TIZIANA MANCINI

PhD Graduate

PhD program:: XXXVII


advisor: Stefano Lupi
co-supervisor: Federico Bordi

Thesis title: Optical sensing of VOCs and viral biomolecules via IR spectroscopy for air pollution monitoring

In current times where climate changes, environmental pollution and pandemic risk are heavily burdening and threatening our society, the scientific community has to face major challenges in order to preserve human and environmental health, safety and equilibrium. An essential element for the application of preventive actions is to have an accurate, efficient and rapid monitoring of air-quality status, in order to immediately understand which is the problem, how to intervene for contrasting it and to guarantee human and nature safety. With this objective, the work reported in this PhD thesis is the result of a project aiming to introduce a technological advancement in the field of (bio)sensing, overcoming the limitations of current detection tools with the design of a novel optical sensing strategy based on Infrared (IR) spectroscopy for the detection of chemical and biological pollutants in air. In the first part, the development of an IR spectroscopy sensor system for the detection of gaseous Volatile Organic Compounds (VOCs) is shown. Nine toxic chemical pollutants are studied both alone and in mixtures and a Machine Learning (ML) algorithm is combined with the optical setup, providing in the overall a high-sensitive, specific and rapid detection. In the second part, IR spectroscopy is applied for the optical detection of viral biomarker, aiming to airborne pathogen monitoring. Spike protein from SARS-CoV-2 virus is considered and, combining spectral data with computational analysis and predictions, the characterization and structural investigation of S protein domains is provided, focusing both on the wild type virus and on different mutants. Finally, preliminary results are reported about the design of a biofunctionalized sensor platform based on the technology of Metal-Organic Frameworks (MOFs) biocomposites. This work falls in the context of sustainability, aiming to face environmental and health emergencies and to contribute to the building of a green society, bringing innovations in the field of health, occupational and environmental safety.

Research products

11573/1736211 - 2025 - Fourier transform infrared spectroscopy investigation of SARS-CoV-2 ssRNA.
Bertela, Federica; Mancini, Tiziana; Mosetti, Rosanna; D’Arco, Annalisa; Macis, Salvatore; Lupi, Stefano - 04d Abstract in atti di convegno
conference: Protein Misfolding and aggregation in disease (Mantova)
book: Book of Abstract - ()

11573/1742284 - 2025 - Studying SARS-CoV-2 ssRNA key sequence combining Fourier transform infrared spectroscopy and theoretical folding model
Mancini, Tiziana; Bertelà, Federica; Di Fabrizio, Marta; Macis, Salvatore; Mosetti, Rosanna; Lupi, Stefano; D'arco, Annalisa - 01a Articolo in rivista
paper: EUROPEAN BIOPHYSICS JOURNAL (Heidelberg; Berlin : Springer) pp. - - issn: 0175-7571 - wos: WOS:001506872500001 (0) - scopus: 2-s2.0-105007900454 (0)

11573/1736209 - 2025 - Structural differences in protein domains of SARS-CoV-s Spike glycoprotein induced by mutations: infrared spectroscopy, circular dichroism and computational analysis
Mancini, Tiziana; Luchetti, Nicole; Macis, Salvatore; Minicozzi, Velia; Mosetti, Rosanna; Nucara, Alessandro; Lupi, Stefano; D’Arco, Annalisa - 04d Abstract in atti di convegno
conference: Protein Misfolding and aggregation in disease (Mantova)
book: Book of Abstract - ()

11573/1737653 - 2025 - Ultrahigh-sensitive and real-time detection of BTXs for occupational safety via infrared spectroscopy coupled with machine learning technique
Mancini, Tiziana; Radica, Francesco; Mosesso, Lorenzo; Paolozzi, Maria Chiara; Macis, Salvatore; Marcelli, Augusto; Tamascelli, Stefano; Tranfo, Giovanna; Della Ventura, Giancarlo; Lupi, Stefano; D’Arco, Annalisa - 01a Articolo in rivista
paper: JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (Amsterdam : Elsevier) pp. - - issn: 2213-3437 - wos: (0) - scopus: (0)

11573/1742283 - 2025 - SARS-CoV-2 Variants: A Comparative Investigation Through Spectroscopy and Computational Simulations of S1 protein domains
Mosetti, Rosanna; D’Arco, Annalisa; Mancini, Tiziana; Macis, Salvatore; Nucara, Alessandro; Luchetti, Nicole; Minicozzi, Velia; Lupi, Stefano - 04d Abstract in atti di convegno
conference: 4th MOSBRI Scientific Conference (MOSBRI2025) (Paris, France)
book: Book of Abstract - ()

