype–phenotype discordance
Nuovo, Sara; Baglioni, Valentina; De Mori, Roberta; Tardivo, Silvia; Caputi, Caterina; Ginevrino, Monia; Micalizzi, Alessia; Masuelli, Laura; Federici, Giulia; Casella, Antonella; Lorefice, Elisa; Anello, Danila; Tolve, Manuela; Farini, Donatella; Bertini, Enrico; Zanni, Ginevra; Travaglini, Lorena; Vasco, Gessica; Sette, Claudio; Carducci, Carla; Valente, Enza M.; Leuzzi, Vincenzo - 01i Case report
rivista: HUMAN MUTATION (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 67-73 - issn: 1059-7794 - wos: WOS:000718316900001 (8) - scopus: 2-s2.0-85119252960 (7)

11573/1474906 - 2020 - Anti-dopamine D2 receptor antibodies in chronic tic disorders
Addabbo, F.; Baglioni, V.; Schrag, A.; Schwarz, M. J.; Dietrich, A.; Hoekstra, P. J.; Martino, D.; Buttiglione, M.; Anastasiou, Z.; Apter, A.; Ball, J.; Bartolini, E.; Benaroya-Milshtein, N.; Bodmer, B.; Bognar, E.; Burger, B.; Buse, J.; Cardona, F.; Correa Vela, M.; Creti, R.; Debes, N. M.; Efstratiou, A.; Ferro, M. C.; Fremer, C.; Garcia-Delgar, B.; Gariup, M.; Georgitsi, M.; Gulisano, M.; Hagen, A.; Hagstrom, J.; Hedderly, T. J.; Heyman, I.; Huyser, C.; Imperi, M.; Karagiannidis, I.; Laviola, G.; Macri, S.; Madruga-Garrido, M.; Margarit, I.; Marotta, A.; Meier, U. C.; Mir, P.; Moll, N.; Morer, A.; Muller-Vahl, K.; Munchau, A.; Nagy, P.; Neri, V.; Openneer, T. J. C.; Orefici, G.; Paschou, P.; Perianez, A.; Pellico, V. A.; Petruzzelli, O.; Plessen, K.; Porcelli, C.; Redondo, M.; Rizzo, R.; Roazzi, P.; Roessner, V.; Ruhrman, D.; Schnell, J. M. L.; Schutze, G. A.; Silvestri, P. R.; Skov, L.; Steinberg, T.; Stober, S.; Tallon, M.; Gloor, F. T.; Walitza, S.; Tubing, J.; Turner, V.; Weidinger, E.; Tarnok, Z. - 01a Articolo in rivista
rivista: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. 1205-1212 - issn: 0012-1622 - wos: WOS:000546418300001 (6) - scopus: 2-s2.0-85087733504 (9)

11573/1474899 - 2020 - Adverse Mental Health Impact of the COVID-19 Lockdown in Individuals With Tourette Syndrome in Italy: An Online Survey
Conte, G.; Baglioni, V.; Valente, F.; Chiarotti, F.; Cardona, F. - 01a Articolo in rivista
rivista: FRONTIERS IN PSYCHIATRY (Lausanne, Switzerland: Frontiers Media S.A. All Rights Reserved) pp. - - issn: 1664-0640 - wos: WOS:000598126300001 (22) - scopus: 2-s2.0-85097596072 (29)

11573/1429287 - 2020 - The Relationship Between Parental Care and Pain in Children With Headache: A Narrative Review
Natalucci, G.; Faedda, N.; Baglioni, V.; Guidetti, V. - 01g Articolo di rassegna (Review)
rivista: HEADACHE (Blackwell Science Incorporated:350 Main Street, Sixth Floor:Malden, MA 02148:(888)661-5800, (781)388-8250, EMAIL: csjournals@blacksci.com, INTERNET: http://www.blackwell-science.com, Fax: (781)388-8232) pp. 1217-1224 - issn: 0017-8748 - wos: WOS:000536492800019 (4) - scopus: 2-s2.0-85085628400 (7)

