MATTEO FRANCHITTO

PhD Graduate

PhD program:: XXXII


supervisor: Claudio Talora
co-supervisor: Isabella Scepanti

Thesis title: PLK1 and NOTCH1 at the interface of DNA Damage Checkpoint and tolerance to genotoxic stress


Research products

11573/1721054 - 2024 - First proof-of-concept study on targeting Hedgehog pathway in intrahepatic cholangiocarcinoma histological subtypes
Paradiso, S.; Carpino, G.; Di Meo, C.; Quaglio, D.; Infante, P.; Di Marcotullio, L.; De Luca, T.; Franchitto, M.; Botta, B.; Gaudio, E.; Alvaro, D.; Cardinale, V. - 04f Poster
conference: 64th annual Meeting of the Italian Cancer Society: "Science-driven approaches to achieve early diagnosis of cancer and to overcome therapy” (Milan, Italy)
book: 64nd Annual Meeting of the Italian Cancer Society: "Science-driven approaches to achieve early diagnosis of cancer and to overcome therapy resistance" - Abstract Book - ()

11573/1722499 - 2024 - Dissecting the hindrance of Hedgehog pathway in Intrahepatic Cholangiocarcinoma: a step towards targeted therapy
Paradiso, S.; Carpino, G.; Infante, P.; Di Marcotullio, L.; Quaglio, D.; Di Meo, C.; Franchitto, M.; De Luca, T.; Botta, B.; Gaudio, E.; Alvaro, D.; Cardinale, V. - 04d Abstract in atti di convegno
paper: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL ([London] : SAGE Publications) pp. 61-61 - issn: 2050-6414 - wos: (0) - scopus: (0)
conference: 32nd United European Gastroenterology Week 2024 (Vienna, Austria)
book: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL - ()

11573/1705007 - 2024 - Imparing proliferation, survival and invasiveness of Intrahepatic Cholangiocarcinoma through a novel natural Hedgehog pathway inhibitor
Paradiso, S.; Carpino, G.; Quaglio, D.; Ghirga, F.; Di Meo, C.; Paoletti, L.; De Luca, T.; Franchitto, M.; Di Marcotullio, L.; Infante, P.; Gaudio, E.; Alvaro, D.; Cardinale, V. - 04f Poster
conference: Liver Cancer Summit 2024 (Rotterdam - Netherlands)
book: Liver Cancer Summit 2024 - Abstract Book - ()

11573/1706413 - 2024 - Targeting Hedgehog signaling pathway by a natural compound: a promising approach for anti-cancer therapeutic development in Intrahepatic Cholangiocarcinoma
Paradiso, S.; Carpino, G.; Quaglio, D.; Ghirga, F.; Di Meo, C.; Paoletti, L.; De Luca, T.; Franchitto, M.; Di Marcotullio, L.; Infante, P.; Gaudio, E.; Alvaro, D.; Cardinale, V. - 04f Poster
conference: 56th Annual Meeting of the Italian Association for the Study of the Liver (Rome; Italy)
book: Digestive and Liver Disease - ()

11573/1707903 - 2024 - Potential of a natural compound as hedgehog pathway inhibitor for the treatment of intrahepatic cholangiocarcinoma
Paradiso, S.; Carpino, G.; Quaglio, D.; Ghirga, F.; Di Meo, C.; Paoletti, L.; De Luca, T.; Franchitto, M.; Di Marcotullio, L.; Infante, P.; Gaudio, E.; Alvaro, D.; Cardinale, V. - 04d Abstract in atti di convegno
paper: DIGESTIVE AND LIVER DISEASE (-Roma: Editrice Gastroenterologica Italiana; Milano: Elsevier -Roma: Editrice Gastroenterologica Italiana. -Ospedaletto Pisa: Pacini) pp. 156-156 - issn: 1590-8658 - wos: (0) - scopus: (0)
conference: 30th National Congress of Digestive Disease Italian Federation of Societies of Digestive Diseases – FISMAD (Rome; Italy)
book: 30th National Congress of Digestive Disease Italian Federation of Societies of Digestive Diseases – FISMAD - ()

