MARIARITA TARALLO

Dottoressa di ricerca

ciclo: XXXIV



Titolo della tesi: Identification of cancer hallmarks in patients with non-metastatic colon cancer after surgical resection

Colon cancer is one of the most common cancers in the world, and the therapeutic workflow is dependent on the TNM staging system and the presence of clinical risk factors. However, in the case of patients with non-metastatic disease, evaluating the benefit of adjuvant chemotherapy is a clinical challenge. Radiomics could be seen as a non-invasive novel imaging biomarker able to outline tumor phenotype and to predict patient prognosis by analyzing preoperative medical images. Radiomics might provide decisional support for oncologists with the goal to reduce the number of arbitrary decisions in the emerging era of personalized medicine. To date, much evidence highlights the strengths of radiomics in cancer workup, but several aspects limit the use of radiomics methods as routine. The study aimed to develop a radiomic model able to identify high-risk colon cancer by analyzing pre-operative CT scans. The study population comprised 148 patients: 108 with non-metastatic colon cancer were retrospectively enrolled from January 2015 to June 2020, and 40 patients were used as the external validation cohort. The population was divided into two groups—High-risk and No-risk—following the presence of at least one high-risk clinical factor. All patients had baseline CT scans, and 3D cancer segmentation was performed on the portal phase by two expert radiologists using open-source software (3DSlicer v4.10.2). Among the 107 radiomic features extracted, stable features were selected to evaluate the inter-class correlation (ICC) (cut-off ICC > 0.8). Stable features were compared between the two groups (T-test or Mann–Whitney), and the significant features were selected for univariate and multivariate logistic regression to build a predictive radiomic model. The radiomic model was then validated with an external cohort. In total, 58/108 were classified as High-risk and 50/108 as No-risk. A total of 35 radiomic features were stable (0.81 ≤ ICC <  0.92). Among these, 28 features were significantly different between the two groups (p < 0.05), and only 9 features were selected to build the radiomic model. The radiomic model yielded an AUC of 0.73 in the internal cohort and 0.75 in the external cohort. In conclusion, the radiomic model could be seen as a performant, non-invasive imaging tool to properly stratify colon cancers with high-risk disease

Produzione scientifica

  • 11573/617807 - 2014 - A rare case of malignant epithelioid angiomyolipoma in multiple locations: Multifocal disease or metastases? (01a Articolo in rivista)
    CROCETTI, DANIELE; PEDULLA', GIUSEPPE; TARALLO, MARIARITA; DE GORI, ANTONIETTA; PALIOTTA, ANNALISA; CAVALLARO, GIUSEPPE; DE TOMA, GIORGIO
  • 11573/617803 - 2014 - Surgical treatment of pheochromocytoma in MEN 2. (01a Articolo in rivista)
    PEDULLA', GIUSEPPE; CROCETTI, DANIELE; PALIOTTA, ANNALISA; TARALLO, MARIARITA; DE GORI, ANTONIETTA; CAVALLARO, GIUSEPPE; DE TOMA, GIORGIO
