MARIA ANELE ROMEO

Dottoressa di ricerca

ciclo: XXXIII



Titolo della tesi: HHV-6 DYSREGULATES AUTOPHAGY AND UPR IN THE INFECTED CELLS: IMPACT ON IMMUNE RESPOSE AND NEURODEGENERATIVE DISEASE

HHV-6A and HHV-6B are herpesviruses characterized by high level of homology, both isolated for the first time from immune-suppressed patients but able to infect different target cells. HHV-6B is the causative agent of exanthema subitum, a self-limiting disease that arises in young children, while no diseases have been shown to be caused by HHV-6A primary infection. These viruses are known to induce immune suppression and share the characteristic to be neurotropic, even if HHV6-A more efficiently replicate in neuronal cells compare to HHV-6B. However, HHV-6A and B have been associated with central nervous system (CNS) diseases, particularly a high number of HHV-6A viral copies have been found in the brains of patients suffering of Alzheimer’s disease (AD). Autophagy is a cellular process involved in several physiologic processes including immune response and CNS homeostasis. Although mostly of viruses, including Herpesviruses, have been shown to subvert autophagy to their own advantage, this PhD project reports for the first time that HHV-6A and HHV-6B are able to manipulate autophagy in the cells in which they replicate, and more importantly in monocytes in which this effect and the consequent ER stress induction prevents their differentiation into dendritic cells. Viral infection, in addition to ER stress, increased the level of intracellular ROS and activated STAT1 and STAT3 pathway, up-regulating PD-L1, to further induce immune dysfunction and favoring viral escape from immune recognition. Another consequence of autophagy dysregulation and ER stress/UPR induction by HHV-6A infection was the A accumulation and Tau protein hyperphosphorylation in astrocytes and primary neurons, which support a possible association of HHV-6A with AD. In conclusion this study evidences for that HHV-6A and HHV-6B infection has a strong impact on autophagy and ER stress/UPR in different cell types and that through this effect these viruses promote immune dysfunction and diseases.

Produzione scientifica

11573/1696204 - 2023 - NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells
Arena, Andrea; Di Crosta, Michele; Gonnella, Roberta; Zarrella, Roberta; Romeo, Maria Anele; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Santarelli, Roberta; D’Orazi, Gabriella; Cirone, Mara - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:001036167700001 (0) - scopus: 2-s2.0-85166018355 (0)

11573/1696270 - 2023 - JQ-1/bortezomib combination strongly impairs MM and PEL survival by inhibiting c-Myc and mTOR despite the activation of prosurvival mechanisms
Arena, Andrea; Romeo, Maria Anele; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Cirone, Mara - 01a Articolo in rivista
rivista: EXPERIMENTAL HEMATOLOGY (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 28-41 - issn: 0301-472X - wos: WOS:000957826000001 (2) - scopus: 2-s2.0-85147270519 (2)

11573/1696290 - 2023 - NRF2 and STAT3: friends or foes in carcinogenesis?
Arena, Andrea; Romeo, Maria Anele; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Santarelli, Roberta; Gonnella, Roberta; D'orazi, Gabriella; Cirone, Mara - 01g Articolo di rassegna (Review)
rivista: DISCOVER ONCOLOGY ([New York]: Springer, 2021-) pp. 37- - issn: 2730-6011 - wos: WOS:000961857300002 (2) - scopus: 2-s2.0-85153108305 (2)

11573/1671685 - 2023 - Different outcome of targeting ERN1/IRE1 alpha and EIF2AK3/PERK in NSG mice engrafted with primary effusion lymphoma
Arena, Andrea; Romeo, Maria Anele; Focaccetti, Chiara; Anastasiadou, Eleni; Trivedi, Pankaj; Cifaldi, Loredana; Gilardini Montani, Maria Saveria; Benedetti, Rossella; Santarelli, Roberta; Gonnella, Roberta; Benvenuto, Monica; Marchese, Cinzia; Masuelli, Laura; Bei, Roberto; Cirone, Mara - 01f Lettera, Nota
rivista: BRITISH JOURNAL OF HAEMATOLOGY (Oxford]: [Blackwell Science].) pp. 1-4 - issn: 1365-2141 - wos: WOS:000935692900001 (0) - scopus: 2-s2.0-85148023663 (0)

