TOMMASO ALBERTO SALAMONE

Dottore di ricerca

ciclo: XXXVI


supervisore: Prof.ssa Ilaria Fratoddi

Titolo della tesi: The Nanoparticles Point of View: Au, Ag, Pd, and Polymer-based Systems for Nanomedicine and Optoelectronics

This Ph.D work focussed on the synthesis and characterisation of metal nanoparticles (Au, Ag, Pd), methyl methacrylate-based polymeric nanoparticles and their hybrids. The synthesis of the nanoparticles was obtained carried out via wet chemical method, the reduction of metal precursor with sodium borohydride (MNPs) and surfactant-free emulsion polymerisation (PNPs). A critical parameter in order to fine tune their physico-chemical properties is the functionalisation of the surface of metal nanoparticles, which was carried out using hydrophilic and hydrophobic thiols, yielding isolated or interconnected nanoparticles. The obtained nanoparticles had small diameters and proved stable from a colloidal point of view, thus they were tested for different applications, in nanomedicine and optoelectronics. Hydrophilic gold nanoparticles, both functionalised with one and with a mixed thiol layer, were used as drug delivery probes, confirming their non-cytotoxicity and improving the cytotoxicity of drugs non-covalently loaded on their surface. Moreover, they were also used for colorimetric sensing of food adulterants. Mixed thiol systems were studied in depth by µ-liquid jet SR-XPS. Hydrophobic metal nanoparticles, both functionalised with mono- or dithiols, were synthesised and their properties in optoelectronics were explored. Extended networks of MNPs functionalised with an organometallic linker were synthesised and characterised in order to explore in depth the size of the nanoparticles and of the network and the chemical structure of both the linker and the nanoparticles. Isolated and interconnected nanoparticles networks were tested as chemiresistive sensors to assess their ability to respond to analytes in gaseous or vapour form, such as Hg0vap and BTX. Thin films with tunable morphology based on hybrid blends with P3HT and PLA of interconnected AuNPs were developed and their electrical behaviour was assessed. Polymeric nanoparticles based on MMA and DMMA were synthesised via surfactant free emulsion polymerisation, and they were efficiently loaded with 89Y3+ as a model for the radiotracer 90Y3+, their cytotoxicity was studied, and they were found to be non-toxic. Moreover, a dye, FITC isomer I, was physically encapsulated inside the PNPs as a proof of concept for the development of multimodal imaging agents. PNPs were also covalently linked to AuNPs by using p(MMA-co-UNTS) polymeric nanoparticles, exploiting the nucleation of AuNPs on the surface of PNPs thanks to the presence of a thiolate moiety, this hybrid system has the potential to be used in nanomedicine as a theranostic agent. The characterisation of these colloidal systems can be challenging, and a number of different techniques have been used in order to understand the structure, size, and stability of the nanosystems.

Produzione scientifica

11573/1685635 - 2023 - Acrylates-based hydrophilic co-polymeric nanobeads as nanocarriers for imaging agents
Cerra, S.; Dini, V.; Salamone, T. A.; Hajareh Haghighi, F.; Mercurio, M.; Cartoni, A.; Del Giudice, A.; Marsotto, M.; Venditti, I.; Battocchio, C.; Scaramuzzo, F. A.; Matassa, R.; Nottola, S.; Faccini, R.; Mirabelli, R.; Fratoddi, I. - 01a Articolo in rivista
rivista: COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0927-7757 - wos: WOS:001057756500001 (2) - scopus: 2-s2.0-85162129612 (2)

11573/1685772 - 2023 - Noble metal nanoparticles networks stabilized by rod-like organometallic bifunctional thiols
Cerra, S; Carlini, L; Salamone, Ta; Hajareh Haghighi, F; Mercurio, M; Pennacchi, B; Sappino, C; Battocchio, C; Nottola, S; Matassa, R; Fratoddi, I - 01a Articolo in rivista
rivista: CHEMISTRYSELECT (John Wiley & Sons, Inc) pp. 1-8 - issn: 2365-6549 - wos: WOS:000961818300001 (1) - scopus: 2-s2.0-85152082957 (1)

