Dottore di ricerca

ciclo: XXXV


Abstract The intricate relationship between age at onset, underlying pathophysiology, and disease progression in Parkinson's disease (PD) has yet to be fully elucidated, particularly during the early stages of the illness. In our retrospective study, we aimed to explore the clinical presentation and progression of both motor and non-motor symptoms, as well as complications associated with treatment within the first five years following disease onset among individuals stratified by age. We classified 131 participants into "Early-Onset PD" (EOPD; onset before 50 years), "Middle-Onset PD" (MOPD; onset between 50-69 years), and "Late-Onset PD" (LOPD; onset after 70 years) groups. The T0 visit coincided with the clinical diagnosis, while the T1 visit occurred five years (±5 months) later. At T0, the groups exhibited no significant disparities in motor characteristics. However, by T1, LOPD patients displayed a markedly higher occurrence of gait dysfunction and postural instability. Moreover, LOPD participants demonstrated a significantly elevated prevalence of non-motor symptoms, particularly within the cardiovascular, cognitive, and neuropsychiatric spheres. Our research underscores a notably divergent progression of motor and non-motor symptoms during the early phase of PD, contingent upon age at onset. These insights help clarify the role of age at onset in disease progression, inform the design of tailored pharmacological and non-pharmacological approaches for PD management, and implement specialised rehabilitation strategies. Keywords: age at onset; motor symptoms; non-motor symptoms; Late-Onset PD; Middle-Onset PD; Early-Onset PD; Parkinson's disease.

Produzione scientifica

11573/1606425 - 2023 - Identification of gait unbalance and fallers among subjects with cerebellar ataxia by a set of trunk acceleration-derived indices of gait
Castiglia, Stefano Filippo; Trabassi, Dante; Tatarelli, Antonella; Ranavolo, Alberto; Varrecchia, Tiwana; Fiori, Lorenzo; Di Lenola, Davide; Cioffi, Ettore; Raju, Manikandan; Coppola, Gianluca; Caliandro, Pietro; Casali, Carlo; Serrao, Mariano - 01a Articolo in rivista
rivista: THE CEREBELLUM (New York: Springer London: Martin Dunitz Ltd, 2002-) pp. - - issn: 1473-4222 - wos: WOS:000746782400001 (17) - scopus: 2-s2.0-85123493466 (13)

11573/1664957 - 2023 - Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
De Carolis, Lanfranco; Galli, Silvia; Bianchini, Edoardo; Rinaldi, Domiziana; Raju, Manikandan; Caliò, Bianca; Alborghetti, Marika; Pontieri, Francesco E. - 01a Articolo in rivista
rivista: BRAIN SCIENCES (Basel: Molecular Diversity Preservation International) pp. 157- - issn: 2076-3425 - wos: WOS:000938373600001 (2) - scopus: 2-s2.0-85148855591 (2)

11573/1622161 - 2022 - Clinical effectiveness of focal muscle vibration on gait and postural stability in individuals with neurological disorders: A systematic review
Alashram, Anas R.; Padua, Elvira; Romagnoli, Cristian; Raju, Manikandan; Annino, Giuseppe - 01g Articolo di rassegna (Review)
rivista: PHYSIOTHERAPY RESEARCH INTERNATIONAL (ONLINE) (London ; Lawrence, KS : Whurr Publishers, [1996]-) pp. 1-13 - issn: 1471-2865 - wos: WOS:000767943700001 (2) - scopus: 2-s2.0-85126107141 (3)

11573/1622168 - 2022 - "Transcranial direct current stimulation for upper extremity spasticity rehabilitation in stroke survivors: A systematic review of randomized controlled trials"
Alashram, Anas; Padua, Elvira; Abrub, Aseel; Raju, Manikandan; Annino, Giuseppe - 01g Articolo di rassegna (Review)
rivista: PM & R ([Hoboken NJ]: Wiley New York NY: Elsevier) pp. 1-23 - issn: 1934-1563 - wos: WOS:000798478300001 (9) - scopus: 2-s2.0-85130292815 (10)