11573/1691548 - 2023 - The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice
Arena, Andrea; Romeo, Maria Anele; Po, Agnese; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Gonnella, Roberta; Santarelli, Roberta; Gaeta, Aurelia; De Smaele, Enrico; Cirone, Mara - 01a Articolo in rivista
rivista: MICROBIOLOGY SPECTRUM (Washington, DC : ASM Press, 2014-) pp. 1-6 - issn: 2165-0497 - wos: WOS:001095474200001 (0) - scopus: 2-s2.0-85180012834 (0)

11573/1696201 - 2023 - mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines
Germano, Concetta Anna; Clemente, Giuseppe; Storniolo, Antonello; Romeo, Maria Anele; Ferretti, Elisabetta; Cirone, Mara; Di Renzo, Livia Maria - 01a Articolo in rivista
rivista: BIOLOGY (Basel : MDPI) pp. - - issn: 2079-7737 - wos: WOS:000995573100001 (1) - scopus: 2-s2.0-85160229201 (1)

11573/1691546 - 2023 - HHV-6A Infection of Papillary Thyroid Cancer Cells Induces Several Effects Related to Cancer Progression
Mardente, Stefania; Romeo, Maria Anele; Asquino, Angela; Po, Agnese; Gilardini Montani, Maria Saveria; Cirone, Mara - 01a Articolo in rivista
rivista: VIRUSES (Basel: MDPI) pp. - - issn: 1999-4915 - wos: WOS:001093625400001 (0) - scopus: 2-s2.0-85175165732 (0)

11573/1696294 - 2023 - Acetylation increases expression, interaction with TRAPPC4 and surface localization of PD-L1
Romeo, Maria Anele; Gilardini Montani, Maria Saveria; Santarelli, Roberta; Benedetti, Rossella; Arena, Andrea; Cirone, Mara - 01a Articolo in rivista
rivista: DISCOVER ONCOLOGY ([New York]: Springer, 2021-) pp. 152- - issn: 2730-6011 - wos: WOS:001052800600002 (0) - scopus: 2-s2.0-85168487188 (0)

11573/1587456 - 2022 - DNA damage triggers an interplay between wtp53 and c-Myc affecting lymphoma cell proliferation and Kaposi sarcoma herpesvirus replication
Arena, A.; Gilardini Montani, M. S.; Romeo, M. A.; Benedetti, R.; Gaeta, A.; Cirone, M. - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-11 - issn: 0167-4889 - wos: WOS:000717326400005 (15) - scopus: 2-s2.0-85118539605 (15)

11573/1640499 - 2022 - Targeting c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple Myeloma Cells
Arena, A.; Romeo, M. A.; Benedetti, R.; Gilardini Montani, M. S.; Cirone, M. - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel : MDPI) pp. 1-12 - issn: 2227-9059 - wos: WOS:000786755100001 (9) - scopus: 2-s2.0-85127699313 (9)

11573/1640511 - 2022 - The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells
Arena, A.; Romeo, M. A.; Benedetti, R.; Gilardini Montani, M. S.; Cirone, M. - 01a Articolo in rivista
rivista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (San Diego [etc.]: Elsevier [etc.]) pp. 19-25 - issn: 0006-291X - wos: WOS:000878132700004 (2) - scopus: 2-s2.0-85129320111 (2)

11573/1659741 - 2022 - Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP. A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas
Benedetti, R.; Arena, A.; Romeo, M. A.; Gilardini Montani, M. S.; Gonnella, R.; Santarelli, R.; Trivedi, P.; Cirone, M. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-13 - issn: 1661-6596 - wos: WOS:000846661400001 (3) - scopus: 2-s2.0-85137722317 (3)

11573/1671667 - 2022 - ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress
Benedetti, Rossella; Romeo, Maria Anele; Arena, Andrea; Gilardini Montani, Maria Saveria; Di Renzo, Livia; D'orazi, Gabriella; Cirone, Mara - 01a Articolo in rivista
rivista: CELL DEATH DISCOVERY ([London]: Nature Publishing Group, 2015-) pp. 1-12 - issn: 2058-7716 - wos: WOS:000815638500001 (9) - scopus: 2-s2.0-85132944532 (9)

11573/1640535 - 2022 - p62/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation
Gilardini Montani, Maria Saveria; Tarquini, Greta; Santarelli, Roberta; Gonnella, Roberta; Romeo, Maria Anele; Benedetti, Rossella; Arena, Andrea; Faggioni, Alberto; Cirone, Mara - 01a Articolo in rivista
rivista: CARCINOGENESIS (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 277-287 - issn: 0143-3334 - wos: WOS:000756810200001 (9) - scopus: 2-s2.0-85129269602 (10)

