- David Weatherall Chair in Medicine, University of Liverpool.
- NHS Chair of Pharmacogenetics, UK.
- Consultant Physician, Royal Liverpool University Hospital.
- Director, Centre for Drug Safety Sciences, Wolfson Centre for Personalized Medicine, and HDR North.
Education and Training
- MB ChB in Medicine – basic clinical training in medicine and surgery.
- PhD in Pharmacology / Medicine – advanced training in clinical pharmacology and translational research.
- Additional specialist and honorary titles (FRCPE, FRCP, FFPM, FRSB, FBPhS, FMedSci).
Policy and Leadership Roles:
- Non‑Executive Director, NHS England Board (since 2020).
- Commissioner on Human Medicines (MHRA).
- President, British Pharmacological Society (2020–2021).
- President, Association of Physicians (current).
- Chair, Prix Galien UK (2023–2024).
Scientific Expertise:
- Clinical Pharmacology – optimisation of drug therapy across major disease areas.
- Pharmacogenetics / Pharmacogenomics – genetic determinants of drug response and toxicity.
- Personalized Medicine – clinical implementation of genomic biomarkers.
- Drug Safety – mechanistic and clinical studies on adverse drug reactions, especially in cardiovascular disease.
Methodological Expertise:
- Clinical and pharmacoepidemiological studies on ADRs.
- Genetic association studies and development of pharmacogenetic panels.
- Integration of clinical and genomic data into risk prediction tools.
Research Activities
Main Research Areas:
1. Precision Medicine and Pharmacogenetics
- Discovery of genetic variants affecting drug efficacy and toxicity.
- Development of clinical decision tools for genotype-guided therapy.
2. Drug Safety and Adverse Reactions
- Mechanistic and translational studies on serious ADRs.
- Strategies to reduce ADR-related morbidity, mortality and healthcare costs.
3. Data Integration and Implementation Science
- Integration of clinical, genomic and outcome data into guidelines and health‑system pathways.
- Extensive collaborations with UK and international centres in clinical pharmacology and precision medicine.
- Leadership in clinical pharmacogenetic studies and implementation trials in real‑world healthcare settings.
- Extensive publication record in clinical pharmacology, pharmacogenetics and precision medicine, with multiple international awards (EACPT Lifetime Achievement Award 2025 and others).