11573/1305589 - 2019 - Antibodies to neuronal surface proteins in Tourette Syndrome: lack of evidence in a European paediatric cohort
Baglioni, Valentina; Coutinho, Ester; Menassa, David; Pia Giannoccaro, Maria; Jacobson, Leslie; Buttiglione, Maura; Petruzzelli, Onofrio; Cardona, Francesco Carmelo Giovanni; Vincent, Angela - 01a Articolo in rivista
rivista: BRAIN BEHAVIOR AND IMMUNITY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. - - issn: 0889-1591 - wos: WOS:000488135800068 (9) - scopus: 2-s2.0-85070883035 (10)

11573/1339059 - 2019 - Behavioral therapies in headache: focus on mindfulness and cognitive behavioral therapy in children and adolescents
Faedda, Noemi; Natalucci, Giulia; Baglioni, Valentina; Giannotti, Flavia; Cerutti, Rita; Guidetti, Vincenzo - 01g Articolo di rassegna (Review)
rivista: EXPERT REVIEW OF NEUROTHERAPEUTICS (-London, United Kingdom: Expert Reviews Ltd -London, United Kingdom: Future Drugs Limited) pp. 1219-1228 - issn: 1473-7175 - wos: WOS:000481644200001 (11) - scopus: 2-s2.0-85070975330 (14)

11573/1351616 - 2019 - The Premonitory Urge for Tics Scale in a large sample of children and adolescents: psychometric properties in a developmental context. An EMTICS study
Openneer, T. J. C.; Tarnok, Z.; Bognar, E.; Benaroya-Milshtein, N.; Garcia-Delgar, B.; Morer, A.; Steinberg, T.; Hoekstra, P. J.; Dietrich, A.; Apter, A.; Baglioni, V.; Ball, J.; Bodmer, B.; Burger, B.; Buse, J.; Cardona, F.; Correavela, M.; Debes, N. M.; Ferro, M. C.; Fremer, C.; Gulisano, M.; Hagen, A.; Hagstrom, J.; Hedderly, T. J.; Heyman, I.; Huyser, C.; Madruga-Garrido, M.; Marotta, A.; Mir, P.; Muller, N.; Muller-Vahl, K.; Munchau, A.; Nagy, P.; Neri, V.; Openneer, T. J. C.; Pellico, A.; Plessen, K. J.; Porcelli, C.; Redondo, M.; Rizzo, R.; Roessner, V.; Ruhrman, D.; Schnell, J. M. L.; Silvestri, P. R.; Skov, L.; Tagwerkergloor, F.; Tubing, J.; Turner, V. L.; Visscher, F. - 01a Articolo in rivista
rivista: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (Berlin: Springer, 1992- Seattle Wash.; Bern; Göttingen: Hogrefe & Huber Darmstadt: Steinkopff Verlag Heidelberg: Steinkopff Verlag) pp. - - issn: 1018-8827 - wos: WOS:000500602800001 (12) - scopus: 2-s2.0-85076006668 (21)

11573/1681901 - 2019 - European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents
Schrag, A; Martino, D; Apter, A; Ball, J; Bartolini, E; Benaroya-Milshtein, N; Buttiglione, M; Cardona, F; Creti, R; Efstratiou, A; Gariup, M; Georgitsi, M; Hedderly, T; Heyman, I; Margarit, I; Mir, P; Moll, N; Morer, A; Müller, N; Müller-Vahl, K; Münchau, A; Orefici, G; Plessen, Kj; Porcelli, C; Paschou, P; Rizzo, R; Roessner, V; Schwarz, Mj; Steinberg, T; Tagwerker Gloor, F; Tarnok, Z; Walitza, S; Dietrich, A; Hoekstra, Pj; Zacharias, Anastasiou; Isobel, Heyman; Chaim, Huyser; Marcos, Madruga; Pablo, Mir; Astrid, Morer; Nanette Mol Debes, ; Natalie, Moll; Norbert Mu ̈Ller, ; Peter, Nagy; Kerstin Jessica Plessen, ; Cesare, Porcelli; Renata, Rizzo; Veit, Roessner; Jaana, Schnell; Liselotte, Skov; Zsanett, Tarnok; Susanne, Walitza; Andrea, Dietrich; Baglioni, Valentina; Juliane, Ball; Emese, Bognar; Bianka, Burger; Judith, Buse; Marta Correa Vela, ; Maria Cristina Ferro, ; Carolin, Fremer; Mariangela, Gulisano; Annelieke, Hagen; Julie, Hagstrøm; Chaim, Huyser; Anna, Marotta; Neri, Valeria; Thaïra J, C Openneer; Pellico, Alessandra; Kerstin, J Plessen; Veit, Roessner; Daphna, Ruhrman; Jaana M, L Schnell; Silvestri, Paola Rosaria; Liselotte, Skov; Tamar, Steinberg; Friederike Tagwerker Gloor, ; Susanne, Walitza; Elif, Weidinger - 01a Articolo in rivista
rivista: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (Berlin: Springer, 1992- Seattle Wash.; Bern; Göttingen: Hogrefe & Huber Darmstadt: Steinkopff Verlag Heidelberg: Steinkopff Verlag) pp. - - issn: 1018-8827 - wos: WOS:000456945300009 (30) - scopus: 2-s2.0-85049568242 (32)