11573/1614983 - 2022 - VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor
Romeo, M. A.; Gilardini Montani, M. S.; Benedetti, R.; Arena, A.; D'orazi, G.; Cirone, M. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-14 - issn: 1661-6596 - wos: WOS:000772044700001 (11) - scopus: 2-s2.0-85124907434 (12)

11573/1627726 - 2022 - The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells
Romeo, M. A.; Gilardini Montani, M. S.; Benedetti, R.; Arena, A.; Gaeta, A.; Cirone, M. - 01a Articolo in rivista
rivista: VIRUS RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-9 - issn: 0168-1702 - wos: WOS:000777670800001 (2) - scopus: 2-s2.0-85125851175 (1)

11573/1659739 - 2022 - c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway
Romeo, Maria Anele; Gilardini Montani, Maria Saveria; Arena, Andrea; Benedetti, Rossella; D’Orazi, Gabriella; Cirone, Mara - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel : MDPI) pp. 1-13 - issn: 2227-9059 - wos: WOS:000872167900001 (1) - scopus: 2-s2.0-85140649876 (1)

11573/1587474 - 2021 - New insights into curcumin-and resveratrol-mediated anti-cancer effects
Arena, A.; Romeo, M. A.; Benedetti, R.; Masuelli, L.; Bei, R.; Gilardini Montani, M. S.; Cirone, M. - 01a Articolo in rivista
rivista: PHARMACEUTICALS (Basel : MDPI, Molecular Diversity Preservation International, 2004-) pp. 1-12 - issn: 1424-8247 - wos: WOS:000727825100001 (22) - scopus: 2-s2.0-85117921973 (25)

11573/1577796 - 2021 - Role of upr sensor activation in cell death–survival decision of colon cancer cells stressed by dpe treatment
Benedetti, R.; Gilardini Montani, M. S.; Romeo, M. A.; Arena, A.; Santarelli, R.; D'orazi, G.; Cirone, M. - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel : MDPI) pp. 1-14 - issn: 2227-9059 - wos: WOS:000699083100001 (10) - scopus: 2-s2.0-85115785094 (10)

11573/1551365 - 2021 - PGE2 released by pancreatic cancer cells undergoing ER stress transfers the stress to DCs impairing their immune function
Gilardini Montani, M. S.; Benedetti, R.; Piconese, S.; Pulcinelli, F. M.; Timperio, A. M.; Romeo, M. A.; Masuelli, L.; Mattei, M.; Bei, R.; D'orazi, G.; Cirone, M. - 01a Articolo in rivista
rivista: MOLECULAR CANCER THERAPEUTICS (Philadelphia, PA : American Association for Cancer Research, c2001-) pp. 934-945 - issn: 1535-7163 - wos: WOS:000648517900015 (12) - scopus: 2-s2.0-85105258016 (12)

11573/1542801 - 2021 - Ire1 alpha/xbp1 axis sustains primary effusion lymphoma cell survival by promoting cytokine release and stat3 activation
Gonnella, R.; Gilardini Montani, M. S.; Guttieri, L.; Romeo, M. A.; Santarelli, R.; Cirone, M. - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel : MDPI) pp. 1-11 - issn: 2227-9059 - wos: WOS:000622162300001 (18) - scopus: 2-s2.0-85100188279 (17)

11573/1542820 - 2021 - p53-R273H Sustains ROS, Pro-Inflammatory Cytokine Release and mTOR Activation While Reducing Autophagy, Mitophagy and UCP2 Expression, Effects Prevented by wtp53
Romeo, M. A.; Gilardini Montani, M. S.; Benedetti, R.; Arena, A.; D'orazi, G.; Cirone, M. - 01a Articolo in rivista
rivista: BIOMOLECULES (Basel: MDPI) pp. 1-14 - issn: 2218-273X - wos: WOS:000633432800001 (5) - scopus: 2-s2.0-85101254797 (4)

11573/1581319 - 2021 - Anticancer effect of AZD2461 PARP inhibitor against colon cancer cells carrying wt or dysfunctional p53
Romeo, M. A.; Gilardini Montani, M. S.; Benedetti, R.; Arena, A.; Maretto, M.; Bassetti, E.; Caiazzo, R.; D'orazi, G.; Cirone, M. - 01a Articolo in rivista
rivista: EXPERIMENTAL CELL RESEARCH (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 1-9 - issn: 0014-4827 - wos: WOS:000708776900014 (10) - scopus: 2-s2.0-85116884973 (9)

