Dottore di ricerca

ciclo: XXXIII

supervisore: Professor Patrizia Pantano
co-supervisore: Professor Alfredo Berardelli


Tourette Syndrome (TS) is a neurodevelopmental disorder defined by multiple motor or phonic tics accompanied by several comorbidities predominantly Obsessive-compulsive disorder (OCD). Apart from the context of TS, OCD may manifest independently as a disorder characterized by recurrent intrusive thoughts (obsessions) and compulsions. TS and OCD particularly appear as two intertwined disorders since they not only both exhibit repetitive behaviors, whose characterization into complex tics and compulsions might be clinically challenging at times. Accordingly, patients manifesting TS with OCD may exhibit an intermediate clinical phenotype (TS+OCD) which is characterized by the overlapping pathophysiological features of both TS and OCD. Addressing this issue, our first study focused on using a data-driven approach to elucidate functional connectivity patterns in a cohort of drug-naïve children with TS, TS+OCD and OCD and age-matched controls. We revealed significant abnormalities in pre-defined resting state networks (RSNs), especially in the cerebellar network. The findings of our exploratory study provided us with the necessary framework to use a hypothesis driven approach for our follow-up study where we investigated and highlighted the alterations in cerebellar structural and functional connectivity in our drug-naïve children with TS and OCD.

Produzione scientifica

11573/1700202 - 2023 - Effective connectivity abnormalities in Lewy body disease with visual hallucinations
Leodori, Giorgio; Fabbrini, Andrea; Suppa, Antonio; Mancuso, Marco; Tikoo, Sankalp; Belvisi, Daniele; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL:, INTERNET:, Fax: 011 353 61 709114) pp. 156-165 - issn: 1388-2457 - wos: WOS:001111952700001 (0) - scopus: 2-s2.0-85176578597 (1)

11573/1663112 - 2022 - Differential white matter involvement in drug-naïve children with obsessive-compulsive disorder and Tourette syndrome
Conte, Giulia; Bharti, Komal; Suppa, Antonio; Tikoo, Sankalp; Tommasin, Silvia; Gianni, Costanza; Mirabella, Giovanni; Pantano, Patrizia; Cardona, Francesco - 04c Atto di convegno in rivista
rivista: NEUROSCIENCE APPLIED (Amsterdam: Elsevier B.V) pp. - - issn: 2772-4085 - wos: (0) - scopus: (0)
congresso: 35th ECNP Congress (Vienna)

11573/1701955 - 2022 - Tourette Syndrome and Obsessive-Compulsive Disorder: different neural correlates from a multimodal neuroimaging study in drug-naïve children
Conte, Giulia; Tikoo, Sankalp; Barthi, Komal; Tommasin, Silvia; Gianni, Costanza; Suppa, Antonio; Pantano, Patrizia; Cardona, Francesco - 04f Poster
congresso: 14th European Conference on Tourette Syndrome & Tic Disorders (Lausanne)
libro: Congress book of the 14th European Conference on Tourette Syndrome & Tic Disorder - ()

11573/1573580 - 2021 - The Cerebellum in Drug-naive Children with Tourette Syndrome and Obsessive–Compulsive Disorder
Tikoo, Sankalp; Suppa, Antonio; Tommasin, Silvia; Gianni', Costanza; Conte, Giulia; Mirabella, Giovanni; Cardona, Francesco Carmelo Giovanni; Pantano, Patrizia - 01a Articolo in rivista
rivista: THE CEREBELLUM (New York: Springer London: Martin Dunitz Ltd, 2002-) pp. - - issn: 1473-4230 - wos: WOS:000702233800002 (15) - scopus: 2-s2.0-85116162642 (13)

11573/1442373 - 2020 - Resting-state functional connectivity in drug-naive pediatric patients with Tourette syndrome and obsessive-compulsive disorder
Tikoo, S.; Cardona, F.; Tommasin, S.; Gianni, C.; Conte, G.; Upadhyay, N.; Mirabella, G.; Suppa, A.; Pantano, P. - 01a Articolo in rivista
rivista: JOURNAL OF PSYCHIATRIC RESEARCH (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL:,, INTERNET:,, Fax: 011 44 1865 843010) pp. 129-140 - issn: 0022-3956 - wos: WOS:000571186500021 (14) - scopus: 2-s2.0-85087959991 (14)

11573/1454858 - 2020 - Functional disconnection of the dentate nucleus in essential tremor
Tikoo, S.; Pietracupa, S.; Tommasin, S.; Bologna, M.; Petsas, N.; Bharti, K.; Berardelli, A.; Pantano, P. - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 1358-1367 - issn: 0340-5354 - wos: WOS:000528817600016 (30) - scopus: 2-s2.0-85078356219 (34)

11573/1513131 - 2019 - Resting state Functional Connectivity differences in Pediatric Patients with Tourette syndrome and Obsessive-compulsive disorder
Tikoo, S.; Cardona, F.; Tommasin, S.; Giannì, C.; Upadhyay, N.; Bharti, K.; Conte, G.; Mirabella, G.; Suppa, A.; Pantano, P. - 04c Atto di convegno in rivista
rivista: MOVEMENT DISORDERS (New York, N.Y. : John Wiley & Sons) pp. 833-833 - issn: 1531-8257 - wos: WOS:000487785005007 (0) - scopus: (0)
congresso: International Congress of Parkinson's Disease and Movement Disorders (Nice, France)

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