11573/1666235 - 2023 - Thiol-functionalized palladium nanoparticles networks. Synthesis, characterization, and room temperature (toxic) vapor detection
Cerra, Sara; Salamone, Tommaso A.; Bearzotti, Andrea; Hajareh Haghighi, Farid; Mercurio, Martina; Marsotto, Martina; Battocchio, Chiara; Fioravanti, Raoul; Diociaiuti, Marco; Fratoddi, Ilaria - 01a Articolo in rivista
rivista: PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. - - issn: 0934-0866 - wos: WOS:000917983000001 (2) - scopus: 2-s2.0-85147009737 (2)

11573/1689111 - 2023 - Surface modification of TiO2 nanoparticles with organic molecules and their biological applications
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso Alberto; Binaymotlagh, Roya; Palocci, Cleofe; Romano Spica, Vincenzo; Fratoddi, Ilaria - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF MATERIALS CHEMISTRY. B (Cambridge : RSC Publishing, 2012-) pp. 2334-2366 - issn: 2050-7518 - wos: WOS:000939746800001 (23) - scopus: 2-s2.0-85149257759 (24)

11573/1685768 - 2023 - Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment. From synthesis to in vitro studies on neuroblastoma cell lines
Salamone, Ta; Rutigliano, L; Pennacchi, B; Cerra, S; Matassa, R; Nottola, S; Sciubba, F; Battocchio, C; Marsotto, M; Del Giudice, A; Chumakov, A; Davydok, A; Grigorian, S; Canettieri, G; Agostinelli, E; Fratoddi, I. - 01a Articolo in rivista
rivista: JOURNAL OF COLLOID AND INTERFACE SCIENCE (San Diego: Elsevier Drive:Orlando, FL: Academic Press Incorporated) pp. 264-278 - issn: 0021-9797 - wos: WOS:001033080200001 (3) - scopus: 2-s2.0-85163213065 (3)

11573/1654482 - 2022 - Synthesis and characterizations of highly stable magnetite-silver (Fe3O4-Ag) nanohybrid for recyclable antibacterial materials
Hajareh Haghighi, Farid; Cerra, Sara; Salamone, Tommaso A.; Mercurio, Martina; Fratoddi, Ilaria - 04f Poster
congresso: NanoInnovation2022 (Faculty of Civil and Industrial Engineering, Sapienza University of Rome)
libro: NanoInnovation2022 conference and exhibition - ()

11573/1650120 - 2022 - Chemical conjugation of highly stable Ag nanoparticles with silane-functionalized TiO2 nanoparticles for potential dual antibacterial effect
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Marsotto, Martina; Battocchio, Chiara; Fratoddi, Ilaria - 04f Poster
congresso: The workshop "Novel frontiers in nanocarriers preparation and characterization" (Rome, Italy)
libro: The workshop "Novel frontiers in nanocarriers preparation and characterization" - ()

11573/1650266 - 2022 - Silane-functionalized metal oxide nanoparticles link silver nanoparticles: a new platform for antibacterial applications
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Matassa, Roberto; Marsotto, Martina; Battocchio, Chiara; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: The First Symposium for Young Chemists: Innovation and Sustainability (Sync2022) (Rome, Italy)
libro: The First Symposium for Young Chemists: Innovation and Sustainability (Sync2022) - ()

11573/1663315 - 2022 - Organoselenium compounds as functionalizing agents for gold nanoparticles in cancer therapy
Lorenzoni, Sara; Cerra, Sara; Angulo-Elizari, Eduardo; Salamone, Tommaso A.; Battocchio, Chiara; Marsotto, Martina; Scaramuzzo, Francesca A.; Sanmartín, Carmen; Plano, Daniel; Fratoddi, Ilaria - 01a Articolo in rivista
rivista: COLLOIDS AND SURFACES. B, BIOINTERFACES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0927-7765 - wos: WOS:000897791100005 (5) - scopus: 2-s2.0-85137730881 (5)

