POSITION:
Physician at Department of Pediatric Hematology and Oncology -IRCCS Bambino Gesù Children's Hospital
WORK EXPERIENCE:
From April 2022:
Physician at Department of Pediatric Hematology and Oncology -IRCCS Bambino Gesù Children's Hospital
Director: Prof. Franco Locatelli
From February 2019:
Freelance contract Doctor at Day Hospital of Bone Marrow Transplant Unit,
Department of Pediatric Hematology and Oncology -IRCCS Bambino Gesù Children's Hospital
From December 2018:
Freelance contract Doctor at Department of Pediatric Hematology and Oncology -IRCCS Bambino Gesù Children's Hospital
From May to August 2018:
Resident at Department of Pediatric Hematology and Oncology at "A. Cao" Microcitemico Hospital - Cagliari
Director: Dr. Rosa Maria Mura
From March 2016 to March 2017 and from November 2017 to May 2018:
Resident at S.C. Pediatric Oncology – Fondazione IRCCS Istituto Nazionale dei Tumori of Milan
Director: Maura Massimino
EDUCATION AND TRAINING:
March 2012: Medical and Surgical License (register number 1151) to Ordine dei Medici Chirurghi e degli Odontoiatri della Provincia di Oristano
July 2012: Medical and Surgical Degree
Final grades 110/110 summa cum laude (the highest possible grade in the Italian system)
University of Cagliari, Faculty of Medicine and Surgery
July 2004: High School Diploma
Final grade 100/100 (the highest possible grade in the Italian system)
Scientific High School "A. Volta" - Ghilarza (OR), Sardinia, Italy
SKILLS:
- clinical assistance to patients undergoing hematopoietic stem cell transplantation for malignant and non-malignant diseases at the Bone Marrow Transplant Unit, both in the pre-transplant screening and in the post-transplant follow-up;
- executor of bone marrow needle aspiration, bone marrow biopsies, diagnostic and therapeutic lumbar punctures and bone marrow harvest procedures
- prescription of chemotherapies and immunotherapies
- clinical assistance to patients undergoing hematopoietic stem cell transplantation involved in clinical trials
- clinical assistance to patients involved in clinical trials of gene therapy and/or genome editing
RESEARCH PROJECT:
Improve knowledge about cancer hereditary predisposition in pediatric and adolescent cohorts and provide new insights that may be useful to further improve Cancer Predisposition Syndromes (CPS) diagnosis, treatment, surveillance, and follow-up.
In particular:
- discover potential correlations between germline genetic variation and somatic mutation profile
- identify new molecular alterations associated with CPS by studying the variants of uncertain significance (VUS) and defining their pathogenetic role in performing functional studies
- discover potential new diagnostic and therapeutic targets
- improve epidemiological data on CPS in children and adolescents with cancer
PUBLICATIONS AND ABSTRACTS:
“Nascite residue di beta-talassemia major in Sardegna”
R. Galanello, S. Barella, R. Carta
VII National Congress S.I.T.E. Brindisi 27-29th September 2012
“Confronto fra parametri di funzione ventricolare destra in pazienti talassemici intermedi con e senza ipertensione polmonare, studio preliminare”
P.Bina, M.R. Manca, R. Carta
VIII National Congress S.I.T.E. Genova, 9-11th October 2014
“An Unespected Enemy”
R. Carta, C. Fanni, C. Loddo, F. Sau, C. Soddu, A.M. Nurchi.
10th International Workshop on Neonatology, Cagliari 21-25th October 2014, published on “Journal of Pediatric and Neonatal Individualized Medicine”.
“Diagnosis of tuberous sclerosis complex in the neonatal period: a case report”
C. Loddo, P. Neroni, S. Floris, M.A. Marcialis, R. Carta, C. Fanni, D. Pruna, G. Ottonello
10th International Workshop on Neonatology, Cagliari 21-25th October 2014, published on “Journal of Pediatric and Neonatal Individualized Medicine”.
“Malattia di Menkes: evoluzione del quadro clinico e progressione dell’epilessia”
R. Carta, C. Soddu, S. Marras, F. Sau, A. Cirina, A.M. Nurchi
XL National Congress of Italian Society of Pediatric Neurology, Palermo 27-29th November 2014
“Thalassemia major: who is afraid of serum ferritin < 500 µg/L?”