11573/1256547 - 2019 - Developmental motor profile in preschool children with primary stereotypic movement disorder
Valente, Francesca; Pesola, Chiara; Baglioni, Valentina; Teresa Giannini, Maria; Chiarotti, Flavia; Caravale, Barbara; Cardona, Francesco - 01a Articolo in rivista
rivista: BIOMED RESEARCH INTERNATIONAL ([London]: [Hindawi] Cairo: Hindawi Publishing Corporation) pp. -6 - issn: 2314-6133 - wos: WOS:000459652400001 (6) - scopus: 2-s2.0-85062358419 (6)

11573/1175485 - 2018 - Don't judge a book by its cover. factitious disorder imposed on children-report on 2 cases
Faedda, N; Baglioni, V; Natalucci, G; Ardizzone, I; Camuffo, M; Cerutti, R; Guidetti, V - 01a Articolo in rivista
rivista: FRONTIERS IN PEDIATRICS (Lausanne : Frontiers Media S.A., 2013-) pp. 1-5 - issn: 2296-2360 - wos: WOS:000430342300001 (10) - scopus: 2-s2.0-85046693701 (7)

11573/1139416 - 2018 - Inhibition is impaired in children with obsessive-compulsive symptoms but not in those with tics
Mancini, Christian; Cardona, Francesco Carmelo Giovanni; Baglioni, Valentina; Panunzi, Sara; Pantano, Patrizia; Suppa, Antonio; Mirabella, Giovanni - 01a Articolo in rivista
rivista: MOVEMENT DISORDERS (-WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030 -Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 950-959 - issn: 0885-3185 - wos: WOS:000439829100011 (36) - scopus: 2-s2.0-85050506148 (37)

11573/1189532 - 2018 - Self-concept and self-esteem in patients with chronic tic disorders: a systematic literature review
Silvestri, Paola R.; Baglioni, Valentina; Cardona, Francesco; Cavanna, Andrea E. - 01g Articolo di rassegna (Review)
rivista: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY (Harcourt Publishers Limited:Foots Cray High Street, Sidcup Kent DA14 5HP United Kingdom:011 44 20 83085700, EMAIL: journals@harcourt.com, INTERNET: http://www.harcourt-international.com, Fax: 011 44 20 83085876) pp. 749-756 - issn: 1090-3798 - wos: WOS:000447105600006 (17) - scopus: 2-s2.0-85047754802 (20)

11573/873562 - 2016 - Pharmacological strategies in the prevention of Migraine in Children
Baglioni, Valentina; Guidetti, Vincenzo - 02a Capitolo o Articolo
libro: Pharmacological Management of Headaches - (978-3-319-19911-5)

11573/905656 - 2016 - Developmental profile and diagnoses in children presenting with motor stereotypies
Cardona, Francesco Carmelo Giovanni; Valente, Francesca; Miraglia, Daniela; D'ardia, Caterina; Baglioni, Valentina; Flavia, Chiarotti - 01a Articolo in rivista
rivista: FRONTIERS IN PEDIATRICS (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-2360 - wos: WOS:000388329000001 (6) - scopus: 2-s2.0-85053085037 (6)

