Phd in IINNOVATION IN IMMUNO-MEDIATED AND HEMATOLOGICAL DISORDERS

email: sabina.chiaretti@uniroma1.it
phone: 06-441639824

Education
1989: High school graduation at L:S:S.“A. Labriola”
1995: Degree in Medicine with highest honors, at “Sapienza” University of Rome
1999: Specialty in Hematology with highest honors, at “Sapienza” University of Rome
2005: PhD in Hematologic Sciences, at “Sapienza” University of Rome

Positions and Employment
1993-1995: Attends as a medical student the Pediatric Unit of Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome.
1995-1999: Works as Resident in Hematology in the Pediatric and Day-Hospital Unit of the Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome.
2000-2004: Ph.D. student in Hematological Sciences, Division of Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome. During the PhD period, she worked for three years at the Dana Farber Cancer Institute, Boston, MA, Department of Adult Oncology where she set up the oligonucleotide array technology; applied this technology for the study of acute and chronic lymphoproliferative disorders.
From June 2004 onwards: Works at the Division of Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome. She has set up facility the oligonucleotide array technology, used for the analysis of acute and chronic lymphoproliferative disorders.

Clinical activity
During the specialty training, she provided assistance to children with acute leukemias, Hodgkin and non-Hodgkin lymphomas, receiving chemotherapy and bone marrow transplantation.

Research activity
She worked for a brief period in the flow cytometry laboratory of the Division of Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome, where she used immunophenotypic analysis for the characterization of hemopoietic cells (neoplastic and non-neoplastic).
She later participated to a project aimed at generating dendritic cells from primary cells of patients with chronic lymphocytic leukemia, and at evaluating their functionality.
During the PhD period, she spent three years in the Division of Hematologic Neoplasia at the Dana-Farber Cancer Institute, Harvard Medical School in Boston, where she focused on the use of gene expression profile for the characterization of human leukemias, in particular of acute lymphoblastic leukemias and chronic lymphocytic leukemia.
Back in Italy, she set up (Division of Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome), a genomic facility and used gene expression profiling for further characterization of acute and chronic lymphoid disorders, as well as for the evaluation of changes in gene expression profiling in different cell population after a given stimulus.
Finally, she is involved in a project aimed at identifying microRNAs that are differentially expressed in chronic and acute lymphoid disorders, and therefore might play a pivotal role in malignant transformation.

Didactical activity
She is supervisor of PhD students in Hematologic Sciences as well as students of Medical , Molecular and Cellular Biotechnologies.
She is teacher of PhD program of Innovation in Immuno-mediated and hematological disorders
Teacher of nurse program in course W, S and Civitavecchia

Scientific interest
She firstly focused on immunophenotypic characterization of leukemic and non-leukemic cells, for both diagnostic and research purposes.
She then later moved on the study of immune compartment of oncohematologic disorders.
She actively uses gene expression profiling approaches per the characterization of acute and chronic lymphoproliferative disorders ,wit the aim of identifying novel mechanisms of transformations, whose recognition may prove useful in patients' stratification.
She is also interested in microRNA (MIR) analysis.
Together with Prof. P. Corradini e Prof. R. Foà, she contributed to the book Manuale di Ematologia, Edizioni Minerva Medica, by writing the chapter I microarrays in Ematologia, together with Prof. R. Foà.
She also contributed to the following Presearch project, leaded by Prof. R. Foà or Dr A. Guarini:
- AIRC 2004. A GIMEMA (Gruppo Italiano Malattie EMatologiche dell’Adulto) genomic and post-genomic center for the study of adult hematologic malignancies.
- COFIN 2005. Characterization of the clinico-biological heterogeneity of acute lymphoblastic leukemia harboring molecular aberrations in the different decades of life through high density oligonucleotide arrays.
- AIRC 2006. Novel targeted therapies in human acute and chronic lymphoid leukemias based on the gene expression profile.
- PRIN 2007. New frontiers in the stratification of acute lymphoblastic leukemia (ALL): integration between non-conventional cytogenetics, genomics and post-genomics.
- Fondazione Cenci Bolognetti 2007. Potential role of miRs in IgM-mediated signal transduction in normal and neoplastic cells.
- AIRC 2007. Novel targeted therapies in human acute and chronic lymphoid leukemias based on the gene expression profile.
- Progetti di ricerca di facoltà 2009: “Caratterizzazione molecolare di un nuovo sottogruppo di pazienti adulti affetti da leucemia acuta linfoide T; implicazioni terapeutiche e prognostiche, e potenziale ruolo del miR-223 e di CEBPA”.
-AIRC Special Program Molecular Clinical Oncology 5 per mille 2010. Genetics-driven targeted management of lymphoid malignancies.
- AIRC 2011. A GIMEMA (Gruppo Italiano Malattie EMatologiche dell'Adulto) genomic and post-genomic center for the study of adult hematologic malignancies.
- Bando progetti universitari 2012. MicroRNA profiling in non-Hodgkin lymphomas (NHL) from HBV and/or HCV positive patients.
- Bando progetti universitari 2013. Integration of novel gene mutations into karyotype-based subgroups as a prognostic risk stratification tool in chronic lymphocytic leukemia.
- Bando progetti universitari 2014. Identification of BCR/ABL-like acute lymphoblastic leukemia patients by using the expression levels of 9 genes evaluated by quantitative PCR: a diagnostic model.
- Bando progetti universitari 2015. Definition of the genomic complexity of adult BCR/ABL1 positive acute lymphoblastic leukemia (ALL): potential prognostic significance.
- Bando di progetti universitari 2021. Identifying novel pathways for KMT2A-mediated leukemogenesis. Role of CXCR4/CXCL12 and PD1/PDL1 axes, and NG2 expression: potential therapeutic implications
-PRIN 2017. Open questions in acute lymphoblastic leukemia.
-PRIN 2017. Open questions in acute lymphoblastic leukemia.
-AIRC Special Program Molecular Clinical Oncology 5 per mille 2017. Molecular bases of disease dissemination in lymphoid malignancies to optimize curative therapeutic strategies
-She was also involved in the international Project MILE (Microarray Innovations in LEukemia), aimed at evalutating the sensitivity ofoligonucleotide arrays in a diagnostic context.