SERENA FRAGIOTTA

Dottoressa di ricerca

ciclo: XXXIV



Titolo della tesi: Drusen remodeling in intermediate age-related macular degeneration: functional and morphological correlates.

Purpose: To assess the effect of drusen morphometric changes and choroidal vascular modifications on retinal sensitivity (RS) evaluated through microperimetry in intermediate age-related macular degeneration (iAMD). Methods: A retrospective review of 18 iAMD patients (18 eyes) with a 12-month follow-up was performed. Eye-tracked spectral-domain optical coherence tomography was obtained with the automatic segmentation of outer retinal layer (ORL) delineating the drusen area from the external limiting membrane to Bruch’s membrane and outer nuclear layer (ONL) thickness maps adjusted manually, as needed. Microperimetry obtained under mesopic conditions was overlaid with the corresponding thickness maps through Fiji software. Choroidal vascularity index (CVI) was calculated in the subfoveal b-scan and volumetric in the central 1-mm subfield. Results: A reduced central ONL thickness was strongly associated with an RS decline at the same region (r=0.69, p=0.002), and globally (r=0.80, p<0.001) at baseline, but also at 1-year in the central subfield (central: r=0.70, p=0.001). One-year subfoveal CVI variation, differently from volumetric CVI, directly influenced the central (r=0.64, p=0.004) and global RS (r=0.59, p=0.009), indicating that a CVI reduction negatively affected RS. A greater volumetric CVI within central 1-mm was associated with an ORL thickening at 1-year (r=0.61, p=0.008). Conclusions: Progressive degeneration of the ONL is related to a photoreceptor irreversible dysfunction in iAMD. Likewise, choroidal vascular modifications are associated with a significant functional decline in the central region and diffusely. Longitudinal evaluation of drusen remodeling reveals functional implications for the drusen resorption, describing an end-stage drusen lifecycle with irreversible changes in cellular activity and critical photoreceptor loss.