11573/1742280 - 2025 - Mid-Infrared Classification for post-consumer plastics combining Infrared spectroscopy and open-source data mining.
Mosetti, Rosanna; Mancini, Tiziana; Bertelà, Federica; Macis, Salvatore; D’Arco, Annalisa; Lupi, Stefano - 04d Abstract in atti di convegno
conference: Machine Learning Methods for Complex and Quantum System (Camerino, Italy)
book: Book of Abstract - ()

11573/1736208 - 2025 - From receptor binding domain to Spike glycoprotein: infrared spectroscopic investigation of SARS-CoV-2 protein domain
Mosetti, Rosanna; Mancini, Tiziana; Macis, Salvatore; Luchetti, Nicole; Minicozzi, Velia; Notargiacomo, Andrea; Pea, Marialilia; Marcelli, Augusto; Della Ventura, Giancarlo; D’Arco, Annalisa; Lupi, Stefano - 04d Abstract in atti di convegno
conference: Protein Misfolding and aggregation in disease (Mantova)
book: Book of Abstract - ()

11573/1714131 - 2024 - FT-IR spectroscopy coupled with Machine Learning for highly sensitive detection and discrimination of gaseous Volatile Organic Compounds
D’Arco, Annalisa; Mosesso, Lorenzo; Paolozzi, Maria Chiara; Macis, Salvatore; Mancini, Tiziana; Marcelli, Augusto; Radica, Francesco; Tranfo, Giovanna; Della Ventura, Giancarlo; Lupi, Stefano - 04d Abstract in atti di convegno
conference: Rome Technopole Spoke 6 - International Young Researcher Workshop (Rome)
book: Book of Abstract - Rome Technopole Spoke 6 - International Young Researcher Workshop - ()

11573/1708113 - 2024 - Terahertz Technologies as New Frontiers for Pathogenic Microorganism Sensing: Drawbacks, Potentialities and Applications
D'arco, Annalisa; Macis, Salvatore; Mancini, Tiziana; Lupi, Stefano - 04d Abstract in atti di convegno
conference: Teradays 2024 (Napoli)
book: Book of Abstracts Teradays 2024 - ()

11573/1709015 - 2024 - UV Light Stereoselective Limonene Sensor Using Electrospun PVP Composite Nanofibers
Macagnano, Antonella; Molinari, Fabricio N.; Mancini, Tiziana; Lupi, Stefano; De Cesare, Fabrizio - 01h Abstract in rivista
paper: PROCEEDINGS (Basel : MDPI AG, 2017-) pp. - - issn: 2504-3900 - wos: (0) - scopus: (0)

11573/1714289 - 2024 - Nanofibrous conductive sensor for limonene. One-step synthesis via electrospinning and molecular imprinting
Macagnano, Antonella; Nicolas Molinari, Fabricio; Papa, Paolo; Mancini, Tiziana; Lupi, Stefano; D’Arco, Annalisa; Rita Taddei, Anna; Serrecchia, Simone; De Cesare, Fabrizio - 01a Articolo in rivista
paper: NANOMATERIALS (Basel : MDPI) pp. 1-23 - issn: 2079-4991 - wos: WOS:001269109100001 (2) - scopus: 2-s2.0-85198420847 (3)

11573/1711675 - 2024 - First step toward the development of an optical biosensor based on vibrational spectroscopy for the detection of airborne pathogens
Mancini, Tiziana; D’Arco, Annalisa; Mosetti, Rosanna; Macis, Salvatore; Della Ventura, Giancarlo; Marcelli, Augusto; Lupi, Stefano - 04d Abstract in atti di convegno
conference: 3rd MOSBRI Scientific Conference (Ljubljana, Slovenia)
book: Book of Abstract - 3rd MOSBRI Scientific Conference Programme & Abstracts - (978-961-6104-94-4)

11573/1721855 - 2024 - Optical Infrared biosensing for ultrasensitive monitoring of SARS-CoV-2 variants
Mancini, Tiziana; D’Arco, Annalisa; Mosetti, Rosanna; Macis, Salvatore; Luchetti, Nicole; Minicozzi, Velia; Notargiacomo, Andrea; Pea, Marialilia; Falcaro, Paolo; Carraro, Francesco; Della Ventura, Giancarlo; Marcelli, Augusto; Lupi, Stefano - 04f Poster
conference: EOSAM2024 European Optical Society Annual Meeting (Napoli)
book: Online Book of Abstract - ()