11573/929731 - 2016 - A preliminary examination of self-concept in older adolescents and young adults with Gilles de la Tourette syndrome.
Silvestri, Paola Rosaria; Chiarotti, F; Baglioni, Valentina; Neri, Valeria; Cardona, Francesco Carmelo Giovanni; Cavanna, Ae - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY (Harcourt Publishers Limited:Foots Cray High Street, Sidcup Kent DA14 5HP United Kingdom:011 44 20 83085700, EMAIL: journals@harcourt.com, INTERNET: http://www.harcourt-international.com, Fax: 011 44 20 83085876) pp. - - issn: 1090-3798 - wos: WOS:000401209200008 (10) - scopus: 2-s2.0-85010807420 (10)

11573/892809 - 2016 - Health-related quality of life in patients with Gilles de la Tourette syndrome at the transition between adolescence and adulthood
Silvestri, Paola Rosaria; Chiarotti, Flavia; Baglioni, Valentina; Neri, Valeria; Cardona, Francesco Carmelo Giovanni; Cavanna, Andrea E. - 01a Articolo in rivista
rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:000386371400016 (13) - scopus: 2-s2.0-84979516947 (14)

11573/978606 - 2015 - Headache disorders in children and adolescents Comorbidity in childhood headache: a case report of a rare condition of migraine without and with aura and intra/extracranial malformation
Baglioni, Valentina; Guidetti, Vincenzo; Verdecchia, P. - 04a Atto di comunicazione a congresso
rivista: CEPHALALGIA (-Attuale:BLACKWELL PUBLISHING, 9600 GARSINGTON RD, OXFORD, ENGLAND, OXON, OX4 2DQ -Scandinavian University Press:PO Box 508, Sentrum, 0105 Oslo Norway:011 47 24 147500, INTERNET: http://www.universitsforlaget.no, Fax: 011 47 24 147501) pp. 203-203 - issn: 0333-1024 - wos: (0) - scopus: (0)
congresso: International Headache Society Congress (Valencia)

11573/838735 - 2015 - The challenge for the categorical diagnosis of motor stereotypes in pre-scholar children
D'ardia, Caterina; Baglioni, Valentina; Miraglia, Daniela; Giovannone, Federica; Giannini, Maria Teresa; Sideri, Barbara; Pesola, Chiara; Cardona, Francesco Carmelo Giovanni - 04c Atto di convegno in rivista
rivista: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (Berlin: Springer, 1992- Seattle Wash.; Bern; Göttingen: Hogrefe & Huber Darmstadt: Steinkopff Verlag Heidelberg: Steinkopff Verlag) pp. 223-223 - issn: 1018-8827 - wos: (0) - scopus: (0)

11573/854812 - 2015 - The effect of the virtual interactions on wellbeing in adolescence: exploring the relationship between internet addiction, headache and depressive symptoms
Guidetti, Vincenzo; Cerutti, Rita; Presaghi, Fabio; Spensieri, Valentina; Valastro, Carmela; Baglioni, Valentina - 04d Abstract in atti di convegno
rivista: CEPHALALGIA (-Attuale:BLACKWELL PUBLISHING, 9600 GARSINGTON RD, OXFORD, ENGLAND, OXON, OX4 2DQ -Scandinavian University Press:PO Box 508, Sentrum, 0105 Oslo Norway:011 47 24 147500, INTERNET: http://www.universitsforlaget.no, Fax: 011 47 24 147501) pp. 204-205 - issn: 0333-1024 - wos: WOS:000354559400408 (2) - scopus: (0)

11573/529657 - 2014 - Prevalenza dei disturbi d’ansia in pazienti con sindrome di Tourette e disturbo da tic
Baglioni, Valentina; Maddalena, Stornelli; Guido, Molica; Flavia, Chiarotti; Cardona, Francesco Carmelo Giovanni - 01a Articolo in rivista
rivista: RIVISTA DI PSICHIATRIA (Roma : Il Pensiero Scientifico) pp. 243-250 - issn: 2038-2502 - wos: WOS:000343965500007 (4) - scopus: 2-s2.0-85007022352 (5)