Produzione scientifica

  • 11573/516703 - 2013 - Subconjunctival Loiasis :case reports and review of cases described in Italy (01a Articolo in rivista)
    FRAGIOTTA, SERENA; VINGOLO, ENZO MARIA
  • 11573/525905 - 2013 - Microperimetric biofeedback in a patient with oculocutaneous albinism (01b Commento, Erratum, Replica e simili)
    TRABUCCO, PAOLO; FRAGIOTTA, SERENA; VINGOLO, ENZO MARIA
  • 11573/495231 - 2012 - Optical Coherence Tomography evaluation in X-linked retinoschisis. (01a Articolo in rivista)
    DOMANICO, DANIELA; NEBBIOSO, MARCELLA; FRAGIOTTA, SERENA; VINGOLO, ENZO MARIA
  • 11573/843436 - 2015 - Ocular manifestations of ebola virus disease: an ophthalmologist's guide to prevent infection and panic (01g Articolo di rassegna (Review))
    VINGOLO, ENZO MARIA; MESSANO, GIUSEPPE ALESSIO; FRAGIOTTA, SERENA; SPADEA, LEOPOLDO; PETTI, STEFANO
  • 11573/929085 - 2016 - Acute Macular Neuroretinopathy presenting as bitemporal defects on Humphrey Visual Field (01i Case report)
    FRAGIOTTA, SERENA
  • 11573/446407 - 2012 - Diagnostic aspects and retinal imaging in ocular toxocariasis: a case report from Italy. (01a Articolo in rivista)
    FRAGIOTTA, SERENA; VINGOLO, ENZO MARIA
  • 11573/525907 - 2013 - Fixation stability measurements in patients with neovascular age-related macular degeneration treated with ranibizumab (01a Articolo in rivista)
    FRAGIOTTA, SERENA; LUPO, STEFANO; MARENCO, MARCO; VINGOLO, ENZO MARIA
  • 11573/355059 - 2011 - Combine Use Of Platelet Gel And Autolougus Serum Eye Drop In The Management Of Non-Healing Corneal Ulcer: in vivo confocal microscopy study. (04a Atto di comunicazione a congresso)
    MARENCO, MARCO; GHARBIYA, MAGDA; FRAGIOTTA, SERENA; VINGOLO, ENZO MARIA
  • 11573/516692 - 2013 - Cystoid macular edema induced by low doses of nicotinic Acid. (01a Articolo in rivista)
    FRAGIOTTA, SERENA; VINGOLO, ENZO MARIA
  • 11573/512518 - 2012 - OCT e retinite Pigmentosa (02a Capitolo o Articolo)
    VINGOLO, ENZO MARIA; FRAGIOTTA, SERENA
  • 11573/1145971 - 2018 - Factors influencing fixation stability area: a comparison of two methods of recording (01a Articolo in rivista)
    FRAGIOTTA, SERENA; CARNEVALE, CARMELA; CUTINI, ALESSANDRO; VINGOLO, ENZO MARIA
  • 11573/1345748 - 2020 - OCT En Face Analysis of the Posterior Vitreous Reveals Topographic Relationships among Premacular Bursa, Prevascular Fissures, and Cisterns (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1345681 - 2019 - Postural changes revealing orbital venous malformation using ultrasound in blue rubber bleb nevus syndrome (01i Case report)
    FRAGIOTTA, SERENA; SEPE MONTI, MICAELA; SCUDERI, LUCA; SCUDERI, GIANLUCA
  • 11573/1345673 - 2020 - Relationship between choroidal vascular hyperpermeability, choriocapillaris flow density, and choroidal thickness in eyes with pachychoroid pigment epitheliopathy (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1345714 - 2019 - Multimodal imaging of a presumed embolic cilioretinal artery occlusion (01i Case report)
    FRAGIOTTA, SERENA
  • 11573/1345743 - 2019 - Linear and planar reflection artifacts on swept-source and spectral-domain optical coherence tomography due to hyperreflective crystalline deposits (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1343340 - 2014 - Functional parameters in patients with ocular hypertension and primary open-angle glaucoma (01h Abstract in rivista)
    SALOMONE, MARIA ANTONIETTA; VERBOSCHI, FRANCESCA; FRAGIOTTA, SERENA; DOMANICO, DANIELA; SPADEA, LEOPOLDO; VINGOLO, ENZO MARIA
  • 11573/1343326 - 2014 - Normal values and repeatibility of bivariate contour ellipse area (BCEA) with Microperimeter Mp-1 (01h Abstract in rivista)
    FRAGIOTTA, SERENA; SPADEA, LEOPOLDO; SALOMONE, MARIA ANTONIETTA; VINGOLO, ENZO MARIA
  • 11573/1343335 - 2014 - Predictive factors on spectral domain optical coherence tomography in neovascular age-related macular degeneration (01h Abstract in rivista)
    FRAGIOTTA, SERENA; SPADEA, LEOPOLDO; SALOMONE, MARIA ANTONIETTA; VINGOLO, ENZO MARIA
