MARIA LAURA DE SCISCIO

PhD Student

PhD program:: XXXVII
email: marialaura.desciscio@uniroma1.it
building: CU014
room: 358




supervisor: Marco D'Abramo

Research: In silico methods for the early biopharmaceutical development and formulation

Maria Laura De Sciscio was born in Benevento on 09/01/96. In 2018, she obtained a Bachelor's Degree in Chemistry at Sapienza University of Rome, discussing an experimental thesis entitled "Synthesis of 5-hydroxyimino-6-oxohexyl 2-methylpropanoate and polymerization tests ", under the supervision of Prof. Patrizia Gentili. In March 2021 she obtained the Master's Degree in Chemistry, Bio-Organic address, at Alma Mater Studiorum University of Bologna, with final mark of 110/110. For her thesis, she carried out an experimental internship in Biochemistry at Campus Bio-Medico University of Rome, with Prof. Mauro Maccarrone and Prof. Matteo Calvaresi as external and internal supervisor, respectively. Since April 2021 she has a collaboration agreement with Campus Bio-Medico University of Rome, for the study of the effect of innovative compounds on endocannabinoid system activity. Since January 2022 she is a PON PhD student in Chemistry, at Sapienza University of Rome, with Prof. Marco D'abramo as tutor.

Research products

11573/1707635 - 2024 - Modelling the assembly and flexibility of antibody structures
Guo, Dongjun; De Sciscio, Maria Laura; Chi-Fung Ng, Joseph; Fraternali, Franca - 01g Articolo di rassegna (Review)
paper: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. - - issn: 0959-440X - wos: WOS:001142966400001 (0) - scopus: 2-s2.0-85180584780 (0)

11573/1693500 - 2023 - Computational and Experimental Drug Repurposing of FDA-Approved Compounds Targeting the Cannabinoid Receptor CB1
Criscuolo, Emanuele; De Sciscio, Maria Laura; De Cristofaro, Angela; Nicoara, Catalin; Maccarrone, Mauro; Fezza, Filomena - 01a Articolo in rivista
paper: PHARMACEUTICALS (Basel : MDPI, Molecular Diversity Preservation International, 2004-) pp. - - issn: 1424-8247 - wos: WOS:001131337300001 (0) - scopus: (0)

11573/1693390 - 2023 - Molecular Modeling of the Deamidation Reaction in Solution: A Theoretical-Computational Study
De Sciscio, Maria Laura; Nardi, Alessandro Nicola; Centola, Fabio; Rossi, Mara; Guarnera, Enrico; D'abramo, Marco - 01a Articolo in rivista
paper: THE JOURNAL OF PHYSICAL CHEMISTRY. B (Columbus, OH : American Chemical Society, 1997-) pp. 9550-9559 - issn: 1520-5207 - wos: WOS:001098413700001 (0) - scopus: 2-s2.0-85176509378 (0)

11573/1665426 - 2023 - Effect of salts on the conformational dynamics of the Cytochrome P450 OleP
De Sciscio, Maria Laura; Nardi, Alessandro Nicola; Parisi, Giacomo; Bulfaro, Giovanni; Costanzo, Antonella; Gugole, Elena; Exertier, Cécile; Freda, Ida; Savino, Carmelinda; Vallone, Beatrice; Montemiglio, Linda Celeste; D’Abramo, Marco - 01a Articolo in rivista
paper: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000927697700001 (0) - scopus: 2-s2.0-85146781706 (0)

11573/1688794 - 2023 - Fatty acid amide hydrolase, anandamide, and neurological diseases
Fezza, F.; Criscuolo, E.; De Sciscio, M. L.; Maccarrone, M. - 02a Capitolo o Articolo
book: Neurobiology and Physiology of the Endocannabinoid System - (9780323908771)

11573/1664892 - 2022 - Theoretical evaluation of sulfur-based reactions as a model for biological antioxidant defense
De Sciscio, Maria Laura; D’Annibale, Valeria; D’Abramo, Marco - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000896382800001 (2) - scopus: 2-s2.0-85143774799 (3)

11573/1603246 - 2021 - In silico and in vitro analysis of major cannabis-derived compounds as fatty acid amide hydrolase inhibitors
Criscuolo, E.; De Sciscio, M. L.; Fezza, F.; Maccarrone, M. - 01a Articolo in rivista
paper: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. 1-8 - issn: 1420-3049 - wos: WOS:000606119100001 (5) - scopus: 2-s2.0-85099116033 (7)

11573/1603248 - 2021 - Exploring the role of l10 loop in new delhi metallo-β-lactamase (Ndm-1): Kinetic and dynamic studies
Piccirilli, A.; Criscuolo, E.; Brisdelli, F.; Mercuri, P. S.; Cherubini, S.; De Sciscio, M. L.; Maccarrone, M.; Galleni, M.; Amicosante, G.; Perilli, M. - 01a Articolo in rivista
paper: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. 1-14 - issn: 1420-3049 - wos: WOS:000701939200001 (4) - scopus: 2-s2.0-85114912058 (4)

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