MARTA FISCHETTI

PhD

PhD program:: XXXIII


tutor: Adalberto Sciubba
advisor: Vincenzo Patera
supervisor: Vincenzo Patera

Thesis title: Inter-fractional monitoring in Particle Therapy treatments with 12C ions exploiting the detection of secondary particles: simulation studies and clinical trial results at the CNAO facility

In Particle Therapy morphological variations occurring within the treatment delivery may significantly modify the actual absorbed dose with respect to that one calculated at planning stage, affecting the treatment efficacy and the enhancing the Normal Tissue Complication Probability. In the clinical practice at CNAO (Centro Nazionale di Adroterapia Oncologica, Pavia, Italy) a mid-treatment control CT is scheduled for patients pathologies in which significant toxicities or tumour volume modifications are expected. In these cases, the treatment is re-planned if the detected variations are significantly affecting the dose absorbed by the PTV. The afore-mentioned strategy, cannot exclude that some of the patients that are not monitored may experience a variation resulting into an unwanted dose absorption inside the normal tissues and the organs at risk, together with an underdosage of the target volume. Furthermore, the monitored patients in which no change is observed receive an unnecessary additional dose from the imaging. The Dose Profiler, developed in the framework of the INSIDE collaboration, is a scintillating fiber-based tracker detector designed to monitor 12C ions treatments reconstructing the large-angle charged particles produced by the primary beam fragmentation. As the fragments yield is correlated with the tissue density, morphological variations can be identified comparing the reconstructed 3D spatial distributions of the fragments emission points in different fractions, with the aim of providing an experimental reliable criterium for scheduling a re-evaluation CT only when needed. The Dose Profiler is currently operating at CNAO in the context of a clinical trial (ClinicalTrials.gov Identifier: NCT03662373) started in 2019. This thesis aims to evaluate the Dose Profiler capability and sensitivity in detecting morphological changes arising in pathologies of the neck-head district using the data collected during the clinical trial. After each monitored fraction (for a total of ~ 5 treatment sessions per patient), the 3D image of the fragments emission positions is reconstructed back-projecting the tracks detected in the DP towards the patient, and then compared against the one obtained in the first fraction. The applicability of such technique in the clinical routine and its limitation will be discussed analysing in detail all the collected clinical cases.