  • 11573/1192383 - 2018 - Association between choroidal caverns and choroidal vascular hyperpermeability in eyes with pachychoroid diseases (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1192434 - 2018 - Cilioretinal artery hypoperfusion and its association with paracentral acute middle maculopathy (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1345479 - 2019 - The fate and prognostic implications of hyperreflective crystalline deposits in nonneovascular age-related macular degeneration (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1345667 - 2019 - Volumetric analysis of vascularized serous pigment epithelial detachment progression in neovascular agerelated macular degeneration using optical coherence tomography angiography (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1345656 - 2018 - Cuticular drusen associated with aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy) (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1345546 - 2019 - A proposed mechanism influencing structural patterns in X-linked retinoschisis and stellate nonhereditary idiopathic foveomacular retinoschisis (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1345557 - 2019 - Pachychoroid disease (02a Capitolo o Articolo)
    FRAGIOTTA, SERENA
  • 11573/1345538 - 2018 - Acute exudative polymorphous vitelliform maculopathy: to bolus or not to bolus? (01i Case report)
    FRAGIOTTA, SERENA; CUTINI, ALESSANDRO; VINGOLO, ENZO MARIA
  • 11573/1307471 - 2019 - Vitreo-macular interface disorders in retinitis pigmentosa (01a Articolo in rivista)
    FRAGIOTTA, SERENA; TRICARICO, STEFANO; CASILLO, LORENZO; SCUDERI, GIANLUCA; VINGOLO, ENZO MARIA
  • 11573/1018384 - 2018 - Microperimetric biofeedback training: fundamentals, strategies and perspectives (01g Articolo di rassegna (Review))
    VINGOLO, ENZO MARIA; NAPOLITANO, GIUSEPPE; FRAGIOTTA, SERENA
  • 11573/768492 - 2015 - Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up (01a Articolo in rivista)
    DOMANICO, DANIELA; FRAGIOTTA, SERENA; CUTINI, ALESSANDRO; CARNEVALE, CARMELA; ZOMPATORI, LUIGI; VINGOLO, ENZO MARIA
  • 11573/941319 - 2017 - Vitreous and plasma changes of endothelin-1, adrenomedullin and vascular endothelium growth factor in patients with proliferative diabetic retinopathy (01a Articolo in rivista)
    VINGOLO, ENZO MARIA; FRAGIOTTA, SERENA; MAFRICI, MARCO; CUTINI, ALESSANDRO; MARINELLI, CRISTIANO; CONCISTRE, ANTONIO; IANNUCCI, GINO; PETRAMALA, LUIGI; LETIZIA, CLAUDIO
  • 11573/786299 - 2015 - Psychosis, mood and behavioral disorders in usher syndrome: review of the literature (01g Articolo di rassegna (Review))
    DOMANICO, DANIELA; FRAGIOTTA, SERENA; CUTINI, ALESSANDRO; VINGOLO, ENZO MARIA
  • 11573/929087 - 2018 - Predictive factors for development of neovascular age-related macular degeneration. A spectral-domain optical coherence tomography study (01a Articolo in rivista)
    FRAGIOTTA, SERENA; CUTINI, ALESSANDRO; VINGOLO, ENZO MARIA
  • 11573/927817 - 2016 - Epiteliopatia pigmentar placóide multifocal posterior aguda (02a Capitolo o Articolo)
    VINGOLO, ENZO MARIA; FRAGIOTTA, SERENA; CARNEVALE, CARMELA; CUTINI, ALESSANDRO
  • 11573/878509 - 2016 - Enhanced depth imaging optical coherence tomography in adult-onset foveomacular vitelliform dystrophy (01a Articolo in rivista)
    FRAGIOTTA, SERENA; CUTINI, ALESSANDRO; VINGOLO, ENZO MARIA
  • 11573/954573 - 2017 - Correlation between retinal function and microstructural foveal changes in intermediate age related macular degeneration (01a Articolo in rivista)
    FRAGIOTTA, SERENA; CARNEVALE, CARMELA; CUTINI, ALESSANDRO; VINGOLO, ENZO MARIA
  • 11573/972735 - 2017 - Microperimetric evaluation in patients with adult-onset foveomacular vitelliform dystrophy (01a Articolo in rivista)
    FRAGIOTTA, SERENA; CUTINI, ALESSANDRO; VINGOLO, ENZO MARIA
  • 11573/877345 - 2016 - Visual recovery after primary retinal detachment surgery: biofeedback rehabilitative strategy (01a Articolo in rivista)
    VINGOLO, ENZO MARIA; FRAGIOTTA, SERENA; DOMANICO, DANIELA; NEBBIOSO, MARCELLA; SPADEA, LEOPOLDO
  • 11573/1440237 - 2020 - Multimodal imaging features and clinical relevance of subretinal lipid globules (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1440235 - 2019 - BACILLARY LAYER DETACHMENT OVERLYING REDUCED CHORIOCAPILLARIS FLOW IN ACUTE IDIOPATHIC MACULOPATHY (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1440231 - 2020 - Diagnostic and Therapeutic Challenges (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1436518 - 2020 - Role of CD 20+ T cells and related cytokines in mediating retinal microvascular changes and ocular complications in chronic-plaque type psoriasis (01a Articolo in rivista)