F. Pinna, R. Carta, M. Morittu, C. Dessì, P. Moi, G.B. Leoni, M.L. Foschini, R. Origa
Published on Acta Haematologica. 2015;134(3):183-4
“Neural tube defects: not just cutaneous anomalies”
R. Carta, C. Fanni, M. Melis, M. Carboni, G. Carboni, C. Porcu, G. Ottonello
11th International Workshop on Neonatology, Cagliari 26 – 31 October 2015, published on “Journal of Pediatric and Neonatal Individualized Medicine”.
“Pai or not Pai”
C. Fanni, M. Melis, R. Carta, MA Marcialis, E. Coni, C. Loddo, G. Carboni, G. Ottonello
11th International Workshop on Neonatology, Cagliari 26 – 31 October 2015, published on “Journal of Pediatric and Neonatal Individualized Medicine”.
“Transanal irrigation in neurogenic bladder and bowel management from paediatric to adult age”
G. Masnata, L. Chia, F. Esu, R. Carta, A. Calarota, G.Melis, V. Manca
National Congress of Italian Urodynamics Society (SIUD), June 2016
“Practical clinical approach to treatment of monosymptomatic nocturnal enuresis”
G. Masnata, L. Chia, F. Esu, V. Manca, G. Melis, C. Guzzetti, R. Carta
National Congress of Italian Urodynamics Society (SIUD), June 2016
“Pseudo-precocious puberty in infancy as exordious of secreting germ cell tumors”.
R. Carta1, E. Schiavello2, V. Biassoni2, M.C. Magni2, M. Massimino2
1Pediatric Unit, University of Cagliari, Cagliari, Italy
2Pediatric Oncology Unit, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy
12th International Workshop on Neonatology, Cagliari 19 – 22 October 2016, published on “Journal of Pediatric and Neonatal Individualized Medicine”.
“Response to pazopanib in two pediatric patients with pretreated relapsing synovial sarcoma”.
Casanova M, Basso E, Magni C, Bergamaschi L, Chiaravalli S, Carta R, Tirtei E, Massimino M, Fagioli F, Ferrari A.
Tumori Journal 2016.
“Immunohistochemical and molecular profile of salivary gland cancer in children”.
Locati LD, Collini P, Imbimbo M, Barisella M, Testi A, Licitra LF, Löning T, Tiemann K, Quattrone P, Bimbatti E, Chiaravalli S, Casanova M, Tamborini E, Carta R, Gasparini P, Guzzo M, Massimino M, Ferrari A.
Pediatr Blood Cancer. 2017 Jan 31.
“Prevalenza del Linfoma di Hodgkin nodulare a prevalenza linfocitaria: studio retrospettivo osservazionale”.
Cara L, Carta R, Murru C, Nonnis A, Corongiu F, Atzeni C, Mura R.
3° Regional Congress: "Congresso Regionale di Area Pediatrica"
Cagliari 9-11 November 2017
“Sopravvivenza, fattori prognostici e sequele a lungo termine in bambini affetti da Medulloblastoma con età alla diagnosi inferiore a 3 anni “
R.Carta, V.Biassoni, M.Massimino, R.Mura
Congress of Pediatric Italian Society, Sardinia Section
Nuoro, 13 October 2018
“Emorragia intracranica ed ecchimosi diffuse in un neonato”
R.Carta, A.Nonnis, M.B.Piludu, A.Cualbu, R.Mura, A.B.Aru
Congress of Pediatric Italian Society, Sardinia Section
Nuoro 13 October 2018
“Malattia veno-occlusiva epatica in età pediatrica”
R. Carta, F. Locatelli
L’esperienza clinica per una diagnosi tempestiva di sVOD in età pediatrica.
Current Therapeutics. Anno XXII, N.3, Aprile 2019. Springer Healthcare Communications.
“Risultati Clinici: Leucemia linfoblastica acuta”
F. Del Bufalo, R. Carta, F. Locatelli
Published on: “Progressi in Ematologia”, n° 1/2019, nuove immunoterapie-CAR T.
“Long-term outcome of children with acute leukemia (AL) given alphabeta T and B-cell depleted HLA-haploidentical hematopoietic stem cell transplantation (TB depl-haploHSCT)”
P.Merli, D.Pagliara, M.Algeri,(…) R.Carta, A.Ruggeri, and F.Locatelli
Oral Abstract
ASH Annual Meeting, Orlando, FL, December 7-10, 2019
“Canonical and Noncanonical Roles of Fanconi Anemia Proteins: Implications in Cancer Predisposition”
G.Milletti, L.Strocchio, D.Pagliara, K.Girardi, R.Carta, A.Mastronuzzi, F.Locatelli, F.Nazio.
Cancers (Basel). 2020 Sep 20;12(9):2684.
“Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era”
R.Carta, G.Del Baldo, E.Miele, A.Po, Z.M.Besharat, F.Nazio, G.S.Colafati, E.Piccirilli, E.Agolini, M.Rinelli, M.Lodi, A.Cacchione, A.Carai, L.Boccuto, E.Ferretti, F.Locatelli, A.Mastronuzzi.
Front Oncol. 2020 Oct 29;10:566822.
“Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas”
G.Ceglie, G.Del Baldo, E.Agolini, M.Rinelli, A.Cacchione, F.Del Bufalo, M.Vinci, R.Carta, L.Boccuto, E.Miele, A.Mastronuzzi, F.Locatelli and A.Carai.
Front Pediatr. 2020 Nov 12;8:561487.
“Medulloblastoma Associated with Down Syndrome: From a Rare Event Leading to a Pathogenic Hypothesis”
Boni A, Ranalli M, Del Baldo G, Carta R, Lodi M, Agolini E, Rinelli M, Valentini D, Rossi S, Alesi V, Cacchione A, Miele E, Alessi I, Caroleo AM, Colafati GS, De Ioris MA, Boccuto L, Balducci M, Carai A, Mastronuzzi A.
Diagnostics (Basel). 2021 Feb 7;11(2):254.
“Use of ruxolitinib to control graft-versus-host-like disease in Omenn syndrome and successfully bridging to HSCT”
Grasso AG, Del Bufalo F, Boccieri E, Russo AF, Carta R, Algeri M, Lombardo M, Pagliara D, Corsetti T, Locatelli F, Merli P.
J Allergy Clin Immunol Pract. 2021 Feb 23:S2213-2198(21)00199-9.
“Rhabdoid Tumor Predisposition Syndrome: From Clinical Suspicion to General Management”
Del Baldo G, Carta R, Alessi I, Merli P, Agolini E, Rinelli M, Boccuto L, Milano GM, Serra A, Carai A, Locatelli F, Mastronuzzi A.
Front Oncol. 2021 Feb 22;11:586288.
“Alphabeta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT) in Children with Myelodysplastic Syndromes”
Pietro Merli, Daria Pagliara, Tommaso Mina, Valentina Bertaina, Giuseppina Li Pira, Stefania Lazzaro, Simone Biagini, Federica Galaverna, Luisa Strocchio, Roberto Carta, Francesco Quagliarella, Marco Becilli, Emilia Boccieri, Francesca Del Bufalo, Arianna Panigari, Annalisa Agostini, Mattia Algeri, Marco Zecca, Franco Locatelli
Abstract. Blood (2021) 138 (Supplement 1): 170. https://doi.org/10.1182/blood-2021-153913
Pharmacokinetic Evaluation of Eltrombopag in ITP Pediatric Patients.
Dionisi M, Cairoli S, Simeoli R, De Gennaro F, Paganelli V, Carta R, Rossi F, Dionisi-Vici C, Palumbo G, Goffredo BM.
Front Pharmacol. 2021 Dec 6;12:772873.
"Case Report: Massive Intestinal Pneumatosis and Pneumoretroperitoneum Following Hematopoietic Stem Cell Transplantation in a 2-Year-Old Child".
Contini G, Bertocchini A, Carta R, Merli P, Inserra A, Bagolan P, Morini F.
Front Pediatr. 2021 Dec 8;9:700736.
“Case Report: Early Association of Vemurafenib to Standard Chemotherapy in Multisystem Langerhans Cell Histiocytosis in a Newborn: Taking a Chance for a Better Outcome?”
Gaspari S, Di Ruscio V, Stocchi F, Carta R, Becilli M, De Ioris MA.
Front Oncol. 2021 Dec 13;11:794498.
“Long-term immune monitoring following TcR αβ/CD19 cell depleted haploidentical stem cell transplantation in children”
V. Bertaina, R. Sborgia, O. Marini, R. Carta, M. Becilli, F. Quagliarella, E. Boccieri, E. Velardi, M. Algeri, D. Pagliara, P. Merli, F. Galaverna, F. Locatelli.
Abstract. EBMT 48th Annual Meeting
19-23 March 2022
“Brentuximab vedotin as a single agent in the treatment of a pediatric primary cutaneous CD30 + lymphoproliferative disorder: A case report”
Ceglie G, De Vito R, Cossutta M, Tiberi A, Carta R, Boccieri E, Palumbo G
Pediatric Blood & Cancer; Volume 69, Issue 6; March 2022
“Alpha-beta T and B-cell depleted HLA-haploidentical HSCT in children with myelodysplastic syndromes”
Merli P, Pagliara D, Mina T, Bertaina V, Li Pira G, Lazzaro S, Biagini S, Galaverna F, Strocchio L, Carta R, Catanoso ML, Quagliarella F, Becilli M, Boccieri E, Del Bufalo F, Panigari A, Agostini A, Pedace L, Pizzi S, Perotti C, Algeri M, Zecca M, Locatelli F.