Research products

  • 11573/1115684 - 2018 - Scintillating fiber devices for particle therapy applications (01a Articolo in rivista)
    DE SIMONI, MICOL; FISCHETTI, MARTA; MAGI, MARCO; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; SARTI, ALESSIO; SCIUBBA, ADALBERTO; SOLFAROLI CAMILLOCCI, ELENA; TOPPI, MARCO; TRAINI, GIACOMO; PATERA, VINCENZO
  • 11573/1264021 - 2018 - Position sensitive β- Detector based on p-terphenyl scintillator for medical applications (01a Articolo in rivista)
    COLLAMATI, FRANCESCO; DE SIMONI, MICOL; FACCINI, RICCARDO; FISCHETTI, MARTA; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; TRAINI, GIACOMO; SOLFAROLI CAMILLOCCI, ELENA
  • 11573/1310290 - 2018 - The FOOT (FragmentatiOn Of Target) experiment (01a Articolo in rivista)
    DE SIMONI, MICOL; FACCINI, RICCARDO; FERRONI, FERNANDO; FISCHETTI, MARTA; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; TRAINI, GIACOMO
  • 11573/1310121 - 2019 - Development and characterization of a ΔE-TOF detector prototype for the FOOT experiment (01a Articolo in rivista)
    DE SIMONI, MICOL; FACCINI, RICCARDO; FERRONI, FERNANDO; FISCHETTI, MARTA; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; TRAINI, GIACOMO
  • 11573/1310053 - 2019 - Review and performance of the Dose Profiler, a particle therapy treatments online monitor (01a Articolo in rivista)
    TRAINI, GIACOMO; DE SIMONI, MICOL; FISCHETTI, MARTA; MAGI, MARCO; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; PATERA, VINCENZO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; SOLFAROLI CAMILLOCCI, ELENA; SARTI, ALESSIO
  • 11573/1310055 - 2019 - Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 16O ion beams in a PMMA target at large angles (01a Articolo in rivista)
    TRAINI, GIACOMO; DE SIMONI, MICOL; FISCHETTI, MARTA; GIOSCIO, ELIANA; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; SOLFAROLI CAMILLOCCI, ELENA; PATERA, VINCENZO
  • 11573/1310127 - 2019 - Ion charge separation with new generation of nuclear emulsion films (01a Articolo in rivista)
    DE SIMONI, MICOL; FACCINI, RICCARDO; FERRONI, FERNANDO; FINCK, CHRISTIAN; FISCHETTI, MARTA; IAROCCI, ENZO; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; TRAINI, GIACOMO
  • 11573/1310247 - 2018 - Characterisation of the MONDO detector response to neutrons by means of a FLUKA Monte Carlo simulation (01a Articolo in rivista)
    DE SIMONI, MICOL; FISCHETTI, MARTA; GIOSCIO, ELIANA; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCIUBBA, ADALBERTO; TRAINI, GIACOMO
  • 11573/1310260 - 2018 - In-room test results at CNAO of an innovative PT treatments online monitor (Dose Profiler) (01a Articolo in rivista)
    DE SIMONI, MICOL; FISCHETTI, MARTA; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; SOLFAROLI CAMILLOCCI, ELENA; TRAINI, GIACOMO
  • 11573/1310256 - 2018 - Characterisation of the secondary-neutron production in particle therapy treatments with the MONDO tracking detector (01a Articolo in rivista)
    FISCHETTI, MARTA; DE SIMONI, MICOL; GIOSCIO, ELIANA; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; TRAINI, GIACOMO
  • 11573/1339846 - 2019 - A 16 × 8 Digital-SiPM Array with Distributed Trigger Generator for Low SNR Particle Tracking (04d Abstract in atti di convegno)
    GIOSCIO, ELIANA; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; ZOU, YAYAN; DE SIMONI, MICOL; FISCHETTI, MARTA
  • 11573/1339851 - 2019 - Characterisation of a β detector on positron emitters for medical applications (01a Articolo in rivista)
    CARTONI, ANTONELLA; DE SIMONI, MICOL; FACCINI, RICCARDO; FISCHETTI, MARTA; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; SOLFAROLI CAMILLOCCI, ELENA
  • 11573/1310938 - 2018 - Charged particles and neutron trackers: applications to particle therapy (01a Articolo in rivista)
    DE SIMONI, MICOL; FISCHETTI, MARTA; GIOSCIO, ELIANA; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; SARTI, ALESSIO; SCIUBBA, ADALBERTO; SOLFAROLI CAMILLOCCI, ELENA; TRAINI, GIACOMO; PATERA, VINCENZO