11573/1713943 - 2024 - First step toward the development of an optical biosensor based on vibrational spectroscopy for airborne pathogens detection
Mancini, Tiziana; D’Arco, Annalisa; Mosetti, Rosanna; Macis, Salvatore; Tranfo, Giovanna; Della Ventura, Giancarlo; Marcelli, Augusto; Lupi, Stefano - 04f Poster
conference: Rome Technopole Spoke 6 - International Young Researcher Workshop (Rome)
book: Book of Abstract - Rome Technopole Spoke 6 - International Young Researcher Workshop - ()

11573/1712945 - 2024 - HIGH SENSITIVITY AND SPECIFICITY MONITORING OF GASEOUS VOCS COUPLING A MULTIPASS GAS CELL SETUP WITH FTIR SPECTROSCOPY AND MACHINE LEARNING
Mancini, Tiziana; D’Arco, Annalisa; Paolozzi, Maria Chiara; Mosesso, Lorenzo; Mosetti, Rosanna; Macis, Salvatore; Marcelli, Augusto; Radica, Francesco; Tranfo, Giovanna; Della Ventura, Giancarlo; Lupi, Stefano - 04f Poster
conference: XXVII CONGRESSO NAZIONALE SIBPA 2024 (Genova)
book: Book of Abstract XXVII CONGRESSO NAZIONALE SIBPA 2024 - ()

11573/1716232 - 2024 - Infrared spectroscopy of SARS‐CoV‐2 viral protein. From receptor binding domain to spike protein
Mancini, Tiziana; Macis, Salvatore; Mosetti, Rosanna; Luchetti, Nicole; Minicozzi, Velia; Notargiacomo, Andrea; Pea, Marialilia; Marcelli, Augusto; Ventura, Giancarlo Della; Lupi, Stefano; D'arco, Annalisa - 01a Articolo in rivista
paper: ADVANCED SCIENCE (Weinheim: Wiley-VCH, 2014) pp. 1-9 - issn: 2198-3844 - wos: (0) - scopus: 2-s2.0-85198413370 (3)

11573/1711678 - 2024 - Secondary structure investigation of SARS-CoV-2 spike protein Domains via attenuated total reflectance infrared spectroscopy
Mosetti, Rosanna; D’Arco, Annalisa; Mancini, Tiziana; Macis, Salvatore; Della Ventura, Giancarlo; Marcelli, Augusto; Tranfo, Giovanna; Minicozzi, Velia; Luchetti, Nicole; Lupi, Stefano - 04d Abstract in atti di convegno
conference: 3rd MOSBRI Scientific Conference (Ljubljana, Slovenia)
book: Book of Abstract - 3rd MOSBRI Scientific Conference Programme & Abstracts - (978-961-6104-94-4)

11573/1714130 - 2024 - ATR-IR spectroscopy: secondary structure investigation of SARS-CoV-2 spike protein Domains
Mosetti, Rosanna; D’Arco, Annalisa; Mancini, Tiziana; Macis, Salvatore; Della Ventura, Giancarlo; Marcelli, Augusto; Tranfo, Giovanna; Minicozzi, Velia; Luchetti, Nicole; Lupi, Stefano - 04d Abstract in atti di convegno
conference: Rome Technopole Spoke 6 - International Young Researcher Workshop (Rome)
book: Book of Abstract - Rome Technopole Spoke 6 - International Young Researcher Workshop - ()

11573/1712876 - 2024 - INFRARED SPECTROSCOPY INVESTIGATION OF SARS-COV-2 SPIKE PROTEIN DOMAINS
Mosetti, Rosanna; D’Arco, Annalisa; Mancini, Tiziana; Macis, Salvatore; Di Fabrizio, Marta; Minicozzi, Velia; Della Ventura, Giancarlo; Marcelli, Augusto; Luchetti, Nicole; Lupi, Stefano - 04f Poster
conference: XXVII CONGRESSO NAZIONALE SIBPA 2024 (Genova)
book: Book of Abstract XXVII CONGRESSO NAZIONALE SIBPA 2024 - ()