Haematologica. 2022 Aug 25.
“Brentuximab-Bendamustine in children, adolescent and young adults with relapsed/refractory anaplastic large cell lymphoma”.
Vinti L, Lucarelli B, De Vito R, Tangari F, Mussolin L, Girardi K, Carta R, Locatelli F.
Leukemia Research. 2022. Oct 121:S65
DOI:10.1016/S0145-2126(22)00303-4
“Human leukocyte antigen evolutionary divergence influences outcomes of paediatric patients and young adults affected by malignant disorders given allogeneic haematopoietic stem cell transplantation from unrelated donors”.
Merli P, Crivello P, Strocchio L, Pinto RM, Algeri M, Del Bufalo F, Pagliara D, Becilli M, Carta R, Gaspari S, Galaverna F, Quagliarella F, Boz G, Catanoso ML, Boccieri E, Troiano M, Fleischhauer K, Andreani M, Locatelli F.
Br J Haematol. 2022 Nov 16.
“Mucosal-Associated Invariant T (MAIT) Cells Are Functionally Impaired in Pediatric Patients Following HCT and Their Recovery Is Associated with the Onset of GvHD”
Velardi E, Flamini S, Galaverna F, Boccieri E, De Luca CD, Benini F, Quagliarella F, Rosichini M, Catanoso ML, Cardinale A, Velardi S, Volpe G, Pitisci A, Coccetti M, Carta R, Del Bufalo F, Bertaina V, Becilli M, Pagliara D, Algeri M, Merli P, Locatelli F.
Blood. 2022. Nov 140(Supplement 1):10523-10524
DOI:10.1182/blood-2022-166317
Updated Analysis on the Outcomes of Children with Acute Leukemia (AL) Receiving an Alpha/Beta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)”.
Merli P, Algeri M, Galaverna F, Quagliarella F, Bertaina V, Girolami E, Meschini A, Del Principe G, Biagini S, Sborgia R, Lucarelli B, Pagliara D, Catanoso ML, Rosignoli C, Cossutta M, Lanzaro F, Canino C, Cefalo MG, Strocchio L, Boccieri E, Becilli M, Carta R, Del Bufalo F, Li Pira G, Locatelli F.
Blood. 2022 Nov; 140(Supplement 1): 1879-1881
DOI:10.1182/blood-2022-166903
“Achievement of operational tolerance in a pediatric liver transplant recipient following successful hematopoietic stem cell transplantation from a different donor”
Algeri M, Velardi E, Spada M, Galaverna F, Carta R, Vinti L, Palumbo G, Gaspari S, Pietrobattista A, Boccieri E, Becilli M, Francalanci P, Bertaina V, Merli P, Locatelli F.
Am J Tranplant. 2023 Apr 13;S1600-6135(23)00400-8
“Hematopoietic Stem/Progenitor Cells and Engineering: LONG-TERM DATA ON IMMUNE MONITORING OF CHILDREN GIVEN TCRαβ/CD19 CELL DEPLETED HLA-HAPLOIDENTICAL STEM TRANSPLANTATION (HAPLO-HSCT)”.
Bertaina V, Sborgia R., Marini O. De Luca CD, Carta R, Becilli M, Pagliara D, Quagliarella F, Lucarelli B, Boccieri E, Velardi E, Algeri M, Merli P, Galaverna F, Locatelli F.
Cytotherapy. 2023 May 25(6):S14-S15
DOI:10.1016/S1465-3249(23)00150-0
“Allogeneic, donor-derived, second-generation, CD19-CAR-T cell for the treatment of pediatric relapsed/refractory BCP-ALL”.
Del Bufalo F, Becilli M, Rosignoli C, De Angelis B, Algeri M, Hanssens L, Gunetti M, Iacovelli S, Li Pira G, Girolami E, Leone G, Lazzaro S, Bertaina V, Sinibaldi M, Di Cecca S, Iaffaldano L, Künkele A, Boccieri E, Del Baldo G, Pagliara D, Merli P, Carta R, Quintarelli C, Locatelli F
Blood. 2023 May 12;blood.2023020023.
doi: 10.1182/blood.2023020023.