  • 11573/1387877 - 2020 - Development of a novel neutron tracker for the characterisation of secondary neutrons emitted in Particle Therapy (01a Articolo in rivista)
    GIOSCIO, ELIANA; DE SIMONI, MICOL; FISCHETTI, MARTA; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; TOPPI, MARCO
  • 11573/1387929 - 2020 - Tumor-non-tumor discrimination by a β- detector for Radio Guided Surgery on ex-vivo neuroendocrine tumors samples (01a Articolo in rivista)
    COLLAMATI, FRANCESCO; DE SIMONI, MICOL; FISCHETTI, MARTA; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; SOLFAROLI CAMILLOCCI, ELENA; TRAINI, GIACOMO; FACCINI, RICCARDO
  • 11573/1466348 - 2020 - FRED: A fast Monte Carlo code on GPU for quality control in particle therapy (01a Articolo in rivista)
    DE SIMONI, MICOL; FISCHETTI, MARTA; GIOSCIO, ELIANA; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; TRAINI, GIACOMO
  • 11573/1466324 - 2020 - The MONDO tracker: characterisation and study of secondary ultrafast neutrons production in carbon ion radiotherapy (01a Articolo in rivista)
    TOPPI, MARCO; DE MARIA, PATRIZIA; DE SIMONI, MICOL; FISCHETTI, MARTA; FRANCIOSINI, GAIA; MAGI, MARCO; MATTEI, FABRIZIO IVO; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; TRAINI, GIACOMO
  • 11573/1466344 - 2020 - Performance of the ToF detectors in the foot experiment (01a Articolo in rivista)
    TRAINI, GIACOMO; DE SIMONI, MICOL; FACCINI, RICCARDO; FERRONI, FERNANDO; FINCK, CHRISTIAN; FISCHETTI, MARTA; FRANCIOSINI, GAIA; IAROCCI, ENZO; MIRABELLI, RICCARDO; PATERA, VINCENZO; SARTI, ALESSIO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO
  • 11573/1466354 - 2020 - Inter-fractional monitoring of 12 C ions treatments: results from a clinical trial at the CNAO facility (01a Articolo in rivista)
    FISCHETTI, MARTA; DE MARIA, PATRIZIA; DE SIMONI, MICOL; DI LULLO, BENEDETTA; FRANCIOSINI, GAIA; GALANTE, FEDERICA; MAGI, MARCO; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; PATERA, VINCENZO; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; SOLFAROLI CAMILLOCCI, ELENA; TOPPI, MARCO; TRAINI, GIACOMO; SARTI, ALESSIO
  • 11573/1486665 - 2020 - Stability and efficiency of a CMOS sensor as detector of low energy β and γ particles (01a Articolo in rivista)
    COLLAMATI, FRANCESCO; AMORUSO, ROSA; BIASINI, MARIA CLAUDIA; DE MARIA, PATRIZIA; DE SIMONI, MICOL; FISCHETTI, MARTA; FRANCIOSINI, GAIA; MANCINI TERRACCIANO, CARLO; MEDDI, FRANCO; MORGANTI, STEFANO; MIRABELLI, RICCARDO; SOLFAROLI CAMILLOCCI, ELENA; FACCINI, RICCARDO
  • 11573/1487095 - 2020 - Performance Evaluation of the TOF-Wall Detector of the FOOT Experiment (01a Articolo in rivista)
    CIARROCCHI, ERIKA; DE SIMONI, MICOL; FISCHETTI, MARTA; MIRABELLI, RICCARDO; SARTI, ALESSIO; SPORTELLI, GIUSEPPE; TRAINI, GIACOMO
  • 11573/1487063 - 2020 - A DROP-IN beta probe for robot-assisted 68Ga-PSMA radioguided surgery: first ex vivo technology evaluation using prostate cancer specimens (01a Articolo in rivista)
    COLLAMATI, FRANCESCO; DE SIMONI, MICOL; FACCINI, RICCARDO; FISCHETTI, MARTA; MANCINI TERRACCIANO, CARLO; MORETTI, RICCARDO; SOLFAROLI CAMILLOCCI, ELENA
  • 11573/1571152 - 2021 - Monitoring Carbon Ion Beams Transverse Position Detecting Charged Secondary Fragments: Results From Patient Treatment Performed at CNAO (01a Articolo in rivista)
    TOPPI, MARCO; DE MARIA, PATRIZIA; DE SIMONI, MICOL; FISCHETTI, MARTA; FRANCIOSINI, GAIA; MAGI, MARCO; MANCINI TERRACCIANO, CARLO; MATTEI, FABRIZIO IVO; MIRABELLI, RICCARDO; MIRANDOLA, ANTONIO; PATERA, VINCENZO; SCIUBBA, ADALBERTO; SOLFAROLI CAMILLOCCI, ELENA; SPORTELLI, GIUSEPPE; VITOLO, VALERIO; SARTI, ALESSIO
  • 11573/1571178 - 2021 - Charge identification of fragments with the emulsion spectrometer of the FOOT experiment (01a Articolo in rivista)