11573/1721915 - 2024 - SARS-CoV-2 Glycoprotein Spike Variants: spectroscopic and computational comparative investigations
Mosetti, Rosanna; D’Arco, Annalisa; Mancini, Tiziana; Macis, Salvatore; Nucara, Alessandro; Luchetti, Nicole; Minicozzi, Velia; Lupi, Stefano - 04d Abstract in atti di convegno
conference: Multi-Messenger Monitoring for occupational health & safety (SARS 3M) (Roma)
book: Book of Abstract - ()

11573/1721857 - 2024 - SARS-CoV-2 protein: infrared spectroscopic investigation from Receptor Binding Domain to Spike protein
Mosetti, Rosanna; Mancini, Tiziana; Macis, Salvatore; Luchetti, Nicole; Minicozzi, Velia; Notargiacomo, Andrea; Pea, Marialilia; Marcelli, Augusto; Della Ventura, Giancarlo; D’Arco, Annalisa; Lupi, Stefano - 04d Abstract in atti di convegno
conference: EOSAM2024 European Optical Society Annual Meeting (Napoli)
book: Book of Abstract - ()

11573/1722018 - 2024 - FT-IR spectroscopy coupled with machine learning for a high sensitive detection and discrimination of gaseous volatile organic compounds.
Paolozzi, M. C.; Mancini, T.; D'arco, A.; Mosesso, L.; Macis, S.; Marcelli, A.; Radica, F.; Tranfo, G.; Della Ventura, G.; Tamascelli, S.; Lupi, S. - 04d Abstract in atti di convegno
conference: 110° Congresso Nazionale della Società Italiana di Fisica (Bologna)
book: 110° Congresso Nazionale della Società Italiana di Fisica - ()

11573/1682362 - 2023 - Secondary Structures of MERS-CoV, SARS-CoV, and SARS-CoV-2 Spike Proteins Revealed by Infrared Vibrational Spectroscopy
D’Arco, Annalisa; Di Fabrizio, Marta; Mancini, Tiziana; Mosetti, Rosanna; Macis, Salvatore; Tranfo, Giovanna; Della Ventura, Giancarlo; Marcelli, Augusto; Petrarca, Massimo; Lupi, Stefano - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001006128500001 (5) - scopus: 2-s2.0-85161662339 (6)

11573/1673919 - 2023 - New frontier in terahertz technologies for virus sensing: drawbacks and potentialities
D'arco, A.; Mancini, T.; Mosetti, R.; Della Ventura, G.; Marcelli, A.; Lupi, S. - 04d Abstract in atti di convegno
conference: BRIC ID 7/2019 project: “An integrated array of fixed and mobile sensors for dynamical spatiotemporal mapping of volatile compounds in work environments” (Roma, Frascati)
book: An integrated array of fixed and mobile sensors for dynamical spatio- temporal mapping of volatile compounds in work environments. - (978-88-6683-166-2)

11573/1677508 - 2023 - High-resolution quantitative monitoring of VOCs using MIR (medium infrared) spectroscopy coupled with a multipass cell
Della Ventura, Giancarlo; Radica, Francesco; Marcelli, Augusto; Tranfo, Giovanna; Macis, Salvatore; Mancini, Tiziana; Paolozzi, Maria Chiara; Mosesso, Lorenzo; D'arco, Annalisa; Lupi, Stefano - 04d Abstract in atti di convegno
conference: BRIC ID 7/2019 project: “An integrated array of fixed and mobile sensors for dynamical spatiotemporal mapping of volatile compounds in work environments” (Frascati)
book: An integrated array of fixed and mobile sensors for dynamical spatio-temporal mapping of volatile compounds in work environments - (978-88-6683-166-2)

11573/1708098 - 2023 - TiO2 nanostructured array for optical ultrasensitive biosensing
Mancini, Tiziana; D’Arco, Annalisa; Macis, Salvatore; Mosetti, Rosanna; Della Ventura, Giancarlo; Marcelli, Augusto; Palocci, Cleofe; Chronopoulou, Laura; Comini, Elisabetta; Galstyan, Vardan; Lupi, Stefano - 04f Poster
conference: Biophysics@Rome2023 Research on the path and sustainability (CNR - Rome, Italy)
book: // - ()

