Current Positions:
- Chair, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York
- David D. Thompson Professor of Pathology, Weill Cornell Medicine
- Professor of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Pathologist-in-Chief, NewYork-Presbyterian/Weill Cornell Medical Center
Education and Training
- 1980: MD, Medicine and Surgery (summa cum laude), University of Milan, Italy
- Board Certification: American Board of Pathology
- Specialized training in Anatomic Pathology at Harvard institutions
Professional Background:
- Career development at Dana-Farber Cancer Institute, Harvard Medical School, and Brigham and Women's Hospital
- Former Chair, Department of Oncologic Pathology, Dana-Farber Cancer Institute
- Former Chief, Division of Translational and Molecular Oncologic Pathology, Dana-Farber Cancer Institute/Brigham and Women's Hospital
- Clinical Expertise: Surgical Pathology, with particular focus on urologic oncology pathology
Clinical Skills:
- Surgical pathology with expertise in urologic oncology pathology
- Histopathologic and molecular diagnosis of prostate carcinoma and other solid tumors
- Pathologist-in-Chief at one of the major US academic medical centers
- Leadership in integrated diagnostic pathology
Scientific Skills:
- Biochemical and genomic approaches to study metabolic reprogramming in prostate cancer and other solid tumors
- Biology of tumor metabolism
- Metabolic pathways supporting tumor growth
- Molecular and translational pathology in oncology
- Integration of computational pathology and large-scale data analytics
Academic Leadership:
- Expansion of diagnostic capabilities through computational pathology
- Integration of large-scale data analytics in pathology
- Recruitment of new faculty to strengthen translational research and training
- Direction of Pathology Department at one of the most prestigious US medical centers (Weill Cornell Medicine/NewYork-Presbyterian)
Research Activities
Main Research Areas:
1. Prostate Cancer Metabolism:
- Metabolic reprogramming in prostate carcinoma cells
- Metabolic pathways supporting tumor growth
- Metabolic vulnerabilities as therapeutic targets
2. Solid Tumors and Metabolism:
- Study of metabolism in different types of solid tumors
- Biochemical approaches integrated with genomic analysis
- Identification of tumor metabolic signatures
3. Translational Molecular Pathology:
- Integration of genomic, transcriptomic and proteomic data
- Development of diagnostic and prognostic biomarkers
- Computational pathology and digital pathology
4. Precision Medicine:
- Molecular stratification of cancer patients
- Molecular pathology approaches for precision medicine
- Integration of multi-omic data for tumor characterization
Activities at Weill Cornell Medicine and Meyer Cancer Center:
- Expansion of diagnostic capabilities through computational pathology
- Integration of large-scale data analytics
- Recruitment of new faculty for translational research
- Development of advanced training programs
International Experiences:
- Training in Italy (University of Milan)
- Academic career developed in the United States at excellence institutions:
- Dana-Farber Cancer Institute, Boston
- Harvard Medical School, Boston
- Brigham and Women's Hospital, Boston
- Weill Cornell Medicine, New York
International Leadership Roles:
- Chair of Pathology, Weill Cornell Medicine (one of the leading US pathology departments)
- Pathologist-in-Chief, NewYork-Presbyterian/Weill Cornell Medical Center
- International collaborations in molecular and oncologic pathology
- Officer of the Order of the Star of Italy (2015) - recognition by Italian Government
Translational Contributions:
- Development of innovative diagnostic approaches in oncologic pathology
- Integration of computational pathology into clinical practice
- Studies on metabolic biomarkers in prostate carcinoma
- Applications of precision medicine in urologic oncology
Scientific Output:
Numerous publications in molecular pathology, tumor metabolism and translational oncology
Awards and Honours:
- Stowell-Orbison Award, US and Canadian Academy of Pathology (1980, 1997)
- Claudia Adams Barr Investigator in Cancer Research Award, Dana-Farber Cancer Institute (1998)
- Daland Award, Dana-Farber Cancer Institute (1998)
- Daland Award, New England Cancer Society (1998)
- Donald S. Coffey-CaP CURE Physician-Scientist Award (2003)
- Officer of the Order of the Star of Italy - appointed by Italian Government (2015)
- Elected to Association of American Physicians (2015)
Scientific Leadership:
- Internationally recognized leader in molecular oncologic pathology
- Fundamental contributions to understanding prostate cancer metabolism
- Pioneer in integration of computational pathology and big data analytics