11573/1542828 - 2021 - The cross-talk between STAT1/STAT3 and ROS up-regulates PD-L1 and promotes the release of pro-inflammatory/immune suppressive cytokines in primary monocytes infected by HHV-6B
Romeo, M. A.; Gilardini Montani, M. S.; Benedetti, R.; Giambelli, L.; D'aprile, R.; Gaeta, A.; Faggioni, A.; Cirone, M. - 01a Articolo in rivista
rivista: VIRUS RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-6 - issn: 0168-1702 - wos: WOS:000604213400010 (11) - scopus: 2-s2.0-85097384111 (10)

11573/1577880 - 2021 - Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross-talk with p53 to activate p21
Santarelli, R.; Pompili, C.; Gilardini Montani, M. S.; Romeo, M. A.; Gonnella, R.; D'orazi, G.; Cirone, M. - 01a Articolo in rivista
rivista: IUBMB LIFE (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 968-977 - issn: 1521-6543 - wos: WOS:000652534200001 (6) - scopus: 2-s2.0-85106304315 (6)

11573/1410146 - 2020 - KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
Gilardini Montani, M. S.; Falcinelli, L.; Santarelli, R.; Granato, M.; Romeo, M. A.; Cecere, N.; Gonnella, R.; D'orazi, G.; Faggioni, A.; Cirone, M. - 01a Articolo in rivista
rivista: BRITISH JOURNAL OF CANCER (London: Springer Nature Basingstoke Hampshire UK: 3 London: H K Lewis and Co Ltd, 1947-) pp. 1-9 - issn: 0007-0920 - wos: WOS:000534399300003 (21) - scopus: 2-s2.0-85084978969 (20)

11573/1410107 - 2020 - PBA preferentially impairs cell survival of glioblastomas carrying mutp53 by reducing its expression level, stabilizing wtp53, downregulating the mevalonate kinase and dysregulating UPR
Romeo, M. A.; Gilardini Montani, M. S.; Benedetti, R.; Garufi, A.; D'orazi, G.; Cirone, M. - 01a Articolo in rivista
rivista: BIOMOLECULES (Basel: MDPI) pp. 1-11 - issn: 2218-273X - wos: WOS:000539492400092 (4) - scopus: 2-s2.0-85083418218 (4)

11573/1447617 - 2020 - STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway
Romeo, M. A.; Gilardini Montani, M. S.; Benedetti, R.; Santarelli, R.; D'orazi, G.; Cirone, M. - 01a Articolo in rivista
rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. 1-11 - issn: 2234-943X - wos: WOS:000555932000001 (20) - scopus: 2-s2.0-85088513415 (20)

11573/1546732 - 2020 - Viral Infection and Autophagy Dysregulation. The Case of HHV-6, EBV and KSHV
Romeo, M. A.; Santarelli, R.; Gilardini Montani, M. S.; Gonnella, R.; Benedetti, R.; Faggioni, A.; Cirone, M. - 01g Articolo di rassegna (Review)
rivista: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 1-8 - issn: 2073-4409 - wos: WOS:000601802000001 (6) - scopus: 2-s2.0-85097915798 (7)

11573/1374144 - 2020 - HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease
Romeo, Maria Anele; Gilardini Montani, M. S.; Gaeta, A.; D'orazi, G.; Faggioni, A.; Cirone, M. - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-8 - issn: 0925-4439 - wos: WOS:000510504400007 (20) - scopus: 2-s2.0-85076694510 (21)

11573/1426937 - 2020 - KSHV dysregulates bulk macroautophagy, mitophagy and UPR to promote endothelial to mesenchymal transition and CCL2 release, key events in viral-driven sarcomagenesis
Santarelli, Roberta; Arteni, Ana Maria Brindusa; Gilardini Montani, Maria Saveria; Romeo, Maria Anele; Gaeta, Aurelia; Gonnella, Roberta; Faggioni, Alberto; Cirone, Mara - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF CANCER (Hoboken N.J.: Wiley New York NY: Wiley-Liss) pp. 1-12 - issn: 0020-7136 - wos: WOS:000551168700001 (14) - scopus: 2-s2.0-85088397694 (15)

11573/1325331 - 2019 - Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy
Gilardini Montani, M. S.; Falcinelli, L.; Santarelli, R.; Romeo, M. A.; Granato, M.; Faggioni, A.; Cirone, M. - 01a Articolo in rivista
rivista: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. - - issn: 1357-2725 - wos: WOS:000483649800008 (5) - scopus: 2-s2.0-85067888885 (5)