11573/1668040 - 2022 - Proprioceptive Focal Stimulation (Equistasi") for gait and postural balance rehabilitation in patients with Parkinson’s disease: A systematic review
R Alashram, Anas; Annino, Giuseppe; Romagnoli, Cristian; Raju, Manikandan; Padua, Elvira - 01g Articolo di rassegna (Review)
rivista: PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS. PART H, JOURNAL OF ENGINEERING IN MEDICINE (Professional Engineering Publications:PO Box 24 Northgate Avenue, Bury St. Edmunds, IP32 6BW United Kingdom:011 44 1284 718681, 011 44 1284 724384, EMAIL:, INTERNET:, Fax: 011 44 1284 704006) pp. 1-12 - issn: 0954-4119 - wos: WOS:000898307600001 (2) - scopus: 2-s2.0-85144229955 (2)

11573/1607908 - 2021 - Effects of Repetitive Transcranial Magnetic Stimulation on Upper Extremity Spasticity Post-Stroke: A Systematic Review
Alashram , Anas R.; Padua, Elvira; Romagnoli, Cristian; Raju, Manikandan; Annino, Giuseppe - 01g Articolo di rassegna (Review)
rivista: PHYSIKALISCHE MEDIZIN REHABILITATIONSMEDIZIN KURORTMEDIZIN (Georg Thieme Verlag Stuttgart:Postfach 301120, D-70451 Stuttgart Germany:011 49 711 8931321, EMAIL:, INTERNET:, Fax: 011 49 711 8931422) pp. 1-10 - issn: 0940-6689 - wos: WOS:000730417300001 (5) - scopus: 2-s2.0-85122007454 (6)

11573/1607910 - 2021 - Transcutaneous spinal cord stimulation effects on spasticity in patients with spinal cord injury: A systematic review
R Alashram, Anas; Padua, Elvira; Raju, Manikandan; Romagnoli, Cristian; Annino, Giuseppe - 01g Articolo di rassegna (Review)
rivista: THE JOURNAL OF SPINAL CORD MEDICINE (American Paraplegia Society:7520 Astoria Boulevard:Jackson Heights, NY 11370:(718)803-3782, EMAIL: aps@UnitedSpinal.ORG, INTERNET:, Fax: (718)803-0414) pp. 1-9 - issn: 1079-0268 - wos: WOS:000725463700001 (8) - scopus: 2-s2.0-85120893319 (4)

11573/1542189 - 2021 - Rehabilitation of limb apraxia in patients following stroke: a systematic review
Radi Alashram, Anas; Annino, Giuseppe; Aldajah, Salameh; Raju, Manikandan; Padua, Elvira - 01g Articolo di rassegna (Review)
rivista: APPLIED NEUROPSYCHOLOGY. ADULT (Philadelphia, PA: Taylor & Francis Group) pp. - - issn: 2327-9095 - wos: WOS:000640138700001 (6) - scopus: 2-s2.0-85104419150 (5)

11573/1443027 - 2020 - Effects of physical therapy interventions on balance ability in people with traumatic brain injury: A systematic review
Raju, Manikandan - 01g Articolo di rassegna (Review)
rivista: NEUROREHABILITATION (Amsterdam Netherlands: IOS Press Reading MA: Andover Medical Publishers) pp. 1-12 - issn: 1053-8135 - wos: WOS:000550036100002 (12) - scopus: 2-s2.0-85088249342 (14)

11573/1467956 - 2020 - Practical Operating Theatre Management: Measuring and Improving Performance and Patient Experience
Raju, Manikandan - 01d Recensione
rivista: EUROPEAN JOURNAL OF ANAESTHESIOLOGY (Editore attuale GREENWICH MEDICAL MEDIA LTD, 137 EUSTON RD, 4TH FLOOR, LONDON, ENGLAND, NW1 2AA -Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL:, INTERNET:, Fax: 011 44 1865 721205) pp. 1-2 - issn: 0265-0215 - wos: WOS:000517084400019 (0) - scopus: (0)

11573/1443029 - 2019 - Re-awakening the carotid bodies after anaesthesia: managing hypnotic and neuromuscular blocking agents
Raju, Manikandan - 01m Editorial/Introduzione in rivista
rivista: ANAESTHESIA (-London : Academic Press ; New York ; San Francisco : Grune & Stratton, 1946- - London : W.B. Saunders - Oxford : Blackwell Science) pp. 1-4 - issn: 0003-2409 - wos: WOS:000512575200003 (7) - scopus: 2-s2.0-85070811265 (6)

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma