STEFANO SACCHETTI

Dottore di ricerca

ciclo: XXXIII



Titolo della tesi: Reward Size and Motor Effort Modulate the Activity of Phasically Active Neurons in the Monkey Striatum

Motivation underlies human behavior. Over the years, motivation has been studied under many aspects, both from a psychological and neurophysiological point of view. Several brain areas have been involved in the motivational process, but it seems that the striatum plays a fundamental role given its implication in the reward system. To investigate the role of the striatum in motivation, and the role that force and reward play in the modulation of the phasically active neurons of the striatum, two monkeys were used in a task in which the monkeys had to modulate the force exerted on a lever (high or low) to receive two different amounts of rewards (high or low) at the end of the trial. Behavioral results showed that monkeys preferred the high reward condition over the low reward condition. At the neural level, we have identified three different subpopulations of phasically active neurons that had a peak of activation centred on three different period of the task. The neural analyses showed how all three populations were modulated by both force and reward, thus showing the involvement of the striatum in the motivational process. Analysis with the decoding algorithm also showed that these neurons were modulated by force and reward even outside their peak of maximum activity.

Produzione scientifica

11573/1708983 - 2024 - Neurons in the monkey frontopolar cortex encode learning stage and goal during a fast learning task
Nougaret, Simon; Ferrucci, Lorenzo; Ceccarelli, Francesco; Sacchetti, Stefano; Benozzo, Danilo; Fascianelli, Valeria; Saunders, Richard C; Renaud, Luc; Genovesio, Aldo - 01a Articolo in rivista
rivista: PLOS BIOLOGY (San Francisco, CA : Public Library of Science, c2003-) pp. - - issn: 1545-7885 - wos: WOS:001168784500001 (0) - scopus: 2-s2.0-85185411196 (1)

11573/1633384 - 2022 - n-3 PUFA improve emotion and cognition during menopause: A systematic review
Decandia, Davide; Landolfo, Eugenia; Sacchetti, Stefano; Gelfo, Francesca; Petrosini, Laura; Cutuli, Debora - 01g Articolo di rassegna (Review)
rivista: NUTRIENTS (Basel, Switzerland: Molecular Diversity Preservation International (MDPI)) pp. 1-21 - issn: 2072-6643 - wos: WOS:000799322200001 (7) - scopus: 2-s2.0-85129597706 (7)

11573/1669443 - 2022 - Chronic administration of palmitoylethanolamide counteracts cognitive decline in Tg2576 Mice
Decandia, Davide; Sacchetti, Stefano; Landolfo, Eugenia; Massa, Greta; Allegretti, Elena; Giacovazzo, Giacomo; Cutuli, Debora - 04d Abstract in atti di convegno
congresso: BraYn 2022 (Rome)
libro: Neurology International - ()

11573/1660818 - 2022 - Social monitoring of actions in the macaque frontopolar cortex
Ferrucci, Lorenzo; Nougaret, Simon; Ceccarelli, Francesco; Sacchetti, Stefano; Fascianelli, Valeria; Benozzo, Danilo; Genovesio, Aldo - 01a Articolo in rivista
rivista: PROGRESS IN NEUROBIOLOGY (-Oxford:PERGAMON-ELSEVIER SCIENCE LTD, -Oxford; New York; Toronto; Rushcutters Bay; Braunschweig: Pergamon Press Vieweg & Sohn.) pp. 102339- - issn: 0301-0082 - wos: WOS:000857205900002 (4) - scopus: 2-s2.0-85136710586 (5)

11573/1669447 - 2022 - n-3 PUFA improves psychological well-being during menopausal transition
Sacchetti, Stefano; Decandia, Davide; Landolfo, Eugenia; Gelfo, Francesca; Cutuli, Debora - 04d Abstract in atti di convegno
congresso: BraYn 2022 (Rome)
libro: Neurology International - ()

11573/1669451 - 2022 - Specialized pro-resolving mediator RvD1 reduces neuroinflammation in a transgenic rat model of Parkinson’s disease
Tiberi, Marta; Matteocci, Alessandro; Massaro, Mariangela; Fazio, Federico; Sacchetti, Stefano; Decandia, Davide; Batocchi, Vladimiro; Cutuli, Debora; Biago Mercuri, Nicola; Chiurchiù, Valerio - 04d Abstract in atti di convegno
congresso: BraYn 2022 (Rome)
libro: Neurology International - ()

11573/1511620 - 2021 - Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
Sacchetti, Stefano; Ceccarelli, Francesco; Ferrucci, Lorenzo; Benozzo, Danilo; Brunamonti, Emiliano; Nougaret, Simon; Genovesio, Aldo - 01a Articolo in rivista
rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000616811600007 (6) - scopus: 2-s2.0-85100008525 (6)

11573/1601718 - 2021 - Behavioral effects of long-term administration of palmitoylethanolamide on Tg2576 mice
Sacchetti, Stefano; Landolfo, Eugenia; Decandia, Davide; Giacovazzo, Giacomo; Cutuli, Debora - 04d Abstract in atti di convegno
congresso: XVII Brain Aging (Napoli)
libro: https://www.psicogeriatria.it/usr_files/eventi/corsi-nazionali/13-14-dicembre-2021-napoli.pdf - ()

11573/1373085 - 2020 - Neuroprotective role of dietary supplementation with Omega-3 fatty acids in the presence of basal forebrain cholinergic neurons degeneration in aged mice
Cutuli, Debora; Landolfo, Eugenia; Decandia, Davide; Nobili, Annalisa; Viscomi, Maria Teresa; La Barbera, Livia; Sacchetti, Stefano; De Bartolo, Paola; Curci, Annacarmen; D'amelio, Marcello; Farioli-Vecchioli, Stefano; Petrosini, Laura - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000524908500192 (13) - scopus: 2-s2.0-85081029752 (13)

11573/1477543 - 2020 - Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice
Cutuli, Debora; Landolfo, Eugenia; Nobili, Annalisa; De Bartolo, Paola; Sacchetti, Stefano; Chirico, Doriana; Marini, Federica; Pieroni, Luisa; Ronci, Maurizio; D’Amelio, Marcello; Romana D’Amato, Francesca; Farioli-Vecchioli, Stefano; Petrosini, Laura - 01a Articolo in rivista
rivista: ALZHEIMER'S RESEARCH & THERAPY ([London] : BioMed Central Ltd., c2009-) pp. - - issn: 1758-9193 - wos: WOS:000594437200002 (13) - scopus: 2-s2.0-85096052098 (16)

11573/1120513 - 2018 - The role of physical exercise and omega-3 fatty acids in depressive illness in the elderly
Farioli Vecchioli, Stefano; Sacchetti, Stefano; Nicolis Di Robilant, Vittoria; Cutuli, Debora. - 01a Articolo in rivista
rivista: CURRENT NEUROPHARMACOLOGY (Hilversum: Bentham Science Publishers) pp. 308-326 - issn: 1570-159X - wos: WOS:000427438900006 (36) - scopus: 2-s2.0-85043568938 (41)

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