11573/1651531 - 2022 - Silver nanoparticles as stimulating agents for arbuscular mycorrhizal fungi growth: a new perspective for agri-food
Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Hajareh Haghighi, Farid; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: The First Symposium for YouNg Chemists: Innovation and Sustainability (SYNC2022) (Sapienza University of Rome)
libro: The First Symposium for YouNg Chemists: Innovation and Sustainability (SYNC2022) - ()

11573/1651535 - 2022 - Silver nanoparticles as efficient tool in agrifood applications
Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Hajareh Haghighi, Farid; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: YoungInnovation - The State of Research communicated by Young Researchers (Faculty of Civil and Industrial Engineering, Sapienza University of Rome)
libro: YoungInnovation - The State of Research communicated by Young Researchers - ()

11573/1651539 - 2022 - Nanotechnology in agriculture: the role of silver nanoparticles in mycorrhization process
Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Hajareh Haghighi, Farid; Pagliarani, Sofia; Morales-Rodriguez, Carmen; Kuzminsky, Elena; Vannini, Andrea; Fratoddi, Ilaria - 04f Poster
congresso: XLVIII Italian Conference of Inorganic Chemistry (Polo Didattico San Rossore 1938)
libro: XLVIII Italian Conference of Inorganic Chemistry - ()

11573/1617428 - 2022 - Hydrophilic gold nanoparticles as Anti-PD-L1 antibody carriers. Synthesis and interface properties
Venditti, I.; Cartoni, A.; Cerra, S.; Fioravanti, R.; Salamone, T. A.; Sciubba, F.; Tabocchini, M. A.; Dini, V.; Battocchio, C.; Iucci, G.; Carlini, L.; Faccini, R.; Collamati, F.; Mancini T, C.; Solfaroli C, E.; Morganti, S.; Giordano, A.; Scotognella, T.; Maccora, D.; Rotili, D.; Marchese, C.; Anastasiadou, E.; Trivedi, P.; Fratoddi, I. - 01a Articolo in rivista
rivista: PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 1-12 - issn: 0934-0866 - wos: WOS:000753440400001 (9) - scopus: 2-s2.0-85124617698 (10)

11573/1579484 - 2021 - Methylmethacrylate-based polymeric nanoparticles as platform for multimodal imaging
Cerra, Sara; Dini, Valentina; Salamone, Tommaso Alberto; Hajareh Haghighi, Farid; Scaramuzzo, Francesca Anna; Matassa, Roberto; Marsotto, Martina; Battocchio, Chiara; Cartoni, Antonella; Fratoddi, Ilaria - 04f Poster
congresso: XXVII CONGRESSO NAZIONALE DELLA SOCIETÀ CHIMICA ITALIANA (Virtual)
libro: Book of abstract - ()

11573/1616211 - 2021 - Functionalized gold nanoparticles in colorimetric and chemoresistive sensors: synthesis, sensing mechanism and interface properties
Cerra, Sara; Salamone, Tommaso A.; Hajareh Haghighi, Farid; Matassa, Roberto; Maria Beltrán, Ana; Scaramuzzo, Francesca A.; Marsotto, Martina; Battocchio, Chiara; Li Voti, Roberto; Sibilia, Concetta; Bearzotti, Andrea; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: NanoInnovation 2021 (Virtual (Università degli Studi di Roma “La Sapienza” Facoltà di Ingegneria Civile e Industriale, Roma))
libro: Book of abstracts - ()