  • 11573/1680921 - 2023 - Neoadjuvant Treatments for Pancreatic Ductal Adenocarcinoma: Where We Are and Where We Are Going (01g Articolo di rassegna (Review))
    COPPOLA, ALESSANDRO; IANNONE, IMMACOLATA; TARALLO, MARIARITA
  • 11573/1690012 - 2023 - MITHOCONDRIA-RELATED OXIDATIVE STRESS: AN UNEXPLORED FIELD IN DIVERTICULAR DISEASE (04d Abstract in atti di convegno)
    CAPPELLETTI, MARTINA; CASELLA, GIOVANNI; TARALLO, MARIARITA; PISANO, ANNALINDA; TATTOLI, IVAN; PALLOTTA, LUCIA; GIORDANO, CARLA; SEVERI, CAROLA
  • 11573/1690014 - 2023 - Short oral presentation award (14a Premio o riconoscimento scientifico)
    CAPPELLETTI, MARTINA; CASELLA, GIOVANNI; TARALLO, MARIARITA; PISANO, ANNALINDA; TATTOLI, IVAN; PALLOTTA, LUCIA; GIORDANO, CARLA; SEVERI, CAROLA
  • 11573/1691257 - 2023 - Longitudinal myopathy and oxidative imbalance in asymptomatic diverticulosis and complicated diverticular disease (01h Abstract in rivista)
    PALLOTTA, LUCIA; CAPPELLETTI, MARTINA; PISANO, ANNALINDA; CASELLA, GIOVANNI; TARALLO, MARIARITA; BURRELLI SCOTTI, GIORGIA; GIORDANO, CARLA; SEVERI, CAROLA
  • 11573/1680085 - 2023 - Laparoscopic transversus abdominis plane block is useful in pain relief after laparoscopic stapled repair of diastasis recti and ventral hernia (01a Articolo in rivista)
    CAVALLARO, GIUSEPPE; GAZZANELLI, SERGIO; IORIO, OLGA; IOSSA, ANGELO; GIORDANO, LUCA; ESPOSITO, LUCA; CROCETTI, DANIELE; TARALLO, MARIARITA; SIBIO, SIMONE; BRAUNEIS, STEFANO; POLISTENA, ANDREA
  • 11573/1691255 - 2023 - Diverticular disease and oxidative stress: the link with mitochondria alterations in the different clinical phenotypes (01h Abstract in rivista)
    CAPPELLETTI, MARTINA; CASTAGNETO GISSEY, LIDIA; TARALLO, MARIARITA; PISANO, ANNALINDA; TATTOLI, IVAN; PALLOTTA, LUCIA; GIORDANO, CARLA; SEVERI, CAROLA
  • 11573/1680118 - 2022 - Achieving the learning curve in total thyroidectomy: a prospective evaluation on resident’s training by CUSUM and KPSS analysis (01a Articolo in rivista)
    TARALLO, MARIARITA; CROCETTI, DANIELE; IORIO, OLGA; IOSSA, ANGELO; CARUSO, DAMIANO; BONONI, MARCO; CHIAPPINI, AMBRA; TESTINI, MARIO; POLISTENA, ANDREA; CAVALLARO, GIUSEPPE
  • 11573/1679094 - 2023 - T.02.5 OXIDATIVE STRESS IN DIVERTICULAR DISEASE: MITOCHONDRIA INVOLVEMENT OF IN THE DIFFERENT CLINICAL PHENOTYPES (04f Poster)
    CAPPELLETTI, MARTINA; PISANO, ANNALINDA; CASTAGNETO GISSEY, LIDIA; TARALLO, MARIARITA; GIORDANO, CARLA; SEVERI, CAROLA; PALLOTTA, LUCIA
  • 11573/1686132 - 2023 - Radiomics analysis in gastrointestinal imaging: a narrative review (01g Articolo di rassegna (Review))
    DE SANTIS, DOMENICO; DEL GAUDIO, ANTONELLA; ZERUNIAN, MARTA; POLICI, MICHELA; GUIDO, GISELLA; TARALLO, MARIARITA; MASCI, BENEDETTA; IANNICELLI, ELSA; LAGHI, ANDREA; CARUSO, DAMIANO
  • 11573/876647 - 2016 - Pancreas preserving surgery for duodenal gastrointestinal stromal tumor removal (01a Articolo in rivista)
    CROCETTI, DANIELE; SAPIENZA, PAOLO; CISANO, CLAUDIO; TARALLO, MARIARITA; POLISTENA, ANDREA; VENTURINI, LUIGI; PEDULLA', GIUSEPPE; DE TOMA, GIORGIO
  • 11573/1271618 - 2019 - Preservation of left colic artery with lymph node dissection of IMA root during laparoscopic surgery for rectosigmoid cancer. Results of a retrospective analysis (01a Articolo in rivista)