    CIARROCCHI, ERIKA; FACCINI, RICCARDO; FINCK, CHRISTIAN; FISCHETTI, MARTA; FRANCHINI, MARCO; FRANCIOSINI, GAIA; GIRAUDO, GIANLUCA; IAROCCI, ENZO; IONICA, ANGELA MONICA; MATTEI, FABRIZIO IVO; MURTAS, FEDERICA; PATERA, VINCENZO; ROSSO, VITTORIO; SARTI, ALESSIO; SARTORELLI, GIORGIA; SCIFONI, EMANUELE; SCIUBBA, ADALBERTO; SPORTELLI, GIUSEPPE; TOPPI, MARCO
  • 11573/1571156 - 2021 - Enhancing the understanding of fragmentation processes in hadrontherapy and radioprotection in space with the FOOT experiment (01a Articolo in rivista)
    CIARROCCHI, ERIKA; DE SIMONI, MICOL; FACCINI, RICCARDO; FINCK, CHRISTIAN; FISCHETTI, MARTA; FRANCHINI, MARCO; FRANCIOSINI, GAIA; GIRAUDO, GIANLUCA; IAROCCI, ENZO; IONICA, ANGELA MONICA; MATTEI, FABRIZIO IVO; MURTAS, FEDERICA; PATERA, VINCENZO; ROSSO, VITTORIO; SARTI, ALESSIO; SARTORELLI, GIORGIA; SCIFONI, EMANUELE; SCIUBBA, ADALBERTO; SPORTELLI, GIUSEPPE; TOPPI, MARCO
  • 11573/1551181 - 2021 - Detection of Interfractional Morphological Changes in Proton Therapy: A Simulation and In Vivo Study With the INSIDE In-Beam PET (01a Articolo in rivista)
    DE SIMONI, MICOL; FISCHETTI, MARTA; FRANCIOSINI, GAIA; GIRAUDO, GIANLUCA; MANCINI TERRACCIANO, CARLO; MATTEI, FABRIZIO IVO; MIRABELLI, RICCARDO; MIRANDOLA, ANTONIO; PATERA, ANTONIO; PATERA, VINCENZO; RIVETTI, ARIANNA; SARTI, ALESSIO; SCIUBBA, ADALBERTO; SOLFAROLI CAMILLOCCI, ELENA; SPORTELLI, GIUSEPPE; TOPPI, MARCO; VITOLO, VALERIO
  • 11573/1551179 - 2021 - PAPRICA: The Pair Production Imaging Chamber—Proof of Principle (01a Articolo in rivista)
    TOPPI, MARCO; CALVI, GIULIA MARIA; DE SIMONI, MICOL; FRANCIOSINI, GAIA; FISCHETTI, MARTA; PATERA, VINCENZO; RONCHETTI, FRANCESCO; SARTI, ALESSIO; SCIUBBA, ADALBERTO; TRAINI, GIACOMO; MATTEI, FABRIZIO IVO
  • 11573/1551175 - 2021 - Charge identification of nuclear fragments with the FOOT Time-Of-Flight system (01a Articolo in rivista)
    AMBROSI, GIUSEPPE; CIARROCCHI, ERIKA; DE SIMONI, MICOL; FACCINI, RICCARDO; FINCK, CHRISTIAN; FISCHETTI, MARTA; FRANCHINI, MARCO; FRANCIOSINI, GAIA; GIRAUDO, GIANLUCA; IAROCCI, ENZO; IONICA, ANGELA MONICA; MATTEI, FABRIZIO IVO; MURTAS, FEDERICA; PATERA, VINCENZO; RIDOLFI, ROBERTO; SARTI, ALESSIO; SARTORELLI, GIORGIA; SCHIAVI, ANGELO; SCIFONI, EMANUELE; SCIUBBA, ADALBERTO; SPORTELLI, GIUSEPPE; TOPPI, MARCO; TRAINI, GIACOMO
  • 11573/1598557 - 2021 - Deep seated tumour treatments with electrons of high energy delivered at FLASH rates: the example of prostate cancer (01a Articolo in rivista)
    SARTI, ALESSIO; DE MARIA, PATRIZIA; DE SIMONI, MICOL; DI FELICE, CINZIA; FISCHETTI, MARTA; FRANCIOSINI, GAIA; MARAMPON, FRANCESCO; MIRABELLI, RICCARDO; PACILIO, MASSIMILIANO; PALUMBO, LUIGI; ROCCA, LOREDANA; SCHIAVI, ANGELO; SCIUBBA, ADALBERTO; TOMBOLINI, VINCENZO; TOPPI, MARCO; TRIGILIO, ANTONIO; PATERA, VINCENZO
  • 11573/1387842 - 2020 - Radioguided surgery with β− radiation in pancreatic Neuroendocrine tumors: a feasibility study (01a Articolo in rivista)
    COLLAMATI, FRANCESCO; CARTONI, ANTONELLA; DE SIMONI, MICOL; FISCHETTI, MARTA; FRATODDI, ILARIA; MANCINI TERRACCIANO, CARLO; MIRABELLI, RICCARDO; ROTILI, DANTE; SOLFAROLI CAMILLOCCI, ELENA; TRAINI, GIACOMO; VENDITTI, IOLE; FACCINI, RICCARDO
  • 11573/1640304 - 2022 - A Data-Driven Fragmentation Model for Carbon Therapy GPU-Accelerated Monte-Carlo Dose Recalculation (01a Articolo in rivista)
    DE SIMONI, MICOL; DE GREGORIO, ANGELICA; DE MARIA, PATRIZIA; FISCHETTI, MARTA; FRANCIOSINI, GAIA; PATERA, VINCENZO; SARTI, ALESSIO; TOPPI, MARCO; TRIGILIO, ANTONIO; SCHIAVI, ANGELO
  • 11573/1659802 - 2022 - GPU-accelerated Monte Carlo simulation of electron and photon interactions for radiotherapy applications (01a Articolo in rivista)
    FRANCIOSINI, GAIA; DE GREGORIO, ANGELICA; DE MARIA, PATRIZIA; DE SIMONI, MICOL; FISCHETTI, MARTA; MIRABELLI, RICCARDO; MUSCATO, ANNALISA; PATERA, VINCENZO; SARTI, ALESSIO; SCIUBBA, ADALBERTO; TOPPI, MARCO; TRIGILIO, ANTONIO; SCHIAVI, ANGELO

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