11573/1709016 - 2023 - High-sensitivity monitoring of VOCs in air via FTIR spectroscopy using a multipass gas cell setup
Mancini, Tiziana; D’Arco, Annalisa; Paolozzi, Maria Chiara; Macis, Salvatore; Mosesso, Lorenzo; Marcelli, Augusto; Petrarca, Massimo; Radica, Francesco; Tranfo, Giovanna; Lupi, Stefano; Della Ventura, Giancarlo - 01a Articolo in rivista
paper: IL NUOVO CIMENTO C (Bologna: Società italiana di fisica) pp. 1-4 - issn: 2037-4909 - wos: WOS:001065269800005 (0) - scopus: (0)

11573/1682475 - 2023 - Infrared characterization of spike protein of MERS-CoV, SARS-CoV, SARS-CoV-2 and its variants: first steps toward an optical biosensing device
Mancini, Tiziana; D'arco, Annalisa; Di Fabrizio, Marta; Mosetti, Rosanna; Macis, Salvatore; Tranfo, Giovanna; Della Ventura, Giancarlo; Marcelli, Augusto; Petrarca, Massimo; Lupi, Stefano - 04b Atto di convegno in volume
conference: SPIE Optics + Optoelectronics, 2023 (Prague, CZECH REPUBLIC)
book: Proceedings Volume 12572, Optical Sensors 2023 - (9781510662643; 9781510662650)

11573/1668260 - 2023 - New frontier in terahertz technologies for virus sensing
Mancini, Tiziana; Marcelli, Augusto; Lupi, Stefano; D’Arco, Annalisa - 01g Articolo di rassegna (Review)
paper: ELECTRONICS (Basel : MDPI) pp. 1-19 - issn: 2079-9292 - wos: WOS:000909770700001 (1) - scopus: 2-s2.0-85145943343 (1)

11573/1685131 - 2023 - Synthesis of WO3 nanopowder using a green surfactant for efficient gas sensing applications
Pakdel, H.; Galstyan, V.; D'arco, A.; Mancini, T.; Lupi, S.; Moumen, A.; Borsi, M.; Comini, E. - 01a Articolo in rivista
paper: CERAMICS INTERNATIONAL (Oxford: Elsevier Ltd.) pp. 30501-30509 - issn: 1873-3956 - wos: WOS:001147723100001 (12) - scopus: 2-s2.0-85164421900 (13)

11573/1657777 - 2022 - Infrared spectroscopy characterization of MERS-CoV, SARS-CoV and SARS-CoV-2 spike proteins for sensoristic platform.
D’Arco, Annalisa; Di Fabrizio, Marta; Mancini, Tiziana; Mosetti, Rosanna; Della Ventura, Giancarlo; Marcelli, Augusto; Petrarca, Massimo; Lupi, Stefano - 04d Abstract in atti di convegno
conference: 108° CONGRESSO NAZIONALE Società Italiana di Fisica (Milano)
book: Abstract in atti di congresso - (978-88-7438-130-2)

11573/1657700 - 2022 - High sensitivity monitoring of VOCs in air through FTIR spectroscopy using a multipass gas cell setup
D'arco, A; Mancini, T; Paolozzi, Mc; Macis, S; Mosesso, L; Marcelli, A; Petrarca, M; Radica, F; Tranfo, G; Lupi, S; Della Ventura, G - 01a Articolo in rivista
paper: SENSORS (Basel : Molecular Diversity Preservation International (MDPI), 2001-) pp. 5624- - issn: 1424-8220 - wos: WOS:000839895200001 (11) - scopus: 2-s2.0-85136342455 (11)

11573/1657778 - 2022 - Detection of low VOCs concentration through IR spectroscopy
Mancini, T; Paolozzi, M C; D’Arco, A; Macis, S; Marcelli, A; Radica, F; Tranfo, G; Lupi, S; Della Ventura, G - 04d Abstract in atti di convegno
conference: 108° CONGRESSO NAZIONALE Società Italiana di Fisica (Milano)
book: Abstract in atti di congresso - (978-88-7438-130-2)

11573/1624979 - 2022 - Terahertz Spectroscopic Analysis in Protein Dynamics: Current Status
Mancini, Tiziana; Mosetti, Rosanna; Marcelli, Augusto; Petrarca, Massimo; Lupi, Stefano; D’Arco, Annalisa - 01g Articolo di rassegna (Review)
paper: RADIATION (Basel: MDPI AG) pp. 100-123 - issn: 2673-592X - wos: (0) - scopus: (0)

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