    CROCETTI, DANIELE; CAVALLARO, GIUSEPPE; TARALLO, MARIARITA; CHIAPPINI, AMBRA; POLISTENA, ANDREA; SAPIENZA, PAOLO; FIORI, ENRICO; DE TOMA, GIORGIO
  • 11573/1303412 - 2019 - Does aberrant right hepatic artery influence the surgical short- and long-term outcome of pancreatoduodenectomy? (01a Articolo in rivista)
    CROCETTI, DANIELE; SAPIENZA, PAOLO; OSSOLA, PAOLO; TARALLO, MARIARITA; CAVALLARO, GIUSEPPE; GRANDE, RAFFAELE; MINGOLI, ANDREA; FIORI, ENRICO; DE TOMA, GIORGIO
  • 11573/1305688 - 2019 - Pneumothorax: a rare complication of colonoscopy. A systematic review of literature (01g Articolo di rassegna (Review))
    CROCETTI, DANIELE; FIORI, ENRICO; COSTI, UMBERTO; TARALLO, MARIARITA; DE GORI, ANTONIETTA; CAVALLARO, GIUSEPPE; DE TOMA, GIORGIO
  • 11573/1309736 - 2019 - Second jejunal loop adenocarcinoma associated with celiac disease. The first case report (01i Case report)
    URSI, PIETRO; TARALLO, MARIARITA; CROCETTI, DANIELE; CAVALLARO, GIUSEPPE; FIORI, ENRICO; D'ANDREA, VITO; DE TOMA, GIORGIO
  • 11573/1345728 - 2019 - Resection or stenting in the treatment of symptomatic advanced metastatic rectal cancer: a dilemma (01a Articolo in rivista)
    FIORI, ENRICO; CROCETTI, DANIELE; LAMAZZA, ANTONIETTA; DE FELICE, FRANCESCA; TARALLO, MARIARITA; STERPETTI, ANTONIO; MINGOLI, ANDREA; SAPIENZA, PAOLO; DE TOMA, GIORGIO
  • 11573/1680376 - 2015 - Cystic adrenal lesions: clinical and surgical management. The experience of a referral centre (01a Articolo in rivista)
    CAVALLARO, GIUSEPPE; CROCETTI, DANIELE; PALIOTTA, ANNALISA; DE GORI, ANTONIETTA; TARALLO, MARIARITA; LETIZIA, CLAUDIO; DE TOMA, GIORGIO
  • 11573/1394141 - 2020 - MYOGENIC OXIDATIVE STRESS IMPAIRES COLONIC LONGITUDINAL MUSCLE IN DIVERTICULAR DISEASE (01h Abstract in rivista)
    PALLOTTA, LUCIA; CICENIA, ALESSIA; TARALLO, MARIARITA; CARABOTTI, MARILIA; TELLAN, GUGLIELMO; FIORI, ENRICO; SEVERI, CAROLA
  • 11573/1449777 - 2020 - Criticism of learning curve in laparoscopic adrenalectomy. A systematic review (01g Articolo di rassegna (Review))
    TARALLO, MARIARITA; CROCETTI, DANIELE; FIORI, ENRICO; SAPIENZA, PAOLO; LETIZIA, CLAUDIO; DE TOMA, GIORGIO; CAVALLARO, GIUSEPPE
  • 11573/1443839 - 2020 - Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19 (01a Articolo in rivista)
    WATANABE, MIKIKO; CARUSO, DAMIANO; RISI, RENATA; ZERUNIAN, MARTA; POLICI, MICHELA; PUCCIARELLI, FRANCESCO; TARALLO, MARIARITA; MARIANI, STEFANIA; BASCIANI, SABRINA; LUBRANO, CARLA; LAGHI, ANDREA; GNESSI, LUCIO
  • 11573/1551964 - 2021 - Radiomics in oncology, part 1: technical principles and gastrointestinal application in CT and MRI (01g Articolo di rassegna (Review))
    CARUSO, DAMIANO; POLICI, MICHELA; ZERUNIAN, MARTA; PUCCIARELLI, FRANCESCO; GUIDO, GISELLA; POLIDORI, TIZIANO; LANDOLFI, FEDERICA; NICOLAI, MATTEO; LUCERTINI, ELENA; TARALLO, MARIARITA; BRACCI, BENEDETTA; NACCI, ILARIA; RUCCI, CARLOTTA; IANNICELLI, ELSA; LAGHI, ANDREA
  • 11573/1564148 - 2021 - Surgical management of adrenocortical carcinoma: current highlights (01a Articolo in rivista)
    CAVALLARO, GIUSEPPE; TARALLO, MARIARITA; CHIAPPINI, AMBRA; CROCETTI, DANIELE; POLISTENA, ANDREA; PETRAMALA, LUIGI; SIBIO, SIMONE; DE TOMA, GIORGIO; FIORI, ENRICO; LETIZIA, CLAUDIO