11573/577860 - 2014 - Intense imagery movements: a common and distinct paediatric subgroup of motor stereotypies.
Robinson, S.; M., Woods; Cardona, Francesco Carmelo Giovanni; V., Baglioni; T., Hedderly - 01a Articolo in rivista
rivista: DEVELOPMENTAL MEDICINE & CHILD NEUROLOGY ([Cambridge, UK] : Cambridge University Press ; Oxford : Blackwell) pp. 1212-1218 - issn: 1469-8749 - wos: WOS:000344786500017 (16) - scopus: 2-s2.0-84911451954 (27)

11573/559957 - 2013 - Executive function deficits in ADHD and Asperger syndrome
C., Paloscia; Baglioni, Valentina; R., Alessandrelli; C., Rosa; R., Guerini; Aceti, Franca; A., Pasini - 01a Articolo in rivista
rivista: RIVISTA DI PSICHIATRIA (Roma : Il Pensiero Scientifico) pp. 441-447 - issn: 2038-2502 - wos: WOS:000339137000004 (5) - scopus: 2-s2.0-84896306673 (4)

11573/525272 - 2013 - Sindrome di Tourette. Fenomenologia clinica, percorso diagnostico e trattamento
Silvestri, Paola R.; Neri, Valeria; Valentina, Baglioni; Cardona, Francesco Carmelo Giovanni - 02a Capitolo o Articolo
libro: LA DIAGNOSI E IL TRATTAMENTO DEI DISORDINI DEL MOVIMENTO IN ETÀ PEDIATRICA - DISTONIA, COREA, MIOCLONO, PARKINSONISMO E TIC - (9788820451011)

11573/512523 - 2012 - Perinatal and postpartum depression: From attachment to personality. A pilot study
Aceti, Franca; Aveni, F.; Baglioni, Valentina; Carluccio, Giuseppe Mattia; Colosimo, D.; Giacchetti, Nicoletta; Marini, Isabella; Meuti, Valentina; Motta, Paola; Zaccagni, Michela; Biondi, Massimo - 01a Articolo in rivista
rivista: JOURNAL OF PSYCHOPATHOLOGY (Pisa: Pacini) pp. 328-334 - issn: 2284-0249 - wos: (0) - scopus: 2-s2.0-84874237889 (17)

11573/512540 - 2012 - Valutazione dello stile di attaccamento e della personalità nella depressione post-partum.
Aceti, Franca; Aveni, F; Baglioni, V; Di Lorenzo, F; Giacchetti, Nicoletta; Marini, I; Meuti, Valentina; Motta, P; Zaccagni, M; Biondi, Massimo - 04b Atto di convegno in volume

11573/480591 - 2012 - Modelli di attaccamento e personalità nella depressione post partum. [Maternal attachment patterns and personality in post partum depression]
Aceti, Franca; Baglioni, Valentina; Ciolli, Paola; De Bei, Francesco; Di Lorenzo, Flavia; Ferracuti, Stefano; Giacchetti, Nicoletta; Marini, Isabella; Meuti, Valentina; Motta, Paola; Roma, Paolo; Zaccagni, Michela; Williams, Riccardo - 01a Articolo in rivista
rivista: RIVISTA DI PSICHIATRIA (Roma: Il Pensiero Scientifico Editore) pp. 214-220 - issn: 0035-6484 - wos: WOS:000307262400005 (14) - scopus: 2-s2.0-84864677095 (17)

11573/402396 - 2012 - Self-, parent-, and teacher-reported behavioral symptoms in youngsters with Tourette syndrome: A case-control study
Cardona, Francesco Carmelo Giovanni; Baglioni, Valentina; Silvestri, Paola Rosaria; Flavia, Chiarotti - 01b Commento, Erratum, Replica e simili
rivista: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY (Harcourt Publishers Limited:Foots Cray High Street, Sidcup Kent DA14 5HP United Kingdom:011 44 20 83085700, EMAIL: journals@harcourt.com, INTERNET: http://www.harcourt-international.com, Fax: 011 44 20 83085876) pp. 213-214 - issn: 1090-3798 - wos: WOS:000301216700019 (1) - scopus: 2-s2.0-84857369401 (1)

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