    FRAGIOTTA, SERENA; MANGINO, GIORGIO; IULIANO, MARCO; POTENZA, CONCETTA; SKROZA, NEVENA; VINGOLO, ENZO MARIA; ROMEO, GIOVANNA
  • 11573/1413714 - 2020 - The controversial drive for intervention with ophthalmologic screening for Candida bloodstream infections (01f Lettera, Nota)
    FRAGIOTTA, SERENA
  • 11573/1413724 - 2020 - Ganglion cell complex analysis in glaucoma patients: what can it tell us? (01g Articolo di rassegna (Review))
    SCUDERI, GIANLUCA; FRAGIOTTA, SERENA; SCUDERI, LUCA
  • 11573/1506257 - 2021 - Reply (01a Articolo in rivista)
    FRAGIOTTA, SERENA
  • 11573/1505811 - 2020 - Effect of intraocular pressure lowering on the capillary density of optic nerve head and retinal nerve fiber layer in patients with glaucoma (01a Articolo in rivista)
    DE PAULA, ALESSANDRO; FRAGIOTTA, SERENA; SCUDERI, GIANLUCA
  • 11573/1600117 - 2021 - Choroidal vascularity index in adult-onset foveomacular vitelliform dystrophy: a pilot study (01a Articolo in rivista)
    ABDOLRAHIMZADEH, SOLMAZ; FRAGIOTTA, SERENA; DI PIPPO, MARIACHIARA; SCUDERI, GIANLUCA
  • 11573/1575125 - 2021 - Clinical manifestations of cuticular drusen. Current perspectives (01g Articolo di rassegna (Review))
    FRAGIOTTA, SERENA; SCUDERI, GIANLUCA
  • 11573/1604107 - 2021 - Significance of hyperreflective foci as an optical coherence tomography biomarker in retinal diseases: characterization and clinical implications (01g Articolo di rassegna (Review))
    FRAGIOTTA, SERENA; ABDOLRAHIMZADEH, SOLMAZ; SCUDERI, GIANLUCA
  • 11573/1541375 - 2021 - Current concepts on ocular vascular abnormalities in the phakomatoses (01g Articolo di rassegna (Review))
    DE PAULA, ALESSANDRO; ABDOLRAHIMZADEH, SOLMAZ; FRAGIOTTA, SERENA; DI PIPPO, MARIACHIARA; SCUDERI, GIANLUCA
  • 11573/1617285 - 2022 - Understanding Neurodegeneration from a Clinical and Therapeutic Perspective in Early Diabetic Retinopathy (01g Articolo di rassegna (Review))
    FRAGIOTTA, SERENA; SCUDERI, GIANLUCA
  • 11573/1575091 - 2021 - Near-infrared reflectance imaging in retinal diseases affecting young patients (01g Articolo di rassegna (Review))
    ABDOLRAHIMZADEH, SOLMAZ; CIANCIMINO, CHIARA; GRASSI, FLAMINIA; SORDI, EDOARDO; FRAGIOTTA, SERENA; SCUDERI, GIANLUCA
  • 11573/1643268 - 2022 - Differences in cysts characteristics and related influence on the anatomical response after dexamethasone implant in diabetic macular oedema (01a Articolo in rivista)
    FRAGIOTTA, SERENA; DE GERONIMO, DANIELE
  • 11573/1575109 - 2021 - Volume rendering of angiographic optical coherence tomography angiography in fovea plana and normal foveal pit (01a Articolo in rivista)
    FRAGIOTTA, SERENA; CIANCIMINO, CHIARA; DE PAULA, ALESSANDRO; ABDOLRAHIMZADEH, SOLMAZ; SCUDERI, GIANLUCA
  • 11573/1643272 - 2022 - Functional correlates of outer retina remodeling in intermediate age-related macular degeneration using microperimetry (01a Articolo in rivista)
    FRAGIOTTA, SERENA; DE GERONIMO, DANIELE; SCUDERI, GIANLUCA
  • 11573/1651247 - 2022 - Nab-Paclitaxel related cystoid macular edema (01g Articolo di rassegna (Review))
    DI PIPPO, MARIACHIARA; DI STASO, FEDERICO; FRAGIOTTA, SERENA; ABDOLRAHIMZADEH, SOLMAZ
  • 11573/1657298 - 2022 - Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective (01d Recensione)
    FRAGIOTTA, SERENA; SCUDERI, LUCA; IODICE, CLEMENTE MARIA; RULLO, DARIA; DI PIPPO, MARIACHIARA; ABDOLRAHIMZADEH, SOLMAZ
  • 11573/872865 - 2017 - Visual outcomes and contrast sensitivity after bilateral implantation of multifocal intraocular lenses with +2.50 or +3.0 diopter addition: 12-month follow-up (01a Articolo in rivista)
    VINGOLO, ENZO MARIA; CARNEVALE, CARMELA; FRAGIOTTA, SERENA
  • 11573/496698 - 2012 - Genetic analysis for two italian siblings with usher syndrome and schizophrenia. (01i Case report)
    DOMANICO, DANIELA; FRAGIOTTA, SERENA; NEBBIOSO, MARCELLA; VINGOLO, ENZO MARIA
  • 11573/1343331 - 2014 - Bivariate contour ellipse area (BCEA) variability: comparison of two methods for recording (01h Abstract in rivista)
    SPADEA, LEOPOLDO; FRAGIOTTA, SERENA; VINGOLO, ENZO MARIA

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