  • 11573/1551962 - 2021 - Radiomics in oncology, part 2: thoracic, genito-urinary, breast, neurological, hematologic and musculoskeletal applications (01g Articolo di rassegna (Review))
    CARUSO, DAMIANO; POLICI, MICHELA; ZERUNIAN, MARTA; PUCCIARELLI, FRANCESCO; GUIDO, GISELLA; POLIDORI, TIZIANO; LANDOLFI, FEDERICA; NICOLAI, MATTEO; LUCERTINI, ELENA; TARALLO, MARIARITA; BRACCI, BENEDETTA; NACCI, ILARIA; RUCCI, CARLOTTA; IANNICELLI, ELSA; LAGHI, ANDREA
  • 11573/1632135 - 2022 - Endoscopic stenting and palliative chemotherapy in advanced colorectal cancer: friends or foes? An analysis of the current literature (01a Articolo in rivista)
    SAPIENZA, PAOLO; LAPOLLA, PIERFRANCESCO; CROCETTI, DANIELE; TARALLO, MARIARITA; BRACHINI, GIOIA; MINGOLI, ANDREA; FIORI, ENRICO
  • 11573/1619948 - 2022 - Role of new anatomy, biliopancreatic reflux, and helicobacter pylori status in postgastrectomy stump cancer (01g Articolo di rassegna (Review))
    BASSO, LUIGI; GALLO, GAETANO; BIACCHI, DANIELE; CARATI, MARIA VITTORIA; CAVALLARO, GIUSEPPE; ESPOSITO, LUCA; GIULIANI, ANDREA; IZZO, LUCIANO; LAMAZZA, ANTONIETTA; POLISTENA, ANDREA; TARALLO, MARIARITA; FIORI, ENRICO
  • 11573/766151 - 2013 - Surgical management of abdominal manifestation of type 1 neurofibromatosis: experience of a single center (04a Atto di comunicazione a congresso)
    PEDULLA', GIUSEPPE; CROCETTI, DANIELE; TARALLO, MARIARITA; CAVALLARO, GIUSEPPE; DE TOMA, GIORGIO
  • 11573/766149 - 2013 - Laparoscopic adrenal-sparing surgery: experience of a referral Centre (04a Atto di comunicazione a congresso)
    CROCETTI, DANIELE; PEDULLA', GIUSEPPE; TARALLO, MARIARITA; CAVALLARO, GIUSEPPE; DE TOMA, GIORGIO
  • 11573/766148 - 2013 - Adrenal cysts: clinical and surgical management (04a Atto di comunicazione a congresso)
    CROCETTI, DANIELE; PEDULLA', GIUSEPPE; TARALLO, MARIARITA; CAVALLARO, GIUSEPPE; DE TOMA, GIORGIO
  • 11573/766156 - 2014 - Role of partial adrenalectomy in patient with von hipple-lindau syndrome and bilateral pheocromocytoma. Case report (04a Atto di comunicazione a congresso)
    CROCETTI, DANIELE; PEDULLA', GIUSEPPE; TARALLO, MARIARITA
  • 11573/1644256 - 2022 - A case report of multiple gastrointestinal stromal tumors: imaging findings, surgical approach, and review of the literature (01i Case report)
    TARALLO, MARIARITA; CARRUEZZO, CRISTINA; DEL GAUDIO, ANTONELLA; CARUSO, DAMIANO; POLICI, MICHELA; CROCETTI, DANIELE; COSTI, UMBERTO; POLISTENA, ANDREA; PANZUTO, FRANCESCO; LAGHI, ANDREA; CAVALLARO, GIUSEPPE; FIORI, ENRICO
  • 11573/1651040 - 2022 - Radiomic cancer hallmarks to identify high-risk patients in non-metastatic colon cancer (01a Articolo in rivista)
    CARUSO, DAMIANO; POLICI, MICHELA; ZERUNIAN, MARTA; DEL GAUDIO, ANTONELLA; PARRI, EMANUELA; GIALLORENZI, MARIA AGOSTINA; DE SANTIS, DOMENICO; TARANTINO, GIULIA; TARALLO, MARIARITA; DENTICE DI ACCADIA CAPOZZI, FILIPPO MARIA MICHELE FREDERICK; IANNICELLI, ELSA; GARBARINO, GIOVANNI MARIA; CANALI, GIULIA; MERCANTINI, PAOLO; FIORI, ENRICO; LAGHI, ANDREA
  • 11573/1651886 - 2022 - CT-based radiomics for prediction of therapeutic response to Everolimus in metastatic neuroendocrine tumors (01a Articolo in rivista)