11573/1544670 - 2021 - Study of the interaction mechanism between hydrophilic thiol capped gold nanoparticles and melamine in aqueous medium
Cerra, Sara; Salamone, Tommaso A.; Sciubba, Fabio; Marsotto, Martina; Battocchio, Chiara; Nappini, Silvia; Scaramuzzo, Francesca A.; Li Voti, Roberto; Sibilia, Concita; Matassa, Roberto; Beltrán, Ana Maria; Familiari, Giuseppe; Fratoddi, Ilaria - 01a Articolo in rivista
rivista: COLLOIDS AND SURFACES. B, BIOINTERFACES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-9 - issn: 0927-7765 - wos: WOS:000663412100003 (10) - scopus: 2-s2.0-85103590491 (12)

11573/1615942 - 2021 - Truffle farming and nanomaterials: a new technology for the optimization of the mycorrhization process and release of "helper" microorganisms
Fratoddi, I.; Bodo, E.; Cerra, S.; Salamone, T. A.; Hajareh Haghighi, F.; Bovi, M.; Bonaconsa, M.; Kuzminsky, E.; Morales-Rodriguez, C.; Pagliarani, S.; Vannini, A. - 04f Poster
congresso: XXVII Congresso Nazionale della Società Chimica Italiana (Virtual)
libro: in book of abstract - ()

11573/1544681 - 2021 - Functionalized gold nanoparticles as an active layer for mercury vapor detection at room temperature
Fratoddi, Ilaria; Cerra, Sara; Salamone, Tommaso A.; Fioravanti, Raoul; Sciubba, Fabio; Zampetti, Emiliano; Macagnano, Antonella; Generosi, Amanda; Paci, Barbara; Scaramuzzo, Francesca A.; Matassa, Roberto; Familiari, Giuseppe; Battocchio, Chiara; Marsotto, Martina; Papa, Paolo; Bearzotti, Andrea - 01a Articolo in rivista
rivista: ACS APPLIED NANO MATERIALS (Washington DC : American Chemical Society) pp. 2930-2940 - issn: 2574-0970 - wos: WOS:000635462900068 (10) - scopus: 2-s2.0-85103480333 (11)

11573/1616223 - 2021 - Silane-functionalized TiO2 nanoparticles decorated with Ag nanoparticles for dual antimicrobial effects
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: XXVII Congresso Nazionale della Società Chimica Italiana (Virtual)
libro: Book of abstracts - ()

11573/1615694 - 2021 - In situ conjugation of silver nanoparticles with silane-functionalized TiO2 nanoparticles for antibacterial applications
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Marsotto, Martina; Battocchio, Chiara; Fratoddi, Ilaria - 04f Poster
congresso: NanoInnovation 2021 (Virtual (Università degli Studi di Roma “La Sapienza” Facoltà di Ingegneria Civile e Industriale, Roma))
libro: In situ conjugation of silver nanoparticles with silane-functionalized TiO2 nanoparticles for antibacterial applications - ()

11573/1573870 - 2021 - Photoacoustics for listening to metal nanoparticle super-aggregates
Li Voti, R.; Leahu, G.; Sibilia, C.; Matassa, R.; Familiari, G.; Cerra, S.; Salamone, T. A.; Fratoddi, I. - 01a Articolo in rivista
rivista: NANOSCALE ADVANCES (Cambridge: Royal Society of Chemistry) pp. 4692-4701 - issn: 2516-0230 - wos: WOS:000671324600001 (11) - scopus: 2-s2.0-85112530530 (13)

11573/1616520 - 2021 - Functionalised gold nanoparticles loaded with methotrexate for the treatment of neuroblastoma: synthesis, characterisation, and in vitro study
Salamone, Tommaso A.; Rutigliano, Lavinia; Cerra, Sara; Hajareh Haghighi, Farid; Mongillo, Marzia; Fratoddi, Ilaria; Agostinelli, Enzo - 04f Poster
congresso: XXVII Congresso Nazionale della Società Chimica Italiana (Virtual)
libro: Book of abstracts - ()

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