11573/1659953 - 2023 - Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential
Cardinale, Vincenzo; Carpino, Guido; Overi, Diletta; Safarikia, Samira; Zhang, Wencheng; Kanke, Matt; Franchitto, Antonio; Costantini, Daniele; Riccioni, Olga; Nevi, Lorenzo; Chiappetta, Michele; Onori, Paolo; Franchitto, Matteo; Bini, Simone; Hung, Yu-Han; Lai, Quirino; Zizzari, Ilaria; Nuti, Marianna; Nicoletti, Carmine; Checquolo, Saula; Di Magno, Laura; Giuli, Maria Valeria; Rossi, Massimo; Sethupathy, Praveen; Reid, Lola M; Alvaro, Domenico; Gaudio, Eugenio - 01a Articolo in rivista
paper: JOURNAL OF HEPATOLOGY (Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377) pp. 165-179 - issn: 0168-8278 - wos: WOS:000927845200015 (7) - scopus: 2-s2.0-85138931448 (8)

11573/1693758 - 2023 - GLI1-selective inhibitor, Glabrescione B, impairs proliferation in intrahepatic cholangiocarcinoma
Paradiso, S.; Carpino, G.; Quaglio, D.; Ghirga, F.; Di Meo, C.; Paoletti, L.; De Luca, T.; Cremisini, F.; Franchitto, M.; Di Marcotullio, L.; Infante, P.; Gaudio, E.; Alvaro, D.; Cardinale, V. - 04f Poster
paper: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL ([London] : SAGE Publications) pp. 1335-1336 - issn: 2050-6414 - wos: (0) - scopus: (0)
conference: 31st United European Gastroenterology Week 2023 (Copenhagen, Denmark)
book: United European Gastroenterology JournalVolume 11: 31st United European Gastroenterology Week 2023 - ()

11573/1572090 - 2021 - Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma
Carpino, Guido; Cardinale, Vincenzo; Di Giamberardino, Alessandra; Overi, Diletta; Donsante, Samantha; Colasanti, Tania; Amato, Gaia; Mennini, Gianluca; Franchitto, Matteo; Conti, Fabrizio; Rossi, Massimo; Riminucci, Mara; Gaudio, Eugenio; Alvaro, Domenico; Mancone, Carmine - 01a Articolo in rivista
paper: JOURNAL OF HEPATOLOGY (Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377) pp. - - issn: 0168-8278 - wos: WOS:000727375100014 (53) - scopus: 2-s2.0-85114186872 (55)

11573/1534264 - 2021 - Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes
De Blasio, Carlo; Verma, Nagendra; Moretti, Marta; Cialfi, Samantha; Zonfrilli, Azzurra; Franchitto, Matteo; Truglio, Federica; De Smaele, Enrico; Ichijo, Hidenori; Naguro, Isao; Screpanti, Isabella; Talora, Claudio - 01a Articolo in rivista
paper: CELL DEATH DISCOVERY ([London]: Nature Publishing Group, 2015-) pp. 1-8 - issn: 2058-7716 - wos: WOS:000639923300002 (3) - scopus: 2-s2.0-85104240779 (3)

11573/1345710 - 2019 - Hypotonic, acidic oxidizing solution containing hypochlorous acid (HClO) as a potential treatment of hailey-hailey disease
Cialfi, S.; Calabro, S.; Franchitto, M.; Zonfrilli, A.; Screpanti, I.; Talora, C. - 01a Articolo in rivista
paper: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000507299600005 (4) - scopus: 2-s2.0-85076267842 (4)

11573/1345708 - 2019 - PLK1 targets NOTCH1 during DNA damage and mitotic progression
De Blasio, Carlo; Zonfrilli, A.; Franchitto, Matteo; Mariano, G.; Cialfi, S.; Verma, Nagendra; Checquolo, S.; Bellavia, D.; Palermo, R.; Benelli, D.; Screpanti, I.; Talora, C. - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 17941-17950 - issn: 0021-9258 - wos: WOS:000504206800020 (16) - scopus: 2-s2.0-85075566790 (16)

11573/1258524 - 2019 - DNA damage stress: Cui prodest?
Verma, Nagendra; Franchitto, Matteo; Zonfrilli, Azzurra; Cialfi, Samantha; Palermo, Rocco; Talora, Claudio - 01g Articolo di rassegna (Review)
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000462542300072 (13) - scopus: 2-s2.0-85062408385 (14)

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