LUIGI SAMPIRISI

PhD Graduate

PhD program:: XXXVI


supervisor: Santoro A.
advisor: Santoro A.
co-supervisor: dimarcotullio L.

Thesis title: The role of MEX3A in glioma as a biomarker and prognostic marker

Abstract Background: Gliomas are the most common primary brain tumor often associated with treatment resistance and poor prognosis. Gliomas engage various mechanisms to promote its progression and among these, the post-transcriptional factors with a deregulated expression of non-coding RNAs having been implicated in onset, progression, invasiveness, and recurrence. MEX3A participates in the degradation or inhibition of mRNA by ubiquitination and various studies provided evidence that it plays an important role in the occurrence and development of gliomas. However, at present there are no in vivo studies that correlate MEX3A expression with the clinical and molecular characteristics of diagnosed gliomas. Methods: We performed an observational study of a consecutive series of surgically treated patients suffering from intracranial brain tumors, with the aim to analyze the expression of MEX3A in glioma cells and its correlations with clinical and molecular aspects. Results: The final cohort consisted in 76 patients with histologically diagnosed glioma, 46 males and 30 females. We identified a positive correlation with age, namely that patients over 64 years old had higher MEX3A expression (27/44, 61.3%, p=0.028). We found the correlation with EGFR expression where 17/27 patients (63%) had high expression of MEX3A. Mex3A also appears to be significantly related to tumor grading (p=0.05) and cell replication index identified as ki67 % expression where for values above 20% there was high expression (24/41 patients, 59%, p=0.02). Conclusions: Our study highlights the relationship between MEX3A expression with clinical and molecular characteristics of a large series of glioma-patients, identifying how its expression correlates closely with patient age, tumor grading, cell replication index, and EGFR expression, suggesting its role as a tumor marker and negative prognostic factor.

Research products

11573/1655722 - 2022 - Extradural Clinoidectomy in Clinoidal Meningiomas: Analysis of the Surgical Technique and Evaluation of the Clinical Outcome
Sampirisi, Luigi; D’Angelo, Luca; Palmieri, Mauro; Pesce, Alessandro; Santoro, Antonio - 01a Articolo in rivista
paper: TOMOGRAPHY (Basel: MDPI Ann Arbor Michigan: Grapho Publications LLC, [2015]-) pp. 2360-2368 - issn: 2379-139X - wos: WOS:000873468000001 (2) - scopus: 2-s2.0-85140599881 (3)

11573/1363095 - 2021 - A rare case of spinal epidural sarcoidosis: case report and review of the literature
Paglia, F.; D'angelo, L.; Armocida, D.; Sampirisi, L.; Giangaspero, F.; De Vincentiis, L.; Santoro, A. - 01a Articolo in rivista
paper: ACTA NEUROLOGICA BELGICA (Association for the Society of Scientifique Medica Belgique:Weldadigheidsstraat 49, 3000 Leuven Belgium:011 32 16 232000, EMAIL: acta.cardiologica@chello.be, INTERNET: http://www.ulb.ac.be/medecine/loce/amb.htm, Fax: 011 32 16 231800) pp. 415-420 - issn: 0300-9009 - wos: WOS:000628751700014 (3) - scopus: 2-s2.0-85068848133 (4)

11573/1384478 - 2020 - The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i
Bufalieri, F.; Caimano, M.; Severini, L. L.; Basili, I.; Paglia, F.; Sampirisi, L.; Loricchio, E.; Petroni, M.; Canettieri, G.; Santoro, A.; D'angelo, L.; Infante, P.; Di Marcotullio, L. - 01a Articolo in rivista
paper: CANCERS (Basel: MDPI) pp. 321- - issn: 2072-6694 - wos: WOS:000522477300067 (42) - scopus: 2-s2.0-85079068523 (40)

11573/1473068 - 2020 - Role of endoscopic surgical biopsy in diagnoses of intraventricular/periventricular tumors: review of literature including a monocentric case series
D'angelo, L.; Armocida, D.; Sampirisi, L.; Paglia, F.; Berra, L. V.; Santoro, A. - 01g Articolo di rassegna (Review)
paper: ACTA NEUROLOGICA BELGICA (Association for the Society of Scientifique Medica Belgique:Weldadigheidsstraat 49, 3000 Leuven Belgium:011 32 16 232000, EMAIL: acta.cardiologica@chello.be, INTERNET: http://www.ulb.ac.be/medecine/loce/amb.htm, Fax: 011 32 16 231800) pp. 517-530 - issn: 0300-9009 - wos: WOS:000516934500002 (7) - scopus: 2-s2.0-85080118187 (8)

11573/1473088 - 2019 - Atypical manifestation of direct low-flow carotid-cavernous fistula. Case report and review of the literature
D'angelo, L.; Paglia, F.; Caporlingua, A.; Sampirisi, L.; Guidetti, G.; Santoro, A. - 01g Articolo di rassegna (Review)
paper: WORLD NEUROSURGERY (Amsterdam : Elsevier) pp. 456-460 - issn: 1878-8750 - wos: WOS:000466491700237 (7) - scopus: 2-s2.0-85063261996 (9)

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