11573/1277323 - 2019 - Mutant p53, stabilized by its interplay with HSP90, activates a positive feed-back loop between NRF2 and p62 that induces chemio-resistance to Apigenin in pancreatic cancer cells
Gilardini Montani, Ms; Cecere, N; Granato, M; Romeo, Ma; Falcinelli, L; Ciciarelli, U; D'orazi, G; Faggioni, A; Cirone, M - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000472738300116 (41) - scopus: 2-s2.0-85067192294 (48)

11573/1353969 - 2019 - Quercetin interrupts the positive feedback loop between STAT3 and IL-6, promotes autophagy, and reduces ROS, preventing EBV-driven B cell immortalization
Granato, M.; Gilardini Montani, M. S.; Zompetta, C.; Santarelli, R.; Gonnella, R.; Romeo, M. A.; D'orazi, G.; Faggioni, A.; Cirone, M. - 01a Articolo in rivista
rivista: BIOMOLECULES (Basel: MDPI) pp. - - issn: 2218-273X - wos: WOS:000489102800094 (25) - scopus: 2-s2.0-85072585581 (27)

11573/1353967 - 2019 - HHV-6B reduces autophagy and induces ER stress in primary monocytes impairing their survival and differentiation into dendritic cells
Romeo, M. A.; Gilardini Montani, M. S.; Falcinelli, L.; Gaeta, A.; Nazzari, C.; Faggioni, A.; Cirone, M. - 01a Articolo in rivista
rivista: VIRUS RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-7 - issn: 0168-1702 - wos: WOS:000493220800005 (11) - scopus: 2-s2.0-85072241353 (12)

11573/1277319 - 2019 - Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease?
Romeo, Ma; Faggioni, A; Cirone, M - 01a Articolo in rivista
rivista: NEURAL REGENERATION RESEARCH (Shenyang : Publishing House of Neural Regeneration Research.) pp. - - issn: 1673-5374 - wos: WOS:000468060200006 (15) - scopus: 2-s2.0-85065851659 (17)

11573/1212285 - 2019 - Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress
Romeo, Maria Anele; Masuelli, Laura; Gaeta, Aurelia; Nazzari, Cristina; Granato, Marisa; Gilardini Montani, Maria Saveria; Faggioni, Alberto; Cirone, Mara - 01a Articolo in rivista
rivista: JOURNAL OF GENERAL VIROLOGY (Society for General Microbiology:Marlboro House, Basingstoke Road, Spencers Wood, Reading RG7 1AE United Kingdom:011 44 118 9881814, EMAIL: d.smith@sgm.ac.ukadmin@socgenmicrobiol.org.uk, INTERNET: http://www.sgm.ac.uk, Fax: 011 44 118 9885656) pp. - - issn: 0022-1317 - wos: WOS:000454716800011 (21) - scopus: 2-s2.0-85059381446 (22)

11573/1277339 - 2019 - Stat3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation
Santarelli, R; Carillo, V; Romeo, Ma; Gaeta, A; Nazzari, C; Gonnella, R; Granato, M; D'orazi, G; Faggioni, A; Cirone, M - 01a Articolo in rivista
rivista: VIROLOGY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 137-143 - issn: 0042-6822 - wos: WOS:000459526400015 (18) - scopus: 2-s2.0-85060047040 (18)

11573/1026134 - 2017 - Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation
Granato, Marisa; Gilardini Montani, Maria Saveria; Romeo, Maria Anele; Santarelli, Roberta; Gonnella, Roberta; D'orazi, Gabriella; Faggioni, Alberto; Cirone, Mara - 01a Articolo in rivista
rivista: CELLULAR SIGNALLING (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 239-247 - issn: 0898-6568 - wos: WOS:000414620900025 (21) - scopus: 2-s2.0-85030310970 (23)

11573/1026126 - 2017 - Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy
Granato, Marisa; Romeo, Maria Anele; Tiano, Mariangela Sara; Santarelli, Roberta; Gonnella, Roberta; Gilardini Montani, Maria Saveria; Faggioni, Alberto; Cirone, Mara - 01a Articolo in rivista
rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000412950600043 (28) - scopus: 2-s2.0-85031301053 (31)

11573/895980 - 2016 - Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma
Granato, Marisa; Rizzello, Celeste; Romeo, Maria Anele; Yadav, Shivangi; Santarelli, Roberta; D'orazi, Gabriella; Faggioni, Alberto; Cirone, Mara - 01a Articolo in rivista
rivista: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 393-400 - issn: 1357-2725 - wos: WOS:000386985900042 (45) - scopus: 2-s2.0-84987936801 (53)

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