- Full Professor, Charité – Universitätsmedizin Berlin.
- Head of Science‑IT, Charité.
- Department Head, Institute of Physiology, Charité.
- Group leader, Structural Bioinformatics Group.
Education and Training
- University training and advanced academic development in structural bioinformatics and related disciplines at Charité – Universitätsmedizin Berlin.
Scientific Expertise:
- Structural Bioinformatics – analysis of protein structure, function and interactions.
- Large‑scale Biomedical Data Analysis – integration of omics, structural and clinical data.
- Pharmacogenomics and Pharmacokinetics modelling.
- Development of widely used tools for toxicity prediction and drug‑target interaction analysis (ProTox, SuperPred, SuperTarget, SuperCYP).
Methodological Expertise:
- Structural modelling and molecular docking.
- Machine learning and statistical modelling of large biomedical datasets.
- Design and implementation of public web‑servers and databases.
Research Activities
Main Research Areas:
1. Protein Evolution, Structure and Function
- Relationships between sequence, structure and biological function.
2. Drug–Target Interactions and Toxicity
- Computational prediction of drug targets and toxicity profiles from chemical structure.
- Design of tools such as ProTox, SuperPred, SuperTarget, SuperCYP.
3. Applications in Immunology and Cancer
- Network and pathway‑level analyses in immune‑mediated and neoplastic diseases.
- Active collaborations with national and international centres in computational pharmacology, oncology and immunology.
- Key contributor to software platforms widely used in preclinical toxicology and drug discovery.
- Numerous high‑impact publications; >19,000 citations (Google Scholar), major influence in pharmacogenomics, pharmacokinetics and computational biology.