    CARUSO, DAMIANO; POLICI, MICHELA; RINZIVILLO, MARIA; ZERUNIAN, MARTA; NACCI, ILARIA; MARASCO, MATTEO; MAGI, LUDOVICA; TARALLO, MARIARITA; GARGIULO, SIMONA; IANNICELLI, ELSA; ANNIBALE, BRUNO; LAGHI, ANDREA; PANZUTO, FRANCESCO
  • 11573/1620011 - 2021 - Surgical treatment and management of syndromic paraganglioma. The experience of a referral center (01a Articolo in rivista)
    TARALLO, MARIARITA; CROCETTI, DANIELE; CAVALLARO, GIUSEPPE; CARUSO, DAMIANO; CHIAPPINI, AMBRA; PETRAMALA, LUIGI; SAPIENZA, PAOLO; LETIZIA, CLAUDIO; FIORI, ENRICO; DE TOMA, GIORGIO
  • 11573/1614939 - 2022 - Oxidative imbalance and muscular alterations in diverticular disease (01a Articolo in rivista)
    PALLOTTA, LUCIA; CICENIA, ALESSIA; CARABOTTI, MARILIA; CAPPELLETTI, MARTINA; GIOIA, ALESSIA; TARALLO, MARIARITA; TELLAN, GUGLIELMO; FIORI, ENRICO; SEVERI, CAROLA
  • 11573/1657272 - 2022 - PARALLELISM IN MYOGENIC OXIDATIVE ALTERATIONS BETWEEN UNCOMPLICATED AND COMPLICATED DIVERTICULAR DISEASE (04d Abstract in atti di convegno)
    CAPPELLETTI, MARTINA; GIOIA, ALESSIA; TARALLO, MARIARITA; PISANO, ANNALINDA; GIORDANO, CARLA; SEVERI, CAROLA; PALLOTTA, LUCIA
  • 11573/1668502 - 2023 - Identification of cancer hallmarks in patients with non-metastatic colon cancer after surgical resection (07a Tesi di Dottorato)
    TARALLO, MARIARITA
  • 11573/1574865 - 2021 - Perioperative chemotherapy with FLOT scheme in resectable gastric adenocarcinoma: a preliminary correlation between TRG and radiomics (01a Articolo in rivista)
    GARBARINO, GIOVANNI MARIA; ZERUNIAN, MARTA; BERARDI, EVA; MAINARDI, FEDERICO; PILOZZI, EMANUELA; POLICI, MICHELA; GUIDO, GISELLA; RUCCI, CARLOTTA; POLIDORI, TIZIANO; TARALLO, MARIARITA; LARACCA, GIOVANNI GUGLIELMO; IANNICELLI, ELSA; MERCANTINI, PAOLO; ANNIBALE, BRUNO; LAGHI, ANDREA; CARUSO, DAMIANO
  • 11573/1645877 - 2022 - OC.04.1 OXIDATIVE MUSCLE-DRIVEN ALTERATIONS: PARALLELISM BETWEEN UNCOMPLICATED AND COMPLICATED DIVERTICULAR DISEASE (04d Abstract in atti di convegno)
    CAPPELLETTI, MARTINA; GIOIA, ALESSIA; CASTAGNETO GISSEY, LIDIA; TARALLO, MARIARITA; PISANO, ANNALINDA; SEVERI, CAROLA; PALLOTTA, LUCIA
  • 11573/1658353 - 2022 - Adrenal lesions: a review of imaging (01a Articolo in rivista)
    BRACCI, BENEDETTA; DE SANTIS, DOMENICO; DEL GAUDIO, ANTONELLA; FAUGNO, MARIA CARLA; ROMANO, ALLEGRA; TARALLO, MARIARITA; ZERUNIAN, MARTA; GUIDO, GISELLA; POLICI, MICHELA; POLIDORI, TIZIANO; PUCCIARELLI, FRANCESCO; LAGHI, ANDREA; CARUSO, DAMIANO
  • 11573/1629388 - 2014 - Recurrence of paratesticular liposarcoma: a case report and review of the literature (01i Case report)
    GABRIELE, RAIMONDO; TARALLO, MARIARITA; DE GORI, ANTONIETTA; IZZO, LUCIANO
  • 11573/1673265 - 2023 - Laparoscopic transversus abdominis plane block is useful in pain relief after laparoscopic stapled repair of diastasis recti and ventral hernia (01a Articolo in rivista)
    CAVALLARO, GIUSEPPE; GAZZANELLI, SERGIO; IORIO, OLGA; IOSSA, ANGELO; GIORDANO, LUCA; ESPOSITO, LUCA; CROCETTI, DANIELE; TARALLO, MARIARITA; SIBIO, SIMONE; BRAUNEIS, STEFANO; POLISTENA, ANDREA

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