Phd in ENDOCRINOLOGICAL SCIENCES

Research: Gut microbiota-Thyroid metabolism interaction: the role of beta-glucuronidase in idiopathic malabsorption

Education and Training Novembre 2025 - Present PhD student in Endocrinological Sciences (41st cycle) at the Department of Experimental Medicine of Sapienza University of Rome PhD project Title: Gut microbiota-Thyroid metabolism interaction: the role of beta-glucuronidase in idiopathic malabsorption Overview: characterization of the enzymatic activity of the fecal microbiota in patients with Hashimoto's thyroiditis in current euthyroidism, with a particular focus on patients with increased requirements for levothyroxine therapy. Supervisor: Prof. Camilla Virili 27 January 2025 Specialist in Endocrinology and Metabolic Diseases at Sapienza University of Rome Thesis title: 'Premature ovarian failure in patients with thyroid-related polyautoimmunity' Supervisor: Prof Marco Centanni 30 October 2019 Degree in Medicine and Surgery at Sapienza University of Rome, Thesis title: ‘Cytokine patterns in Hashimoto's thyroiditis: correlation with thyroid functional evolution’ Supervisor: Prof Marco Centanni Scientific Activity Clinical Research Actively engaged in clinical research with a primary focus on: - thyroid autoimmunity and autoimmune polyendocrine syndromes - thyroxine malabsorption associated with gastrointestinal disorders Publications 1. Daily requirement of softgel thyroxine is independent from gastric juice pH C. Virili S. Capriello I. Stramazzo N. Brusca M. G. Santaguida L. Gargano M. F. Bagaglini G. Bruno C. Severi M. Centanni Frontiers in Endocrinology Published on 26 Sep 2022 2. The relationship between thyroid disorders and vitamin A.: A narrative minireview S. Capriello I. Stramazzo M. F. Bagaglini N. Brusca C. Virili M. Centanni Frontiers in Endocrinology Published on 11 Oct 2022 3.The relationship between thyroid and human-associated microbiota: A systematic review of reviews Virili C, Stramazzo I, Bagaglini MF, Carretti AL, Capriello S, Romanelli F, Trimboli P, Centanni M. Reviews in Endocrine and Metabolic Disorders, 2024 February 4. CD20 + T lymphocytes in isolated Hashimoto's thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study I. Stramazzo , G. Mangino , S. Capriello , G. Romeo , S. M. Ferrari , P. Fallahi , M. F. Bagaglini , M.Centanni , C.Virili J Endocrinol Invest. 2024 Nov 5. Differences and analogies in thyroid cancer discovered incidentally or by thyroid related screening: A multicenter study. Croce L, Ruggeri RM, Virili C, Cappelli C, Teliti M, Costa P, Chytiris S, Nicocia A, Coperchini F, Bagaglini MF, Magri F, Campenni A, Rotondi M. Eur Thyroid J. 2025 Jan Conference contributions 1. CD3+CD8+CD20+ T cells as markers of the inflammatory phase in autoimmune thyroid diseases and related polyautoimmune disorders: a pilot study. Stramazzo, C. Virili, S. Capriello, N. Brusca, M. F. Bagaglini, G. Romeo, G. Mangino & M. Centanni Endocrine Abstracts September 2022 2. Systematic evaluation of polyautoimmunity in patients with confirmed lymphocytic thyroiditis. M. Centanni, I. Stramazzo, S. Capriello, M. F. Bagaglini, M. G. Santaguida, L. Gargano, N. Brusca, C. Virili Endocrine Abstracts August 2023 Conference contributions – POSTER 1. Unilateral dysthyroid orbitopathy as the only sign of occult coeliac disease: effect of a gluten-free diet I. Stramazzo, N. Brusca, M.F. Bagaglini, L. Gargano, M. Centanni, C. Virili Poster presentation, 41st National Congress of the Italian Society of Endocrinology, Rome, 14-17 July 2021 2. Effect of anti-B lymphocyte immunomodulatory drugs on the course of chronic lymphocytic thyroiditis in a patient with APS-3 A.L. Carretti, M. F. Bagaglini, I. Stramazzo, M. Centanni, C. Virili Poster presentation, 43rd National Congress of the Italian Society of Endocrinology, Turin, 11-14 June 2025 3. Premature ovarian failure in the context of thyroid-related polyautoimmune disorders M. Centanni, M.F. Bagaglini, I. Stramazzo, C. Virili Poster presentation, 17th International Congress on the Thyroid, Rio de Janeiro, 18-22 June 2025 Conference presentations 1. Levothyroxine malabsorption: a kaleidoscope of comorbidities Maria Flavia Bagaglini Personalising thyroxine therapy: treating patients, not numbers! Latina, 25 June 2022 2. Thyroxine as doping Maria Flavia Bagaglini Effective thyroxine therapy: instructions for use in clinical practice Rome, 19 November 2022 3. Unilateral dysthyroid orbitopathy as the only sign of occult coeliac disease Maria Flavia Bagaglini Thyroid: one, none and a hundred thousand POEMA (Collegium of Professors of Endocrinology, Metabolism and Andrology) Webinar 29 May 2023 4. Autonomy is not always an asset Maria Flavia Bagaglini Thyroid Masterclass POEMA (Collegium of Professors of Endocrinology, Metabolism and Andrology), Webinar 10 June 2024 5. Premature ovarian failure in patients with thyroid-related polyautoimmunity Maria Flavia Bagaglini Congress of the Italian Thyroid Association 2024, Varese, 28-30 November 2024 6. The patient with malabsorption Maria Flavia Bagaglini The kaleidoscope of thyroid disorders Latina, 15 March 2025 Skills - Performing and reporting thyroid ultrasounds - Performing thyroid fine needle aspiration - Performing and reporting REMS (radiofrequency echographic multi spectrometry) tests for the diagnosis and monitoring of osteoporosis